www.multichannelsystems.com

Innovations in Electrophysiology

Cardiac myocytes

Abbate E, Boulakia M, Coudière Y, Gerbeau J-F, Zitoun P, Zemzemi N (2017) In silico assessment of the effects of various compounds in MEA/hiPSC-CM assays: Modelling and numerical simulations. In: Inria.

Can UI, Nagarajan N, Vural DC, Zorlutuna P (2017) Muscle-Cell-Based “Living Diodes”. Advanced Biosystems 1:n/a-n/a.

Giacomelli E, Bellin M, Sala L, van Meer BJ, Tertoolen LGJ, Orlova VV, Mummery CL (2017) Three-dimensional cardiac microtissues composed of cardiomyocytes and endothelial cells co-differentiated from human pluripotent stem cells. Development 144:1008-1017.

Goineau S, Castagne V (2017) Proarrhythmic risk assessment using conventional and new in vitro assays. Regul Toxicol Pharmacol 88:1-11.

Hulsmann J, Aubin H, Wehrmann A, Lichtenberg A, Akhyari P (2017) The impact of left ventricular stretching in model cultivations with neonatal cardiomyocytes in a whole-heart bioreactor. Biotechnol Bioeng 114:1107-1117.

Kienast R, Handler M, Stoger M, Baumgarten D, Hanser F, Baumgartner C (2017) Modeling hypothermia induced effects for the heterogeneous ventricular tissue from cellular level to the impact on the ECG. PLoS ONE 12:e0182979.

Koh CH, Wu J, Chung YY, Liu Z, Zhang RR, Chong K, Korzh V, Ting S, Oh S, Shim W, Tian HY, Wei H (2017) Electronic supplementary materialIdentification of a Na+/K+-ATPase inhibition-independent proarrhythmic ionic mechanisms of cardiac glycosides. Sci Rep 7:2465.

Kuroda Y, Yuasa S, Watanabe Y, Ito S, Egashira T, Seki T, Hattori T, Ohno S, Kodaira M, Suzuki T, Hashimoto H, Okata S, Tanaka A, Aizawa Y, Murata M, Aiba T, Makita N, Furukawa T, Shimizu W, Kodama I, Ogawa S, Kokubun N, Horigome H, Horie M, Kamiya K, Fukuda K (2017) Flecainide ameliorates arrhythmogenicity through NCX flux in Andersen-Tawil syndrome-iPS cell-derived cardiomyocytes. Biochemistry and Biophysics Reports 9:245-256.

Kuusela J, Larsson K, Shah D, Prajapati C, Aalto-Setala K (2017) Low extracellular potassium prolongs repolarization and evokes early afterdepolarization in human induced pluripotent stem cell-derived cardiomyocytes. Biol Open 6:777-784.

Li B, Yang H, Wang X, Zhan Y, Sheng W, Cai H, Xin H, Liang Q, Zhou P, Lu C, Qian R, Chen S, Yang P, Zhang J, Shou W, Huang G, Liang P, Sun N (2017) Engineering human ventricular heart muscles based on a highly efficient system for purification of human pluripotent stem cell-derived ventricular cardiomyocytes. Stem Cell Res Ther 8:202.

Lin ZC, McGuire AF, Burridge PW, Matsa E, Lou H-Y, Wu JC, Cui B (2017) Accurate nanoelectrode recording of human pluripotent stem cell-derived cardiomyocytes for assaying drugs and modeling disease. Microsystems & Nanoengineering 3:16080.

Marcoux D, Xiao H-Y, Murali Dhar TG, Xie J, Lehman-McKeeman LD, Wu D-R, Dabros M, Yang X, Taylor TL, Zhou XD, Heimrich EM, Thomas R, McIntyre KW, Shi H, Levesque PC, Sun H, Yang Z, Marino AM, Cornelius G, D'Arienzo CJ, Gupta A, Pragalathan B, Rampulla R, Mathur A, Shen DR, Cvijic ME, Salter-Cid L, Lombardo LJ, Carter PH, Dyckman AJ (2017) Identification of potent tricyclic prodrug S1P1 receptor modulators. MedChemComm.

Park S-J, Kim K-H, Jeon W-Y, Seo J, Han J-M, Kim J-S, Chung H-M, Lee J-H, Moon S-H, Kim H-H (2017) Enzyme catalyzed electrostimulation of human embryonic stem cell-derived cardiomyocytes influence contractility and synchronization. Biochemical Engineering Journal 123:95-109.

Protze SI, Liu J, Nussinovitch U, Ohana L, Backx PH, Gepstein L, Keller GM (2017) Sinoatrial node cardiomyocytes derived from human pluripotent cells function as a biological pacemaker. Nat Biotechnol 35:56-68.

Sala L, Ward-van Oostwaard D, Tertoolen LGJ, Mummery CL, Bellin M (2017) Electrophysiological Analysis of human Pluripotent Stem Cell-derived Cardiomyocytes (hPSC-CMs) Using Multi-electrode Arrays (MEAs).e55587.

Schürlein S, Al Hijailan R, Weigel T, Kadari A, Rücker C, Edenhofer F, Walles H, Hansmann J (2017) Generation of a Human Cardiac Patch Based on a Reendothelialized Biological Scaffold (BioVaSc). Advanced Biosystems 1:1600005-n/a.

Shen N, Knopf A, Westendorf C, Kraushaar U, Riedl J, Bauer H, Pöschel S, Layland SL, Holeiter M, Knolle S, Brauchle E, Nsair A, Hinderer S, Schenke-Layland K (2017) Steps toward Maturation of Embryonic Stem Cell-Derived Cardiomyocytes by Defined Physical Signals. Stem Cell Reports 9:122-135.

Smit NW, Cócera Ortega L, Végh AMD, Meijborg VMF, Smits AM, Klerk M, Tijsen AJM, Tan HL, Goumans M-JHT, Boink GJJ, Coronel R (2017) Human Cardiomyocyte Progenitor Cells in Co-culture with Rat Cardiomyocytes Form a Pro-arrhythmic Substrate: Evidence for Two Different Arrhythmogenic Mechanisms. Frontiers in Physiology 8.

Smit NW, Ten Sande JN, Parvizi M, van Amersfoorth SCM, Plantinga JA, van Spreuwel-Goossens C, van Dongen E, van Dessel P, Kluijtmans S, Meijborg VMF, de Bakker JMT, Harmsen MC, Coronel R (2017) Recombinant human collagen-based microspheres mitigate cardiac conduction slowing induced by adipose tissue-derived stromal cells. PLoS ONE 12:e0183481.

Ten Sande JN, Smit NW, Parvizi M, van Amersfoorth SC, Plantinga JA, van Dessel PF, de Bakker JM, Harmsen MC, Coronel R (2017) Differential Mechanisms of Myocardial Conduction Slowing by Adipose Tissue-Derived Stromal Cells Derived from Different Species. Stem Cells Transl Med 6:22-30.

Tertoolen LG, Braam SR, van Meer BJ, Passier R, Mummery CL (2017) Interpretation of field potentials measured on a multi electrode array in pharmacological toxicity screening on primary and human pluripotent stem cell-derived cardiomyocytes. Biochem Biophys Res Commun.

Tixier E, Raphel F, Lombardi D, Gerbeau J-F (2017) Optimal Biomarkers Design for Drug Safety Evaluation Using Microelectrode Array Measurements. In.

Vuorenpaa H, Penttinen K, Heinonen T, Pekkanen-Mattila M, Sarkanen JR, Ylikomi T, Aalto-Setala K (2017) Maturation of human pluripotent stem cell derived cardiomyocytes is improved in cardiovascular construct. Cytotechnology.

Wu J, Wang X, Chung YY, Koh CH, Liu Z, Guo H, Yuan Q, Wang C, Su S, Wei H (2017) L-Type Calcium Channel Inhibition Contributes to the Proarrhythmic Effects of Aconitine in Human Cardiomyocytes. PLoS ONE 12:e0168435.

Zhu H, Scharnhorst KS, Stieg AZ, Gimzewski JK, Minami I, Nakatsuji N, Nakano H, Nakano A (2017) Two dimensional electrophysiological characterization of human pluripotent stem cell-derived cardiomyocyte system. Sci Rep 7:43210.

Denning C, Borgdorff V, Crutchley J, Firth KS, George V, Kalra S, Kondrashov A, Hoang MD, Mosqueira D, Patel A, Prodanov L, Rajamohan D, Skarnes WC, Smith JG, Young LE (2016) Cardiomyocytes from human pluripotent stem cells: From laboratory curiosity to industrial biomedical platform. Biochim Biophys Acta 1863:1728-1748.

Dhar TGM, Xiao H-Y, Xie J, Lehman-McKeeman LD, Wu D-R, Dabros M, Yang X, Taylor TL, Zhou XD, Heimrich EM, Thomas R, McIntyre KW, Warrack B, Shi H, Levesque PC, Zhu JL, Hennan J, Balimane P, Yang Z, Marino AM, Cornelius G, D’Arienzo CJ, Mathur A, Shen DR, Cvijic ME, Salter-Cid L, Barrish JC, Carter PH, Dyckman AJ (2016) Identification and Preclinical Pharmacology of BMS-986104: A Differentiated S1P1 Receptor Modulator in Clinical Trials. ACS Medicinal Chemistry Letters 7:283-288.

Feiner R, Engel L, Fleischer S, Malki M, Gal I, Shapira A, Shacham-Diamand Y, Dvir T (2016) Engineered hybrid cardiac patches with multifunctional electronics for online monitoring and regulation of tissue function. Nat Mater.

Hernandez D, Millard R, Sivakumaran P, Wong RC, Crombie DE, Hewitt AW, Liang H, Hung SS, Pebay A, Shepherd RK, Dusting GJ, Lim SY (2016) Electrical Stimulation Promotes Cardiac Differentiation of Human Induced Pluripotent Stem Cells. Stem Cells Int 2016:1718041.

Kuusela J, Kim J, Rasanen E, Aalto-Setala K (2016) The Effects of Pharmacological Compounds on Beat Rate Variations in Human Long QT-Syndrome Cardiomyocytes. Stem Cell Rev.

Kuusela J, Kujala VJ, Kiviaho A, Ojala M, Swan H, Kontula K, Aalto-Setala K (2016) Effects of cardioactive drugs on human induced pluripotent stem cell derived long QT syndrome cardiomyocytes. Springerplus 5:234.

Li J, Minami I, Yu L, Tsuji K, Nakajima M, Qiao J, Suzuki M, Shimono K, Nakatsuji N, Kotera H, Liu L, Chen Y (2016) Extracellular Recordings of Patterned Human Pluripotent Stem Cell-Derived Cardiomyocytes on Aligned Fibers. Stem Cells Int 2016:2634013.

Masse S, Magtibay K, Jackson N, Asta J, Kusha M, Zhang B, Balachandran R, Radisic M, Deno DC, Nanthakumar K (2016) Resolving Myocardial Activation With Novel Omnipolar Electrograms. Circ Arrhythm Electrophysiol 9:e004107.

Matschke V, Piccini I, Schubert J, Wrobel E, Lang F, Matschke J, Amedonu E, Meuth SG, Strunker T, Strutz-Seebohm N, Greber B, Scherkenbeck J, Seebohm G (2016) The Natural Plant Product Rottlerin Activates Kv7.1/KCNE1 Channels. Cell Physiol Biochem 40:1549-1558.

Niehoff J, Matzkies M, Nguemo F, Hescheler J, Reppel M (2016) Beat Rate Variability in Murine Embryonic Stem Cell-Derived Cardiomyocytes: Effect of Antiarrhythmic Drugs. Cell Physiol Biochem 38:646-658.

Nozaki Y, Honda Y, Watanabe H, Saiki S, Koyabu K, Itoh T, Nagasawa C, Nakamori C, Nakayama C, Iwasaki H, Suzuki S, Washio I, Takahashi E, Miyamoto K, Yamanishi A, Endo H, Shinozaki J, Nogawa H, Kunimatsu T (2016) CSAHi study: Validation of multi-electrode array systems (MEA60/2100) for prediction of drug-induced proarrhythmia using human iPS cell-derived cardiomyocytes -assessment of inter-facility and cells lot-to-lot-variability. Regul Toxicol Pharmacol 77:75-86.

Okata S, Yuasa S, Suzuki T, Ito S, Makita N, Yoshida T, Li M, Kurokawa J, Seki T, Egashira T, Aizawa Y, Kodaira M, Motoda C, Yozu G, Shimojima M, Hayashiji N, Hashimoto H, Kuroda Y, Tanaka A, Murata M, Aiba T, Shimizu W, Horie M, Kamiya K, Furukawa T, Fukuda K (2016) Embryonic type Na+ channel beta-subunit, SCN3B masks the disease phenotype of Brugada syndrome. Sci Rep 6:34198.

Rast G, Kraushaar U, Buckenmaier S, Ittrich C, Guth BD (2016) Influence of field potential duration on spontaneous beating rate of human induced pluripotent stem cell-derived cardiomyocytes: Implications for data analysis and test system selection. Journal of Pharmacological and Toxicological Methods 82:74-82.

Sala L, Bellin M, Mummery CL (2016) Integrating cardiomyocytes from human pluripotent stem cells in safety pharmacology: has the time come? Br J Pharmacol.

Trieschmann J, Bettin D, Haustein M, Köster A, Molcanyi M, Halbach M, Hanna M, Fouad M, Brockmeier K, Hescheler J, Pfannkuche K, Hannes T (2016) The Interaction between Adult Cardiac Fibroblasts and Embryonic Stem Cell-Derived Cardiomyocytes Leads to Proarrhythmic Changes in In Vitro Cocultures. Stem Cells International 2016:12.

Asakura K, Hayashi S, Ojima A, Taniguchi T, Miyamoto N, Nakamori C, Nagasawa C, Kitamura T, Osada T, Honda Y, Kasai C, Ando H, Kanda Y, Sekino Y, Sawada K (2015) Improvement of acquisition and analysis methods in multi-electrode array experiments with iPS cell-derived cardiomyocytes. J Pharmacol Toxicol Methods.

Friedrichs S, Malan D, Voss Y, Sasse P (2015) Scalable Electrophysiological Investigation of iPS Cell-Derived Cardiomyocytes Obtained by a Lentiviral Purification Strategy Journal of Clinical Medicine 4:102-123.

Hannes T, Wolff M, Doss MX, Pfannkuche K, Haustein M, Muller-Ehmsen J, Sachinidis A, Hescheler J, Khalil M, Halbach M (2015) Electrophysiological characteristics of embryonic stem cell-derived cardiomyocytes are cell line-dependent. Cell Physiol Biochem 35:305-314.

Nussinovitch U, Gepstein L (2015) Optogenetics for suppression of cardiac electrical activity in human and rat cardiomyocyte cultures. Neurophotonics 2:031204.

Pisano F, Altomare C, Cervio E, Barile L, Rocchetti M, Ciuffreda MC, Malpasso G, Copes F, Mura M, Danieli P, Viarengo G, Zaza A, Gnecchi M (2015) Combination of miRNA499 and miRNA133 exerts a synergic effect on cardiac differentiation. Stem Cells 33:1187-1199.

Rast G, Weber J, Disch C, Schuck E, Ittrich C, Guth BD (2015) An integrated platform for simultaneous multi-well field potential recording and Fura-2-based calcium transient ratiometry in human induced pluripotent stem cell (hiPSC)-derived cardiomyocytes. J Pharmacol Toxicol Methods.

Sallam K, Li Y, Sager PT, Houser SR, Wu JC (2015) Finding the rhythm of sudden cardiac death: new opportunities using induced pluripotent stem cell-derived cardiomyocytes. Circ Res 116:1989-2004.

Shimizu H, Schredelseker J, Huang J, Lu K, Naghdi S, Lu F, Franklin S, Fiji HD, Wang K, Zhu H, Tian C, Lin B, Nakano H, Ehrlich A, Nakai J, Stieg AZ, Gimzewski JK, Nakano A, Goldhaber JI, Vondriska TM, Hajnoczky G, Kwon O, Chen JN (2015) Mitochondrial Ca(2+) uptake by the voltage-dependent anion channel 2 regulates cardiac rhythmicity. Elife 4.

Trantidou T, Terracciano CM, Kontziampasis D, Humphrey EJ, Prodromakis T (2015) Biorealistic cardiac cell culture platforms with integrated monitoring of extracellular action potentials. Sci Rep 5:11067.

Ben-Ari M, Schick R, Barad L, Novak A, Ben-Ari E, Lorber A, Itskovitz-Eldor J, Rosen MR, Weissman A, Binah O (2014) From beat rate variability in induced pluripotent stem cell-derived pacemaker cells to heart rate variability in human subjects. Heart Rhythm.

Bingen BO, Engels MC, Schalij MJ, Jangsangthong W, Neshati Z, Feola I, Ypey DL, Askar SF, Panfilov AV, Pijnappels DA, de Vries AA (2014) Light-induced termination of spiral wave arrhythmias by optogenetic engineering of atrial cardiomyocytes. Cardiovasc Res 104:194-205.

Kienast R, Stoger M, Handler M, Hanser F, Baumgartner C (2014) Alterations of field potentials in isotropic cardiomyocyte cell layers induced by multiple endogenous pacemakers under normal and hypothermal conditions. Am J Physiol Heart Circ Physiol 307:H1013-1023.

Lin ZC, Xie C, Osakada Y, Cui Y, Cui B (2014) Iridium oxide nanotube electrodes for sensitive and prolonged intracellular measurement of action potentials. Nat Commun 5:3206.

Mehta A, Verma V, Nandihalli M, Ramachandra CJ, Sequiera GL, Sudibyo Y, Chung Y, Sun W, Shim W (2014) A systemic evaluation of cardiac differentiation from mRNA reprogrammed human induced pluripotent stem cells. PLoS ONE 9:e103485.

Riedel M, Jou CJ, Lai S, Lux RL, Moreno AP, Spitzer KW, Christians E, Tristani-Firouzi M, Benjamin IJ (2014) Functional and pharmacological analysis of cardiomyocytes differentiated from human peripheral blood mononuclear-derived pluripotent stem cells. Stem Cell Reports 3:131-141.

Xu B, Binczak S, Jacquir S, Pont O, Yahia H (2014) Complexity analysis of experimental cardiac arrhythmia. In: 2014 IEEE Region 10 Technical Symposium (TENSYMP). Kuala Lumpur.

Zhang M, D'Aniello C, Verkerk AO, Wrobel E, Frank S, Ward-van Oostwaard D, Piccini I, Freund C, Rao J, Seebohm G, Atsma DE, Schulze-Bahr E, Mummery CL, Greber B, Bellin M (2014) Recessive cardiac phenotypes in induced pluripotent stem cell models of Jervell and Lange-Nielsen syndrome: disease mechanisms and pharmacological rescue. Proc Natl Acad Sci U S A 111:E5383-5392.

Caspi O, Huber I, Gepstein A, Arbel G, Maizels L, Boulos M, Gepstein L (2013) Modeling of arrhythmogenic right ventricular cardiomyopathy with human induced pluripotent stem cells. Circ Cardiovasc Genet 6:557-568.

Harris K, Aylott M, Cui Y, Louttit JB, McMahon NC, Sridhar A (2013) Comparison of electrophysiological data from human-induced pluripotent stem cell-derived cardiomyocytes to functional preclinical safety assays. Toxicol Sci 134:412-426.

Kapoor N, Liang W, Marban E, Cho HC (2013) Direct conversion of quiescent cardiomyocytes to pacemaker cells by expression of Tbx18. Nat Biotechnol 31:54-62.

Khan JM, Lyon AR, Harding SE (2013) The case for induced pluripotent stem cell-derived cardiomyocytes in pharmacological screening. Br J Pharmacol 169:304-317.

Lehmann M, Nguemo F, Wagh V, Pfannkuche K, Hescheler J, Reppel M (2013) Evidence for a critical role of catecholamines for cardiomyocyte lineage commitment in murine embryonic stem cells. PLoS ONE 8:e70913.

Mandenius CF, Meyer T (2013) HIGH-THROUGHPUT SCREENING ASSAYS TO EVALUATE THE CARDIOTOXIC POTENTIAL OF DRUGS. In: High-Throughput Screening Methods in Toxicity Testing (Steinberg P, ed).

Matsa E, Dixon JE, Medway C, Georgiou O, Patel MJ, Morgan K, Kemp PJ, Staniforth A, Mellor I, Denning C (2013) Allele-specific RNA interference rescues the long-QT syndrome phenotype in human-induced pluripotency stem cell cardiomyocytes. Eur Heart J.

Mureli S, Gans CP, Bare DJ, Geenen DL, Kumar NM, Banach K (2013) Mesenchymal stem cells improve cardiac conduction by upregulation of connexin 43 through paracrine signaling. Am J Physiol Heart Circ Physiol 304:H600-609.

Ohno Y, Yuasa S, Egashira T, Seki T, Hashimoto H, Tohyama S, Saito Y, Kunitomi A, Shimoji K, Onizuka T, Kageyama T, Yae K, Tanaka T, Kaneda R, Hattori F, Murata M, Kimura K, Fukuda K (2013) Distinct iPS Cells Show Different Cardiac Differentiation Efficiency. In: Hindawi Publishing Corporation Stem Cells International.

Pradhapan P, Kuusela J, Viik J, Aalto-Setala K, Hyttinen J (2013) Cardiomyocyte MEA data analysis (CardioMDA)--a novel field potential data analysis software for pluripotent stem cell derived cardiomyocytes. PLoS ONE 8:e73637.

Rubach M, Adelmann R, Haustein M, Drey F, Pfannkuche K, Xiao B, Koester A, Udink Ten Cate FE, Choi YH, Neef K, Fatima A, Hannes T, Pillekamp F, Hescheler J, Saric T, Brockmeier K, Khalil M (2013) Mesenchymal Stem Cells and their Conditioned Medium Improve Integration of purified Induced Pluripotent Stem-Cell Derived Cardiomyocyte Clusters into Myocardial Tissue. Stem Cells Dev.

Xu B, Jacquir S, Laurent G, Bilbault JM, Binczak S (2013) Phase space reconstruction of an experimental model of cardiac field potential in normal and arrhythmic conditions. In: 35th Annual International Conference of the IEEE Engineering in Medicine and Biology Society.

Braam SR, Tertoolen L, Casini S, Matsa E, Lu HR, Teisman A, Passier R, Denning C, Gallacher DJ, Towart R, Mummery CL (2012) Repolarization reserve determines drug responses in human pluripotent stem cell derived cardiomyocytes. Stem Cell Res 10:48-56.

Daus AW, Layer PG, Thielemann C (2012) A spheroid-based biosensor for the label-free detection of drug-induced field potential alterations. Sensors and Actuators B: Chemical 165:53-58.

Enochson L, Sandstedt J, Strandberg H, Emanuelsson C, Ornberg A, Lindahl A, Karlsson C (2012) Triphasic and quadriphasic waveforms are superior to biphasic waveforms for synchronized beating of cardiomyocytes. J Electrocardiol.

Fendyur A, Spira ME (2012) Toward on-chip, in-cell recordings from cultured cardiomyocytes by arrays of gold mushroom-shaped microelectrodes. Front Neuroeng 5:21.

Gizurarson S, Shao Y, Miljanovic A, Ramunddal T, Boren J, Bergfeldt L, Omerovic E (2012) Electrophysiological Effects of Lysophosphatidylcholine on HL-1 Cardiomyocytes Assessed with a Microelectrode Array System. Cell Physiol Biochem 30:477-488.

Kujala K, Ahola A, Pekkanen-Mattila M, Ikonen L, Kerkela E, Hyttinen J, Aalto-Setala K (2012) Electrical Field Stimulation with a Novel Platform: Effect on Cardiomyocyte Gene Expression but not on Orientation. Int J Biomed Sci 8:109-120.

Kujala V, Pekkanen-Mattila M, Aalto-Setala K (2012) Human Pluripotent Stem Cell-Derived Cardiomyocytes: Maturity and Electrophysiology. In: Embryonic Stem Cells - Differentiation and Pluripotent Alternatives (Kallos MS, ed).

Ma Z, Liu Q, Liu H, Yang H, Yun JX, Eisenberg C, Borg TK, Xu M, Gao BZ (2012) Laser-patterned stem-cell bridges in a cardiac muscle model for on-chip electrical conductivity analyses. Lab Chip 12:566-573.

Mandel Y, Weissman A, Schick R, Barad L, Novak A, Meiry G, Goldberg S, Lorber A, Rosen MR, Itskovitz-Eldor J, Binah O (2012) Human embryonic and induced pluripotent stem cell-derived cardiomyocytes exhibit beat rate variability and power-law behavior. Circulation 125:883-893.

Mehta A, Chung YY, Sequiera GL, Wong P, Liew R, Shim W (2012) Pharmaco-Electrophysiology of Viral-Free Induced Pluripotent Stem Cell-Derived Human Cardiomyocytes. Toxicol Sci.

Nick C, Joshi R, Schneider JJ, Thielemann C (2012) Three-dimensional carbon nanotube electrodes for extracellular recording of cardiac myocytes. Biointerphases 7:58.

Sequiera GL, Mehta A, Ooi TH, Shim W (2012) Ontogenic Development of Cardiomyocytes Derived from Transgene-Free Human Induced Pluripotent Stem Cells and Its Homology with Human Heart. Life Sci.

Shao Y, Redfors B, Stahlman M, Tang MS, Miljanovic A, Mollmann H, Troidl C, Szardien S, Hamm C, Nef H, Boren J, Omerovic E (2012) A mouse model reveals an important role for catecholamine-induced lipotoxicity in the pathogenesis of stress-induced cardiomyopathy. Eur J Heart Fail.

Zwi-Dantsis L, Huber I, Habib M, Winterstern A, Gepstein A, Arbel G, Gepstein L (2012) Derivation and cardiomyocyte differentiation of induced pluripotent stem cells from heart failure patients. Eur Heart J.

Abilez OJ, Wong J, Prakash R, Deisseroth K, Zarins CK, Kuhl E (2011) Multiscale computational models for optogenetic control of cardiac function. Biophys J 101:1326-1334.

Askar SF, Ramkisoensing AA, Schalij MJ, Bingen BO, Swildens J, van der Laarse A, Atsma DE, de Vries AA, Ypey DL, Pijnappels DA (2011) Antiproliferative treatment of myofibroblasts prevents arrhythmias in vitro by limiting myofibroblast-induced depolarization. Cardiovasc Res 90:295-304.

Bax NA, Pijnappels DA, van Oorschot AA, Winter EM, de Vries AA, van Tuyn J, Braun J, Maas S, Schalij MJ, Atsma DE, Goumans MJ, Gittenberger-de Groot AC (2011) Epithelial-to-mesenchymal transformation alters electrical conductivity of human epicardial cells. J Cell Mol Med 15:2675-2683.

Daus AW, Goldhammer M, Layer PG, Thielemann C (2011) Electromagnetic exposure of scaffold-free three-dimensional cell culture systems. Bioelectromagnetics 32:351-359.

Elliott DA, Braam SR, Koutsis K, Ng ES, Jenny R, Lagerqvist EL, Biben C, Hatzistavrou T, Hirst CE, Yu QC, Skelton RJ, Ward-van Oostwaard D, Lim SM, Khammy O, Li X, Hawes SM, Davis RP, Goulburn AL, Passier R, Prall OW, Haynes JM, Pouton CW, Kaye DM, Mummery CL, Elefanty AG, Stanley EG (2011) NKX2-5(eGFP/w) hESCs for isolation of human cardiac progenitors and cardiomyocytes. Nat Methods 8:1037-1040.

Grunow B, Wenzel J, Terlau H, Langner S, Gebert M, Kruse C (2011) In vitro developed spontaneously contracting cardiomyocytes from rainbow trout as a model system for human heart research. Cell Physiol Biochem 27:1-12.

Guo L, Abrams RM, Babiarz JE, Cohen JD, Kameoka S, Sanders MJ, Chiao E, Kolaja KL (2011) Estimating the risk of drug-induced proarrhythmia using human induced pluripotent stem cell-derived cardiomyocytes. Toxicol Sci 123:281-289.

Guo L, Qian JY, Abrams R, Tang HM, Weiser T, Sanders MJ, Kolaja KL (2011) The electrophysiological effects of cardiac glycosides in human iPSC-derived cardiomyocytes and in guinea pig isolated hearts. Cell Physiol Biochem 27:453-462.

Hofshi A, Itzhaki I, Gepstein A, Arbel G, Gross GJ, Gepstein L (2011) A combined gene and cell therapy approach for restoration of conduction. Heart Rhythm 8:121-130.

Itzhaki I, Maizels L, Huber I, Zwi-Dantsis L, Caspi O, Winterstern A, Feldman O, Gepstein A, Arbel G, Hammerman H, Boulos M, Gepstein L (2011) Modelling the long QT syndrome with induced pluripotent stem cells. Nature.

Jacquir S, Binczak S, Xu B, Laurent G, Vandroux D, Athias P, Bilbault JM (2011) INVESTIGATION OF MICRO SPIRAL WAVES AT CELLULAR LEVEL USING A MICROELECTRODE ARRAYS TECHNOLOGY. International Journal of Bifurcation and Chaos 21 1:209-223.

Kapoor N, Galang G, Marban E, Cho HC (2011) Transcriptional suppression of Connexin43 by Tbx18 undermines cell-cell electrical coupling in postnatal cardiomyocytes. J Biol Chem.

Kraushaar U, Meyer T, Hess D, Gepstein L, C LM, S RB, Guenther E (2011) Cardiac safety pharmacology: from human ether-a-gogo related gene channel block towards induced pluripotent stem cell based disease models. Expert Opin Drug Saf.

Kujala VJ, Jimenez ZC, Vaisanen J, Tanskanen JM, Kerkela E, Hyttinen J, Aalto-Setala K (2011) Averaging in vitro cardiac field potential recordings obtained with microelectrode arrays. Comput Methods Programs Biomed.

Kujala VJ, Pekkanen-Mattila M, Aalto-Setala K (2011) Human Pluripotent Stem Cell-Derived Cardiomyocytes: Maturity and Electrophysiology. In: Embryonic Stem Cells - Differentiation and Pluripotent Alternatives (Kallos MS, ed).

Lahti AL, Kujala VJ, Chapman H, Koivisto AP, Pekkanen-Mattila M, Kerkela E, Hyttinen J, Kontula K, Swan H, Conklin BR, Yamanaka S, Silvennoinen O, Aalto-Setala K (2011) Model for long QT syndrome type 2 using human iPS cells demonstrates arrhythmogenic characteristics in cell culture. Dis Model Mech.

Mandenius CF, Steel D, Noor F, Meyer T, Heinzle E, Asp J, Arain S, Kraushaar U, Bremer S, Class R, Sartipy P (2011) Cardiotoxicity testing using pluripotent stem cell-derived human cardiomyocytes and state-of-the-art bioanalytics: a review. J Appl Toxicol.

Matsa E, Rajamohan D, Dick E, Young L, Mellor I, Staniforth A, Denning C (2011) Drug evaluation in cardiomyocytes derived from human induced pluripotent stem cells carrying a long QT syndrome type 2 mutation. Eur Heart J.

Mehta A, Chung YY, Ng A, Iskandar F, Atan S, Wei H, Dusting G, Sun W, Wong P, Shim W (2011) Pharmacological response of human cardiomyocytes derived from virus-free induced pluripotent stem cells. Cardiovasc Res 91:577-586.

Natarajan A, Stancescu M, Dhir V, Armstrong C, Sommerhage F, Hickman JJ, Molnar P (2011) Patterned cardiomyocytes on microelectrode arrays as a functional, high information content drug screening platform. Biomaterials 32:4267-4274.

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