Innovations in Electrophysiology

Dissociated cell cultures, hippocampus

Aebersold MJ, Dermutz H, Demko L, Saenz Cogollo JF, Lin SC, Burchert C, Schneider M, Ling D, Forro C, Han H, Zambelli T, Voros J (2017) Local Chemical Stimulation of Neurons with the FluidFM. Chemphyschem.

Dermutz H, Thompson-Steckel G, Forro C, de Lange V, Dorwling-Carter L, Voros J, Demko L (2017) Paper-based patterned 3D neural cultures as a tool to study network activity on multielectrode arrays. RSC Advances 7:39359-39371.

Dzyubenko E, Juckel G, Faissner A (2017) The antipsychotic drugs olanzapine and haloperidol modify network connectivity and spontaneous activity of neural networks in vitro. Sci Rep 7:11609.

Gladkov AA, Kolpakov VN, Pigareva YI, Kazantsev V, Mukhina IV, Pimashkin A (2017) Functional Connectivity of Neural Network in Dissociated Hippocampal Culture Grown on Microelectrode Array.

Habibey R, Latifi S, Mousavi H, Pesce M, Arab-Tehrany E, Blau A (2017) A multielectrode array microchannel platform reveals both transient and slow changes in axonal conduction velocity. Sci Rep 7:8558.

Jung H, Kang H, Nam Y (2017) Digital micromirror based near-infrared illumination system for plasmonic photothermal neuromodulation. Biomedical Optics Express 8:2866-2878.

Li Y, Chen X, Dzakpasu R, Conant K (2017) Dopamine-dependent effects on basal and glutamate stimulated network dynamics in cultured hippocampal neurons. J Neurochem 140:550-560.

Liu H, Bridges D, Randall C, Solla SA, Wu B, Hansma P, Yan X, Kosik K, Bouchard K (2017) Use of a Neural Circuit Probe to Validate in silico Predictions of Inhibitory Connections. BioRxiv.

Narula U, Ruiz A, McQuaide M, DeMarse TB, Wheeler BC, Brewer GJ (2017) Narrow microtunnel technology for the isolation and precise identification of axonal communication among distinct hippocampal subregion networks. PLoS ONE 12:e0176868.

Shtrahman E, Maruyama D, Olariu E, Fink CG, Zochowski M (2017) Understanding spatial and temporal patterning of astrocyte calcium transients via interactions between network transport and extracellular diffusion. Phys Biol 14:016001.

Tovar KR, Bridges DC, Wu B, Randall C, Audouard M, Jang J, Hansma PK, Kosik KS (2017) Recording action potential propagation in single axons using multi-electrode arrays. bioRxiv.

Li Y, Sun R, Wang Y, Li H, Zheng X (2016) A Novel Robot System Integrating Biological and Mechanical Intelligence Based on Dissociated Neural Network-Controlled Closed-Loop Environment. PLoS ONE 11:e0165600.

Shmoel N, Rabieh N, Ojovan SM, Erez H, Maydan E, Spira ME (2016) Multisite electrophysiological recordings by self-assembled loose-patch-like junctions between cultured hippocampal neurons and mushroom-shaped microelectrodes. Sci Rep 6:27110.

Charlesworth P, Cotterill E, Morton A, Grant SG, Eglen SJ (2015) Quantitative differences in developmental profiles of spontaneous activity in cortical and hippocampal cultures. Neural Dev 10:1.

Eisenman LN, Emnett CM, Mohan J, Zorumski CF, Mennerick S (2015) Quantification of bursting and synchrony in cultured hippocampal neurons. J Neurophysiol 114:1059-1071.

Kuebler ES, Tauskela JS, Aylsworth A, Zhao X, Thivierge JP (2015) Burst predicting neurons survive an in vitro glutamate injury model of cerebral ischemia. Sci Rep 5:17718.

Samhaber R, Schottdorf M, Hady AE, Broking K, Daus A, Thielemann C, Stuhmer W, Wolf F (2015) Growing neuronal islands on multi-electrode arrays using an Accurate Positioning-muCP device. J Neurosci Methods.

Schroeter MS, Charlesworth P, Kitzbichler MG, Paulsen O, Bullmore ET (2015) Emergence of rich-club topology and coordinated dynamics in development of hippocampal functional networks in vitro. J Neurosci 35:5459-5470.

Slomowitz E, Styr B, Vertkin I, Milshtein-Parush H, Nelken I, Slutsky M, Slutsky I (2015) Interplay between population firing stability and single neuron dynamics in hippocampal networks. Elife 4.

Tessadori J, Chiappalone M (2015) Closed-loop Neuro-robotic Experiments to Test Computational Properties of Neuronal Networks.e52341.

Bisio M, Bosca A, Pasquale V, Berdondini L, Chiappalone M (2014) Emergence of bursting activity in connected neuronal sub-populations. PLoS ONE 9:e107400.

Frega M, Tedesco M, Massobrio P, Pesce M, Martinoia S (2014) Network dynamics of 3D engineered neuronal cultures: a new experimental model for in-vitro electrophysiology. Sci Rep 4:5489.

George JB, Abraham GM, Singh K, Ankolekar SM, Amrutur B, Sikdar SK (2014) Input coding for neuro-electronic hybrid systems. Biosystems 126C:1-11.

Han H, Hwang SY, Akram F, Hyun JJ, Nam SB, Jun SB, Kim JT, Kim TS (2014) Neural Activity Modulation via Ultrasound Stimulation Measured on Multi-Channel Electrodes. Proceedings of the World Congress on Engineering

Hedrich UB, Liautard C, Kirschenbaum D, Pofahl M, Lavigne J, Liu Y, Theiss S, Slotta J, Escayg A, Dihne M, Beck H, Mantegazza M, Lerche H (2014) Impaired Action Potential Initiation in GABAergic Interneurons Causes Hyperexcitable Networks in an Epileptic Mouse Model Carrying a Human NaV1.1 Mutation. J Neurosci 34:14874-14889.

Korotchenko S, Cingolani LA, Kuznetsova T, Bologna LL, Chiappalone M, Dityatev A (2014) Modulation of network activity and induction of homeostatic synaptic plasticity by enzymatic removal of heparan sulfates. Philos Trans R Soc Lond B Biol Sci 369:20140134.

Biffi E, Regalia G, Menegon A, Ferrigno G, Pedrocchi A (2013) The influence of neuronal density and maturation on network activity of hippocampal cell cultures: a methodological study. PLoS ONE 8:e83899.

Brewer GJ, Boehler MD, Leondopulos S, Pan L, Alagapan S, Demarse TB, Wheeler BC (2013) Toward a self-wired active reconstruction of the hippocampal trisynaptic loop: DG-CA3. Front Neural Circuits 7:165.

Colombi I, Mahajani S, Frega M, Gasparini L, Chiappalone M (2013) Effects of antiepileptic drugs on hippocampal neurons coupled to micro-electrode arrays. Front Neuroeng 6:10.

El Hady A, Afshar G, Broking K, Schluter OM, Geisel T, Stuhmer W, Wolf F (2013) Optogenetic stimulation effectively enhances intrinsically generated network synchrony. Front Neural Circuits 7:167.

Gavello D, Rojo-Ruiz J, Marcantoni A, Franchino C, Carbone E, Carabelli V (2012) Leptin counteracts the hypoxia-induced inhibition of spontaneously firing hippocampal neurons: a microelectrode array study. PLoS ONE 7:e41530.

Leondopulos SS, Boehler MD, Wheeler BC, Brewer GJ (2012) Chronic stimulation of cultured neuronal networks boosts low-frequency oscillatory activity at theta and gamma with spikes phase-locked to gamma frequencies. J Neural Eng 9:026015.

Tessadori J, Bisio M, Martinoia S, Chiappalone M (2012) Modular neuronal assemblies embodied in a closed-loop environment: toward future integration of brains and machines. Front Neural Circuits 6:99.

Wuchter J, Beuter S, Treindl F, Herrmann T, Zeck G, Templin MF, Volkmer H (2012) A comprehensive small interfering RNA screen identifies signaling pathways required for gephyrin clustering. J Neurosci 32:14821-14834.

Geissler M, Faissner A (2011) A new indirect co-culture set up of mouse hippocampal neurons and cortical astrocytes on microelectrode arrays. J Neurosci Methods 204:262-272.

Goyal G, Nam Y (2011) Neuronal Micro-culture Engineering by Microchannel Devices of Cellular Scale Dimensions. Biomed Eng Lett 1:89-98.

Mauceri D, Freitag HE, Oliveira AM, Bengtson CP, Bading H (2011) Nuclear Calcium-VEGFD Signaling Controls Maintenance of Dendrite Arborization Necessary for Memory Formation. Neuron 71:117-130.

Verpelli C, Dvoretskova E, Vicidomini C, Rossi F, Chiappalone M, Schoen M, Di Stefano B, Mantegazza R, Broccoli V, Boeckers TM, Dityatev A, Sala C (2011) Importance of shank3 in regulating metabotropic glutamate receptor 5 (mGluR5) expression and signaling at synapses. J Biol Chem.

Dribben WH, Eisenman LN, Mennerick S (2010) Magnesium induces neuronal apoptosis by suppressing excitability. Cell Death Dis 1:e63.

Feldt S, Wang JX, Shtrahman E, Dzakpasu R, Olariu E, Zochowski M (2010) Functional clustering in hippocampal cultures: relating network structure and dynamics. Phys Biol 7:046004.

Herrmann AM, Gobel K, Simon OJ, Melzer N, Schuhmann MK, Stenner MP, Weishaupt A, Kleinschnitz C, Bittner S, Meuth P, Stuve O, Budde T, Kieseier BC, Wiendl H, Meuth SG (2010) Glatiramer acetate attenuates pro-inflammatory T cell responses but does not directly protect neurons from inflammatory cell death. Am J Pathol 177:3051-3060.

Pegoraro S, Broccard FD, Ruaro ME, Bianchini D, Avossa D, Pastore G, Bisson G, Altafini C, Torre V (2010) Sequential steps underlying neuronal plasticity induced by a transient exposure to gabazine. J Cell Physiol 222:713-728.

Varghese K, Molnar P, Das M, Bhargava N, Lambert S, Kindy MS, Hickman JJ (2010) A new target for amyloid beta toxicity validated by standard and high-throughput electrophysiology. PLoS ONE 5:e8643.

Meuth SG, Herrmann AM, Simon OJ, Siffrin V, Melzer N, Bittner S, Meuth P, Langer HF, Hallermann S, Boldakowa N, Herz J, Munsch T, Landgraf P, Aktas O, Heckmann M, Lessmann V, Budde T, Kieseier BC, Zipp F, Wiendl H (2009) Cytotoxic CD8+ T cell-neuron interactions: perforin-dependent electrical silencing precedes but is not causally linked to neuronal cell death. J Neurosci 29:15397-15409.

Wiegert JS, Hofmann F, Bading H, Bengtson CP (2009) A transcription-dependent increase in miniature EPSC frequency accompanies late-phase plasticity in cultured hippocampal neurons. BMC Neurosci 10:124.

Brewer GJ, Boehler MD, Jones TT, Wheeler BC (2008) NbActiv4 medium improvement to Neurobasal/B27 increases neuron synapse densities and network spike rates on multielectrode arrays. J Neurosci Methods 170:181-187.

Ghezzi D, Menegon A, Pedrocchi A, Valtorta F, Ferrigno G (2008) A Micro-Electrode Array device coupled to a laser-based system for the local stimulation of neurons by optical release of glutamate. J Neurosci Methods.

Runne H, Regulier E, Kuhn A, Zala D, Gokce O, Perrin V, Sick B, Aebischer P, Deglon N, Luthi-Carter R (2008) Dysregulation of gene expression in primary neuron models of Huntington's disease shows that polyglutamine-related effects on the striatal transcriptome may not be dependent on brain circuitry. J Neurosci 28:9723-9731.

Wahl AS, Buchthal B, Rode F, Bomholt SF, Freitag HE, Hardingham GE, Ronn LC, Bading H (2008) Hypoxic/ischemic conditions induce expression of the putative pro-death gene Clca1 via activation of extrasynaptic N-methyl-d-aspartate receptors. Neuroscience.

Baruchi I, Ben-Jacob E (2007) Towards neuro-memory-chip: Imprinting multiple memories in cultured neural networks. Phys Rev E 75:050901.

Boehler MD, Wheeler BC, Brewer GJ (2007) Added astroglia promote greater synapse density and higher activity in neuronal networks. Neuron Glia Biol 3:127-140.

Fuchs E, Ayali A, Robinson A, Hulata E, Ben-Jacob E (2007) Coemergence of regularity and complexity during neural network development. Dev Neurobiol 67:1802-1814.

Jacobi S, Moses E (2007) Variability and corresponding amplitude-velocity relation of activity propagating in one-dimensional neural cultures. J Neurophysiol 97:3597-3606.

Li Y, Zhou W, Li X, Zeng S, Luo Q (2007) Dynamics of learning in cultured neuronal networks with antagonists of glutamate receptors. Biophys J 93:4151-4158.

Mazzoni A, Broccard FD, Garcia-Perez E, Bonifazi P, Ruaro ME, Torre V (2007) On the dynamics of the spontaneous activity in neuronal networks. PLoS ONE 2:e439.

Meyer DA, Carter JM, Johnstone AF, Shafer TJ (2007) Pyrethroid modulation of spontaneous neuronal excitability and neurotransmission in hippocampal neurons in culture. Neurotoxicology.

Rubinsky L, Raichman N, Baruchi I, Shein M, Lavee J, Frenk H, Ben-Jacob E (2007) Study of hypothermia on cultured neuronal networks using multi-electrode arrays. J Neurosci Methods 160:288-293.

Soussou WV, Yoon GJ, Brinton RD, Berger TW (2007) Neuronal network morphology and electrophysiologyof hippocampal neurons cultured on surface-treated multielectrode arrays. IEEE Trans Biomed Eng 54:1309-1320.

Valor LM, Charlesworth P, Humphreys L, Anderson CN, Grant SG (2007) Network activity-independent coordinated gene expression program for synapse assembly. Proc Natl Acad Sci U S A 104:4658-4663.

Volman V, Ben-Jacob E, Levine H (2007) The astrocyte as a gatekeeper of synaptic information transfer. Neural Comput 19:303-326.

Volman V, Gerkin RC, Lau PM, Ben-Jacob E, Bi GQ (2007) Calcium and synaptic dynamics underlying reverberatory activity in neuronal networks. Phys Biol 4:91-103.

Chen C, Chen L, Lin Y, Zeng S, Luo Q (2006) The origin of spontaneous synchronized burst in cultured neuronal networks based on multi-electrode arrays. Biosystems 85:137-143.

Hofmann F, Bading H (2006) Long term recordings with microelectrode arrays: studies of transcription-dependent neuronal plasticity and axonal regeneration. J Physiol Paris 99:125-132.

Soriano FX, Papadia S, Hofmann F, Hardingham NR, Bading H, Hardingham GE (2006) Preconditioning doses of NMDA promote neuroprotection by enhancing neuronal excitability. J Neurosci 26:4509-4518.

Arnold FJ, Hofmann F, Bengtson CP, Wittmann M, Vanhoutte P, Bading H (2005) Microelectrode array recordings of cultured hippocampal networks reveal a simple model for transcription and protein synthesis-dependent plasticity. J Physiol 564:3-19.

Bonifazi P, Ruaro ME, Torre V (2005) Statistical properties of information processing in neuronal networks. Eur J Neurosci 22:2953-2964.

Ruaro ME, Bonifazi P, Torre V (2005) Toward the neurocomputer: image processing and pattern recognition with neuronal cultures. IEEE Trans Biomed Eng 52:371-383.

Guenter E (2004) Microelectrode Array - based Biosensors. Screening:2.

Chawla S, Vanhoutte P, Arnold FJ, Huang CL, Bading H (2003) Neuronal activity-dependent nucleocytoplasmic shuttling of HDAC4 and HDAC5. J Neurochem 85:151-159.

Hardingham GE, Fukunaga Y, Bading H (2002) Extrasynaptic NMDARs oppose synaptic NMDARs by triggering CREB shut-off and cell death pathways. Nat Neurosci 5:405-414.

Hardingham GE, Arnold FJ, Bading H (2001) A calcium microdomain near NMDA receptors: on switch for ERK-dependent synapse-to-nucleus communication. Nat Neurosci 4:565-566.

Hardingham GE, Arnold FJ, Bading H (2001) Nuclear calcium signaling controls CREB-mediated gene expression triggered by synaptic activity. Nat Neurosci 4:261-267.