Innovations in Electrophysiology

In vivo studies

Akbarian B, Erfanian A (2017) Automatic Detection of PTZ-Induced Seizures Based on Functional Brain Connectivity Network in Rats 8th International IEEE EMBS Conference on Neural Engineering.

Ayub S, Gentet LJ, Fiath R, Schwaerzle M, Borel M, David F, Bartho P, Ulbert I, Paul O, Ruther P (2017) Hybrid intracerebral probe with integrated bare LED chips for optogenetic studies. Biomed Microdevices 19:49.

Blanquie O, Yang J-W, Kilb W, Sharopov S, Sinning A, Luhmann HJ (2017) Electrical activity controls area-specific expression of neuronal apoptosis in the mouse developing cerebral cortex. Elife 6:e27696.

Blaschke BM, Tort-Colet N, Guimerà-Brunet A, Weinert J, Rousseau L, Heimann A, Drieschner S, Kempski O, Villa R, Sanchez-Vives MV, Garrido JA (2017) Mapping brain activity with flexible graphene micro-transistors. 2D Materials 4:025040.

Castano-Prat P, Perez-Zabalza M, Perez-Mendez L, Escorihuela RM, Sanchez-Vives MV (2017) Slow and Fast Neocortical Oscillations in the Senescence-Accelerated Mouse Model SAMP8. Frontiers in Aging Neuroscience 9.

Chandra M, Escalante-Alcalde D, Bhuiyan MS, Orr AW, Kevil C, Morris AJ, Nam H, Dominic P, McCarthy KJ, Miriyala S, Panchatcharam M (2017) Cardiac-specific inactivation of LPP3 in mice leads to myocardial dysfunction and heart failure. Redox Biol 14:261-271.

Derafshi Z, Kunzer BE, Mugler EM, Rokhmanova N, Park DW, Tajalli H, Shetty K, Ma Z, Williams JC, Hetling JR (2017) Corneal Potential Maps Measured With Multi-Electrode Electroretinography in Rat Eyes With Experimental Lesions. Invest Ophthalmol Vis Sci 58:2863-2873.

Gerdjikov TV, Bergner CG, Schwarz C (2017) Global Tactile Coding in Rat Barrel Cortex in the Absence of Local Cues. Cereb Cortex:1-13.

Haldar SK, Magtibay K, Porta-Sanchez A, Masse S, Mitsakakis N, Lai PFH, Azam MA, Asta J, Kusha M, Dorian P, Ha ACT, Chauhan V, Deno DC, Nanthakumar K (2017) Resolving Bipolar Electrogram Voltages During Atrial Fibrillation Using Omnipolar Mapping. Circ Arrhythm Electrophysiol 10.

Harms L, Fulham WR, Todd J, Meehan C, Schall U, Hodgson DM, Michie PT (2017) Late deviance detection in rats is reduced, while early deviance detection is augmented by the NMDA receptor antagonist MK-801. Schizophr Res.

Janz P, Schwaderlapp N, Heining K, Haussler U, Korvink JG, von Elverfeldt D, Hennig J, Egert U, LeVan P, Haas CA (2017) Early tissue damage and microstructural reorganization predict disease severity in experimental epilepsy. Elife 6.

Jiang Z, Huxter JR, Bowyer SA, Blockeel AJ, Butler J, Imtiaz SA, Wafford KA, Phillips KG, Tricklebank MD, Marston HM, Rodriguez-Villegas E (2017) TaiNi: Maximizing research output whilst improving animals' welfare in neurophysiology experiments. Sci Rep 7:8086.

Khateb M, Schiller J, Schiller Y (2017) Feedforward motor information enhances somatosensory responses and sharpens angular tuning of rat S1 barrel cortex neurons. Elife 6.

Lecomte A, A. D, Descamps E, Dahan L, Bergaud C (2017) In vitro and in vivo biostability assessment of chronically-implanted Parylene C neural sensors. Sensors and Actuators B: Chemical.

Martin LM, Garcia-Rosales F, Beetz MJ, Hechavarria JC (2017) Processing of temporally patterned sounds in the auditory cortex of Seba's short-tailed bat (Carollia perspicillata). Eur J Neurosci.

McAfee SS, Liu Y, Dhamala M, Heck DH (2017) Thalamocortical transmission of visual information in awake mice involves phase synchronization and spike synchrony at high gamma frequencies. bioRxiv.

McAfee SS, Liu Y, Sillitoe RV, Heck DH (2017) Cerebellar Purkinje cell simple spike activity in awake mice represents phase differences between oscillations in medial prefrontal cortex and hippocampus. bioRxiv.

Schaefer MK, Kossl M, Hechavarria JC (2017) Laminar differences in response to simple and spectro-temporally complex sounds in the primary auditory cortex of ketamine-anesthetized gerbils. PLoS ONE 12:e0182514.

Soma S, Saiki A, Yoshida J, Rios A, Kawabata M, Sakai Y, Isomura Y (2017) Distinct laterality in forelimb-movement representations of rat primary and secondary motor cortical neurons with intratelencephalic and pyramidal tract projections. J Neurosci.

Xiao D, Vanni MP, Mitelut CC, Chan AW, LeDue JM, Xie Y, Chen AC, Swindale NV, Murphy TH (2017) Mapping cortical mesoscopic networks of single spiking cortical or sub-cortical neurons. Elife 6.

Beetz MJ, Hechavarria JC, Kossl M (2016) Cortical neurons of bats respond best to echoes from nearest targets when listening to natural biosonar multi-echo streams. Sci Rep 6:35991.

Cain SM, Ahn S, Garcia E, Zhang Y, Waheed Z, Tyson JR, Yang Y, Van Sung T, Phillips AG, Snutch TP (2016) Heantos-4, a natural plant extract used in the treatment of drug addiction, modulates T-type calcium channels and thalamocortical burst-firing. Mol Brain 9:94.

Fan X, Song Y, Ma Y, Zhang S, Xiao G, Yang L, Xu H, Zhang D, Cai X (2016) In Situ Real-Time Monitoring of Glutamate and Electrophysiology from Cortex to Hippocampus in Mice Based on a Microelectrode Array. Sensors (Basel) 17.

Hechavarria JC, Beetz MJ, Macias S, Kossl M (2016) Vocal sequences suppress spiking in the bat auditory cortex while evoking concomitant steady-state local field potentials. Sci Rep 6:39226.

Klatt N, Scherschel K, Schad C, Lau D, Reitmeier A, Kuklik P, Muellerleile K, Yamamura J, Zeller T, Steven D, Baldus S, Schaffer B, Jungen C, Eickholt C, Wassilew K, Schwedhelm E, Willems S, Meyer C (2016) Development of nonfibrotic left ventricular hypertrophy in an ANG II-induced chronic ovine hypertension model. Physiol Rep 4.

Koulchitsky S, Delairesse C, Beeken T, Monteforte A, Dethier J, Quertemont E, Findeisen R, Bullinger E, Seutin V (2016) Activation of D2 autoreceptors alters cocaine-induced locomotion and slows down local field oscillations in the rat ventral tegmental area. Neuropharmacology.

Kurkela JL, Lipponen A, Hamalainen JA, Naatanen R, Astikainen P (2016) Passive exposure to speech sounds induces long-term memory representations in the auditory cortex of adult rats. Sci Rep 6:38904.

Park S, Bandi A, Lee CR, Margolis DJ (2016) Peripheral optogenetic stimulation induces whisker movement and sensory perception in head-fixed mice. Elife 5.

Pinnell RC, Almajidy RK, Kirch RD, Cassel JC, Hofmann UG (2016) A Wireless EEG Recording Method for Rat Use inside the Water Maze. PLoS ONE 11:e0147730.

Zhou ZC, Yu C, Sellers KK, Frohlich F (2016) Dorso-Lateral Frontal Cortex of the Ferret Encodes Perceptual Difficulty during Visual Discrimination. Sci Rep 6:23568.

Lovell JM, Mylius J, Scheich H, Brosch M (2015) Stimulation of the Dopaminergic Midbrain as a Behavioral Reward in Instrumentally Conditioned Monkeys. Brain Stimul 8:868-874.

Tendler A, Wagner S (2015) Different types of theta rhythmicity are induced by social and fearful stimuli in a network associated with social memory. Elife 4.

Tolstosheeva E, Gordillo-Gonzalez V, Biefeld V, Kempen L, Mandon S, Kreiter AK, Lang W (2015) A multi-channel, flex-rigid ECoG microelectrode array for visual cortical interfacing. Sensors (Basel) 15:832-854.

Xie W, Santulli G, Reiken SR, Yuan Q, Osborne BW, Chen BX, Marks AR (2015) Mitochondrial oxidative stress promotes atrial fibrillation. Sci Rep 5:11427.

Cid E, Gomez-Dominguez D, Martin-Lopez D, Gal B, Laurent F, Ibarz JM, Francis F, Menendez de la Prida L (2014) Dampened hippocampal oscillations and enhanced spindle activity in an asymptomatic model of developmental cortical malformations. Front Syst Neurosci 8:50.

Friedrichs K, Adam M, Remane L, Mollenhauer M, Rudolph V, Rudolph TK, Andrie RP, Stockigt F, Schrickel JW, Ravekes T, Deuschl F, Nickenig G, Willems S, Baldus S, Klinke A (2014) Induction of atrial fibrillation by neutrophils critically depends on CD11b/CD18 integrins. PLoS ONE 9:e89307.

Georgieva P, Brugger D, Schwarz C (2014) Are spatial frequency cues used for whisker-based active discrimination? Front Behav Neurosci 8:379.

Harms L, Fulham WR, Todd J, Budd TW, Hunter M, Meehan C, Penttonen M, Schall U, Zavitsanou K, Hodgson DM, Michie PT (2014) Mismatch Negativity (MMN) in Freely-Moving Rats with Several Experimental Controls. PLoS ONE 9:e110892.

Reyes-Puerta V, Sun JJ, Kim S, Kilb W, Luhmann HJ (2014) Laminar and Columnar Structure of Sensory-Evoked Multineuronal Spike Sequences in Adult Rat Barrel Cortex In Vivo. Cereb Cortex.

Bellistri E, Aguilar J, Brotons-Mas JR, Foffani G, de la Prida LM (2013) Basic properties of somatosensory-evoked responses in the dorsal hippocampus of the rat. J Physiol 591:2667-2686.

Jahnke HG, Heimann A, Azendorf R, Mpoukouvalas K, Kempski O, Robitzki AA, Charalampaki P (2013) Impedance spectroscopy--an outstanding method for label-free and real-time discrimination between brain and tumor tissue in vivo. Biosens Bioelectron 46:8-14.

Yang JW, An S, Sun JJ, Reyes-Puerta V, Kindler J, Berger T, Kilb W, Luhmann HJ (2013) Thalamic network oscillations synchronize ontogenetic columns in the newborn rat barrel cortex. Cereb Cortex 23:1299-1316.

An S, Yang JW, Sun H, Kilb W, Luhmann HJ (2012) Long-term potentiation in the neonatal rat barrel cortex in vivo. J Neurosci 32:9511-9516.

Beckers GJ, Gahr M (2012) Large-Scale Synchronized Activity during Vocal Deviance Detection in the Zebra Finch Auditory Forebrain. J Neurosci 32:10594-10608.

Cao Y, Maran SK, Dhamala M, Jaeger D, Heck DH (2012) Behavior-related pauses in simple-spike activity of mouse purkinje cells are linked to spike rate modulation. J Neurosci 32:8678-8685.

Fernandez-Ruiz A, Makarov VA, Benito N, Herreras O (2012) Schaffer-Specific Local Field Potentials Reflect Discrete Excitatory Events at Gamma Frequency That May Fire Postsynaptic Hippocampal CA1 Units. J Neurosci 32:5165-5176.

Froriep UP, Kumar A, Cosandier-Rimele D, Haussler U, Kilias A, Haas CA, Egert U (2012) Altered theta coupling between medial entorhinal cortex and dentate gyrus in temporal lobe epilepsy. Epilepsia 53:1937-1947.

Grothe I, Neitzel SD, Mandon S, Kreiter AK (2012) Switching neuronal inputs by differential modulations of gamma-band phase-coherence. J Neurosci 32:16172-16180.

Kar K, Krekelberg B (2012) Transcranial electrical stimulation over visual cortex evokes phosphenes with a retinal origin. J Neurophysiol 108:2173-2178.

Klavir O, Genud-Gabai R, Paz R (2012) Low-frequency stimulation depresses the primate anterior-cingulate-cortex and prevents spontaneous recovery of aversive memories. J Neurosci 32:8589-8597.

Amano T, Duvarci S, Popa D, Pare D (2011) The fear circuit revisited: contributions of the Basal amygdala nuclei to conditioned fear. J Neurosci 31:15481-15489.

Blenkinsop TA, Lang EJ (2011) Synaptic action of the olivocerebellar system on cerebellar nuclear spike activity. J Neurosci 31:14708-14720.

Brockmann MD, Poschel B, Cichon N, Hanganu-Opatz IL (2011) Coupled oscillations mediate directed interactions between prefrontal cortex and hippocampus of the neonatal rat. Neuron 71:332-347.

Brodersen KH, Haiss F, Ong CS, Jung F, Tittgemeyer M, Buhmann JM, Weber B, Stephan KE (2011) Model-based feature construction for multivariate decoding. Neuroimage 56:601-615.

Duvarci S, Popa D, Pare D (2011) Central Amygdala Activity during Fear Conditioning. J Neurosci 31:289-294.

Fucke T, Suchanek D, Nawrot MP, Seamari Y, Heck DH, Aertsen A, Boucsein C (2011) Stereotypical spatiotemporal activity patterns during slow-wave activity in the neocortex. J Neurophysiol 106:3035-3044.

Gaunt RA, Bruns TM, Crammond DJ, Tomycz ND, Moossy JJ, Weber DJ (2011) Single- and multi-unit activity recorded from the surface of the dorsal root ganglia with non-penetrating electrode arrays. Conf Proc IEEE Eng Med Biol Soc 2011:6713-6716.

Janiesch PC, Kruger HS, Poschel B, Hanganu-Opatz IL (2011) Cholinergic control in developing prefrontal-hippocampal networks. J Neurosci 31:17955-17970.

Kremer Y, Leger JF, Goodman D, Brette R, Bourdieu L (2011) Late emergence of the vibrissa direction selectivity map in the rat barrel cortex. J Neurosci 31:10689-10700.

Makarova J, Ibarz JM, Makarov VA, Benito N, Herreras O (2011) Parallel readout of pathway-specific inputs to laminated brain structures. Front Syst Neurosci 5:77.

Mueller EE, Momen A, Masse S, Zhou YQ, Liu J, Backx PH, Henkelman RM, Nanthakumar K, Stewart DJ, Husain M (2011) Electrical remodelling precedes heart failure in an endothelin-1-induced model of cardiomyopathy. Cardiovasc Res 89:623-633.

Cymerblit-Sabba A, Schiller Y (2010) Network dynamics during development of pharmacologically induced epileptic seizures in rats in vivo. J Neurosci 30:1619-1630.

Ibarz JM, Foffani G, Cid E, Inostroza M, Menendez de la Prida L (2010) Emergent Dynamics of Fast Ripples in the Epileptic Hippocampus. J Neurosci 30:16249-16261.

Li N, Wehrens XH (2010) Programmed electrical stimulation in mice. J Vis Exp.

Putrino D, Mastaglia FL, Ghosh S (2010) Neural integration of reaching and posture: interhemispheric spike correlations in cat motor cortex. Exp Brain Res 202:765-777.

Stuttgen MC, Schwarz C (2010) Integration of vibrotactile signals for whisker-related perception in rats is governed by short time constants: comparison of neurometric and psychometric detection performance. J Neurosci 30:2060-2069.

Gullo F, Maffezzoli A, Dossi E, Wanke E (2009) Short-latency cross- and autocorrelation identify clusters of interacting cortical neurons recorded from multi-electrode array. J Neurosci Methods 181:186-198.

Haiss F, Butovas S, Schwarz C (2009) A miniaturized chronic microelectrode drive for awake behaving head restrained mice and rats. J Neurosci Methods.

Hosp JA, Molina-Luna K, Hertler B, Atiemo CO, Luft AR (2009) Dopaminergic modulation of motor maps in rat motor cortex: an in vivo study. Neuroscience 159:692-700.

Lottem E, Azouz R (2009) Mechanisms of Tactile Information Transmission through Whisker Vibrations. J Neurosci 29:11686-11697.

Marshall SP, Lang EJ (2009) Local changes in the excitability of the cerebellar cortex produce spatially restricted changes in complex spike synchrony. J Neurosci 29:14352-14362.

Paz R, Bauer EP, Pare D (2009) Measuring correlations and interactions among four simultaneously recorded brain regions during learning. J Neurophysiol 101:2507-2515.

Yang JW, Hanganu-Opatz IL, Sun JJ, Luhmann HJ (2009) Three patterns of oscillatory activity differentially synchronize developing neocortical networks in vivo. J Neurosci 29:9011-9025.

Gireesh ED, Plenz D (2008) Neuronal avalanches organize as nested theta- and beta/gamma-oscillations during development of cortical layer 2/3. Proc Natl Acad Sci U S A.

Hosp JA, Molina-Luna K, Hertler B, Atiemo CO, Stett A, Luft AR (2008) Thin-film epidural microelectrode arrays for somatosensory and motor cortex mapping in rat. J Neurosci Methods 172:255-262.

Mack KF, Leinung M, Stieve M, Lenarz T, Schwab B (2008) Clinical feasibility test on a minimally invasive laser therapy system in microsurgery of nerves. Minim Invasive Ther Allied Technol 17:292-299.

Stuttgen MC, Kullmann S, Schwarz C (2008) Responses of rat trigeminal ganglion neurons to longitudinal whisker stimulation. J Neurophysiol 100:1879-1884.

Stuttgen MC, Schwarz C (2008) Psychophysical and neurometric detection performance under stimulus uncertainty. Nat Neurosci 11:1091-1099.

Butovas S, Schwarz C (2007) Detection psychophysics of intracortical microstimulation in rat primary somatosensory cortex. Eur J Neurosci 25:2161-2169.

Henning J, Koczan D, Glass A, Karopka T, Pahnke J, Rolfs A, Benecke R, Gimsa U (2007) Deep brain stimulation in a rat model modulates TH, CaMKIIa and Homer1 gene expression. Eur J Neurosci 25:239-250.

Meier R, Haussler U, Aertsen A, Deransart C, Depaulis A, Egert U (2007) Short-term changes in bilateral hippocampal coherence precede epileptiform events. Neuroimage 38:138-149.

Molina-Luna K, Buitrago MM, Hertler B, Schubring M, Haiss F, Nisch W, Schulz JB, Luft AR (2007) Cortical stimulation mapping using epidurally implanted thin-film microelectrode arrays. J Neurosci Methods 161:118-125.

Polack PO, Guillemain I, Hu E, Deransart C, Depaulis A, Charpier S (2007) Deep layer somatosensory cortical neurons initiate spike-and-wave discharges in a genetic model of absence seizures. J Neurosci 27:6590-6599.

Schanze T, Hesse L (2007) Intraocular fluid-air exchange reduces retinal ganglion cell activity. Ophthalmologica 221:1-5.

Schrickel JW, Brixius K, Herr C, Clemen CS, Sasse P, Reetz K, Grohe C, Meyer R, Tiemann K, Schroder R, Bloch W, Nickenig G, Fleischmann BK, Noegel AA, Schwinger RH, Lewalter T (2007) Enhanced heterogeneity of myocardial conduction and severe cardiac electrical instability in annexin A7-deficient mice. Cardiovasc Res 76:257-268.

Song D, Chan RH, Marmarelis VZ, Hampson RE, Deadwyler SA, Berger TW (2007) Nonlinear dynamic modeling of spike train transformations for hippocampal-cortical prostheses. IEEE Trans Biomed Eng 54:1053-1066.

Tu Y, Kroener S, Abernathy K, Lapish C, Seamans J, Chandler LJ, Woodward JJ (2007) Ethanol inhibits persistent activity in prefrontal cortical neurons. J Neurosci 27:4765-4775.

Butovas S, Hormuzdi SG, Monyer H, Schwarz C (2006) Effects of electrically coupled inhibitory networks on local neuronal responses to intracortical microstimulation. J Neurophysiol 96:1227-1236.

Hentschke H, Haiss F, Schwarz C (2006) Central signals rapidly switch tactile processing in rat barrel cortex during whisker movements. Cereb Cortex 16:1142-1156.

Lang EJ, Sugihara I, Llinas R (2006) Olivocerebellar modulation of motor cortex ability to generate vibrissal movements in rat. J Physiol 571:101-120.

Möck MS, C. Butovas, S. (2006) Functional Unity of the Ponto-Cerebellum: Evidence That Intrapontine Communication Is Mediated by a Reciprocal Loop with the Cerebellar Nuclei. JNeurophysiology:12.

Stuttgen MC, Ruter J, Schwarz C (2006) Two psychophysical channels of whisker deflection in rats align with two neuronal classes of primary afferents. J Neurosci 26:7933-7941.

Bamford JA, Putman CT, Mushahwar VK (2005) Intraspinal microstimulation preferentially recruits fatigue-resistant muscle fibres and generates gradual force in rat. J Physiol 569:873-884.

Blanche TJ, Spacek MA, Hetke JF, Swindale NV (2005) Polytrodes: high-density silicon electrode arrays for large-scale multiunit recording. J Neurophysiol 93:2987-3000.

Glass A, Henning J, Karopka T, Scheel T, Bansemer S, Koczan D, Gierl L, Rolfs A, Gimsa U (2005) Representation of individual gene expression in completely pooled mRNA samples. Biosci Biotechnol Biochem 69:1098-1103.

Haiss F, Schwarz C (2005) Spatial segregation of different modes of movement control in the whisker representation of rat primary motor cortex. J Neurosci 25:1579-1587.

Hentschke H, Schwarz C, Antkowiak B (2005) Neocortex is the major target of sedative concentrations of volatile anaesthetics: strong depression of firing rates and increase of GABAA receptor-mediated inhibition. Eur J Neurosci 21:93-102.

Leger JF, Stern EA, Aertsen A, Heck D (2005) Synaptic integration in rat frontal cortex shaped by network activity. J Neurophysiol 93:281-293.

Liew CG, Moore H, Ruban L, Shah N, Cosgrove K, Dunne M, Andrews P (2005) Human embryonic stem cells: possibilities for human cell transplantation. Ann Med 37:521-532.

Mikkonen JE, Penttonen M (2005) Frequency bands and spatiotemporal dynamics of beta burst stimulation induced afterdischarges in hippocampus in vivo. Neuroscience 130:239-247.

Wilms M, Eckhorn R (2005) Spatiotemporal receptive field properties of epiretinally recorded spikes and local electroretinograms in cats. BMC Neurosci 6:50.

Aton SJ, Block GD, Tei H, Yamazaki S, Herzog ED (2004) Plasticity of circadian behavior and the suprachiasmatic nucleus following exposure to non-24-hour light cycles. J Biol Rhythms 19:198-207.

Kehat I, Khimovich L, Caspi O, Gepstein A, Shofti R, Arbel G, Huber I, Satin J, Itskovitz-Eldor J, Gepstein L (2004) Electromechanical integration of cardiomyocytes derived from human embryonic stem cells. Nat Biotechnol 22:1282-1289.

Lee S, Bick-Forrester J, Makkar RR, Forrester JS (2004) Stem-cell repair of infarcted myocardium: ready for clinical application? Am Heart Hosp J 2:100-106.

Marshall SP, Lang EJ (2004) Inferior olive oscillations gate transmission of motor cortical activity to the cerebellum. J Neurosci 24:11356-11367.

Yvert B, Branchereau P, Meyrand P (2004) Multiple spontaneous rhythmic activity patterns generated by the embryonic mouse spinal cord occur within a specific developmental time window. J Neurophysiol 91:2101-2109.

Butovas S, Schwarz C (2003) Spatiotemporal effects of microstimulation in rat neocortex: a parametric study using multielectrode recordings. J Neurophysiol 90:3024-3039.

Deransart C, Hellwig B, Heupel-Reuter M, Leger JF, Heck D, Lucking CH (2003) Single-unit analysis of substantia nigra pars reticulata neurons in freely behaving rats with genetic absence epilepsy. Epilepsia 44:1513-1520.

Herzog ED, Huckfeldt RM (2003) Circadian entrainment to temperature, but not light, in the isolated suprachiasmatic nucleus. J Neurophysiol 90:763-770.

Lang EJ, Rosenbluth J (2003) Role of myelination in the development of a uniform olivocerebellar conduction time. J Neurophysiol 89:2259-2270.

Lang EJ (2002) GABAergic and glutamatergic modulation of spontaneous and motor-cortex-evoked complex spike activity. J Neurophysiol 87:1993-2008.