Heart, slices and whole mount preparations

An Z, Wu J, Li SH, Chen S, Lu FL, Xu ZY, Sung HW, Li RK (2021) Injectable conductive hydrogel can reduce pacing threshold and enhance efficacy of cardiac pacemaker. Theranostics 11:3948-3960.

Liu JYH, Du P, Lu Z, Kung JSC, Huang IB, Hui JCM, Ng HSH, Ngan MP, Cui D, Jiang B, Chan SW, Rudd JA (2021) Involvement of TRPV1 and TRPA1 in the modulation of pacemaker potentials in the mouse ileum. Cell Calcium 97:102417.

Xie D, Xiong K, Su X, Wang G, Ji Q, Zou Q, Wang L, Liu Y, Liang D, Xue J, Gao X, Gu X, Liu H, He X, Li L, Yang J, Lu Y, Peng L, Chen YH (2021) Identification of an endogenous glutamatergic transmitter system controlling excitability and conductivity of atrial cardiomyocytes. Cell Res.

Cai H, Li B, Bai A, Huang J, Zhan Y, Sun N, Liang Q, Xu C (2020) Establishing a new human hypertrophic cardiomyopathy-specific model using human embryonic stem cells. Exp Cell Res 387:111736.

Hochman-Mendez C, Pereira de Campos DB, Pinto RS, Mendes BJ, Rocha GM, Monnerat G, Weissmuller G, Sampaio LC, Carvalho AB, Taylor DA, de Carvalho ACC (2020) Tissue-engineered human embryonic stem cell-containing cardiac patches: evaluating recellularization of decellularized matrix. Journal of Tissue Engineering 11:2041731420921482.

Ju J, Hu N, Cairns DM, Liu H, Timko BP (2020) Photo-cross-linkable, insulating silk fibroin for bioelectronics with enhanced cell affinity. Proc Natl Acad Sci U S A 117:15482-15489.

Ma S, Ma J, Tu Q, Zheng C, Chen Q, Lv W (2020) Isoproterenol Increases Left Atrial Fibrosis and Susceptibility to Atrial Fibrillation by Inducing Atrial Ischemic Infarction in Rats. Front Pharmacol 11:493.

Mollenhauer M, Mehrkens D, Klinke A, Lange M, Remane L, Friedrichs K, Braumann S, Geißen S, Simsekyilmaz S, Nettersheim FS, Lee S, Peinkofer G, Geisler AC, Geis B, Schwoerer AP, Carrier L, Freeman BA, Dewenter M, Luo X, El-Armouche A, Wagner M, Adam M, Baldus S, Rudolph V (2020) Nitro-fatty acids suppress ischemic ventricular arrhythmias by preserving calcium homeostasis. Sci Rep 10:15319.

Ng KE, Delaney PJ, Thenet D, Murtough S, Webb CM, Tsisanova E, Walker SLM, Westaby JD, Pennington DJ, Pink R, Kelsell DP, Tinker A (2020) Early cardiac inflammation as a driver of murine model of Arrhythmogenic Cardiomyopathy. bioRxiv:2020.2006.2024.169664.

Rao P, Liu Z, Duan H, Dang S, Li H, Zhong L, Wang X, Wang L, Wang X (2019) Pretreatment with neuregulin-1 improves cardiac electrophysiological properties in a rat model of myocardial infarction. Experimental and Therapeutic Medicine 17:3141-3149.

Shah D, Virtanen L, Prajapati C, Kiamehr M, Gullmets J, West G, Kreutzer J, Pekkanen-Mattila M, Helio T, Kallio P, Taimen P, Aalto-Setala K (2019) Modeling of LMNA-Related Dilated Cardiomyopathy Using Human Induced Pluripotent Stem Cells. Cells 8.

Sun J, Wugeti N, Mahemuti A (2019) Reversal effect of Zhigancao decoction on myocardial fibrosis in a rapid pacing-induced atrial fibrillation model in New Zealand rabbits. J Int Med Res:300060518799819.

Watson SA, Duff J, Bardi I, Zabielska M, Atanur SS, Jabbour RJ, Simon A, Tomas A, Smolenski RT, Harding SE, Perbellini F, Terracciano CM (2019) Biomimetic electromechanical stimulation to maintain adult myocardial slices in vitro. Nat Commun 10:2168.

Aziz Q, Finlay M, Montaigne D, Ojake L, Li Y, Anderson N, Ludwig A, Tinker A (2018) ATP-sensitive potassium channels in the sinoatrial node contribute to heart rate control and adaptation to hypoxia. J Biol Chem.

Chowdhury RA, Tzortzis KN, Dupont E, Selvadurai S, Perbellini F, Cantwell CD, Ng FS, Simon AR, Terracciano CM, Peters NS (2018) Concurrent micro- to macro-cardiac electrophysiology in myocyte cultures and human heart slices. Sci Rep 8:6947.

Hulsmann J, Aubin H, Sugimura Y, Lichtenberg A, Akhyari P (2018) Electrophysiological Stimulation of Whole Heart Constructs in an 8-Pole Electrical Field. Artif Organs.

Ma J, Ma S, Yin C, Wu H (2018) Matrine reduces susceptibility to post-infarct atrial fibrillation in rats due to anti-fibrotic properties. J Cardiovasc Electrophysiol.

Ma J, Ma S, Yin C, Wu H (2018) Shengmai San-derived herbal prevents the development of a vulnerable substrate for atrial fibrillation in a rat model of ischemic heart failure. Biomedicine & Pharmacotherapy 100:156-167.

Ma J, Yin C, Ma S, Qiu H, Zheng C, Chen Q, Ding C, Lv W (2018) Shensong Yangxin capsule reduces atrial fibrillation susceptibility by inhibiting atrial fibrosis in rats with post-myocardial infarction heart failure. Drug Des Devel Ther 12:3407-3418.

Nobles M, Montaigne D, Sebastian S, Birnbaumer L, Tinker A (2018) Differential effects of inhibitory G protein isoforms on G protein-gated inwardly rectifying K(+) currents in adult murine atria. Am J Physiol Cell Physiol 314:C616-C626.

Beiert T, Tiyerili V, Knappe V, Effelsberg V, Linhart M, Stöckigt F, Klein S, Schierwagen R, Trebicka J, Nickenig G, Schrickel JW, Andrié RP (2017) Relaxin reduces susceptibility to post-infarct atrial fibrillation in mice due to anti-fibrotic and anti-inflammatory properties. Biochemical and Biophysical Research Communications 490:643-649.

Jungen C, Scherschel K, Eickholt C, Kuklik P, Klatt N, Bork N, Salzbrunn T, Alken F, Angendohr S, Klene C, Mester J, Klocker N, Veldkamp MW, Schumacher U, Willems S, Nikolaev VO, Meyer C (2017) Disruption of cardiac cholinergic neurons enhances susceptibility to ventricular arrhythmias. Nat Commun 8:14155.

Lane JD, Montaigne D, Tinker A (2017) Tissue-Level Cardiac Electrophysiology Studied in Murine Myocardium Using a Microelectrode Array: Autonomic and Thermal Modulation. J Membr Biol.

Semmler J, Kormann J, Srinivasan SP, Koster A, Salzer D, Reppel M, Hescheler J, Plomann M, Nguemo F (2017) Pacsin 2 is required for the maintenance of a normal cardiac function in the developing mouse heart. Pharmacol Res.

Stockigt F, Beiert T, Knappe V, Baris OR, Wiesner RJ, Clemen CS, Nickenig G, Andrie RP, Schrickel JW (2017) Aging-related mitochondrial dysfunction facilitates the occurrence of serious arrhythmia after myocardial infarction. Biochem Biophys Res Commun.

Zhang L, Meng Q, Zhou X, Li Y, Lu Y, Zhang J, Xing Q, Tang B (2017) Pharmaco-Electrophysiology of Isolated Perfused Rat Heart Assessed with Flexible Microelectrode Arrays. Journal of Veterinary Science & Technology 8.

Jaffer S, Valasek P, Luke G, Batarfi M, Whalley BJ, Patel K (2016) Characterisation of Development and Electrophysiological Mechanisms Underlying Rhythmicity of the Avian Lymph Heart. PLoS ONE 11:e0166428.

Mawad D, Mansfield C, Lauto A, Perbellini F, Nelson GW, Tonkin J, Bello SO, Carrad DJ, Micolich AP, Mahat MM, Furman J, Payne D, Lyon AR, Gooding JJ, Harding SE, Terracciano CM, Stevens MM (2016) A conducting polymer with enhanced electronic stability applied in cardiac models. Science Advances 2.

Rudolph TK, Ravekes T, Klinke A, Friedrichs K, Mollenhauer M, Pekarova M, Ambrozova G, Martiskova H, Kaur JJ, Matthes B, Schwoerer A, Woodcock SR, Kubala L, Freeman BA, Baldus S, Rudolph V (2016) Nitrated fatty acids suppress angiotensin II-mediated fibrotic remodelling and atrial fibrillation. Cardiovasc Res 109:174-184.

Wang Q, Yang H, Bai A, Jiang W, Li X, Wang X, Mao Y, Lu C, Qian R, Guo F, Ding T, Chen H, Chen S, Zhang J, Liu C, Sun N (2016) Functional engineered human cardiac patches prepared from nature's platform improve heart function after acute myocardial infarction. Biomaterials 105:52-65.

Alesutan I, Voelkl J, Stockigt F, Mia S, Feger M, Primessnig U, Sopjani M, Munoz C, Borst O, Gawaz M, Pieske B, Metzler B, Heinzel F, Schrickel JW, Lang F (2015) AMP-activated protein kinase alpha1 regulates cardiac gap junction protein connexin 43 and electrical remodeling following pressure overload. Cell Physiol Biochem 35:406-418.

Finlay MC, Yeoh A, Vyas V, Harmer S, Huang C, Lambiase D, Tinker A (2015) Response to autonomic stimulation is blunted in a murine model of Burgade Syndrome Heart Rhythm 12:S324-S371.

Nembo EN, Atsamo AD, Nguelefack TB, Kamanyi A, Hescheler J, Nguemo F (2015) In vitro chronotropic effects of Erythrina senegalensis DC (Fabaceae) aqueous extract on mouse heart slice and pluripotent stem cell-derived cardiomyocytes. J Ethnopharmacol 165:163-172.

Salvage SC, King JH, Chandrasekharan KH, Jafferji DI, Guzadhur L, Matthews HR, Huang CL, Fraser JA (2015) Flecainide exerts paradoxical effects on sodium currents and atrial arrhythmia in murine RyR2-P2328S hearts. Acta Physiol (Oxf) 214:361-375.

Sun J, Yan H, Wugeti N, Guo Y, Zhang L, Ma M, Guo X, Jiao C, Xu W, Li T (2015) Microelectrode array measurement of potassium ion channel remodeling on the field action potential duration in rapid atrial pacing rabbits model. Int J Clin Exp Med 8:249-256.

Friedrichs K, Adam M, Remane L, Mollenhauer M, Rudolph V, Rudolph TK, Andrie RP, Stockigt F, Schrickel JW, Ravekes T, Deuschl F, Nickenig G, Willems S, Baldus S, Klinke A (2014) Induction of atrial fibrillation by neutrophils critically depends on CD11b/CD18 integrins. PLoS ONE 9:e89307.

Weymann A, Patil NP, Sabashnikov A, Jungebluth P, Korkmaz S, Li S, Veres G, Soos P, Ishtok R, Chaimow N, Patzold I, Czerny N, Schies C, Schmack B, Popov AF, Simon AR, Karck M, Szabo G (2014) Bioartificial heart: a human-sized porcine model--the way ahead. PLoS ONE 9:e111591.

Zhang Y, Guzadhur L, Jeevaratnam K, Salvage SC, Matthews GD, Lammers WJ, Lei M, Huang CL, Fraser JA (2014) Arrhythmic substrate, slowed propagation and increased dispersion in conduction direction in the right ventricular outflow tract of murine Scn5a+/- hearts. Acta Physiol (Oxf) 211:559-573.

Law JK, Yeung CK, Frisch J, Knapp S, Ingebrandt S, Rudd JA, Chan M (2012) Cardioprotective Effects of Potassium Channel Openers on Rat Atria and Isolated Hearts under Acute Hypoxia. J Phys Pharm Adv 2:41-48.

Meyer T, Guenther E, Kraushaar U (2012) Microelectrode Arrays in Cardiac Mapping. In: Cardiac Mapping (Shenasa M, Hindricks G, Borggrefe M, Breithardt G, Josephson ME, eds).

Yi T, Wong J, Feller E, Sink S, Taghli-Lamallem O, Wen J, Kim C, Fink M, Giles W, Soussou W, Chen HS (2012) Electrophysiological mapping of embryonic mouse hearts: mechanisms for developmental pacemaker switch and internodal conduction pathway. J Cardiovasc Electrophysiol 23:309-318.

Camelliti P, Al-Saud SA, Smolenski RT, Al-Ayoubi S, Bussek A, Wettwer E, Banner NR, Bowles CT, Yacoub MH, Terracciano CM (2011) Adult human heart slices are a multicellular system suitable for electrophysiological and pharmacological studies. J Mol Cell Cardiol.

Liang H, Halbach M, Hannes T, Fleischmann BK, Tang M, Schunkert H, Hescheler J, Reppel M (2010) Electrophysiological basis of the first heart beats. Cell Physiol Biochem 25:561-570.

Meyer T, Stuerz K, Guenther E, Edamura M, Kraushaar U (2010) Cardiac slices as a predictive tool for arrhythmogenic potential of drugs and chemicals. Expert Opin Drug Metab Toxicol 6:1461-1475.

Bussek A, Wettwer E, Christ T, Lohmann H, Camelliti P, Ravens U (2009) Tissue slices from adult mammalian hearts as a model for pharmacological drug testing. Cell Physiol Biochem 24:527-536.

Pillekamp F, Halbach M, Reppel M, Pfannkuche K, Nazzal R, Nguemo F, Matzkies M, Rubenchyk O, Hannes T, Khalil M, Bloch W, Sreeram N, Brockmeier K, Hescheler J (2009) Physiological differences between transplanted and host tissue cause functional decoupling after in vitro transplantation of human embryonic stem cell-derived cardiomyocytes. Cell Physiol Biochem 23:65-74.

Artmann GM, Chien S (2008) 7.6 Cardiac Tissue Slices. In: Bioengineering in Cell and Tissue Research, p 145 f: Springer.

Hannes T, Halbach M, Nazzal R, Frenzel L, Saric T, Khalil M, Hescheler J, Brockmeier K, Pillekamp F (2008) Biological pacemakers: characterization in an in vitro coculture model. J Electrocardiol 41:562-566.

Halbach M, Pillekamp F, Brockmeier K, Hescheler J, Muller-Ehmsen J, Reppel M (2006) Ventricular slices of adult mouse hearts--a new multicellular in vitro model for electrophysiological studies. Cell Physiol Biochem 18:1-8.

Pillekamp F, Reppel M, Dinkelacker V, Duan Y, Jazmati N, Bloch W, Brockmeier K, Hescheler J, Fleischmann BK, Koehling R (2005) Establishment and characterization of a mouse embryonic heart slice preparation. Cell Physiol Biochem 16:127-132.