www.multichannelsystems.com

Innovations in Electrophysiology

Heart, slices and whole mount preparations

Beiert T, Tiyerili V, Knappe V, Effelsberg V, Linhart M, Stöckigt F, Klein S, Schierwagen R, Trebicka J, Nickenig G, Schrickel JW, Andrié RP (2017) Relaxin reduces susceptibility to post-infarct atrial fibrillation in mice due to anti-fibrotic and anti-inflammatory properties. Biochemical and Biophysical Research Communications 490:643-649.

Jungen C, Scherschel K, Eickholt C, Kuklik P, Klatt N, Bork N, Salzbrunn T, Alken F, Angendohr S, Klene C, Mester J, Klocker N, Veldkamp MW, Schumacher U, Willems S, Nikolaev VO, Meyer C (2017) Disruption of cardiac cholinergic neurons enhances susceptibility to ventricular arrhythmias. Nat Commun 8:14155.

Lane JD, Montaigne D, Tinker A (2017) Tissue-Level Cardiac Electrophysiology Studied in Murine Myocardium Using a Microelectrode Array: Autonomic and Thermal Modulation. J Membr Biol.

Stockigt F, Beiert T, Knappe V, Baris OR, Wiesner RJ, Clemen CS, Nickenig G, Andrie RP, Schrickel JW (2017) Aging-related mitochondrial dysfunction facilitates the occurrence of serious arrhythmia after myocardial infarction. Biochem Biophys Res Commun.

Jaffer S, Valasek P, Luke G, Batarfi M, Whalley BJ, Patel K (2016) Characterisation of Development and Electrophysiological Mechanisms Underlying Rhythmicity of the Avian Lymph Heart. PLoS ONE 11:e0166428.

Mawad D, Mansfield C, Lauto A, Perbellini F, Nelson GW, Tonkin J, Bello SO, Carrad DJ, Micolich AP, Mahat MM, Furman J, Payne D, Lyon AR, Gooding JJ, Harding SE, Terracciano CM, Stevens MM (2016) A conducting polymer with enhanced electronic stability applied in cardiac models. Science Advances 2.

Wang Q, Yang H, Bai A, Jiang W, Li X, Wang X, Mao Y, Lu C, Qian R, Guo F, Ding T, Chen H, Chen S, Zhang J, Liu C, Sun N (2016) Functional engineered human cardiac patches prepared from nature's platform improve heart function after acute myocardial infarction. Biomaterials 105:52-65.

Alesutan I, Voelkl J, Stockigt F, Mia S, Feger M, Primessnig U, Sopjani M, Munoz C, Borst O, Gawaz M, Pieske B, Metzler B, Heinzel F, Schrickel JW, Lang F (2015) AMP-activated protein kinase alpha1 regulates cardiac gap junction protein connexin 43 and electrical remodeling following pressure overload. Cell Physiol Biochem 35:406-418.

Finlay MC, Yeoh A, Vyas V, Harmer S, Huang C, Lambiase D, Tinker A (2015) Response to autonomic stimulation is blunted in a murine model of Burgade Syndrome Heart Rhythm 12:S324-S371.

Salvage SC, King JH, Chandrasekharan KH, Jafferji DI, Guzadhur L, Matthews HR, Huang CL, Fraser JA (2015) Flecainide exerts paradoxical effects on sodium currents and atrial arrhythmia in murine RyR2-P2328S hearts. Acta Physiol (Oxf) 214:361-375.

Sun J, Yan H, Wugeti N, Guo Y, Zhang L, Ma M, Guo X, Jiao C, Xu W, Li T (2015) Microelectrode array measurement of potassium ion channel remodeling on the field action potential duration in rapid atrial pacing rabbits model. Int J Clin Exp Med 8:249-256.

Friedrichs K, Adam M, Remane L, Mollenhauer M, Rudolph V, Rudolph TK, Andrie RP, Stockigt F, Schrickel JW, Ravekes T, Deuschl F, Nickenig G, Willems S, Baldus S, Klinke A (2014) Induction of atrial fibrillation by neutrophils critically depends on CD11b/CD18 integrins. PLoS ONE 9:e89307.

Weymann A, Patil NP, Sabashnikov A, Jungebluth P, Korkmaz S, Li S, Veres G, Soos P, Ishtok R, Chaimow N, Patzold I, Czerny N, Schies C, Schmack B, Popov AF, Simon AR, Karck M, Szabo G (2014) Bioartificial heart: a human-sized porcine model--the way ahead. PLoS ONE 9:e111591.

Zhang Y, Guzadhur L, Jeevaratnam K, Salvage SC, Matthews GD, Lammers WJ, Lei M, Huang CL, Fraser JA (2014) Arrhythmic substrate, slowed propagation and increased dispersion in conduction direction in the right ventricular outflow tract of murine Scn5a+/- hearts. Acta Physiol (Oxf) 211:559-573.

Law JK, Yeung CK, Frisch J, Knapp S, Ingebrandt S, Rudd JA, Chan M (2012) Cardioprotective Effects of Potassium Channel Openers on Rat Atria and Isolated Hearts under Acute Hypoxia. J Phys Pharm Adv 2:41-48.

Meyer T, Guenther E, Kraushaar U (2012) Microelectrode Arrays in Cardiac Mapping. In: Cardiac Mapping (Shenasa M, Hindricks G, Borggrefe M, Breithardt G, Josephson ME, eds).

Yi T, Wong J, Feller E, Sink S, Taghli-Lamallem O, Wen J, Kim C, Fink M, Giles W, Soussou W, Chen HS (2012) Electrophysiological mapping of embryonic mouse hearts: mechanisms for developmental pacemaker switch and internodal conduction pathway. J Cardiovasc Electrophysiol 23:309-318.

Camelliti P, Al-Saud SA, Smolenski RT, Al-Ayoubi S, Bussek A, Wettwer E, Banner NR, Bowles CT, Yacoub MH, Terracciano CM (2011) Adult human heart slices are a multicellular system suitable for electrophysiological and pharmacological studies. J Mol Cell Cardiol.

Liang H, Halbach M, Hannes T, Fleischmann BK, Tang M, Schunkert H, Hescheler J, Reppel M (2010) Electrophysiological basis of the first heart beats. Cell Physiol Biochem 25:561-570.

Meyer T, Stuerz K, Guenther E, Edamura M, Kraushaar U (2010) Cardiac slices as a predictive tool for arrhythmogenic potential of drugs and chemicals. Expert Opin Drug Metab Toxicol 6:1461-1475.

Bussek A, Wettwer E, Christ T, Lohmann H, Camelliti P, Ravens U (2009) Tissue slices from adult mammalian hearts as a model for pharmacological drug testing. Cell Physiol Biochem 24:527-536.

Pillekamp F, Halbach M, Reppel M, Pfannkuche K, Nazzal R, Nguemo F, Matzkies M, Rubenchyk O, Hannes T, Khalil M, Bloch W, Sreeram N, Brockmeier K, Hescheler J (2009) Physiological differences between transplanted and host tissue cause functional decoupling after in vitro transplantation of human embryonic stem cell-derived cardiomyocytes. Cell Physiol Biochem 23:65-74.

Artmann GM, Chien S (2008) 7.6 Cardiac Tissue Slices. In: Bioengineering in Cell and Tissue Research, p 145 f: Springer.

Hannes T, Halbach M, Nazzal R, Frenzel L, Saric T, Khalil M, Hescheler J, Brockmeier K, Pillekamp F (2008) Biological pacemakers: characterization in an in vitro coculture model. J Electrocardiol 41:562-566.

Halbach M, Pillekamp F, Brockmeier K, Hescheler J, Muller-Ehmsen J, Reppel M (2006) Ventricular slices of adult mouse hearts--a new multicellular in vitro model for electrophysiological studies. Cell Physiol Biochem 18:1-8.

Pillekamp F, Reppel M, Dinkelacker V, Duan Y, Jazmati N, Bloch W, Brockmeier K, Hescheler J, Fleischmann BK, Koehling R (2005) Establishment and characterization of a mouse embryonic heart slice preparation. Cell Physiol Biochem 16:127-132.