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Cardiac in vivo/ex vivo recordings with flexible MEAs
Multi Channel Systems has a long standing reputation for in vitro electrophysiology. Our microelectrode arrays (MEA) have been used for more than two decades to record from cultured cardiomyocytes. Since the evolution of stem cell derived cardiomyocytes (ES and iPS) it was possible to work on human cardiomyocytes with our MEA technology.
Some years ago, we have moved this technology to a flexible substrate. With ultra-thin substrates, we are able to do epicardial mapping, in vivo and ex vivo on a Langendorff heart or in tissue constracts. You can combine this technology with standard Langendorff heart, so you can monitor pressure, volume and other functional parameters of the heart. In addition, you can also record contractility by recording mechanical parameters on circular contracts of cardiomyocytes.