www.multichannelsystems.com

Innovations in Electrophysiology

Cardiophysiology

Abbate E, Boulakia M, Coudière Y, Gerbeau J-F, Zitoun P, Zemzemi N (2017) In silico assessment of the effects of various compounds in MEA/hiPSC-CM assays: Modelling and numerical simulations. In: Inria.

Beiert T, Tiyerili V, Knappe V, Effelsberg V, Linhart M, Stöckigt F, Klein S, Schierwagen R, Trebicka J, Nickenig G, Schrickel JW, Andrié RP (2017) Relaxin reduces susceptibility to post-infarct atrial fibrillation in mice due to anti-fibrotic and anti-inflammatory properties. Biochemical and Biophysical Research Communications 490:643-649.

Chandra M, Escalante-Alcalde D, Bhuiyan MS, Orr AW, Kevil C, Morris AJ, Nam H, Dominic P, McCarthy KJ, Miriyala S, Panchatcharam M (2017) Cardiac-specific inactivation of LPP3 in mice leads to myocardial dysfunction and heart failure. Redox Biol 14:261-271.

Ellis BW, Acun A, Can UI, Zorlutuna P (2017) Human iPSC-derived myocardium-on-chip with capillary-like flow for personalized medicine. Biomicrofluidics 11:024105.

Giacomelli E, Bellin M, Sala L, van Meer BJ, Tertoolen LGJ, Orlova VV, Mummery CL (2017) Three-dimensional cardiac microtissues composed of cardiomyocytes and endothelial cells co-differentiated from human pluripotent stem cells. Development 144:1008-1017.

Goineau S, Castagne V (2017) Proarrhythmic risk assessment using conventional and new in vitro assays. Regul Toxicol Pharmacol 88:1-11.

Haldar SK, Magtibay K, Porta-Sanchez A, Masse S, Mitsakakis N, Lai PFH, Azam MA, Asta J, Kusha M, Dorian P, Ha ACT, Chauhan V, Deno DC, Nanthakumar K (2017) Resolving Bipolar Electrogram Voltages During Atrial Fibrillation Using Omnipolar Mapping. Circ Arrhythm Electrophysiol 10.

Hulsmann J, Aubin H, Wehrmann A, Lichtenberg A, Akhyari P (2017) The impact of left ventricular stretching in model cultivations with neonatal cardiomyocytes in a whole-heart bioreactor. Biotechnol Bioeng 114:1107-1117.

Jungen C, Scherschel K, Eickholt C, Kuklik P, Klatt N, Bork N, Salzbrunn T, Alken F, Angendohr S, Klene C, Mester J, Klocker N, Veldkamp MW, Schumacher U, Willems S, Nikolaev VO, Meyer C (2017) Disruption of cardiac cholinergic neurons enhances susceptibility to ventricular arrhythmias. Nat Commun 8:14155.

Kienast R, Handler M, Stoger M, Baumgarten D, Hanser F, Baumgartner C (2017) Modeling hypothermia induced effects for the heterogeneous ventricular tissue from cellular level to the impact on the ECG. PLoS ONE 12:e0182979.

Koh CH, Wu J, Chung YY, Liu Z, Zhang RR, Chong K, Korzh V, Ting S, Oh S, Shim W, Tian HY, Wei H (2017) Electronic supplementary materialIdentification of a Na+/K+-ATPase inhibition-independent proarrhythmic ionic mechanisms of cardiac glycosides. Sci Rep 7:2465.

Kontonika M, Barka E, Roumpi M, La Rocca V, Lekkas P, Daskalopoulos EP, Vilaeti AD, Baltogiannis GG, Vlahos AP, Agathopoulos S, Kolettis TM (2017) Prolonged intra-myocardial growth hormone administration ameliorates post-infarction electrophysiologic remodeling in rats. Growth Factors 35:1-11.

Kuroda Y, Yuasa S, Watanabe Y, Ito S, Egashira T, Seki T, Hattori T, Ohno S, Kodaira M, Suzuki T, Hashimoto H, Okata S, Tanaka A, Aizawa Y, Murata M, Aiba T, Makita N, Furukawa T, Shimizu W, Kodama I, Ogawa S, Kokubun N, Horigome H, Horie M, Kamiya K, Fukuda K (2017) Flecainide ameliorates arrhythmogenicity through NCX flux in Andersen-Tawil syndrome-iPS cell-derived cardiomyocytes. Biochemistry and Biophysics Reports 9:245-256.

Kuusela J, Larsson K, Shah D, Prajapati C, Aalto-Setala K (2017) Low extracellular potassium prolongs repolarization and evokes early afterdepolarization in human induced pluripotent stem cell-derived cardiomyocytes. Biol Open 6:777-784.

Lane JD, Montaigne D, Tinker A (2017) Tissue-Level Cardiac Electrophysiology Studied in Murine Myocardium Using a Microelectrode Array: Autonomic and Thermal Modulation. J Membr Biol.

Li B, Yang H, Wang X, Zhan Y, Sheng W, Cai H, Xin H, Liang Q, Zhou P, Lu C, Qian R, Chen S, Yang P, Zhang J, Shou W, Huang G, Liang P, Sun N (2017) Engineering human ventricular heart muscles based on a highly efficient system for purification of human pluripotent stem cell-derived ventricular cardiomyocytes. Stem Cell Res Ther 8:202.

Lin ZC, McGuire AF, Burridge PW, Matsa E, Lou H-Y, Wu JC, Cui B (2017) Accurate nanoelectrode recording of human pluripotent stem cell-derived cardiomyocytes for assaying drugs and modeling disease. Microsystems & Nanoengineering 3:16080.

Marcoux D, Xiao H-Y, Murali Dhar TG, Xie J, Lehman-McKeeman LD, Wu D-R, Dabros M, Yang X, Taylor TL, Zhou XD, Heimrich EM, Thomas R, McIntyre KW, Shi H, Levesque PC, Sun H, Yang Z, Marino AM, Cornelius G, D'Arienzo CJ, Gupta A, Pragalathan B, Rampulla R, Mathur A, Shen DR, Cvijic ME, Salter-Cid L, Lombardo LJ, Carter PH, Dyckman AJ (2017) Identification of potent tricyclic prodrug S1P1 receptor modulators. MedChemComm.

Marczenke M, Piccini I, Mengarelli I, Fell J, Ropke A, Seebohm G, Verkerk AO, Greber B (2017) Cardiac Subtype-Specific Modeling of Kv1.5 Ion Channel Deficiency Using Human Pluripotent Stem Cells. Front Physiol 8:469.

Park S-J, Kim K-H, Jeon W-Y, Seo J, Han J-M, Kim J-S, Chung H-M, Lee J-H, Moon S-H, Kim H-H (2017) Enzyme catalyzed electrostimulation of human embryonic stem cell-derived cardiomyocytes influence contractility and synchronization. Biochemical Engineering Journal 123:95-109.

Protze SI, Liu J, Nussinovitch U, Ohana L, Backx PH, Gepstein L, Keller GM (2017) Sinoatrial node cardiomyocytes derived from human pluripotent cells function as a biological pacemaker. Nat Biotechnol 35:56-68.

Raphel F, Boulakia M, Zemzemi N, Coudière Y, Guillon J-M, Zitoun P, Gerbeau J-F (2017) Identification of ion currents components generating field potential recorded in MEA from hiPSC-CM. IEEE Transactions on Biomedical Engineering.

Sala L, Ward-van Oostwaard D, Tertoolen LGJ, Mummery CL, Bellin M (2017) Electrophysiological Analysis of human Pluripotent Stem Cell-derived Cardiomyocytes (hPSC-CMs) Using Multi-electrode Arrays (MEAs).e55587.

Schürlein S, Al Hijailan R, Weigel T, Kadari A, Rücker C, Edenhofer F, Walles H, Hansmann J (2017) Generation of a Human Cardiac Patch Based on a Reendothelialized Biological Scaffold (BioVaSc). Advanced Biosystems 1:1600005-n/a.

Shen N, Knopf A, Westendorf C, Kraushaar U, Riedl J, Bauer H, Pöschel S, Layland SL, Holeiter M, Knolle S, Brauchle E, Nsair A, Hinderer S, Schenke-Layland K (2017) Steps toward Maturation of Embryonic Stem Cell-Derived Cardiomyocytes by Defined Physical Signals. Stem Cell Reports 9:122-135.

Smit NW, Cócera Ortega L, Végh AMD, Meijborg VMF, Smits AM, Klerk M, Tijsen AJM, Tan HL, Goumans M-JHT, Boink GJJ, Coronel R (2017) Human Cardiomyocyte Progenitor Cells in Co-culture with Rat Cardiomyocytes Form a Pro-arrhythmic Substrate: Evidence for Two Different Arrhythmogenic Mechanisms. Frontiers in Physiology 8.

Smit NW, Ten Sande JN, Parvizi M, van Amersfoorth SCM, Plantinga JA, van Spreuwel-Goossens C, van Dongen E, van Dessel P, Kluijtmans S, Meijborg VMF, de Bakker JMT, Harmsen MC, Coronel R (2017) Recombinant human collagen-based microspheres mitigate cardiac conduction slowing induced by adipose tissue-derived stromal cells. PLoS ONE 12:e0183481.

Stillitano F, Hansen J, Kong C-W, Karakikes I, Funck-Brentano C, Geng L, Scott S, Reynier S, Wu M, Valogne Y, Desseaux C, Salem J-E, Jeziorowska D, Zahr N, Li R, Iyengar R, Hajjar RJ, Hulot J-S (2017) Modeling susceptibility to drug-induced long QT with a panel of subject-specific induced pluripotent stem cells. Elife 6:e19406.

Stockigt F, Beiert T, Knappe V, Baris OR, Wiesner RJ, Clemen CS, Nickenig G, Andrie RP, Schrickel JW (2017) Aging-related mitochondrial dysfunction facilitates the occurrence of serious arrhythmia after myocardial infarction. Biochem Biophys Res Commun.

Svoboda O, Skopalik J, Baiazitova L, Gabrielova E, Cmiel V, Provaznik I, Fohlerova Z, Hubalik J (2017) An Evaluation of Different Coatings for TiN Microelectrode Chambers used for Neonatal Cardiomyocytes Computing in Cardiology 43.

Ten Sande JN, Smit NW, Parvizi M, van Amersfoorth SC, Plantinga JA, van Dessel PF, de Bakker JM, Harmsen MC, Coronel R (2017) Differential Mechanisms of Myocardial Conduction Slowing by Adipose Tissue-Derived Stromal Cells Derived from Different Species. Stem Cells Transl Med 6:22-30.

Tertoolen LG, Braam SR, van Meer BJ, Passier R, Mummery CL (2017) Interpretation of field potentials measured on a multi electrode array in pharmacological toxicity screening on primary and human pluripotent stem cell-derived cardiomyocytes. Biochem Biophys Res Commun.

Tixier E, Raphel F, Lombardi D, Gerbeau J-F (2017) Optimal Biomarkers Design for Drug Safety Evaluation Using Microelectrode Array Measurements. In.

Vuorenpaa H, Penttinen K, Heinonen T, Pekkanen-Mattila M, Sarkanen JR, Ylikomi T, Aalto-Setala K (2017) Maturation of human pluripotent stem cell derived cardiomyocytes is improved in cardiovascular construct. Cytotechnology.

Wu J, Wang X, Chung YY, Koh CH, Liu Z, Guo H, Yuan Q, Wang C, Su S, Wei H (2017) L-Type Calcium Channel Inhibition Contributes to the Proarrhythmic Effects of Aconitine in Human Cardiomyocytes. PLoS ONE 12:e0168435.

Zhang L, Li X, Yu X, Li Y, Sun A, Huang C, Xu F, Guo J, Sun Y, Zhang X, Yang X, Zhang C (2017) Construction of vascularized pacemaker tissues by seeding cardiac progenitor cells and endothelial progenitor cells into Matrigel. Life Sci 179:139-146.

Zhu H, Scharnhorst KS, Stieg AZ, Gimzewski JK, Minami I, Nakatsuji N, Nakano H, Nakano A (2017) Two dimensional electrophysiological characterization of human pluripotent stem cell-derived cardiomyocyte system. Sci Rep 7:43210.

Ahuja V, Sharma S, Kamboj R (2016) Current Developments in the Use of Human Stem Cell Derived Cardiomyocytes to Examine Drug-induced Cardiotoxicity. In: Issues in Toxicology No. 29, Human Stem Cell Toxicology (Sherley JL, ed).

Cavero I, Guillon JM, Ballet V, Clements M, Gerbeau JF, Holzgrefe H (2016) Comprehensive in vitro Proarrhythmia Assay (CiPA): Pending issues for successful validation and implementation. J Pharmacol Toxicol Methods.

Denning C, Borgdorff V, Crutchley J, Firth KS, George V, Kalra S, Kondrashov A, Hoang MD, Mosqueira D, Patel A, Prodanov L, Rajamohan D, Skarnes WC, Smith JG, Young LE (2016) Cardiomyocytes from human pluripotent stem cells: From laboratory curiosity to industrial biomedical platform. Biochim Biophys Acta 1863:1728-1748.

Dhar TGM, Xiao H-Y, Xie J, Lehman-McKeeman LD, Wu D-R, Dabros M, Yang X, Taylor TL, Zhou XD, Heimrich EM, Thomas R, McIntyre KW, Warrack B, Shi H, Levesque PC, Zhu JL, Hennan J, Balimane P, Yang Z, Marino AM, Cornelius G, D’Arienzo CJ, Mathur A, Shen DR, Cvijic ME, Salter-Cid L, Barrish JC, Carter PH, Dyckman AJ (2016) Identification and Preclinical Pharmacology of BMS-986104: A Differentiated S1P1 Receptor Modulator in Clinical Trials. ACS Medicinal Chemistry Letters 7:283-288.

Gintant G, Sager PT, Stockbridge N (2016) Evolution of strategies to improve preclinical cardiac safety testing. Nat Rev Drug Discov.

Hernandez D, Millard R, Sivakumaran P, Wong RC, Crombie DE, Hewitt AW, Liang H, Hung SS, Pebay A, Shepherd RK, Dusting GJ, Lim SY (2016) Electrical Stimulation Promotes Cardiac Differentiation of Human Induced Pluripotent Stem Cells. Stem Cells Int 2016:1718041.

Jaffer S, Valasek P, Luke G, Batarfi M, Whalley BJ, Patel K (2016) Characterisation of Development and Electrophysiological Mechanisms Underlying Rhythmicity of the Avian Lymph Heart. PLoS ONE 11:e0166428.

Klatt N, Scherschel K, Schad C, Lau D, Reitmeier A, Kuklik P, Muellerleile K, Yamamura J, Zeller T, Steven D, Baldus S, Schaffer B, Jungen C, Eickholt C, Wassilew K, Schwedhelm E, Willems S, Meyer C (2016) Development of nonfibrotic left ventricular hypertrophy in an ANG II-induced chronic ovine hypertension model. Physiol Rep 4.

Kuusela J, Kim J, Rasanen E, Aalto-Setala K (2016) The Effects of Pharmacological Compounds on Beat Rate Variations in Human Long QT-Syndrome Cardiomyocytes. Stem Cell Rev.

Kuusela J, Kujala VJ, Kiviaho A, Ojala M, Swan H, Kontula K, Aalto-Setala K (2016) Effects of cardioactive drugs on human induced pluripotent stem cell derived long QT syndrome cardiomyocytes. Springerplus 5:234.

Li J, Minami I, Yu L, Tsuji K, Nakajima M, Qiao J, Suzuki M, Shimono K, Nakatsuji N, Kotera H, Liu L, Chen Y (2016) Extracellular Recordings of Patterned Human Pluripotent Stem Cell-Derived Cardiomyocytes on Aligned Fibers. Stem Cells Int 2016:2634013.

Masse S, Magtibay K, Jackson N, Asta J, Kusha M, Zhang B, Balachandran R, Radisic M, Deno DC, Nanthakumar K (2016) Resolving Myocardial Activation With Novel Omnipolar Electrograms. Circ Arrhythm Electrophysiol 9:e004107.

Matschke V, Piccini I, Schubert J, Wrobel E, Lang F, Matschke J, Amedonu E, Meuth SG, Strunker T, Strutz-Seebohm N, Greber B, Scherkenbeck J, Seebohm G (2016) The Natural Plant Product Rottlerin Activates Kv7.1/KCNE1 Channels. Cell Physiol Biochem 40:1549-1558.

Mawad D, Mansfield C, Lauto A, Perbellini F, Nelson GW, Tonkin J, Bello SO, Carrad DJ, Micolich AP, Mahat MM, Furman J, Payne D, Lyon AR, Gooding JJ, Harding SE, Terracciano CM, Stevens MM (2016) A conducting polymer with enhanced electronic stability applied in cardiac models. Science Advances 2.

Niehoff J, Matzkies M, Nguemo F, Hescheler J, Reppel M (2016) Beat Rate Variability in Murine Embryonic Stem Cell-Derived Cardiomyocytes: Effect of Antiarrhythmic Drugs. Cell Physiol Biochem 38:646-658.

Nozaki Y, Honda Y, Watanabe H, Saiki S, Koyabu K, Itoh T, Nagasawa C, Nakamori C, Nakayama C, Iwasaki H, Suzuki S, Washio I, Takahashi E, Miyamoto K, Yamanishi A, Endo H, Shinozaki J, Nogawa H, Kunimatsu T (2016) CSAHi study: Validation of multi-electrode array systems (MEA60/2100) for prediction of drug-induced proarrhythmia using human iPS cell-derived cardiomyocytes -assessment of inter-facility and cells lot-to-lot-variability. Regul Toxicol Pharmacol 77:75-86.

Okata S, Yuasa S, Suzuki T, Ito S, Makita N, Yoshida T, Li M, Kurokawa J, Seki T, Egashira T, Aizawa Y, Kodaira M, Motoda C, Yozu G, Shimojima M, Hayashiji N, Hashimoto H, Kuroda Y, Tanaka A, Murata M, Aiba T, Shimizu W, Horie M, Kamiya K, Furukawa T, Fukuda K (2016) Embryonic type Na+ channel beta-subunit, SCN3B masks the disease phenotype of Brugada syndrome. Sci Rep 6:34198.

Oyunbaatar NE, Lee DH, Patil SJ, Kim ES, Lee DW (2016) Biomechanical Characterization of Cardiomyocyte Using PDMS Pillar with Microgrooves. Sensors (Basel) 16.

Rast G, Kraushaar U, Buckenmaier S, Ittrich C, Guth BD (2016) Influence of field potential duration on spontaneous beating rate of human induced pluripotent stem cell-derived cardiomyocytes: Implications for data analysis and test system selection. Journal of Pharmacological and Toxicological Methods 82:74-82.

Roney CH, Cantwell CD, Qureshi NA, Chowdhury RA, Dupont E, Lim PB, Vigmond EJ, Tweedy JH, Ng FS, Peters NS (2016) Rotor Tracking Using Phase of Electrograms Recorded During Atrial Fibrillation. Ann Biomed Eng.

Sala L, Bellin M, Mummery CL (2016) Integrating cardiomyocytes from human pluripotent stem cells in safety pharmacology: has the time come? Br J Pharmacol.

Trieschmann J, Bettin D, Haustein M, Köster A, Molcanyi M, Halbach M, Hanna M, Fouad M, Brockmeier K, Hescheler J, Pfannkuche K, Hannes T (2016) The Interaction between Adult Cardiac Fibroblasts and Embryonic Stem Cell-Derived Cardiomyocytes Leads to Proarrhythmic Changes in In Vitro Cocultures. Stem Cells International 2016:12.

Wang Q, Yang H, Bai A, Jiang W, Li X, Wang X, Mao Y, Lu C, Qian R, Guo F, Ding T, Chen H, Chen S, Zhang J, Liu C, Sun N (2016) Functional engineered human cardiac patches prepared from nature's platform improve heart function after acute myocardial infarction. Biomaterials 105:52-65.

Alesutan I, Voelkl J, Stockigt F, Mia S, Feger M, Primessnig U, Sopjani M, Munoz C, Borst O, Gawaz M, Pieske B, Metzler B, Heinzel F, Schrickel JW, Lang F (2015) AMP-activated protein kinase alpha1 regulates cardiac gap junction protein connexin 43 and electrical remodeling following pressure overload. Cell Physiol Biochem 35:406-418.

Asakura K, Hayashi S, Ojima A, Taniguchi T, Miyamoto N, Nakamori C, Nagasawa C, Kitamura T, Osada T, Honda Y, Kasai C, Ando H, Kanda Y, Sekino Y, Sawada K (2015) Improvement of acquisition and analysis methods in multi-electrode array experiments with iPS cell-derived cardiomyocytes. J Pharmacol Toxicol Methods.

Finlay MC, Yeoh A, Vyas V, Harmer S, Huang C, Lambiase D, Tinker A (2015) Response to autonomic stimulation is blunted in a murine model of Burgade Syndrome Heart Rhythm 12:S324-S371.

Friedrichs S, Malan D, Voss Y, Sasse P (2015) Scalable Electrophysiological Investigation of iPS Cell-Derived Cardiomyocytes Obtained by a Lentiviral Purification Strategy Journal of Clinical Medicine 4:102-123.

Georgiadis V, Stephanou A, Townsend PA, Jackson TR (2015) MultiElec: A MATLAB Based Application for MEA Data Analysis. PLoS ONE 10:e0129389.

Hannes T, Wolff M, Doss MX, Pfannkuche K, Haustein M, Muller-Ehmsen J, Sachinidis A, Hescheler J, Khalil M, Halbach M (2015) Electrophysiological characteristics of embryonic stem cell-derived cardiomyocytes are cell line-dependent. Cell Physiol Biochem 35:305-314.

Nussinovitch U, Gepstein L (2015) Optogenetics for suppression of cardiac electrical activity in human and rat cardiomyocyte cultures. Neurophotonics 2:031204.

Sallam K, Li X, Sager PT, Houser SR, Wu JC (2015) Finding the Rhythm of Sudden Cardiac Death

New Opportunities Using Induced Pluripotent Stem Cell–Derived Cardiomyocytes. Circulation Research 116:1989-2004.

Sallam K, Li Y, Sager PT, Houser SR, Wu JC (2015) Finding the rhythm of sudden cardiac death: new opportunities using induced pluripotent stem cell-derived cardiomyocytes. Circ Res 116:1989-2004.

Salvage SC, King JH, Chandrasekharan KH, Jafferji DI, Guzadhur L, Matthews HR, Huang CL, Fraser JA (2015) Flecainide exerts paradoxical effects on sodium currents and atrial arrhythmia in murine RyR2-P2328S hearts. Acta Physiol (Oxf) 214:361-375.

Schubring-Giese M (2015) Der Verlauf motorischer Erholung nach Schlaganfall – eine tierexperimentelle Studie am Rattenmodell.

Shimizu H, Schredelseker J, Huang J, Lu K, Naghdi S, Lu F, Franklin S, Fiji HD, Wang K, Zhu H, Tian C, Lin B, Nakano H, Ehrlich A, Nakai J, Stieg AZ, Gimzewski JK, Nakano A, Goldhaber JI, Vondriska TM, Hajnoczky G, Kwon O, Chen JN (2015) Mitochondrial Ca(2+) uptake by the voltage-dependent anion channel 2 regulates cardiac rhythmicity. Elife 4.

Sun J, Yan H, Wugeti N, Guo Y, Zhang L, Ma M, Guo X, Jiao C, Xu W, Li T (2015) Microelectrode array measurement of potassium ion channel remodeling on the field action potential duration in rapid atrial pacing rabbits model. Int J Clin Exp Med 8:249-256.

Trantidou T, Terracciano CM, Kontziampasis D, Humphrey EJ, Prodromakis T (2015) Biorealistic cardiac cell culture platforms with integrated monitoring of extracellular action potentials. Sci Rep 5:11067.

Xie W, Santulli G, Reiken SR, Yuan Q, Osborne BW, Chen BX, Marks AR (2015) Mitochondrial oxidative stress promotes atrial fibrillation. Sci Rep 5:11427.

Ben-Ari M, Schick R, Barad L, Novak A, Ben-Ari E, Lorber A, Itskovitz-Eldor J, Rosen MR, Weissman A, Binah O (2014) From beat rate variability in induced pluripotent stem cell-derived pacemaker cells to heart rate variability in human subjects. Heart Rhythm.

Bingen BO, Engels MC, Schalij MJ, Jangsangthong W, Neshati Z, Feola I, Ypey DL, Askar SF, Panfilov AV, Pijnappels DA, de Vries AA (2014) Light-induced termination of spiral wave arrhythmias by optogenetic engineering of atrial cardiomyocytes. Cardiovasc Res 104:194-205.

Friedrichs K, Adam M, Remane L, Mollenhauer M, Rudolph V, Rudolph TK, Andrie RP, Stockigt F, Schrickel JW, Ravekes T, Deuschl F, Nickenig G, Willems S, Baldus S, Klinke A (2014) Induction of atrial fibrillation by neutrophils critically depends on CD11b/CD18 integrins. PLoS ONE 9:e89307.

Kienast R, Stoger M, Handler M, Hanser F, Baumgartner C (2014) Alterations of field potentials in isotropic cardiomyocyte cell layers induced by multiple endogenous pacemakers under normal and hypothermal conditions. Am J Physiol Heart Circ Physiol 307:H1013-1023.

Lin ZC, Xie C, Osakada Y, Cui Y, Cui B (2014) Iridium oxide nanotube electrodes for sensitive and prolonged intracellular measurement of action potentials. Nat Commun 5:3206.

Mehta A, Verma V, Nandihalli M, Ramachandra CJ, Sequiera GL, Sudibyo Y, Chung Y, Sun W, Shim W (2014) A systemic evaluation of cardiac differentiation from mRNA reprogrammed human induced pluripotent stem cells. PLoS ONE 9:e103485.

Respress JL, Gershovich PM, Wang T, Reynolds JO, Skapura DG, Sutton JP, Miyake CY, Wehrens XH (2014) Long-term simulated microgravity causes cardiac RyR2 phosphorylation and arrhythmias in mice. Int J Cardiol 176:994-1000.

Riedel M, Jou CJ, Lai S, Lux RL, Moreno AP, Spitzer KW, Christians E, Tristani-Firouzi M, Benjamin IJ (2014) Functional and pharmacological analysis of cardiomyocytes differentiated from human peripheral blood mononuclear-derived pluripotent stem cells. Stem Cell Reports 3:131-141.

Rowlands CT (2014) The role of altered calcium handling in the pathogenesis of hypertrophic cardiomyopathy.

Weymann A, Patil NP, Sabashnikov A, Jungebluth P, Korkmaz S, Li S, Veres G, Soos P, Ishtok R, Chaimow N, Patzold I, Czerny N, Schies C, Schmack B, Popov AF, Simon AR, Karck M, Szabo G (2014) Bioartificial heart: a human-sized porcine model--the way ahead. PLoS ONE 9:e111591.

Xu B, Binczak S, Jacquir S, Pont O, Yahia H (2014) Complexity analysis of experimental cardiac arrhythmia. In: 2014 IEEE Region 10 Technical Symposium (TENSYMP). Kuala Lumpur.

Zhang M, D'Aniello C, Verkerk AO, Wrobel E, Frank S, Ward-van Oostwaard D, Piccini I, Freund C, Rao J, Seebohm G, Atsma DE, Schulze-Bahr E, Mummery CL, Greber B, Bellin M (2014) Recessive cardiac phenotypes in induced pluripotent stem cell models of Jervell and Lange-Nielsen syndrome: disease mechanisms and pharmacological rescue. Proc Natl Acad Sci U S A 111:E5383-5392.

Zhang Y, Guzadhur L, Jeevaratnam K, Salvage SC, Matthews GD, Lammers WJ, Lei M, Huang CL, Fraser JA (2014) Arrhythmic substrate, slowed propagation and increased dispersion in conduction direction in the right ventricular outflow tract of murine Scn5a+/- hearts. Acta Physiol (Oxf) 211:559-573.

Caspi O, Huber I, Gepstein A, Arbel G, Maizels L, Boulos M, Gepstein L (2013) Modeling of arrhythmogenic right ventricular cardiomyopathy with human induced pluripotent stem cells. Circ Cardiovasc Genet 6:557-568.

Harris K, Aylott M, Cui Y, Louttit JB, McMahon NC, Sridhar A (2013) Comparison of electrophysiological data from human-induced pluripotent stem cell-derived cardiomyocytes to functional preclinical safety assays. Toxicol Sci 134:412-426.

Kapoor N, Liang W, Marban E, Cho HC (2013) Direct conversion of quiescent cardiomyocytes to pacemaker cells by expression of Tbx18. Nat Biotechnol 31:54-62.

Karakikes I, Senyei GD, Hansen J, Kong CW, Azeloglu EU, Stillitano F, Lieu DK, Wang J, Ren L, Hulot JS, Iyengar R, Li RA, Hajjar RJ (2013) Small Molecule-Mediated Directed Differentiation of Human Embryonic Stem Cells Toward Ventricular Cardiomyocytes. Stem Cells Transl Med.

Khan JM, Lyon AR, Harding SE (2013) The case for induced pluripotent stem cell-derived cardiomyocytes in pharmacological screening. Br J Pharmacol 169:304-317.

Lehmann M, Nguemo F, Wagh V, Pfannkuche K, Hescheler J, Reppel M (2013) Evidence for a critical role of catecholamines for cardiomyocyte lineage commitment in murine embryonic stem cells. PLoS ONE 8:e70913.

Mandenius CF, Meyer T (2013) HIGH-THROUGHPUT SCREENING ASSAYS TO EVALUATE THE CARDIOTOXIC POTENTIAL OF DRUGS. In: High-Throughput Screening Methods in Toxicity Testing (Steinberg P, ed).

Martinelli V, Cellot G, Fabbro A, Bosi S, Mestroni L, Ballerini L (2013) Improving cardiac myocytes performance by carbon nanotubes platforms. Front Physiol 4:239.

Matsa E, Dixon JE, Medway C, Georgiou O, Patel MJ, Morgan K, Kemp PJ, Staniforth A, Mellor I, Denning C (2013) Allele-specific RNA interference rescues the long-QT syndrome phenotype in human-induced pluripotency stem cell cardiomyocytes. Eur Heart J.

Mehnert JM, Brandenburger M, Grunow B (2013) Electrophysiological Characterization of Spontaneously Contracting Cell Aggregates Obtained from Rainbow Trout Larvae with Multielectrode Arrays. Cell Physiol Biochem 32:1374-1385.

Mureli S, Gans CP, Bare DJ, Geenen DL, Kumar NM, Banach K (2013) Mesenchymal stem cells improve cardiac conduction by upregulation of connexin 43 through paracrine signaling. Am J Physiol Heart Circ Physiol 304:H600-609.

Ohno Y, Yuasa S, Egashira T, Seki T, Hashimoto H, Tohyama S, Saito Y, Kunitomi A, Shimoji K, Onizuka T, Kageyama T, Yae K, Tanaka T, Kaneda R, Hattori F, Murata M, Kimura K, Fukuda K (2013) Distinct iPS Cells Show Different Cardiac Differentiation Efficiency. In: Hindawi Publishing Corporation Stem Cells International.

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