www.multichannelsystems.com

Innovations in Electrophysiology

Cardiophysiology

An Z, Wu J, Li SH, Chen S, Lu FL, Xu ZY, Sung HW, Li RK (2021) Injectable conductive hydrogel can reduce pacing threshold and enhance efficacy of cardiac pacemaker. Theranostics 11:3948-3960.

Asulin M, Michael I, Shapira A, Dvir T (2021) One-Step 3D Printing of Heart Patches with Built-In Electronics for Performance Regulation. Advanced Science n/a:2004205.

Finklea FB, Tian Y, Kerscher P, Seeto WJ, Ellis ME, Lipke EA (2021) Engineered Cardiac Tissue Microsphere Production through Direct Differentiation of Hydrogel-encapsulated Human Pluripotent Stem Cells. Biomaterials:120818.

Häkli M, Kreutzer J, Mäki AJ, Välimäki H, Lappi H, Huhtala H, Kallio P, Aalto-Setälä K, Pekkanen-Mattila M (2021) Human induced pluripotent stem cell-based platform for modeling cardiac ischemia. Sci Rep 11:4153.

Hammer KP, Mustroph J, Stauber T, Birchmeier W, Wagner S, Maier LS (2021) Beneficial effect of voluntary physical exercise in Plakophilin2 transgenic mice. PLoS ONE 16:e0252649.

Hong L, Zhang M, Ly OT, Chen H, Sridhar A, Lambers E, Chalazan B, Youn SW, Maienschein-Cline M, Feferman L, Ong SG, Wu JC, Rehman J, Darbar D (2021) Human induced pluripotent stem cell-derived atrial cardiomyocytes carrying an SCN5A mutation identify nitric oxide signaling as a mediator of atrial fibrillation. Stem Cell Reports.

Li J, Liu L, Minami I, Miyagawa S, Sawa Y (2021) Fabrication of Thick and Anisotropic Cardiac TissueCardiac tissue on Nanofibrous Substrate for Repairing Infarcted Myocardium. In: Pluripotent Stem-Cell Derived Cardiomyocytes (Yoshida Y, ed), pp 65-73. New York, NY: Springer US.

Liu JYH, Du P, Lu Z, Kung JSC, Huang IB, Hui JCM, Ng HSH, Ngan MP, Cui D, Jiang B, Chan SW, Rudd JA (2021) Involvement of TRPV1 and TRPA1 in the modulation of pacemaker potentials in the mouse ileum. Cell Calcium 97:102417.

Mustroph J, Sag Can M, Bähr F, Schmidtmann A-L, Gupta Shamindra N, Dietz A, Islam MMT, Lücht CM, Beuthner EB, Pabel S, Baier MJ, El-Armouche A, Sossalla S, Anderson ME, Möllmann J, Lehrke M, Marx N, Mohler PJ, Bers DM, Unsöld B, He T, Dewenter M, Backs J, Maier LS, Wagner S (2021) Loss of CASK Accelerates Heart Failure Development. Circ Res 0.

Niehoff J, Matzkies M, Nguemo F, Hescheler J, Reppel M (2021) The influence of melatonin on the heart rhythm - An in vitro simulation with murine embryonic stem cell derived cardiomyocytes. Biomed Pharmacother 136:111245.

Oláh A, Barta BA, Sayour AA, Ruppert M, Virág-Tulassay E, Novák J, Varga ZV, Ferdinandy P, Merkely B, Radovits T (2021) Balanced Intense Exercise Training Induces Atrial Oxidative Stress Counterbalanced by the Antioxidant System and Atrial Hypertrophy That Is Not Associated with Pathological Remodeling or Arrhythmogenicity. Antioxidants 10:452.

Scott L, Fender AC, Saljic A, Li L, Chen X, Wang X, Linz D, Lang J, Hohl M, Twomey D, Pham TT, Diaz-Lankenau R, Chelu MG, Kamler M, Entman ML, Taffet GE, Sanders P, Dobrev D, Li N (2021) NLRP3 inflammasome is a key driver of obesity-induced atrial arrhythmias. Cardiovasc Res.

Trosclair K, Si M, Watts M, Gautier NM, Voigt N, Traylor J, Bitay M, Baczko I, Dobrev D, Hamilton KA, Bhuiyan MS, Dominic P, Glasscock E (2021) Kv1.1 potassium channel subunit deficiency alters ventricular arrhythmia susceptibility, contractility, and repolarization. Physiol Rep 9:e14702.

Watts M, Kolluru GK, Dherange P, Pardue S, Si M, Shen X, Trosclair K, Glawe J, Al-Yafeai Z, Iqbal M, Pearson BH, Hamilton KA, Orr AW, Glasscock E, Kevil CG, Dominic P (2021) Decreased bioavailability of hydrogen sulfide links vascular endothelium and atrial remodeling in atrial fibrillation. Redox Biology 38:101817.

Xie D, Xiong K, Su X, Wang G, Ji Q, Zou Q, Wang L, Liu Y, Liang D, Xue J, Gao X, Gu X, Liu H, He X, Li L, Yang J, Lu Y, Peng L, Chen YH (2021) Identification of an endogenous glutamatergic transmitter system controlling excitability and conductivity of atrial cardiomyocytes. Cell Res.

Aalders J, Léger L, Van der Meeren L, Van den Vreken N, Skirtach AG, Sinha S, De Backer J, van Hengel J (2020) Effects of fibrillin mutations on the behavior of heart muscle cells in Marfan syndrome. Scientific Reports 10:16756.

Athanasiadis M, Afanasenkau D, Derks W, Tondera C, Murganti F, Busskamp V, Bergmann O, Minev IR (2020) Printed elastic membranes for multimodal pacing and recording of human stem-cell-derived cardiomyocytes. npj Flexible Electronics 4:16.

Balafkan N, Mostafavi S, Schubert M, Siller R, Liang KX, Sullivan G, Bindoff LA (2020) A method for differentiating human induced pluripotent stem cells toward functional cardiomyocytes in 96-well microplates. Sci Rep 10:18498.

Cai H, Li B, Bai A, Huang J, Zhan Y, Sun N, Liang Q, Xu C (2020) Establishing a new human hypertrophic cardiomyopathy-specific model using human embryonic stem cells. Exp Cell Res 387:111736.

Chen S, Hsieh MH, Li SH, Wu J, Weisel RD, Chang Y, Sung HW, Li RK (2020) A conductive cell-delivery construct as a bioengineered patch that can improve electrical propagation and synchronize cardiomyocyte contraction for heart repair. J Control Release 320:73-82.

Gupta A, Fei YD, Kim TY, Xie A, Batai K, Greener I, Tang H, Ciftci-Yilmaz S, Juneman EB, Indik JH, Shi G, Christensen J, Gupta G, Hillery CA, Kansal M, Parikh DS, Zhou T, Yuan JX, Kanthi Y, Bronk P, Koren G, Kittles R, Duarte J, Garcia JGN, Machado RF, Dudley SC, Choi BR, Desai AA (2020) IL-18 mediates sickle cell cardiomyopathy and ventricular arrhythmias. Blood.

He S, Wu J, Li SH, Wang L, Sun Y, Xie J, Ramnath D, Weisel RD, Yau TM, Sung HW, Li RK (2020) The conductive function of biopolymer corrects myocardial scar conduction blockage and resynchronizes contraction to prevent heart failure. Biomaterials 258:120285.

Hochman-Mendez C, Pereira de Campos DB, Pinto RS, Mendes BJ, Rocha GM, Monnerat G, Weissmuller G, Sampaio LC, Carvalho AB, Taylor DA, de Carvalho ACC (2020) Tissue-engineered human embryonic stem cell-containing cardiac patches: evaluating recellularization of decellularized matrix. Journal of Tissue Engineering 11:2041731420921482.

Li J, Zhang L, Yu L, Minami I, Miyagawa S, Horning M, Dong J, Qiao J, Qu X, Hua Y, Fujimoto N, Shiba Y, Zhao Y, Tang F, Chen Y, Sawa Y, Tang C, Liu L (2020) Circulating re-entrant waves promote maturation of hiPSC-derived cardiomyocytes in self-organized tissue ring. Commun Biol 3:122.

Liu H, Bolonduro OA, Hu N, Ju J, Rao AA, Duffy BM, Huang Z, Black LD, Timko BP (2020) Heart-on-a-Chip Model with Integrated Extra- and Intracellular Bioelectronics for Monitoring Cardiac Electrophysiology under Acute Hypoxia. Nano Letters 20:2585-2593.

Ma S, Ma J, Tu Q, Zheng C, Chen Q, Lv W (2020) Isoproterenol Increases Left Atrial Fibrosis and Susceptibility to Atrial Fibrillation by Inducing Atrial Ischemic Infarction in Rats. Front Pharmacol 11:493.

Melle G, Bruno G, Maccaferri N, Iachetta G, Colistra N, Barbaglia A, Dipalo M, De Angelis F (2020) Intracellular Recording of Human Cardiac Action Potentials on Market-Available Multielectrode Array Platforms. Frontiers in Bioengineering and Biotechnology 8.

Mesubi OO, Rokita AG, Abrol N, Wu Y, Chen B, Wang Q, Granger JM, Luczak ED, Banerjee PS, Maier LS, Wehrens XH, Pomerantz JL, Song L-S, Ahima RS, Zachara NE, Hart GW, Anderson ME (2020) O-GlcNAcylation and oxidation contribute to atrial fibrillation in diabetes by activating CaMKII. bioRxiv:2020.2002.2018.954909.

Mollenhauer M, Mehrkens D, Klinke A, Lange M, Remane L, Friedrichs K, Braumann S, Geißen S, Simsekyilmaz S, Nettersheim FS, Lee S, Peinkofer G, Geisler AC, Geis B, Schwoerer AP, Carrier L, Freeman BA, Dewenter M, Luo X, El-Armouche A, Wagner M, Adam M, Baldus S, Rudolph V (2020) Nitro-fatty acids suppress ischemic ventricular arrhythmias by preserving calcium homeostasis. Sci Rep 10:15319.

Mustroph J, Drzymalski M, Baier M, Pabel S, Biedermann A, Memmel B, Durczok M, Neef S, Sag CM, Floerchinger B, Rupprecht L, Schmid C, Zausig Y, Bégis G, Briand V, Ozoux ML, Tamarelle D, Ballet V, Janiak P, Beauverger P, Maier LS, Wagner S (2020) The oral Ca/calmodulin-dependent kinase II inhibitor RA608 improves contractile function and prevents arrhythmias in heart failure. ESC Heart Fail.

Mustroph J, Drzymalski M, Baier M, Pabel S, Biedermann A, Memmel B, Durczok M, Neef S, Sag CM, Floerchinger B, Rupprecht L, Schmid C, Zausig Y, Bégis G, Briand V, Ozoux M-L, Tamarelle D, Ballet V, Janiak P, Beauverger P, Maier LS, Wagner S (2020) The oral Ca/calmodulin-dependent kinase II inhibitor RA608 improves contractile function and prevents arrhythmias in heart failure. ESC Heart Failure n/a.

Ng KE, Delaney PJ, Thenet D, Murtough S, Webb CM, Tsisanova E, Walker SLM, Westaby JD, Pennington DJ, Pink R, Kelsell DP, Tinker A (2020) Early cardiac inflammation as a driver of murine model of Arrhythmogenic Cardiomyopathy. bioRxiv:2020.2006.2024.169664.

Sasserath T, Rumsey JW, McAleer CW, Bridges LR, Long CJ, Elbrecht D, Schuler F, Roth A, Bertinetti-LaPatki C, Shuler ML, Hickman JJ (2020) Differential Monocyte Actuation in a Three-Organ Functional Innate Immune System-on-a-Chip. Advanced Science n/a:2000323.

Sasserath T, Rumsey JW, McAleer CW, Bridges LR, Long CJ, Elbrecht DH, Schuler F, Roth A, Bertinetti-LaPatki C, Shuler ML, Hickman JJ (2020) Differential Monocyte Actuation in a Three-Organ Functional Innate Immune System-on-a-Chip. Advanced Science n/a:2000323.

Schinner C, Erber BM, Yeruva S, Schlipp A, Rötzer V, Kempf E, Kant S, Leube RE, Mueller TD, Waschke J (2020) Stabilization of desmoglein-2 binding rescues arrhythmia in arrhythmogenic cardiomyopathy. JCI Insight 5.

Schneider J, Pease DR, Navaratnarajah CK, Halfmann P, Clemens DJ, Ye D, Kim CS, Barkhymer A, Cohle S, Banks A, Mehta A, Rantus J, Emmerzaal TL, Kozicz T, Howell KG, Charlesworth JE, Christensen TA, Yoshihiro Kawaoka Y, Cooper LT, Ackerman MJ, Cattaneo R (2020) SARS-CoV-2 direct cardiac damage through spike-mediated cardiomyocyte fusion Nature Research.

Shah D (2020) Heart Disease on a Dish. Faculty of Medicine and Health Technology

Stangherlin A, Wong DCS, Barbiero S, Watson JL, Zeng A, Seinkmane E, Chew SP, Beale AD, Hayter EA, Guna A, Inglis AJ, Bartolami E, Matile S, Lequeux N, Pons T, Day JJ, van Ooijen G, Voorhees RM, Bechtold DA, Derivery E, Edgar RS, Newham P, O’Neill JS (2020) Compensatory ion transport buffers daily protein rhythms to regulate osmotic balance and cellular physiology. bioRxiv:2020.2005.2028.118398.

Stauske M, Rodriguez Polo I, Haas W, Knorr DY, Borchert T, Streckfuss-Bömeke K, Dressel R, Bartels I, Tiburcy M, Zimmermann WH, Behr R (2020) Non-Human Primate iPSC Generation, Cultivation, and Cardiac Differentiation under Chemically Defined Conditions. Cells 9.

Tai CH, Pan MK, Tseng SH, Wang TR, Kuo CC (2020) Hyperpolarization of the subthalamic nucleus alleviates hyperkinetic movement disorders. Sci Rep 10:8278.

van Veldhoven JPD, Campostrini G, van Gessel CJE, Ward-van Oostwaard D, Liu R, Mummery CL, Bellin M, Ijzerman AP (2020) Targeting the Kv11.1 (hERG) channel with allosteric modulators. Synthesis and biological evaluation of three novel series of LUF7346 derivatives. European Journal of Medicinal Chemistry:113033.

Wang L, Ma H, Huang P, Xie Y, Near D, Wang H, Xu J, Yang Y, Xu Y, Garbutt T, Zhou Y, Liu Z, Yin C, Bressan M, Taylor JM, Liu J, Qian L (2020) Down-regulation of Beclin1 promotes direct cardiac reprogramming. Sci Transl Med 12.

Amend N, Thiermann H, Worek F, Wille T (2019) The arrhythmogenic potential of nerve agents and a cardiac safety profile of antidotes - A proof-of-concept study using human induced pluripotent stem cells derived cardiomyocytes (hiPSC-CM). Toxicol Lett 308:1-6.

Caluori G, Raiteri R, Tedesco M (2019) Simultaneous AFM Investigation of the Single Cardiomyocyte Electro-Chemo-Mechanics During Excitation-Contraction Coupling. Methods Mol Biol 1886:355-367.

Geng L, Wang S, Zhang F, Xiong K, Huang J, Zhao T, Shi D, Lv F, Li L, Liang D, Cui Y, Liu Y, Xie D, Chen YH (2019) SNX17 (Sorting Nexin 17) Mediates Atrial Fibrillation Onset Through Endocytic Trafficking of the Kv1.5 (Potassium Voltage-Gated Channel Subfamily A Member 5) Channel. Circ Arrhythm Electrophysiol 12:e007097.

Gilmore JL, Xiao HY, Dhar TGM, Yang MG, Xiao Z, Xie J, Lehman-McKeeman LD, Gong L, Sun H, Lecureux L, Chen C, Wu DR, Dabros M, Yang X, Taylor TL, Zhou XD, Heimrich EM, Thomas R, McIntyre KW, Borowski V, Warrack BM, Li Y, Shi H, Levesque PC, Yang Z, Marino AM, Cornelius G, D'Arienzo CJ, Mathur A, Rampulla R, Gupta A, Pragalathan B, Shen DR, Cvijic ME, Salter-Cid LM, Carter PH, Dyckman AJ (2019) Identification and Preclinical Pharmacology of ((1 R,3 S)-1-Amino-3-(( S)-6-(2-methoxyphenethyl)-5,6,7,8-tetrahydronaphthalen-2-yl)cyclopentyl)methanol (BMS-986166): A Differentiated Sphingosine-1-phosphate Receptor 1 (S1P1) Modulator Advanced into Clinical Trials. J Med Chem 62:2265-2285.

Jungen C, Scherschel K, Flenner F, Jee H, Rajendran PS, De Jong KA, Nikolaev VO, Meyer C, Ardell JL, Tompkins JD (2019) Increased arrhythmia susceptibility in type 2 diabetic mice related to dysregulation of ventricular sympathetic innervation. Am J Physiol Heart Circ Physiol.

Kim J, Shah D, Potapov I, Latukka J, Aalto-Setala K, Rasanen E (2019) Scaling and correlation properties of RR and QT intervals at the cellular level. Sci Rep 9:3651.

Köhler T (2019) Auswirkungen elektromagnetischer Strahlung auf die elektrophysiologischen Eigenschaften neuronaler und kardialer Zellnetzwerke Fachbereich Biologie

Kraushaar U, Guenther E (2019) Assay Procedures for Compound Testing of hiPSC-Derived Cardiomyocytes Using Multiwell Microelectrode Arrays. Methods Mol Biol 1994:197-208.

Kugler P, Rast G, Guth BD (2019) Comparison of in vitro and computational experiments on the relation of inter-beat interval and duration of repolarization in a specific type of human induced pluripotent stem cell-derived cardiomyocytes. PLoS ONE 14:e0221763.

Kussauer S, David R, Lemcke H (2019) hiPSCs Derived Cardiac Cells for Drug and Toxicity Screening and Disease Modeling: What Micro- Electrode-Array Analyses Can Tell Us. Cells 8.

Lees JG, Kong AM, Chen YC, Sivakumaran P, Hernandez D, Pebay A, Harvey AI, Gardener DK, Lim SY (2019) Mitochondrial Fusion by M1 Promotes Embryoid Body Cardiac Differentiation of Human Pluripotent Stem Cells. Stem Cells International 2019:12.

Li J, Zhang L, Yu L, Minami I, Hörning M, Dong J, Qiao J, Fujimoto N, Shiba Y, Zhao Y, Tang F, Miyagawa S, Chen Y, Sawa Y, Tang C, Liu L (2019) Rapid pacing by circulating traveling waves improves maturation of hiPSC-derived cardiomyocytes in self-organized tissue ring. bioRxiv:717108.

Ma S, Ma J, Guo L, Bai J, Mao S, Zhang M (2019) Tongguan capsule-derived herb reduces susceptibility to atrial fibrillation by inhibiting left atrial fibrosis via modulating cardiac fibroblasts. J Cell Mol Med 23:1197-1210.

McAleer CW, Pointon A, Long CJ, Brighton RL, Wilkin BD, Bridges LR, Narasimhan Sriram N, Fabre K, McDougall R, Muse VP, Mettetal JT, Srivastava A, Williams D, Schnepper MT, Roles JL, Shuler ML, Hickman JJ, Ewart L (2019) On the potential of in vitro organ-chip models to define temporal pharmacokinetic-pharmacodynamic relationships. Sci Rep 9:9619.

Medeiros P, Negrini-Ferrari SE, Medeiros AC, Ferreira LL, Torres da Silva JR, da Silva JA, Coimbra NC, de Freitas RL (2019) The Primary Motor Cortex Stimulation Attenuates Cold Allodynia in a Chronic Peripheral Neuropathic Pain Condition in Rattus norvegicus. WJNS 9.

Menon A, Hong L, Savio-Galimberti E, Sridhar A, Youn SW, Zhang M, Kor K, Blair M, Kupershmidt S, Darbar D (2019) Electrophysiologic and molecular mechanisms of a frameshift NPPA mutation linked with familial atrial fibrillation. J Mol Cell Cardiol 132:24-35.

Niehoff J, Matzkies M, Nguemo F, Hescheler J, Reppel M (2019) The Effect of Antiarrhythmic Drugs on the Beat Rate Variability of Human Embryonic and Human Induced Pluripotent Stem Cell Derived Cardiomyocytes. Sci Rep 9:14106.

Oleaga C, Jalilvand G, Legters G, Martin C, Ekman G, McAleer CW, Long CJ, Hickman JJ (2019) A human in vitro platform for the evaluation of pharmacology strategies in cardiac ischemia. APL Bioeng 3:036103.

Ornelas-Loredo A, Kany S, Abraham V, Alzahrani Z, Darbar FA, Sridhar A, Ahmed M, Alamar I, Menon A, Zhang M, Chen Y, Hong L, Konda S, Darbar D (2019) Association Between Obesity-Mediated Atrial Fibrillation and Therapy With Sodium Channel Blocker Antiarrhythmic Drugs. JAMA Cardiol.

Park SJ, Kim RY, Park BW, Lee S, Choi SW, Park JH, Choi JJ, Kim SW, Jang J, Cho DW, Chung HM, Moon SH, Ban K, Park HJ (2019) Dual stem cell therapy synergistically improves cardiac function and vascular regeneration following myocardial infarction. Nat Commun 10:3123.

Pianezzi E, Altomare C, Bolis S, Balbi C, Torre T, Rinaldi A, Camici GG, Barile L, Vassalli G (2019) Role of somatic cell sources in the maturation degree of human induced pluripotent stem cell-derived cardiomyocytes. Biochim Biophys Acta Mol Cell Res:118538.

Qian Y, Qian F, Zhang W, Zhao L, Shen M, Ding C, Guo J (2019) Shengjiang Powder ameliorates myocardial injury in septic rats by downregulating the phosphorylation of P38-MAPK. J Biosci 44.

Rao P, Liu Z, Duan H, Dang S, Li H, Zhong L, Wang X, Wang L, Wang X (2019) Pretreatment with neuregulin-1 improves cardiac electrophysiological properties in a rat model of myocardial infarction. Experimental and Therapeutic Medicine 17:3141-3149.

Shah D, Virtanen L, Prajapati C, Kiamehr M, Gullmets J, West G, Kreutzer J, Pekkanen-Mattila M, Helio T, Kallio P, Taimen P, Aalto-Setala K (2019) Modeling of LMNA-Related Dilated Cardiomyopathy Using Human Induced Pluripotent Stem Cells. Cells 8.

Simeonov S, Schaffer TE (2019) Ultrafast Imaging of Cardiomyocyte Contractions by Combining Scanning Ion Conductance Microscopy with a Microelectrode Array. Anal Chem.

Slavik J, Skopalik J, Provaznik I, Hubalek J (2019) Multi-Electrode Array with a Planar Surface for Cell Patterning by Microprinting. Sensors (Basel) 19.

Soucy JR, Askaryan J, Diaz D, Koppes AN, Annabi N, Koppes RA (2019) Glial cells influence cardiac permittivity as evidenced through in vitro and in silico models. Biofabrication.

Sun J, Wugeti N, Mahemuti A (2019) Reversal effect of Zhigancao decoction on myocardial fibrosis in a rapid pacing-induced atrial fibrillation model in New Zealand rabbits. J Int Med Res:300060518799819.

van Meer BJ, Krotenberg A, Sala L, Davis RP, Eschenhagen T, Denning C, Tertoolen LGJ, Mummery CL (2019) Simultaneous measurement of excitation-contraction coupling parameters identifies mechanisms underlying contractile responses of hiPSC-derived cardiomyocytes. Nat Commun 10:4325.

Vanninen SUM, Kujala V, Porsti I, Aalto-Setala K (2019) A Quantitative Comparison of 12-Lead Electrocardiograms and In Vitro Field Potentials of Stem Cell-Derived Cardiomyocytes. International Journal of Stem Cell Research and Therapeutics.

Varzideh F, Mahmoudi E, Pahlavan S (2019) Coculture with noncardiac cells promoted maturation of human stem cell-derived cardiomyocyte microtissues. J Cell Biochem.

Watson SA, Duff J, Bardi I, Zabielska M, Atanur SS, Jabbour RJ, Simon A, Tomas A, Smolenski RT, Harding SE, Perbellini F, Terracciano CM (2019) Biomimetic electromechanical stimulation to maintain adult myocardial slices in vitro. Nat Commun 10:2168.

Wells SP, Waddell HM, Sim CB, Lim SY, Bernasochi GB, Pavlovic D, Kirchhof P, Porrello ER, Delbridge LMD, Bell JR (2019) Cardiomyocyte functional screening - interrogating comparative electrophysiology of high-throughput model cell systems. Am J Physiol Cell Physiol.

Yap L, Wang J-W, Moreno-Moral A, Chong LY, Sun Y, Harmston N, Wang X, Chong SY, Öhman MK, Wei H, Bunte R, Gosh S, Cook S, Hovatta O, de Kleijn DPV, Petretto E, Tryggvason K (2019) Generation of Post-infarct Human Cardiac Muscle by Laminin-Promoted Cardiovascular Progenitors. Cell Reports 26:3231-3245.e3239.

Zlochiver V, Kroboth SL, Beal CR, Cook JA, Joshi-Mukherjee R (2019) Human iPSC-Derived Cardiomyocyte Networks on Multiwell Micro-electrode Arrays for Recurrent Action Potential Recordings. JoVE:e59906.

Anderson DJ, Kaplan DI, Bell KM, Koutsis K, Haynes JM, Mills RJ, Phelan DG, Qian EL, Leitoguinho AR, Arasaratnam D, Labonne T, Ng ES, Davis RP, Casini S, Passier R, Hudson JE, Porrello ER, Costa MW, Rafii A, Curl CL, Delbridge LM, Harvey RP, Oshlack A, Cheung MM, Mummery CL, Petrou S, Elefanty AG, Stanley EG, Elliott DA (2018) NKX2-5 regulates human cardiomyogenesis via a HEY2 dependent transcriptional network. Nat Commun 9:1373.

Aziz Q, Finlay M, Montaigne D, Ojake L, Li Y, Anderson N, Ludwig A, Tinker A (2018) ATP-sensitive potassium channels in the sinoatrial node contribute to heart rate control and adaptation to hypoxia. J Biol Chem.

Becker BV, Seeger T, Beiert T, Antwerpen M, Palnek A, Port M, Ullmann R (2018) Impact of Ionizing Radiation on Electrophysiological Behavior of Human-induced Ipsc-derived Cardiomyocytes on Multielectrode Arrays. Health Phys 115:21-28.

Cantwell CD, Mohamied Y, Tzortzis KN, Garasto S, Houston C, Chowdhury RA, Ng FS, Bharath AA, Peters NS (2018) Rethinking multiscale cardiac electrophysiology with machine learning and predictive modelling. Comput Biol Med.

Chowdhury RA, Tzortzis KN, Dupont E, Selvadurai S, Perbellini F, Cantwell CD, Ng FS, Simon AR, Terracciano CM, Peters NS (2018) Concurrent micro- to macro-cardiac electrophysiology in myocyte cultures and human heart slices. Sci Rep 8:6947.

Dahlmann J, Awad G, Dolny C, Weinert S, Richter K, Fischer KD, Munsch T, Lessmann V, Volleth M, Zenker M, Chen Y, Merkl C, Schnieke A, Baraki H, Kutschka I, Kensah G (2018) Generation of functional cardiomyocytes from rat embryonic and induced pluripotent stem cells using feeder-free expansion and differentiation in suspension culture. PLoS ONE 13:e0192652.

Edwards SL, Zlochiver V, Conrad DB, Vaidyanathan R, Valiquette AM, Joshi-Mukherjee R (2018) A Multiwell Cardiac muGMEA Platform for Action Potential Recordings from Human iPSC-Derived Cardiomyocyte Constructs. Stem Cell Reports.

Fehrentz T, Huber FME, Hartrampf N, Bruegmann T, Frank JA, Fine NHF, Malan D, Danzl JG, Tikhonov DB, Sumser M, Sasse P, Hodson DJ, Zhorov BS, Klöcker N, Trauner D (2018) Optical control of L-type Ca2+ channels using a diltiazem photoswitch. Nature Chemical Biology 14:764-767.

Fleischer S, Jahnke HG, Fritsche E, Girard M, Robitzki AA (2018) Comprehensive human stem cell differentiation in a 2D and 3D mode to cardiomyocytes for long-term cultivation and multiparametric monitoring on a multimodal microelectrode array setup. Biosens Bioelectron 126:624-631.

Ghazizadeh Z, Fattahi F, Mirzaei M, Bayersaikhan D, Lee J, Chae S, Hwang D, Byun K, Tabar MS, Taleahmad S, Mirshahvaladi S, Shabani P, Fonoudi H, Haynes PA, Baharvand H, Aghdami N, Evans T, Lee B, Salekdeh GH (2018) Prospective Isolation of ISL1(+) Cardiac Progenitors from Human ESCs for Myocardial Infarction Therapy. Stem Cell Reports 10:848-859.

Golgooni Z, Mirsadeghi S, Soleymani Baghshah M, Ataee P, Baharvand H, Pahlavan S, Rabiee HR (2018) Deep Learning Based Proarrhythmia Analysis Using Field Potentials Recorded from Human Pluripotent Stem Cells Derived Cardiomyocytes. bioRxiv:244442.

Heselich A, Friess JL, Ritter S, Benz NP, Layer PG, Thielemann C (2018) High LET radiation shows no major cellular and functional effects on primary cardiomyocytes in vitro. Life Sci Space Res (Amst) 16:93-100.

Hoque A, Sivakumaran P, Bond ST, Ling NXY, Kong AM, Scott JW, Bandara N, Hernandez D, Liu GS, Wong RCB, Ryan MT, Hausenloy DJ, Kemp BE, Oakhill JS, Drew BG, Pebay A, Lim SY (2018) Mitochondrial fission protein Drp1 inhibition promotes cardiac mesodermal differentiation of human pluripotent stem cells. Cell Death Discov 4:39.

Hulsmann J, Aubin H, Sugimura Y, Lichtenberg A, Akhyari P (2018) Electrophysiological Stimulation of Whole Heart Constructs in an 8-Pole Electrical Field. Artif Organs.

Krantis A, Tam T, Chichirau A, Kajura K (2018) Cryopreserved Neonatal Rat Ventricular Cardiomyocytes in Long-term Culture Display Normal Morphology and Functional Activity. In.

Lai YC, Li N, Lawrence W, Wang S, Levine A, Burchhardt D, Pautler R, Valderrábano M, Wehrens X, Anderson A (2018) Myocardial remodeling and susceptibility to ventricular tachycardia in a model of chronic epilepsy.

Ma J, Ma S, Yin C, Wu H (2018) Matrine reduces susceptibility to post-infarct atrial fibrillation in rats due to anti-fibrotic properties. J Cardiovasc Electrophysiol.

Ma J, Ma S, Yin C, Wu H (2018) Shengmai San-derived herbal prevents the development of a vulnerable substrate for atrial fibrillation in a rat model of ischemic heart failure. Biomedicine & Pharmacotherapy 100:156-167.

Ma J, Yin C, Ma S, Qiu H, Zheng C, Chen Q, Ding C, Lv W (2018) Shensong Yangxin capsule reduces atrial fibrillation susceptibility by inhibiting atrial fibrosis in rats with post-myocardial infarction heart failure. Drug Des Devel Ther 12:3407-3418.

Mulder P, de Korte T, Dragicevic E, Kraushaar U, Printemps R, Vlaming MLH, Braam SR, Valentin JP (2018) Predicting cardiac safety using human induced pluripotent stem cell-derived cardiomyocytes combined with multi-electrode array (MEA) technology: A conference report. J Pharmacol Toxicol Methods 91:36-42.

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