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Innovations in Electrophysiology

Stem cells

Aaser P, Knudsen M, Ramstad OH, van de Wijdeven R, Nichele S, Sandvig I, Tufte G, Bauer US, Halaas O, Hendseth S, Sandvig A, Valderhaug V (2017) Towards making a cyborg: A closed-loop reservoir-neuro system. In: ECAL 2017, pp 430-437. Lyon: MIT Press.

Abbate E, Boulakia M, Coudière Y, Gerbeau J-F, Zitoun P, Zemzemi N (2017) In silico assessment of the effects of various compounds in MEA/hiPSC-CM assays: Modelling and numerical simulations. In: Inria.

Bhinge A, Namboori SC, Zhang X, VanDongen AMJ, Stanton LW (2017) Genetic Correction of SOD1 Mutant iPSCs Reveals ERK and JNK Activated AP1 as a Driver of Neurodegeneration in Amyotrophic Lateral Sclerosis. Stem Cell Reports 8:856-869.

Ellis BW, Acun A, Can UI, Zorlutuna P (2017) Human iPSC-derived myocardium-on-chip with capillary-like flow for personalized medicine. Biomicrofluidics 11:024105.

Frega M, van Gestel SHC, Linda K, van der Raadt J, Keller J, Van Rhijn J-R, Schubert D, Albers CA, Nadif Kasri N (2017) Rapid Neuronal Differentiation of Induced Pluripotent Stem Cells for Measuring Network Activity on Micro-electrode Arrays. JoVE:e54900.

Gazina EV, Morrisroe E, Mendis GDC, Michalska AE, Chen J, Nefzger CM, Rollo BN, Reid CA, Pera MF, Petrou S (2017) Method of derivation and differentiation of mouse embryonic stem cells generating synchronous neuronal networks. J Neurosci Methods.

Giacomelli E, Bellin M, Sala L, van Meer BJ, Tertoolen LGJ, Orlova VV, Mummery CL (2017) Three-dimensional cardiac microtissues composed of cardiomyocytes and endothelial cells co-differentiated from human pluripotent stem cells. Development 144:1008-1017.

Goineau S, Castagne V (2017) Proarrhythmic risk assessment using conventional and new in vitro assays. Regul Toxicol Pharmacol 88:1-11.

Hall CE, Yao Z, Choi M, Tyzack GE, Serio A, Luisier R, Harley J, Preza E, Arber C, Crisp SJ, Watson PMD, Kullmann DM, Abramov AY, Wray S, Burley R, Loh SHY, Martins LM, Stevens MM, Luscombe NM, Sibley CR, Lakatos A, Ule J, Gandhi S, Patani R (2017) Progressive Motor Neuron Pathology and the Role of Astrocytes in a Human Stem Cell Model of VCP-Related ALS. Cell Rep 19:1739-1749.

Hosseinazdeh Z, Jalligampala A, Zrenner E, Rathbun DL (2017) The Spatial Extent of Epiretinal Electrical Stimulation in the Healthy Mouse Retina. Neurosignals 25:15-25.

Jenkinson SP, Grandgirard D, Heidemann M, Tscherter A, Avondet M, Leib SL (2017) Embryonic Stem Cell-Derived Neurons Grown on Multi-Electrode Arrays as a Novel In vitro Bioassay for the Detection of Clostridium botulinum Neurotoxins. Frontiers in Pharmacology 8.

Koh CH, Wu J, Chung YY, Liu Z, Zhang RR, Chong K, Korzh V, Ting S, Oh S, Shim W, Tian HY, Wei H (2017) Electronic supplementary materialIdentification of a Na+/K+-ATPase inhibition-independent proarrhythmic ionic mechanisms of cardiac glycosides. Sci Rep 7:2465.

Kraushaar U, Guenther E, Hess D (2017) Addressing Functional Neurotoxicity Using the Microelectrode Array (MEA). In: Stem Cell-Derived Models in Toxicology. Methods in Pharmacology and Toxicology (Clements M, Roquemore L, eds). New York: Humana Press.

Kreutzer J, Yla-Outinen L, Maki AJ, Ristola M, Narkilahti S, Kallio P (2017) Cell culture chamber with gas supply for prolonged recording of human neuronal cells on microelectrode array. J Neurosci Methods 280:27-35.

Kuroda Y, Yuasa S, Watanabe Y, Ito S, Egashira T, Seki T, Hattori T, Ohno S, Kodaira M, Suzuki T, Hashimoto H, Okata S, Tanaka A, Aizawa Y, Murata M, Aiba T, Makita N, Furukawa T, Shimizu W, Kodama I, Ogawa S, Kokubun N, Horigome H, Horie M, Kamiya K, Fukuda K (2017) Flecainide ameliorates arrhythmogenicity through NCX flux in Andersen-Tawil syndrome-iPS cell-derived cardiomyocytes. Biochemistry and Biophysics Reports 9:245-256.

Kuusela J, Larsson K, Shah D, Prajapati C, Aalto-Setala K (2017) Low extracellular potassium prolongs repolarization and evokes early afterdepolarization in human induced pluripotent stem cell-derived cardiomyocytes. Biol Open 6:777-784.

Li B, Yang H, Wang X, Zhan Y, Sheng W, Cai H, Xin H, Liang Q, Zhou P, Lu C, Qian R, Chen S, Yang P, Zhang J, Shou W, Huang G, Liang P, Sun N (2017) Engineering human ventricular heart muscles based on a highly efficient system for purification of human pluripotent stem cell-derived ventricular cardiomyocytes. Stem Cell Res Ther 8:202.

Lin ZC, McGuire AF, Burridge PW, Matsa E, Lou H-Y, Wu JC, Cui B (2017) Accurate nanoelectrode recording of human pluripotent stem cell-derived cardiomyocytes for assaying drugs and modeling disease. Microsystems & Nanoengineering 3:16080.

Marcoux D, Xiao H-Y, Murali Dhar TG, Xie J, Lehman-McKeeman LD, Wu D-R, Dabros M, Yang X, Taylor TL, Zhou XD, Heimrich EM, Thomas R, McIntyre KW, Shi H, Levesque PC, Sun H, Yang Z, Marino AM, Cornelius G, D'Arienzo CJ, Gupta A, Pragalathan B, Rampulla R, Mathur A, Shen DR, Cvijic ME, Salter-Cid L, Lombardo LJ, Carter PH, Dyckman AJ (2017) Identification of potent tricyclic prodrug S1P1 receptor modulators. MedChemComm.

Marczenke M, Piccini I, Mengarelli I, Fell J, Ropke A, Seebohm G, Verkerk AO, Greber B (2017) Cardiac Subtype-Specific Modeling of Kv1.5 Ion Channel Deficiency Using Human Pluripotent Stem Cells. Front Physiol 8:469.

Mayer M, Arrizabalaga O, Lieb F, Ciba M, Ritter S, Thielemann C (2017) Electrophysiological investigation of human embryonic stem cell derived neurospheres using a novel spike detection algorithm. Biosens Bioelectron 100:462-468.

Park S-J, Kim K-H, Jeon W-Y, Seo J, Han J-M, Kim J-S, Chung H-M, Lee J-H, Moon S-H, Kim H-H (2017) Enzyme catalyzed electrostimulation of human embryonic stem cell-derived cardiomyocytes influence contractility and synchronization. Biochemical Engineering Journal 123:95-109.

Pistollato F, Canovas-Jorda D, Zagoura D, Bal-Price A (2017) Nrf2 pathway activation upon rotenone treatment in human iPSC-derived neural stem cells undergoing differentiation towards neurons and astrocytes. Neurochem Int 108:457-471.

Pistollato F, Canovas-Jorda D, Zagoura D, Price A (2017) Protocol for the Differentiation of Human Induced Pluripotent Stem Cells into Mixed Cultures of Neurons and Glia for Neurotoxicity Testing. JoVE:e55702.

Protze SI, Liu J, Nussinovitch U, Ohana L, Backx PH, Gepstein L, Keller GM (2017) Sinoatrial node cardiomyocytes derived from human pluripotent cells function as a biological pacemaker. Nat Biotechnol 35:56-68.

Sala L, Ward-van Oostwaard D, Tertoolen LGJ, Mummery CL, Bellin M (2017) Electrophysiological Analysis of human Pluripotent Stem Cell-derived Cardiomyocytes (hPSC-CMs) Using Multi-electrode Arrays (MEAs).e55587.

Schürlein S, Al Hijailan R, Weigel T, Kadari A, Rücker C, Edenhofer F, Walles H, Hansmann J (2017) Generation of a Human Cardiac Patch Based on a Reendothelialized Biological Scaffold (BioVaSc). Advanced Biosystems 1:1600005-n/a.

Seidel D, Jahnke H-G, Englich B, Girard M, Robitzki AA (2017) In vitro field potential monitoring on a multi-microelectrode array for the electrophysiological long-term screening of neural stem cell maturation. Analyst 142:1929-1937.

Shen N, Knopf A, Westendorf C, Kraushaar U, Riedl J, Bauer H, Pöschel S, Layland SL, Holeiter M, Knolle S, Brauchle E, Nsair A, Hinderer S, Schenke-Layland K (2017) Steps toward Maturation of Embryonic Stem Cell-Derived Cardiomyocytes by Defined Physical Signals. Stem Cell Reports 9:122-135.

Smit NW, Cócera Ortega L, Végh AMD, Meijborg VMF, Smits AM, Klerk M, Tijsen AJM, Tan HL, Goumans M-JHT, Boink GJJ, Coronel R (2017) Human Cardiomyocyte Progenitor Cells in Co-culture with Rat Cardiomyocytes Form a Pro-arrhythmic Substrate: Evidence for Two Different Arrhythmogenic Mechanisms. Frontiers in Physiology 8.

Stillitano F, Hansen J, Kong C-W, Karakikes I, Funck-Brentano C, Geng L, Scott S, Reynier S, Wu M, Valogne Y, Desseaux C, Salem J-E, Jeziorowska D, Zahr N, Li R, Iyengar R, Hajjar RJ, Hulot J-S (2017) Modeling susceptibility to drug-induced long QT with a panel of subject-specific induced pluripotent stem cells. Elife 6:e19406.

Ten Sande JN, Smit NW, Parvizi M, van Amersfoorth SC, Plantinga JA, van Dessel PF, de Bakker JM, Harmsen MC, Coronel R (2017) Differential Mechanisms of Myocardial Conduction Slowing by Adipose Tissue-Derived Stromal Cells Derived from Different Species. Stem Cells Transl Med 6:22-30.

Tertoolen LG, Braam SR, van Meer BJ, Passier R, Mummery CL (2017) Interpretation of field potentials measured on a multi electrode array in pharmacological toxicity screening on primary and human pluripotent stem cell-derived cardiomyocytes. Biochem Biophys Res Commun.

Tixier E, Raphel F, Lombardi D, Gerbeau J-F (2017) Optimal Biomarkers Design for Drug Safety Evaluation Using Microelectrode Array Measurements. In.

Zhu H, Scharnhorst KS, Stieg AZ, Gimzewski JK, Minami I, Nakatsuji N, Nakano H, Nakano A (2017) Two dimensional electrophysiological characterization of human pluripotent stem cell-derived cardiomyocyte system. Sci Rep 7:43210.

Ahuja V, Sharma S, Kamboj R (2016) Current Developments in the Use of Human Stem Cell Derived Cardiomyocytes to Examine Drug-induced Cardiotoxicity. In: Issues in Toxicology No. 29, Human Stem Cell Toxicology (Sherley JL, ed).

Cotterill E, Charlesworth P, Thomas CW, Paulsen O, Eglen SJ (2016) A comparison of computational methods for detecting bursts in neuronal spike trains and their application to human stem cell-derived neuronal networks. J Neurophysiol 116:306-321.

Denning C, Borgdorff V, Crutchley J, Firth KS, George V, Kalra S, Kondrashov A, Hoang MD, Mosqueira D, Patel A, Prodanov L, Rajamohan D, Skarnes WC, Smith JG, Young LE (2016) Cardiomyocytes from human pluripotent stem cells: From laboratory curiosity to industrial biomedical platform. Biochim Biophys Acta 1863:1728-1748.

Dhar TGM, Xiao H-Y, Xie J, Lehman-McKeeman LD, Wu D-R, Dabros M, Yang X, Taylor TL, Zhou XD, Heimrich EM, Thomas R, McIntyre KW, Warrack B, Shi H, Levesque PC, Zhu JL, Hennan J, Balimane P, Yang Z, Marino AM, Cornelius G, D’Arienzo CJ, Mathur A, Shen DR, Cvijic ME, Salter-Cid L, Barrish JC, Carter PH, Dyckman AJ (2016) Identification and Preclinical Pharmacology of BMS-986104: A Differentiated S1P1 Receptor Modulator in Clinical Trials. ACS Medicinal Chemistry Letters 7:283-288.

Hernandez D, Millard R, Sivakumaran P, Wong RC, Crombie DE, Hewitt AW, Liang H, Hung SS, Pebay A, Shepherd RK, Dusting GJ, Lim SY (2016) Electrical Stimulation Promotes Cardiac Differentiation of Human Induced Pluripotent Stem Cells. Stem Cells Int 2016:1718041.

Kuusela J, Kujala VJ, Kiviaho A, Ojala M, Swan H, Kontula K, Aalto-Setala K (2016) Effects of cardioactive drugs on human induced pluripotent stem cell derived long QT syndrome cardiomyocytes. Springerplus 5:234.

Lenk K, Priwitzer B, Yla-Outinen L, Tietz LH, Narkilahti S, Hyttinen JA (2016) Simulation of developing human neuronal cell networks. Biomed Eng Online 15:105.

Li J, Minami I, Yu L, Tsuji K, Nakajima M, Qiao J, Suzuki M, Shimono K, Nakatsuji N, Kotera H, Liu L, Chen Y (2016) Extracellular Recordings of Patterned Human Pluripotent Stem Cell-Derived Cardiomyocytes on Aligned Fibers. Stem Cells Int 2016:2634013.

Niehoff J, Matzkies M, Nguemo F, Hescheler J, Reppel M (2016) Beat Rate Variability in Murine Embryonic Stem Cell-Derived Cardiomyocytes: Effect of Antiarrhythmic Drugs. Cell Physiol Biochem 38:646-658.

Nozaki Y, Honda Y, Watanabe H, Saiki S, Koyabu K, Itoh T, Nagasawa C, Nakamori C, Nakayama C, Iwasaki H, Suzuki S, Washio I, Takahashi E, Miyamoto K, Yamanishi A, Endo H, Shinozaki J, Nogawa H, Kunimatsu T (2016) CSAHi study: Validation of multi-electrode array systems (MEA60/2100) for prediction of drug-induced proarrhythmia using human iPS cell-derived cardiomyocytes -assessment of inter-facility and cells lot-to-lot-variability. Regul Toxicol Pharmacol 77:75-86.

Rast G, Kraushaar U, Buckenmaier S, Ittrich C, Guth BD (2016) Influence of field potential duration on spontaneous beating rate of human induced pluripotent stem cell-derived cardiomyocytes: Implications for data analysis and test system selection. Journal of Pharmacological and Toxicological Methods 82:74-82.

Rubio A, Luoni M, Giannelli SG, Radice I, Iannielli A, Cancellieri C, Di Berardino C, Regalia G, Lazzari G, Menegon A, Taverna S, Broccoli V (2016) Rapid and efficient CRISPR/Cas9 gene inactivation in human neurons during human pluripotent stem cell differentiation and direct reprogramming. Sci Rep 6:37540.

Sala L, Bellin M, Mummery CL (2016) Integrating cardiomyocytes from human pluripotent stem cells in safety pharmacology: has the time come? Br J Pharmacol.

Trieschmann J, Bettin D, Haustein M, Köster A, Molcanyi M, Halbach M, Hanna M, Fouad M, Brockmeier K, Hescheler J, Pfannkuche K, Hannes T (2016) The Interaction between Adult Cardiac Fibroblasts and Embryonic Stem Cell-Derived Cardiomyocytes Leads to Proarrhythmic Changes in In Vitro Cocultures. Stem Cells International 2016:12.

Asakura K, Hayashi S, Ojima A, Taniguchi T, Miyamoto N, Nakamori C, Nagasawa C, Kitamura T, Osada T, Honda Y, Kasai C, Ando H, Kanda Y, Sekino Y, Sawada K (2015) Improvement of acquisition and analysis methods in multi-electrode array experiments with iPS cell-derived cardiomyocytes. J Pharmacol Toxicol Methods.

Friedrichs S, Malan D, Voss Y, Sasse P (2015) Scalable Electrophysiological Investigation of iPS Cell-Derived Cardiomyocytes Obtained by a Lentiviral Purification Strategy Journal of Clinical Medicine 4:102-123.

Hannes T, Wolff M, Doss MX, Pfannkuche K, Haustein M, Muller-Ehmsen J, Sachinidis A, Hescheler J, Khalil M, Halbach M (2015) Electrophysiological characteristics of embryonic stem cell-derived cardiomyocytes are cell line-dependent. Cell Physiol Biochem 35:305-314.

Hess D, Kraushaar U, Cesare P, Rascher-Eggstein G, Guenther E (2015) A human integrated in vitro Neurotoxicity Safety Platform using hiPS neurons (Peri.4U neurons). In.

Ng TK, Yung JS, Choy KW, Cao D, Leung CK, Cheung HS, Pang CP (2015) Transdifferentiation of periodontal ligament-derived stem cells into retinal ganglion-like cells and its microRNA signature. Sci Rep 5:16429.

Rast G, Weber J, Disch C, Schuck E, Ittrich C, Guth BD (2015) An integrated platform for simultaneous multi-well field potential recording and Fura-2-based calcium transient ratiometry in human induced pluripotent stem cell (hiPSC)-derived cardiomyocytes. J Pharmacol Toxicol Methods.

Sallam K, Li Y, Sager PT, Houser SR, Wu JC (2015) Finding the rhythm of sudden cardiac death: new opportunities using induced pluripotent stem cell-derived cardiomyocytes. Circ Res 116:1989-2004.

Smith I, Silveirinha V, Stein JL, de la Torre-Ubieta L, Farrimond JA, Williamson EM, Whalley BJ (2015) Human neural stem cell-derived cultures in three-dimensional substrates form spontaneously functional neuronal networks. J Tissue Eng Regen Med.

Ben-Ari M, Schick R, Barad L, Novak A, Ben-Ari E, Lorber A, Itskovitz-Eldor J, Rosen MR, Weissman A, Binah O (2014) From beat rate variability in induced pluripotent stem cell-derived pacemaker cells to heart rate variability in human subjects. Heart Rhythm.

Mehta A, Verma V, Nandihalli M, Ramachandra CJ, Sequiera GL, Sudibyo Y, Chung Y, Sun W, Shim W (2014) A systemic evaluation of cardiac differentiation from mRNA reprogrammed human induced pluripotent stem cells. PLoS ONE 9:e103485.

Riedel M, Jou CJ, Lai S, Lux RL, Moreno AP, Spitzer KW, Christians E, Tristani-Firouzi M, Benjamin IJ (2014) Functional and pharmacological analysis of cardiomyocytes differentiated from human peripheral blood mononuclear-derived pluripotent stem cells. Stem Cell Reports 3:131-141.

Zhang M, D'Aniello C, Verkerk AO, Wrobel E, Frank S, Ward-van Oostwaard D, Piccini I, Freund C, Rao J, Seebohm G, Atsma DE, Schulze-Bahr E, Mummery CL, Greber B, Bellin M (2014) Recessive cardiac phenotypes in induced pluripotent stem cell models of Jervell and Lange-Nielsen syndrome: disease mechanisms and pharmacological rescue. Proc Natl Acad Sci U S A 111:E5383-5392.

Caspi O, Huber I, Gepstein A, Arbel G, Maizels L, Boulos M, Gepstein L (2013) Modeling of arrhythmogenic right ventricular cardiomyopathy with human induced pluripotent stem cells. Circ Cardiovasc Genet 6:557-568.

Harris K, Aylott M, Cui Y, Louttit JB, McMahon NC, Sridhar A (2013) Comparison of electrophysiological data from human-induced pluripotent stem cell-derived cardiomyocytes to functional preclinical safety assays. Toxicol Sci 134:412-426.

Karakikes I, Senyei GD, Hansen J, Kong CW, Azeloglu EU, Stillitano F, Lieu DK, Wang J, Ren L, Hulot JS, Iyengar R, Li RA, Hajjar RJ (2013) Small Molecule-Mediated Directed Differentiation of Human Embryonic Stem Cells Toward Ventricular Cardiomyocytes. Stem Cells Transl Med.

Khan JM, Lyon AR, Harding SE (2013) The case for induced pluripotent stem cell-derived cardiomyocytes in pharmacological screening. Br J Pharmacol 169:304-317.

Kiiski H, Aanismaa R, Tenhunen J, Hagman S, Yla-Outinen L, Aho A, Yli-Hankala A, Bendel S, Skottman H, Narkilahti S (2013) Healthy human CSF promotes glial differentiation of hESC-derived neural cells while retaining spontaneous activity in existing neuronal networks. Biol Open 2:605-612.

Laurenza I, Pallocca G, Mennecozzi M, Scelfo B, Pamies D, Bal-Price A (2013) A human pluripotent carcinoma stem cell-based model for in vitro developmental neurotoxicity testing: effects of methylmercury, lead and aluminum evaluated by gene expression studies. Int J Dev Neurosci 31:679-691.

Lehmann M, Nguemo F, Wagh V, Pfannkuche K, Hescheler J, Reppel M (2013) Evidence for a critical role of catecholamines for cardiomyocyte lineage commitment in murine embryonic stem cells. PLoS ONE 8:e70913.

Matsa E, Dixon JE, Medway C, Georgiou O, Patel MJ, Morgan K, Kemp PJ, Staniforth A, Mellor I, Denning C (2013) Allele-specific RNA interference rescues the long-QT syndrome phenotype in human-induced pluripotency stem cell cardiomyocytes. Eur Heart J.

Mureli S, Gans CP, Bare DJ, Geenen DL, Kumar NM, Banach K (2013) Mesenchymal stem cells improve cardiac conduction by upregulation of connexin 43 through paracrine signaling. Am J Physiol Heart Circ Physiol 304:H600-609.

Ohno Y, Yuasa S, Egashira T, Seki T, Hashimoto H, Tohyama S, Saito Y, Kunitomi A, Shimoji K, Onizuka T, Kageyama T, Yae K, Tanaka T, Kaneda R, Hattori F, Murata M, Kimura K, Fukuda K (2013) Distinct iPS Cells Show Different Cardiac Differentiation Efficiency. In: Hindawi Publishing Corporation Stem Cells International.

Rubach M, Adelmann R, Haustein M, Drey F, Pfannkuche K, Xiao B, Koester A, Udink Ten Cate FE, Choi YH, Neef K, Fatima A, Hannes T, Pillekamp F, Hescheler J, Saric T, Brockmeier K, Khalil M (2013) Mesenchymal Stem Cells and their Conditioned Medium Improve Integration of purified Induced Pluripotent Stem-Cell Derived Cardiomyocyte Clusters into Myocardial Tissue. Stem Cells Dev.

Braam SR, Tertoolen L, Casini S, Matsa E, Lu HR, Teisman A, Passier R, Denning C, Gallacher DJ, Towart R, Mummery CL (2012) Repolarization reserve determines drug responses in human pluripotent stem cell derived cardiomyocytes. Stem Cell Res 10:48-56.

Chabrol FP, Eglen SJ, Sernagor E (2012) GABAergic control of retinal ganglion cell dendritic development. Neuroscience 227:30-43.

Kujala K, Ahola A, Pekkanen-Mattila M, Ikonen L, Kerkela E, Hyttinen J, Aalto-Setala K (2012) Electrical Field Stimulation with a Novel Platform: Effect on Cardiomyocyte Gene Expression but not on Orientation. Int J Biomed Sci 8:109-120.

Kujala V, Pekkanen-Mattila M, Aalto-Setala K (2012) Human Pluripotent Stem Cell-Derived Cardiomyocytes: Maturity and Electrophysiology. In: Embryonic Stem Cells - Differentiation and Pluripotent Alternatives (Kallos MS, ed).

Mandel Y, Weissman A, Schick R, Barad L, Novak A, Meiry G, Goldberg S, Lorber A, Rosen MR, Itskovitz-Eldor J, Binah O (2012) Human embryonic and induced pluripotent stem cell-derived cardiomyocytes exhibit beat rate variability and power-law behavior. Circulation 125:883-893.

Mehta A, Chung YY, Sequiera GL, Wong P, Liew R, Shim W (2012) Pharmaco-Electrophysiology of Viral-Free Induced Pluripotent Stem Cell-Derived Human Cardiomyocytes. Toxicol Sci.

Sequiera GL, Mehta A, Ooi TH, Shim W (2012) Ontogenic Development of Cardiomyocytes Derived from Transgene-Free Human Induced Pluripotent Stem Cells and Its Homology with Human Heart. Life Sci.

Stephens CL, Toda H, Palmer TD, DeMarse TB, Ormerod BK (2012) Adult neural progenitor cells reactivate superbursting in mature neural networks. Exp Neurol 234:20-30.

Zwi-Dantsis L, Huber I, Habib M, Winterstern A, Gepstein A, Arbel G, Gepstein L (2012) Derivation and cardiomyocyte differentiation of induced pluripotent stem cells from heart failure patients. Eur Heart J.

Abilez OJ, Wong J, Prakash R, Deisseroth K, Zarins CK, Kuhl E (2011) Multiscale computational models for optogenetic control of cardiac function. Biophys J 101:1326-1334.

Davis RP, van den Berg CW, Casini S, Braam SR, Mummery CL (2011) Pluripotent stem cell models of cardiac disease and their implication for drug discovery and development. Trends Mol Med 17:475-484.

Elliott DA, Braam SR, Koutsis K, Ng ES, Jenny R, Lagerqvist EL, Biben C, Hatzistavrou T, Hirst CE, Yu QC, Skelton RJ, Ward-van Oostwaard D, Lim SM, Khammy O, Li X, Hawes SM, Davis RP, Goulburn AL, Passier R, Prall OW, Haynes JM, Pouton CW, Kaye DM, Mummery CL, Elefanty AG, Stanley EG (2011) NKX2-5(eGFP/w) hESCs for isolation of human cardiac progenitors and cardiomyocytes. Nat Methods 8:1037-1040.

Guo L, Abrams RM, Babiarz JE, Cohen JD, Kameoka S, Sanders MJ, Chiao E, Kolaja KL (2011) Estimating the risk of drug-induced proarrhythmia using human induced pluripotent stem cell-derived cardiomyocytes. Toxicol Sci 123:281-289.

Guo L, Qian JY, Abrams R, Tang HM, Weiser T, Sanders MJ, Kolaja KL (2011) The electrophysiological effects of cardiac glycosides in human iPSC-derived cardiomyocytes and in guinea pig isolated hearts. Cell Physiol Biochem 27:453-462.

Hofshi A, Itzhaki I, Gepstein A, Arbel G, Gross GJ, Gepstein L (2011) A combined gene and cell therapy approach for restoration of conduction. Heart Rhythm 8:121-130.

Itzhaki I, Maizels L, Huber I, Zwi-Dantsis L, Caspi O, Winterstern A, Feldman O, Gepstein A, Arbel G, Hammerman H, Boulos M, Gepstein L (2011) Modelling the long QT syndrome with induced pluripotent stem cells. Nature.

Kraushaar U, Meyer T, Hess D, Gepstein L, C LM, S RB, Guenther E (2011) Cardiac safety pharmacology: from human ether-a-gogo related gene channel block towards induced pluripotent stem cell based disease models. Expert Opin Drug Saf.

Kujala VJ, Jimenez ZC, Vaisanen J, Tanskanen JM, Kerkela E, Hyttinen J, Aalto-Setala K (2011) Averaging in vitro cardiac field potential recordings obtained with microelectrode arrays. Comput Methods Programs Biomed.

Kujala VJ, Pekkanen-Mattila M, Aalto-Setala K (2011) Human Pluripotent Stem Cell-Derived Cardiomyocytes: Maturity and Electrophysiology. In: Embryonic Stem Cells - Differentiation and Pluripotent Alternatives (Kallos MS, ed).

Lahti AL, Kujala VJ, Chapman H, Koivisto AP, Pekkanen-Mattila M, Kerkela E, Hyttinen J, Kontula K, Swan H, Conklin BR, Yamanaka S, Silvennoinen O, Aalto-Setala K (2011) Model for long QT syndrome type 2 using human iPS cells demonstrates arrhythmogenic characteristics in cell culture. Dis Model Mech.

Mandenius CF, Steel D, Noor F, Meyer T, Heinzle E, Asp J, Arain S, Kraushaar U, Bremer S, Class R, Sartipy P (2011) Cardiotoxicity testing using pluripotent stem cell-derived human cardiomyocytes and state-of-the-art bioanalytics: a review. J Appl Toxicol.

Matsa E, Rajamohan D, Dick E, Young L, Mellor I, Staniforth A, Denning C (2011) Drug evaluation in cardiomyocytes derived from human induced pluripotent stem cells carrying a long QT syndrome type 2 mutation. Eur Heart J.

Mehta A, Chung YY, Ng A, Iskandar F, Atan S, Wei H, Dusting G, Sun W, Wong P, Shim W (2011) Pharmacological response of human cardiomyocytes derived from virus-free induced pluripotent stem cells. Cardiovasc Res 91:577-586.

Pekkanen-Mattila M, Kerkela E, Aalto-Setala K (2011) Differentiation, Characterization and Applications of Human Embryonic Stem Cell – Derived Cardiomyocytes. In: Embryonic Stem Cells: The Hormonal Regulation of Pluripotency and Embryogenesis (Altwoos C, ed).

Ritner C, Wong SS, King FW, Mihardja SS, Liszewski W, Erle DJ, Lee RJ, Bernstein HS (2011) An engineered cardiac reporter cell line identifies human embryonic stem cell-derived myocardial precursors. PLoS ONE 6:e16004.

Walter J, Honsek SD, Illes S, Wellen JM, Hartung HP, Rose CR, Dihne M (2011) A new role for interferon gamma in neural stem/precursor cell dysregulation. Mol Neurodegener 6:18.

Äänismaa R, Yla-Outinen L, Mikkonen JE, Narkilahti S (2010) Human Pluripotent Stem Cell-Derived Neuronal Networks: Their Electrical Functionality and Usability for Modelling and Toxicology. In: Methodological Advances in the Culture, Manipulation and Utilization of Embryonic Stem Cells for Basic and Practical Applications (Atwood C, ed).

Asai Y, Tada M, Otsuji TG, Nakatsuji N (2010) Combination of functional cardiomyocytes derived from human stem cells and a highly-efficient microelectrode array system: an ideal hybrid model assay for drug development. Curr Stem Cell Res Ther 5:227-232.

Braam SR (2010) Human embryonic stem cells - Advancing biology and cardiogenesis towards functional applications

Gupta MK, Illich DJ, Gaarz A, Matzkies M, Nguemo F, Pfannkuche K, Liang H, Classen S, Reppel M, Schultze JL, Hescheler J, Saric T (2010) Global transcriptional profiles of beating clusters derived from human induced pluripotent stem cells and embryonic stem cells are highly similar. BMC Dev Biol 10:98.

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