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The system consists of a signal collector unit (MCS-SCU) for up to four headstages, which also contains a connector for up to four outputs for optical stimulation (optogenetics). The signal collector is connected via eSATA cable to the interface board. Up to two signal collectors can be connected to one MCS-IFB 3.0 multiboot interface board. Headstages have 32 recording channels plus ground and reference inputs. Amplifier, stimulators and A/D converters are all directly on the headstage, which allows low-noise, high quality data acquisition and impedance measuring.
The stimulator units can be connected by software command to any of the recording channels, or to a connector for an external stimulation electrode, which is also located at the headstage. Each of the 32 channels can be used for recording or stimulation, whereas 2 channels can be used for external stimulation electrodes as well.
As part of the system, the MCS-IFB 3.0 Multiboot is a new interface board generation which is able to receive data from a MEA2100-Headstage, a Multiwell-MEA-Headstage, a CMOS-MEA5000-Headstage, a MCS-SCU or a W2100-Receiver. This makes cost-effective combinations with only one interface board and multiple recording systems possible. You can establish for example your experiments on 60, 120, or 256 electrodes with the MEA2100-System, then add the Multiwell-MEA-Headstage and start high-throughput screening. It's also possible to use the same interface board for in vitro MEA experiments and tethered / wireless in vivo recordings. This leaves you with even more flexibility in switching between possible configurations for your specific research needs.
Read more technical specifications
The ME2100-System consists of an interface board (IFB), a signal collector unit (SCU) and the headstage amplifiers.
The interface board is the so called “MCS-IFB 3.0 multi-boot”. It transfers the data to the computer via USB 3.0 and can be used for a variety of applications. The same interface board, that you now get for your ME2100-System, can also be used e.g. for a Wireless-System. All you have to do is add receiver and wireless headstages, and you have complete Wireless-System. You can also use the same interface board for in vitro applications, by adding a MEA2100, Multiwell or CMOS headstage.
The signal collector unit gathers all data from the headstages and transfers them to the interface board. You can connect up to 4 headstages to each SCU, while 2 SCUs can be connected to one IFB. The signal collector unit can also control up to four optical stimulation units including high power LED.
The headstage amplifier is the connection to the probe. It amplifies 32 channels right at the signal source and digitizes the data at a 24bit resolution with 50 kHz sampling rate per channel, minimizing noise and thus optimizing the signal-to-noise ratio. Apart from amplifier and A/D converter, the headstages also include a 2-channel stimulus generator. The headstage is attached to a rod mount, so you can easily fix it to a micromanipulator.
Select any of the 32 electrodes as recording or stimulation electrode
Control two external stimulation electrodes (while still recording from the other 32 electrodes)
Freely select the reference electrode (any of the 32 electrodes can be selected via software)
Apart from the stimulation options, the headstages guarantee very exact data, because they sample the incoming signals at 50 kHz per channel at a resolution of 24bit (unmatched in the industry). They can do all this while keeping an ultra-low noise level (1µVRMS) and offering a large signal input range (±1.25V).
The signal collector unit receives data from up to four headstages. Two signal collector units can be connected to one interface board.
Apart from receiving and transferring data, the SCU is also able to control up to four optical stimulation units, including high power LED.
The ME2100-System offers the possibility to record from up to 8 headstages.
You can connect two signal collector units to one interface board. Each signal collector unit can receive data from up to four headstages. Thereby, you can build a system with 8 headstages, recording from 256 channels.
The interface board and signal collectors are equipped for this high channel count from the beginning. This way, you can start with one headstage (32 channels) and add-on more as you go. This gives you the flexibility to adjust the system to your changing experimental needs.
Multi Channel Systems offers flexible MEAs, made of polyimide foil. The FlexMEA32 and EcoFlexMEA36 can be connected directly to the ME2100-headstage.
You can also use other electrode arrays, for example probes from Neuronexus Technologies or ATLAS Neuroengineering.
The last component of the system is the computer with the software package Multi Channel Suite. The computer is not included in the scope of delivery; however, you can use any computer with a USB connector. What is included, is the Multi Channel Suite software.
It consists of three programs and updates are available for free here.
The ME2100-System is compatible with all kinds of in vivo electrode arrays on the market. Spike and LFP activity from acute or chronically implanted electrodes can be recorded with high resolution. It is possible to monitor any channel as an audio output in real-time, which helps positioning the electrode in the brain. Raw data and detected spikes can be monitored continuously. Additionally, the software offers on-line filtering, simple or complex references, and timer controlled automated recordings.
Multi Channel Systems has a team of highly-qualified scientists, whose only task is to help you with any issue you might have. No matter whether you want to know whether your biological sample is suitable for MEA recordings or if you have a specific software question: Our support team is here to help you.
We have scientists who earned their PhDs in the fields of biology, biophysics, and biochemistry and specialized in:
Our sales team has years of experience in electrophysiology, too. They can help you in choosing the right system for your specific application, give you advice on the general set-up and useful accessories. They are happy to visit you in your lab anytime to:
Worldwide, we are supported by our distribution partners. We have long-lasting cooperations with all of our partners and they are regularly trained on our equipment. Be sure that they have the expertise to advise you on all MCS-Systems.
Please do not hesitate to contact us. Normally, we reply to you within 24 hours. You can contact us via:
Tethered data acquisition system with integrated stimulation with up to 256 channels.
32 channel headstage for ME2100-Systems.