Incub8™ Multiwell MEA System

Tabs

Overview

Incub8 multiwell MEA front open MCS Incub8 headstage with 96w plate - right front

Incub8™ is a next-generation multiwell microelectrode array (MEA) system designed to deliver deeper insight from every experiment by combining electrophysiology and optical access (live-cell imaging) simultaneously. By capturing functional and morphological data simultaneously, researchers can cross-validate results, uncover more complete cellular insights, and generate more predictive, translatable data while reducing the need for parallel experiments. This integrated approach not only strengthens scientific conclusions, but also streamlines workflows, reduces reagent usage, and lowers overall experimental cost.

Watch a video

Built for real-world lab environments, Incub8 is the only multiwell MEA system that records directly inside a humidified CO₂ incubator, preserving stable conditions and eliminating disruptions that can introduce variability. With support for 24- and 96-well plates and scalability up to 768 simultaneous samples, it enables high-throughput screening without compromising data quality. Its flexible, compact design also supports use on the benchtop or under a microscope, while advanced software with barcode-based traceability ensures data integrity and reproducibility in even the most demanding workflows.

Works with our IFB-C Interface Board

One interface. Multiple systems. Total flexibility.

The IFB-C interface board simplifies your setup by connecting multiple Multi Channel Systems platforms through a single, unified interface. Whether you're working with one of our single-well, multiwell, CMOS, or in vivo solutions, the IFB-C allows you to seamlessly switch between configurations without rebuilding your workflow. Start with single-well recordings, scale to high-throughput screening, or move between in vitro and in vivo experiments, all using the same core hardware.

By consolidating multiple systems into one interface, the IFB-C reduces complexity, lowers equipment costs, and gives you the flexibility to adapt your setup as your research evolves.

Key features:

Real-time signal detection and feedback*
Freely programmable DSP*
Multiple inputs/outputs, including digital, analog, and audio
SuperSpeed USB 3.0 ports

*Available for MEA2100(-Mini), ME2100, and W2100 systems.

Description

Record from Inside a Humidified CO₂ Incubator

Record from Inside a Humidified CO₂ Incubator

Incub8 enables electrophysiological recordings directly inside a humidified CO₂ incubator, eliminating the need to transfer samples between environments. By maintaining stable temperature, humidity, and gas conditions throughout the experiment, the system preserves cell integrity and minimizes variability introduced by environmental changes.

This results in more reproducible, physiologically relevant data with higher predictive value. For long-term or sensitive cultures, stable conditions reduce experimental noise and the need for additional replicates, helping you generate reliable data more efficiently.

Run 2 Assays at Once: Simultaneous Electrophysiology & Live-Cell Imaging Data

Incub8 allows for simultaneous electrophysiology and live-cell imaging, allowing researchers to capture functional and morphological data simultaneously. This integrated approach enables direct cross-validation and a more complete understanding of cellular behavior.

By running two assays on the same sample, you reduce reagent usage, save time, and streamline workflows, without compromising data quality. The result is stronger, more reliable conclusions with improved efficiency across your experimental pipeline.

Up to 8 Experiments at Once

Incub8 is designed for scalable throughput, supporting both 24- and 96-well plate formats and enabling up to eight headstages to be linked simultaneously. This allows you to record from up to 768 samples in parallel, making it ideal for high-throughput screening and large-scale studies.

Running all samples under identical environmental conditions improves consistency and reproducibility across datasets. At the same time, the system’s compact footprint makes it easy to scale within standard incubators without increasing your lab footprint.

Incub8 multichannelsystems high throughput mea 768 samples at once

Incub8-Screen Software

Incub8-Screen Software

Incub8-Screen software is designed to support both standard and complex workflows, from experiment setup through data analysis. With automated routines for signal detection, quantification, and visualization, users can quickly move from acquisition to insight.

Advanced features such as barcode-based plate tracking, programmable experiment timing, and dedicated analysis modules for neuronal, cardiac, and compound screening ensure traceability, reproducibility, and efficiency, making it well-suited for both exploratory research and regulated environments.

Incub8-Screen software - multiwell MEA system - Multi Channel Systems HBio

Accessories that Enhance Environmental Control in Your Experiments

EnviroKit Active Heating Plates & CO₂ Control Modules: Maintain controlled environmental conditions for experiments conducted outside the incubator.
AccuTemp Stabilizer Passive Heating Plates: Designed for use inside the incubator, these plates reduce temperature variation across the plate to below 0.5°C, ensuring consistent and stable conditions for all samples. This minimizes edge effects and improves data quality through more precise temperature control.
Plates: Incub8 multiwell plates are optimized for optical measurements, enabling seamless combination of electrophysiology and imaging in a single experiment.
Incub8-VariPlate Base Adapter: While Incub8 plates are optimized for optical workflows, the included adapter allows the headstage to be used with standard, commercially available MEA plates.

Incub8 accessories MCS HBio - variplate_accutemp stabilizer passive heating plate_test plate_bluetoothscanner.

Seamless Integration with 3rd-Party Devices

Need to control other devices during your experiment? Incub8 supports TTL-based integration with third-party systems, enabling complex, multiparametric experiments. Data synchronization is built in, improving workflow efficiency and saving you hours of post hoc dataset alignment.

Products

Documents

Manual:

MCS_Incub8-MEA-System_Manual.pdf

Data sheet:

MCS_Incub8-System_Datasheet.pdf

MEAs

Multiwell MEA Plates

Multiwell plates for the Multiwell-MEA-System:

24 or 96 wells, 288 recording electrodes, 12 or 3 electrodes with reference per well, FR4 or transparent glass substrate, Sterilized by gamma radiation. Not for medical use.

Accessories

Tabs

Products

www.multichannelsystems.com

Innovations in Electrophysiology

Incub8™ Multiwell MEA System

Tabs