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Stimulus Generator

 

 

     

    Completely Software Driven

    two version for complex or simple pulses available

    Current and Voltage Driven Stimulation

    With the MC_Stimulus software you can choose between current or voltage driven stimulation.

    Decide in favour of 2, 4 or even 8 completely independent stimulus outputs

    Arbitrary Analog Waveforms

    freely combine mono- or biphasic rectangular pulses, ramps, or sine waveforms to design a stimulation pattern of unlimited complexity.

    You can do this on each output channel.

    Integrated Isolation Units

    Each of the 2, 4 or 8 output channels is optically isolated, efficiently avoiding cross-talk among channels.

    No additional units, batteries and cables, no additional costs!

    Each Channel - All Features - Full Flexibility

    Each of the 2, 4 or 8 channels is completely independent.

    For all kinds of stimulation patterns- there's no need to combine channels. Every single channel can be used for a complex stimulus output.

     

     

    Three functions- One device

    The Stimulus Generators from MCS are featuring:

    • Current driven stimulation:
      In current mode, the stimulus generator guarantees a stable current output in the range of -1.6 mA to +1.6 mA independent of the electrode impedance @ 120V compliance voltage.
      On request, a version with an extended output range of ± 16 mA is available.
    • Voltage driven stimulation:
      In voltage mode, the voltage level in the range of -8 V to +8 V is held constant and the current output depends on the electrode impedance. The lower the electrode impedance - the higher the output current.
      The maximum output current is ± 20 mA.
    • Controlling and Timing
      For every single stimulus output there is one TTL in- and output. The Stimulators can receive and deliver TTL pulses via BNC connectors.
      These triggers allow you to control and synchronize other instruments like imaging systems, LED-lights, data acquisition systems and many more - at a 20μs precision.

    For a broad range of applications

    • Neuronal networks:
      -Long time stimulation
      -Feedback stimulation
      -White noise stimulation
      -Biological signals as stimulation patterns
      -Multiple files can be applied to one or more electrodes
    • Brainslices:
      -Flexible LTP induction patterns
      -Studies of synaptic plasticity
    • Sceletal Muscle:
      -Evoke isometric and isotonic contractions
    • Cardiac cells and tissues:
      -Study influence of artificial pacemakers
      -Pace cardiac cell cultures
      -Pace tissue preparations like slices, purkinje fibers,
       or papillary muscle
      -Mimic cardiac environment during stem cell differentiation

    Photoconductive Stimulation Device

    "Non-invasive Controlled Depolarization of Excitable Cells"

     

    The Photoconductive Stimulation Device enables neuroscience researchers and pharmaceutical technicians to depolarize dissociated neurons noninvasively and in a highly targeted manner.

     

    • Non-invasive electrical stimulation can be done without causing damage to the cells
    • Enables optical targeting of specific neurons to be depolarized
    • Allows for the controlled variation of frequency and duration of stimulation
    • Short or long term non-invasive cell specific stimulation
    • A replacement for pharmacological agonist stimulation (KCL), which do not allow for targeting and repetitive depolarization
    • The depolarization of a user-defined area of a dissociated culture, not just those cells positioned on an electrode
    • A means for increasing the flexibility of protocol design by having more control over which cells are depolarized and when
    • For controlled cell stimulation in combination with voltage sensitive dyes
    • Depolarize cells with specific patterns of excitation, which allows for detailed investigation of excitable cells over time
    • Significantly reduces the time and skill level required to obtain excitation, in that electrophysiology techniques and equipment are not required