Innovations in Electrophysiology

Acute slices, hippocampus

Cavalier M, Ben Sedrine A, Thevenet L, Crouzin N, Guiramand J, de Jesus Ferreira MC, Cohen-Solal C, Barbanel G, Vignes M (2018) Disturbance of Metabotropic Glutamate Receptor-Mediated Long-Term Depression (mGlu-LTD) of Excitatory Synaptic Transmission in the Rat Hippocampus After Prenatal Immune Challenge. Neurochem Res.

Jammal L, Whalley B, Barkai E (2018) Learning induced modulation of the effect of neuroglial transmission on synaptic plasticity J Neurophysiol.

Arbogast T, Iacono G, Chevalier C, Afinowi NO, Houbaert X, van Eede MC, Laliberte C, Birling MC, Linda K, Meziane H, Selloum M, Sorg T, Nadif Kasri N, Koolen DA, Stunnenberg HG, Henkelman RM, Kopanitsa M, Humeau Y, De Vries BBA, Herault Y (2017) Mouse models of 17q21.31 microdeletion and microduplication syndromes highlight the importance of Kansl1 for cognition. PLoS Genet 13:e1006886.

Castro-Hernandez J, Adlard PA, Finkelstein DI (2017) Pramipexole restores depressed transmission in the ventral hippocampus following MPTP-lesion. Sci Rep 7:44426.

Henningson M, Illes S (2017) Analysis and Modeling of Subthreshold Neural Multi-Electrode Array Data by Statistical Field Theory. Front Comput Neurosci 11.

Horner AE, McLaughlin CL, Afinowi NO, Bussey TJ, Saksida LM, Komiyama NH, Grant SGN, Kopanitsa MV (2017) Enhanced cognition and dysregulated hippocampal synaptic physiology in mice with a heterozygous deletion of PSD-95. Eur J Neurosci.

Kasza A, Penke B, Frank Z, Bozso Z, Szegedi V, Hunya A, Nemeth K, Kozma G, Fulop L (2017) Studies for Improving a Rat Model of Alzheimer's Disease: Icv Administration of Well-Characterized beta-Amyloid 1-42 Oligomers Induce Dysfunction in Spatial Memory. Molecules 22.

Kim HB, Lee S, Hwang ES, Maeng S, Park JH (2017) p-Coumaric acid enhances long-term potentiation and recovers scopolamine-induced learning and memory impairments. Biochem Biophys Res Commun 492:493-499.

Klisch C (2017) Etablierung eines dreistufigen Messkonzepts zur elektrophysiologischen Analyse akuter Hirnschnitte. Fachbereich Biologie, Chemie, Pharmazie 

Liu B-W, Mao J-W, Shi Y-J, Lu Q-C, Liang P-J, Zhang P-M (2017) Dynamics in the neural network of an in vitro epilepsy model. International Journal of Data Mining and Bioinformatics 18:125-143.

Liu Q, Shi J, Lin R, Wen T (2017) Dopamine and dopamine receptor D1 associated with decreased social interaction. Behav Brain Res 324:51-57.

Schreurs A, Sabanov V, Balschun D (2017) Distinct Properties of Long-Term Potentiation in the Dentate Gyrus along the Dorsoventral Axis: Influence of Age and Inhibition. Scientific Reports 7:5157.

Shaban H, O'Connor R, Ovsepian SV, Dinan TG, Cryan JF, Schellekens H (2017) Electrophysiological approaches to unravel the neurobiological basis of appetite and satiety: use of the multielectrode array as a screening strategy. In: Drug Discov Today, 2016/09/17 Edition, pp 31-42.

Sors A, Panayi F, Bert L, Favale D, Nosjean O, Audinot V, Arrang JM, Buisson B, Steidl E, Delbos JM, Huhtala T, Kontkanen O, Chollet AM, Casara P, Lestage P (2017) Mechanistic characterization of S 38093, a novel inverse agonist at histamine H3 receptors. Eur J Pharmacol 803:11-23.

Vogel EW, 3rd, Rwema SH, Meaney DF, Bass CR, Morrison B, 3rd (2017) Primary Blast Injury Depressed Hippocampal Long-Term Potentiation through Disruption of Synaptic Proteins. J Neurotrauma 34:1063-1073.

Akhtar MW, Sanz-Blasco S, Dolatabadi N, Parker J, Chon K, Lee MS, Soussou W, McKercher SR, Ambasudhan R, Nakamura T, Lipton SA (2016) Elevated glucose and oligomeric beta-amyloid disrupt synapses via a common pathway of aberrant protein S-nitrosylation. Nat Commun 7:10242.

Broadhead MJ, Horrocks MH, Zhu F, Muresan L, Benavides-Piccione R, DeFelipe J, Fricker D, Kopanitsa MV, Duncan RR, Klenerman D, Komiyama NH, Lee SF, Grant SG (2016) PSD95 nanoclusters are postsynaptic building blocks in hippocampus circuits. Sci Rep 6:24626.

Chever O, Dossi E, Pannasch U, Derangeon M, Rouach N (2016) Astroglial networks promote neuronal coordination. Sci Signal 9:ra6.

Rubio A, Luoni M, Giannelli SG, Radice I, Iannielli A, Cancellieri C, Di Berardino C, Regalia G, Lazzari G, Menegon A, Taverna S, Broccoli V (2016) Rapid and efficient CRISPR/Cas9 gene inactivation in human neurons during human pluripotent stem cell differentiation and direct reprogramming. Sci Rep 6:37540.

Volkmann RA, Fanger CM, Anderson DR, Sirivolu VR, Paschetto K, Gordon E, Virginio C, Gleyzes M, Buisson B, Steidl E, Mierau SB, Fagiolini M, Menniti FS (2016) MPX-004 and MPX-007: New Pharmacological Tools to Study the Physiology of NMDA Receptors Containing the GluN2A Subunit. PLoS ONE 11:e0148129.

de Vin F, Choi SM, Bolognesi ML, Lefebvre RA (2015) Presynaptic M3 muscarinic cholinoceptors mediate inhibition of excitatory synaptic transmission in area CA1 of rat hippocampus. Brain Res 1629:260-269.

Grosser S (2015) Modulating Hippocampal Output in the Pilocarpine Model of Epilepsy by beta-adrenoceptor Activation. Lebenswissenschaftlichen Fakultät Dr. rer. nat.

Hsiao MC, Yu PN, Song D, Liu CY, Heck CN, Millett D, Berger TW (2015) An in vitro seizure model from human hippocampal slices using multi-electrode arrays. J Neurosci Methods 244:154-163.

Krishnan GP, Filatov G, Shilnikov A, Bazhenov M (2015) Electrogenic properties of the Na+/K+ ATPase controls transitions between normal and pathological brain states. J Neurophysiol:jn 00460 02014.

Menigoz A, Ahmed T, Sabanov V, Philippaert K, Pinto S, Kerselaers S, Segal A, Freichel M, Voets T, Nilius B, Vennekens R, Balschun D (2015) TRPM4-dependent post-synaptic depolarization is essential for the induction of NMDA receptor-dependent LTP in CA1 hippocampal neurons. Pflugers Arch.

Gong XW, Li JB, Lu QC, Liang PJ, Zhang PM (2014) Effective connectivity of hippocampal neural network and its alteration in Mg2+-free epilepsy model. PLoS ONE 9:e92961.

Grosser S, Queenan BN, Lalchandani RR, Vicini S (2014) Hilar Somatostatin Interneurons Contribute to Synchronized GABA Activity in an In Vitro Epilepsy Model. PLoS ONE 9:e86250.

Shi YJ, Gong XW, Gong HQ, Liang PJ, Zhang PM, Lu QC (2014) Effect of the entorhinal cortex on ictal discharges in low-Mg(2)(+)-induced epileptic hippocampal slice models. Neural Plast 2014:205912.

Heistek TS, Ruiperez-Alonso M, Timmerman AJ, Brussaard AB, Mansvelder HD (2013) alpha2-containing GABAA receptors expressed in hippocampal region CA3 control fast network oscillations. J Physiol 591:845-858.

Hsiao MC, Song D, Berger TW (2013) Nonlinear dynamical model based control of in vitro hippocampal output. Front Neural Circuits 7:20.

Liu JS, Li JB, Gong XW, Gong HQ, Zhang PM, Liang PJ, Lu QC (2013) Spatiotemporal dynamics of high-K(+)-induced epileptiform discharges in hippocampal slice and the effects of valproate. Neurosci Bull 29:28-36.

Ryan TJ, Kopanitsa MV, Indersmitten T, Nithianantharajah J, Afinowi NO, Pettit C, Stanford LE, Sprengel R, Saksida LM, Bussey TJ, O'Dell TJ, Grant SG, Komiyama NH (2013) Evolution of GluN2A/B cytoplasmic domains diversified vertebrate synaptic plasticity and behavior. Nat Neurosci 16:25-32.

Balemans MC, Nadif Kasri N, Kopanitsa MV, Afinowi NO, Ramakers G, Peters TA, Beynon AJ, Janssen SM, van Summeren RC, Eeftens JM, Eikelenboom N, Benevento M, Tachibana M, Shinkai Y, Kleefstra T, van Bokhoven H, Van der Zee CE (2012) Hippocampal dysfunction in the Euchromatin histone methyltransferase 1 heterozygous knockout mouse model for Kleefstra syndrome. Hum Mol Genet.

Becker K, Eder M, Ranft A, von Meyer L, Zieglgansberger W, Kochs E, Dodt HU (2012) Low dose isoflurane exerts opposing effects on neuronal network excitability in neocortex and hippocampus. PLoS ONE 7:e39346.

Coba MP, Komiyama NH, Nithianantharajah J, Kopanitsa MV, Indersmitten T, Skene NG, Tuck EJ, Fricker DG, Elsegood KA, Stanford LE, Afinowi NO, Saksida LM, Bussey TJ, O'Dell TJ, Grant SG (2012) TNiK is required for postsynaptic and nuclear signaling pathways and cognitive function. J Neurosci 32:13987-13999.


Gonzalez-Sulser A, Wang J, Queenan BN, Avoli M, Vicini S, Dzakpasu R (2012) Hippocampal neuron firing and local field potentials in the in vitro 4-aminopyridine epilepsy model. J Neurophysiol 108:2568-2580.

Liu MG, Chen XF, He T, Li Z, Chen J (2012) Use of multi-electrode array recordings in studies of network synaptic plasticity in both time and space. Neurosci Bull 28:409-422.

Motamedi GK, Gonzalez-Sulser A, Dzakpasu R, Vicini S (2012) Cellular mechanisms of desynchronizing effects of hypothermia in an in vitro epilepsy model. Neurotherapeutics 9:199-209.

Chong SA, Benilova I, Shaban H, De Strooper B, Devijver H, Moechars D, Eberle W, Bartic C, Van Leuven F, Callewaert G (2011) Synaptic dysfunction in hippocampus of transgenic mouse models of Alzheimer's disease: a multi-electrode array study. Neurobiol Dis 44:284-291.

Filatov G, Krishnan GP, Rulkov NF, Bazhenov M (2011) Dynamics of epileptiform activity in mouse hippocampal slices. J Biol Phys 37:347-360.

Jansen R, Timmerman J, Loos M, Spijker S, van Ooyen A, Brussaard AB, Mansvelder HD, Smit AB, de Gunst M, Linkenkaer-Hansen K (2011) Novel candidate genes associated with hippocampal oscillations. PLoS ONE 6:e26586.

Nivet E, Vignes M, Girard SD, Perrisnard C, Barli N, Deveze A, Magnan J, Lante F, Khrestchatisky M, Feron F, Roman FS (2011) Engraftment of human nasal olfactory stem cells restores neuroplasticity in mice with hippocampal lesions. The Journal of Clinical Investigation.

Poil SS, Jansen R, van Aerde K, Timmerman J, Brussaard AB, Mansvelder HD, Linkenkaer-Hansen K (2011) Fast network oscillations in vitro exhibit a slow decay of temporal auto-correlations. Eur J Neurosci 34:394-403.

Virok DP, Kis Z, Szegedi V, Juhasz G, Zvara A, Jr., Muller G, Levay G, Harsing LG, Rajko R, Penke B, Janka Z, Janaky T, Puskas LG (2011) Functional changes in transcriptomes of the prefrontal cortex and hippocampus in a mouse model of anxiety. Pharmacol Rep 63:348-361.

Boido D, Farisello P, Cesca F, Ferrea E, Valtorta F, Benfenati F, Baldelli P (2010) Cortico-hippocampal hyperexcitability in synapsin I/II/III knockout mice: age-dependency and response to the antiepileptic drug levetiracetam. Neuroscience.

Dinklo T, Shaban H, Thuring JW, Lavreysen H, Stevens KE, Zheng L, Mackie C, Grantham C, Vandenberk I, Meulders G, Peeters L, Verachtert H, De Prins E, Lesage AS (2010) Characterization of 2-[[ 4-fluoro-3-(trifluoromethyl)phenyl]amino]-4-(4-pyridinyl)-5- thiazolemethanol (JNJ-1930942), a novel positive allosteric modulator of the {alpha}7 nicotinic acetylcholine receptor. J Pharmacol Exp Ther.

Gonzalez-Sulser A, Wang J, Motamedi GK, Avoli M, Vicini S, Dzakpasu R (2010) The 4-aminopyridine in vitro epilepsy model analyzed with a perforated multi-electrode array. Neuropharmacology.

Jones NA, Hill AJ, Smith I, Bevan SA, Williams CM, Whalley BJ, Stephens GJ (2010) Cannabidiol displays antiepileptiform and antiseizure properties in vitro and in vivo. J Pharmacol Exp Ther 332:569-577.

Liu JS, Gong XW, Gong HQ, Zhang PM, Liang PJ, Lu QC (2010) [Exploring spatiotemporal patterns of epileptiform discharge in hippocampal slice using multi-electrode arrays.]. Sheng Li Xue Bao 62:163-170.

Valeeva G, Abdullin A, Tyzio R, Skorinkin A, Nikolski E, Ben-Ari Y, Khazipov R (2010) Temporal coding at the immature depolarizing GABAergic synapse. Frontiers in Cellular Neuroscience 4:12.

Yang F, Gong XW, Gong HQ, Zhang PM, Liang PJ, Lu Q (2010) MicroeIectrode array recordings of excitability of Iow Mg2+-induced acute hippocampaI slices. Neural Regen Res 5:1548-1551.

Fernandez E, Collins MO, Uren RT, Kopanitsa MV, Komiyama NH, Croning MD, Zografos L, Armstrong JD, Choudhary JS, Grant SG (2009) Targeted tandem affinity purification of PSD-95 recovers core postsynaptic complexes and schizophrenia susceptibility proteins. Mol Syst Biol 5:269.

Hill AJ, Jones NA, Williams CM, Stephens GJ, Whalley BJ (2009) Development of multi-electrode array screening for anticonvulsants in acute rat brain slices. J Neurosci Methods.

Muratore R, Lamanna J, Szulman E, Kalisz A, Lamprecht M, Simon M, Yu Z, Xu N, Morrison B, 3rd (2009) Bioeffective Ultrasound at Very Low Doses: Reversible Manipulation of Neuronal Cell Morphology and Function in Vitro. 8th International Symposium on Therapeutic Ultrasound.

Dimoka A, Courellis SH, Gholmieh GI, Marmarelis VZ, Berger TW (2008) Modeling the nonlinear properties of the in vitro hippocampal perforant path-dentate system using multielectrode array technology. IEEE Trans Biomed Eng 55:693-702.

Dimoka A, Courellis SH, Marmarelis VZ, Berger TW (2008) Modeling the Nonlinear Dynamic Interactions of Afferent Pathways in the Dentate Gyrus of the Hippocampus. Ann Biomed Eng.

Lante F, Crouzin N, Vignes M (2008) Unveiling novel forms of hippocampal synaptic plasticity with microelectrode arrays. J Integr Neurosci 7:249-270.

Andersson M, Blomstrand F, Hanse E (2007) Astrocytes play a critical role in transient heterosynaptic depression in the rat hippocampal CA1 region. J Physiol 585:843-852.

Gholmieh G, Soussou W, Han M, Ahuja A, Hsiao MC, Song D, Tanguay AR, Jr., Berger TW (2006) Custom-designed high-density conformal planar multielectrode arrays for brain slice electrophysiology. J Neurosci Methods 152:116-129.

Giugliano M, Martinoia S (2006) Substrate arrays of microelectrodes for in vitro electrophysiology. In: Wiley Encyclopedia on Biomedical Engineering, pp 1-11.

Hofmann F, Bading H (2006) Long term recordings with microelectrode arrays: studies of transcription-dependent neuronal plasticity and axonal regeneration. J Physiol Paris 99:125-132.

Kim MT, Soussou W, Gholmieh G, Ahuja A, Tanguay A, Berger TW, Brinton RD (2006) 17beta-Estradiol potentiates field excitatory postsynaptic potentials within each subfield of the hippocampus with greatest potentiation of the associational/commissural afferents of CA3. Neuroscience 141:391-406.

Kopanitsa MV, Afinowi NO, Grant SG (2006) Recording long-term potentiation of synaptic transmission by three-dimensional multi-electrode arrays. BMC Neurosci 7:61.

Lante F, de Jesus Ferreira MC, Guiramand J, Recasens M, Vignes M (2006) Low-frequency stimulation induces a new form of LTP, metabotropic glutamate (mGlu5) receptor- and PKA-dependent, in the CA1 area of the rat hippocampus. Hippocampus 16:345-360.

Steidl EM, Neveu E, Bertrand D, Buisson B (2006) The adult rat hippocampal slice revisited with multi-electrode arrays. Brain Res 1096:70-84.

Egert U (2005) Perforated Microelectrode Arrays Optimize Oxygen Availability and Signal-to-Noise Ratio in Brain Slice Recordings. MSTKongress.

Gholmieh G, Courellis S, Dimoka A, Wills JD, LaCoss J, Granacki JJ, Marmarelis V, Berger T (2004) An algorithm for real-time extraction of population EPSP and population spike amplitudes from hippocampal field potential recordings. J Neurosci Methods 136:111-121.

Heuschkel MO, Fejtl M, Raggenbass M, Bertrand D, Renaud P (2002) A three-dimensional multi-electrode array for multi-site stimulation and recording in acute brain slices. J Neurosci Methods 114:135-148.

Egert M (2001) Application of the microelectrode-array (MEA) technology in pharmaceutical drug research. Neurobiologentagung Göttingen:4.

Gholmieh G, Soussou W, Courellis S, Marmarelis V, Berger T, Baudry M (2001) A biosensor for detecting changes in cognitive processing based on nonlinear systems analysis. Biosens Bioelectron 16:491-501.