Innovations in Electrophysiology


Aziz Q, Finlay M, Montaigne D, Ojake L, Li Y, Anderson N, Ludwig A, Tinker A (2018) ATP-sensitive potassium channels in the sinoatrial node contribute to heart rate control and adaptation to hypoxia. J Biol Chem.

Blinova K, Dang Q, Millard D, Smith G, Pierson J, Guo L, Brock M, Lu HR, Kraushaar U, Zeng H, Shi H, Zhang X, Sawada K, Osada T, Kanda Y, Sekino Y, Pang L, Feaster TK, Kettenhofen R, Stockbridge N, Strauss DG, Gintant G (2018) International Multisite Study of Human-Induced Pluripotent Stem Cell-Derived Cardiomyocytes for Drug Proarrhythmic Potential Assessment. Cell Reports 24:3582-3592.

Brouwer S, Hoffmeister T, Gresch A, Schonhoff L, Dufer M (2018) Resveratrol Influences Pancreatic Islets by Opposing Effects on Electrical Activity and Insulin Release. Mol Nutr Food Res.

Burke JN, Savell KE, Bunner KD (2018) CRISPR/dCas9-Mediated Upregulation of Reelin and Neuronal Excitability. Metamorphosis.

Chong SA, Balosso S, Vandenplas C, Szczesny G, Hanon E, Claes K, Van Damme X, Danis B, Van Eyll J, Wolff C, Vezzani A, Kaminski RM, Niespodziany I (2018) Intrinsic Inflammation Is a Potential Anti-Epileptogenic Target in the Organotypic Hippocampal Slice Model. Neurotherapeutics.

Failor SW, Ng A, Cheng HJ (2018) Monocular enucleation alters retinal waves in the surviving eye. Neural Dev 13:4.

Gamble JR, Zhang ET, Iyer N, Sakiyama-Elbert S, Barbour DL (2018) In Vitro Assay for the Detection of Network Connectivity in Embryonic Stem Cell-Derived Cultures. bioRxiv.

Kapkaeva MR, Genrikhs EE, Stelmashook EV, Kondratenko RV, Isaev NK, Khaspekov LG (2018) Neuronal Networks on Multielectrode Arrays as High Sensitive Biosensors of the Functional State of Nerve Cells. Biochemistry (Moscow), Supplement Series A: Membrane and Cell Biology 12.

Kodama NX, Feng T, Ullett JJ, Chiel HJ, Sivakumar SS, Galan RF (2018) Anti-correlated cortical networks arise from spontaneous neuronal dynamics at slow timescales. Sci Rep 8:666.

Kopanitsa MV, Gou G, Afinowi NO, Bayes A, Grant SGN, Komiyama NH (2018) Chronic treatment with a MEK inhibitor reverses enhanced excitatory field potentials in Syngap1(+/-) mice. Pharmacol Rep 70:777-783.

Kshirsagar P, Martina M, D. JP, Buckenmaier S, Kraushaar U, Chassé T, Fleischer M, Burkhardt CJ (2018) Semitransparent Carbon Microelectrodes for Opto- and Electrophysiology. JOURNAL OF MICROMECHANICS AND MICROENGINEERING.

Ma J, Ma S, Yin C, Wu H (2018) Matrine reduces susceptibility to post-infarct atrial fibrillation in rats due to anti-fibrotic properties. J Cardiovasc Electrophysiol.

Ma J, Ma S, Yin C, Wu H (2018) Shengmai San-derived herbal prevents the development of a vulnerable substrate for atrial fibrillation in a rat model of ischemic heart failure. Biomedicine & Pharmacotherapy 100:156-167.

Makinen ME, Yla-Outinen L, Narkilahti S (2018) GABA and Gap Junctions in the Development of Synchronized Activity in Human Pluripotent Stem Cell-Derived Neural Networks. Front Cell Neurosci 12:56.

Millard D, Dang Q, Shi H, Zhang X, Strock C, Kraushaar U, Zeng H, Levesque P, Lu HR, Guillon JM, Wu JC, Li Y, Luerman G, Anson B, Guo L, Clements M, Abassi YA, Ross J, Pierson J, Gintant G (2018) Cross-Site Reliability of Human Induced Pluripotent Stem-Cell Derived Cardiomyocyte Based Safety Assays using Microelectrode Arrays: Results from a Blinded CiPA Pilot Study. Toxicol Sci.

Perez-Gomez A, Cabrera-Garcia D, Warm D, Marini AM, Salas Puig J, Fernandez-Sanchez MT, Novelli A (2018) Selective Enhancement of Domoic Acid Toxicity in Primary Cultures of Cerebellar Granule Cells by Lowering Extracellular Na+ Concentration. Toxicol Sci 161:103-114.

Perez-Gomez A, Cabrera-Garcia D, Warm D, Marini AM, Salas Puig J, Fernandez-Sanchez MT, Novelli A (2018) From the Cover: Selective Enhancement of Domoic Acid Toxicity in Primary Cultures of Cerebellar Granule Cells by Lowering Extracellular Na+ Concentration. Toxicol Sci 161:103-114.

Prakash M, Medendorp WE, Hochgeschwender U (2018) Defining parameters of specificity for bioluminescent optogenetic activation of neurons using in vitro multi electrode arrays (MEA). J Neurosci Res.

Rodgers J, Hughes S, Pothecary CA, Brown LA, Hickey DG, Peirson SN, Hankins MW (2018) Defining the impact of melanopsin missense polymorphisms using in vivo functional rescue. Hum Mol Genet.

Sakuma R, Takahashi A, Nakano-Doi A, Sawada R, Kamachi S, Beppu M, Takagi T, Yoshimura S, Matsuyama T, Nakagomi T (2018) Comparative characterization of ischemia-induced brain multipotent stem cells with mesenchymal stem cells: Similarities and differences. Stem Cells Dev.

Sardi S, Vardi R, Goldental A, Sheinin A, Uzan H, Kanter I (2018) Adaptive nodes enrich nonlinear cooperative learning beyond traditional adaptation by links. Scientific Reports 8:5100.

Savell KE, Bach SV, Zipperly ME, Revanna JS, Goska NA, Tuscher JJ, Duke CG, Sultan FA, Burke JN, Williams DM, Ianov L, Day JJ (2018) A neuron-optimized CRISPR/dCas9 activation system for robust and specific gene regulation. bioRxiv.

Srivastava PK, van Eyll J, Godard P, Mazzuferi M, Delahaye-Duriez A, Steenwinckel JV, Gressens P, Danis B, Vandenplas C, Foerch P, Leclercq K, Mairet-Coello G, Cardenas A, Vanclef F, Laaniste L, Niespodziany I, Keaney J, Gasser J, Gillet G, Shkura K, Chong SA, Behmoaras J, Kadiu I, Petretto E, Kaminski RM, Johnson MR (2018) A systems-level framework for drug discovery identifies Csf1R as an anti-epileptic drug target. Nat Commun 9:3561.

Svoboda O, Cmiel V, Baiazitova L, Provazník I, Fohlerova Z, Hubalek J (2018) Electrical Stimulation of ASAP1 with a Combination of Microelectrode Array and Fluorescent Techniques. 41st International Conference on Telecommunications and Signal Processing (TSP).

Takeuchi H, Horie S, Moritoh S, Matsushima H, Hori T, Kimori Y, Kitano K, Tsubo Y, Tachibana M, Koike C (2018) Different Activity Patterns in Retinal Ganglion Cells of TRPM1 and mGluR6 Knockout Mice. BioMed Research International 2018:6.

Tourigny DS, Abdul Karim MK, Echeveste R, Kotter MRN, O'Neill JS (2018) Energetic substrate availability regulates synchronous activity in an excitatory neural network. bioRxiv.

Yger P, Spampinato GL, Esposito E, Lefebvre B, Deny S, Gardella C, Stimberg M, Jetter F, Zeck G, Picaud S, Duebel J, Marre O (2018) A spike sorting toolbox for up to thousands of electrodes validated with ground truth recordings in vitro and in vivo. Elife 7.

Aaser P, Knudsen M, Ramstad OH, van de Wijdeven R, Nichele S, Sandvig I, Tufte G, Bauer US, Halaas O, Hendseth S, Sandvig A, Valderhaug V (2017) Towards making a cyborg: A closed-loop reservoir-neuro system. In: ECAL 2017, pp 430-437. Lyon: MIT Press.

Abbate E, Boulakia M, Coudière Y, Gerbeau J-F, Zitoun P, Zemzemi N (2017) In silico assessment of the effects of various compounds in MEA/hiPSC-CM assays: Modelling and numerical simulations. In: Inria.

Aebersold MJ, Dermutz H, Demko L, Saenz Cogollo JF, Lin SC, Burchert C, Schneider M, Ling D, Forro C, Han H, Zambelli T, Voros J (2017) Local Chemical Stimulation of Neurons with the FluidFM. Chemphyschem.

Ameline B, Tshilenge KT, Weber M, Biget M, Libeau L, Caplette R, Mendes-Madeira A, Provost N, Guihal C, Picaud S, Moullier P, Pichard V, Cronin T, Isiegas C (2017) Long-term expression of melanopsin and channelrhodopsin causes no gross alterations in the dystrophic dog retina. Gene Ther.

Artyukhov AS, Dashinimaev EB, Tsvetkov VO, Bolshakov AP, Konovalova EV, Kolbaev SN, Vorotelyak EA, Vasiliev AV (2017) New genes for accurate normalization of qRT-PCR results in study of iPS and iPS-derived cells. Gene 626:234-240.

Becker F, Reid CA, Hallmann K, Tae H-S, Phillips AM, Teodorescu G, Weber YG, Kleefuss-Lie A, Elger C, Perez-Reyes E, Petrou S, Kunz WS, Lerche H, Maljevic S (2017) Functional variants in HCN4 and CACNA1H may contribute to genetic generalized epilepsy. Epilepsia Open 2:334-342.

Bretin S, Louis C, Seguin L, Wagner S, Thomas JY, Challal S, Rogez N, Albinet K, Iop F, Villain N, Bertrand S, Krazem A, Berachochea D, Billiald S, Tordjman C, Cordi A, Bertrand D, Lestage P, Danober L (2017) Pharmacological characterisation of S 47445, a novel positive allosteric modulator of AMPA receptors. PLoS ONE 12:e0184429.

Bridges DC, Tovar KR, Wu B, Hansma PK, Kosik KS (2017) MEA Viewer: a High-performance Interactive Application for Visualizing Electrophysiological Data. bioRxiv.

Can UI, Nagarajan N, Vural DC, Zorlutuna P (2017) Muscle-Cell-Based “Living Diodes”. Advanced Biosystems 1:n/a-n/a.

Castro-Hernandez J, Adlard PA, Finkelstein DI (2017) Pramipexole restores depressed transmission in the ventral hippocampus following MPTP-lesion. Sci Rep 7:44426.

Chew KS, Renna JM, McNeill DS, Fernandez DC, Keenan WT, Thomsen MB, Ecker JL, Loevinsohn GS, VanDunk C, Vicarel DC, Tufford A, Weng S, Gray PA, Cayouette M, Herzog ED, Zhao H, Berson DM, Hattar S (2017) A subset of ipRGCs regulates both maturation of the circadian clock and segregation of retinogeniculate projections in mice. Elife 6:e22861.

Dermutz H, Thompson-Steckel G, Forro C, de Lange V, Dorwling-Carter L, Voros J, Demko L (2017) Paper-based patterned 3D neural cultures as a tool to study network activity on multielectrode arrays. RSC Advances 7:39359-39371.

Eleftheriou CG, Cehajic-Kapetanovic J, Martial FP, Milosavljevic N, Bedford RA, Lucas RJ (2017) Meclofenamic acid improves the signal to noise ratio for visual responses produced by ectopic expression of human rod opsin. Mol Vis 23:334-345.

Ellis BW, Acun A, Can UI, Zorlutuna P (2017) Human iPSC-derived myocardium-on-chip with capillary-like flow for personalized medicine. Biomicrofluidics 11:024105.

Ferrari U, Gardella C, Marre O, Mora T (2017) Closed-loop estimation of retinal network sensitivity reveals signature of efficient coding. bioRxiv.

Goineau S, Castagne V (2017) Proarrhythmic risk assessment using conventional and new in vitro assays. Regul Toxicol Pharmacol 88:1-11.

Hermanstyne TO, Granados-Fuentes D, Mellor RL, Herzog ED, Nerbonne JM (2017) Acute Knockdown of Kv4.1 Regulates Repetitive Firing Rates and Clock Gene Expression in the Suprachiasmatic Nucleus and Daily Rhythms in Locomotor Behavior. eNeuro.

Hoon M, Krishnamoorthy V, Gollisch T, Falkenburger B, Varoqueaux F (2017) Loss of Neuroligin3 specifically downregulates retinal GABAAalpha2 receptors without abolishing direction selectivity. PLoS ONE 12:e0181011.

Jenkinson SP, Grandgirard D, Heidemann M, Tscherter A, Avondet M, Leib SL (2017) Embryonic Stem Cell-Derived Neurons Grown on Multi-Electrode Arrays as a Novel In vitro Bioassay for the Detection of Clostridium botulinum Neurotoxins. Frontiers in Pharmacology 8.

Koh CH, Wu J, Chung YY, Liu Z, Zhang RR, Chong K, Korzh V, Ting S, Oh S, Shim W, Tian HY, Wei H (2017) Electronic supplementary materialIdentification of a Na+/K+-ATPase inhibition-independent proarrhythmic ionic mechanisms of cardiac glycosides. Sci Rep 7:2465.

Kraushaar U, Guenther E, Hess D (2017) Addressing Functional Neurotoxicity Using the Microelectrode Array (MEA). In: Stem Cell-Derived Models in Toxicology. Methods in Pharmacology and Toxicology (Clements M, Roquemore L, eds). New York: Humana Press.

Kreutzer J, Yla-Outinen L, Maki AJ, Ristola M, Narkilahti S, Kallio P (2017) Cell culture chamber with gas supply for prolonged recording of human neuronal cells on microelectrode array. J Neurosci Methods 280:27-35.

Kuroda Y, Yuasa S, Watanabe Y, Ito S, Egashira T, Seki T, Hattori T, Ohno S, Kodaira M, Suzuki T, Hashimoto H, Okata S, Tanaka A, Aizawa Y, Murata M, Aiba T, Makita N, Furukawa T, Shimizu W, Kodama I, Ogawa S, Kokubun N, Horigome H, Horie M, Kamiya K, Fukuda K (2017) Flecainide ameliorates arrhythmogenicity through NCX flux in Andersen-Tawil syndrome-iPS cell-derived cardiomyocytes. Biochemistry and Biophysics Reports 9:245-256.

Lane JD, Montaigne D, Tinker A (2017) Tissue-Level Cardiac Electrophysiology Studied in Murine Myocardium Using a Microelectrode Array: Autonomic and Thermal Modulation. J Membr Biol.

Li B, Yang H, Wang X, Zhan Y, Sheng W, Cai H, Xin H, Liang Q, Zhou P, Lu C, Qian R, Chen S, Yang P, Zhang J, Shou W, Huang G, Liang P, Sun N (2017) Engineering human ventricular heart muscles based on a highly efficient system for purification of human pluripotent stem cell-derived ventricular cardiomyocytes. Stem Cell Res Ther 8:202.

Liu H, Bridges D, Randall C, Solla SA, Wu B, Hansma P, Yan X, Kosik K, Bouchard K (2017) Use of a Neural Circuit Probe to Validate in silico Predictions of Inhibitory Connections. BioRxiv.

Liu Q, Shi J, Lin R, Wen T (2017) Dopamine and dopamine receptor D1 associated with decreased social interaction. Behav Brain Res 324:51-57.

Maczewsky J, Sikimic J, Bauer C, Krippeit-Drews P, Wolke C, Lendeckel U, Barthlen W, Drews G (2017) The LXR Ligand T0901317 Acutely Inhibits Insulin Secretion by Affecting Mitochondrial Metabolism. Endocrinology 158:2145-2154.

Marcoux D, Xiao H-Y, Murali Dhar TG, Xie J, Lehman-McKeeman LD, Wu D-R, Dabros M, Yang X, Taylor TL, Zhou XD, Heimrich EM, Thomas R, McIntyre KW, Shi H, Levesque PC, Sun H, Yang Z, Marino AM, Cornelius G, D'Arienzo CJ, Gupta A, Pragalathan B, Rampulla R, Mathur A, Shen DR, Cvijic ME, Salter-Cid L, Lombardo LJ, Carter PH, Dyckman AJ (2017) Identification of potent tricyclic prodrug S1P1 receptor modulators. MedChemComm.

Marczenke M, Piccini I, Mengarelli I, Fell J, Ropke A, Seebohm G, Verkerk AO, Greber B (2017) Cardiac Subtype-Specific Modeling of Kv1.5 Ion Channel Deficiency Using Human Pluripotent Stem Cells. Front Physiol 8:469.

Masnada S, Hedrich UBS, Gardella E, Schubert J, Kaiwar C, Klee EW, Lanpher BC, Gavrilova RH, Synofzik M, Bast T, Gorman K, King MD, Allen NM, Conroy J, Ben Zeev B, Tzadok M, Korff C, Dubois F, Ramsey K, Narayanan V, Serratosa JM, Giraldez BG, Helbig I, Marsh E, O’Brien M, Bergqvist CA, Binelli A, Porter B, Zaeyen E, Horovitz DD, Wolff M, Marjanovic D, Caglayan HS, Arslan M, Pena SDJ, Sisodiya SM, Balestrini S, Syrbe S, Veggiotti P, Lemke JR, Møller RS, Lerche H, Rubboli G (2017) Clinical spectrum and genotype–phenotype associations of KCNA2-related encephalopathies. Brain 140:2337-2354.

Miller DC, Harmer SC, Poliandri A, Nobles M, Edwards EC, Ware JS, Sharp TV, McKay TR, Dunkel L, Lambiase PD, Tinker A (2017) Ajmaline blocks INa and IKr without eliciting differences between Brugada syndrome patient and control human pluripotent stem cell-derived cardiac clusters. Stem Cell Res 25:233-244.

Moller RS, Wuttke TV, Helbig I, Marini C, Johannesen KM, Brilstra EH, Vaher U, Borggraefe I, Talvik I, Talvik T, Kluger G, Francois LL, Lesca G, de Bellescize J, Blichfeldt S, Chatron N, Holert N, Jacobs J, Swinkels M, Betzler C, Syrbe S, Nikanorova M, Myers CT, Larsen LH, Vejzovic S, Pendziwiat M, von Spiczak S, Hopkins S, Dubbs H, Mang Y, Mukhin K, Holthausen H, van Gassen KL, Dahl HA, Tommerup N, Mefford HC, Rubboli G, Guerrini R, Lemke JR, Lerche H, Muhle H, Maljevic S (2017) Mutations in GABRB3: From febrile seizures to epileptic encephalopathies. Neurology 88:483-492.

Murayama S, Yamamoto K, Kaneko M, Ogiso B, Kobayashi M (2017) Ablation of C-fibers decreases quantal size of GABAergic synaptic transmission in the insular cortex. Neuroscience.

Neuille M, Cao Y, Caplette R, Guerrero-Given D, Thomas C, Kamasawa N, Sahel JA, Hamel CP, Audo I, Picaud S, Martemyanov KA, Zeitz C (2017) LRIT3 Differentially Affects Connectivity and Synaptic Transmission of Cones to ON- and OFF-Bipolar Cells. Invest Ophthalmol Vis Sci 58:1768-1778.

Park S-J, Kim K-H, Jeon W-Y, Seo J, Han J-M, Kim J-S, Chung H-M, Lee J-H, Moon S-H, Kim H-H (2017) Enzyme catalyzed electrostimulation of human embryonic stem cell-derived cardiomyocytes influence contractility and synchronization. Biochemical Engineering Journal 123:95-109.

Pérez-Gómez A, Cabrera-García D, Warm D, Marini AM, Salas Puig J, Fernández-Sánchez MT, Novelli A (2017) Selective Enhancement of Domoic Acid Toxicity in Primary Cultures of Cerebellar Granule Cells by Lowering Extracellular Na+ Concentration. Toxicological Sciences:kfx201-kfx201.

Protze SI, Liu J, Nussinovitch U, Ohana L, Backx PH, Gepstein L, Keller GM (2017) Sinoatrial node cardiomyocytes derived from human pluripotent cells function as a biological pacemaker. Nat Biotechnol 35:56-68.

Qiu W, Zhou J, Chen Y, Su M, Li G, Zhao H, Gu X, Meng, Wang C, Xiao Y, Lam KH, Dai J, Zheng H (2017) A Portable Ultrasound System for Non-Invasive Ultrasonic Neuro-Stimulation. IEEE Trans Neural Syst Rehabil Eng 25:2509-2515.

Raphel F, Boulakia M, Zemzemi N, Coudière Y, Guillon J-M, Zitoun P, Gerbeau J-F (2017) Identification of ion currents components generating field potential recorded in MEA from hiPSC-CM. IEEE Transactions on Biomedical Engineering.

Rojas Cifuentes CA, Tedesco M, Massobrio P, Marino A, Ciofani G, Martinoia S, Raiteri R (2017) Acoustic stimulation can induce a selective neural network response mediated by piezoelectric nanoparticles. J Neural Eng.

Sala L, Ward-van Oostwaard D, Tertoolen LGJ, Mummery CL, Bellin M (2017) Electrophysiological Analysis of human Pluripotent Stem Cell-derived Cardiomyocytes (hPSC-CMs) Using Multi-electrode Arrays (MEAs). JoVE:e55587.

Sardi S, Vardi R, Sheinin A, Goldental A, Kanter I (2017) New Types of Experiments Reveal that a Neuron Functions as Multiple Independent Threshold Units. Sci Rep 7:18036.

Schürlein S, Al Hijailan R, Weigel T, Kadari A, Rücker C, Edenhofer F, Walles H, Hansmann J (2017) Generation of a Human Cardiac Patch Based on a Reendothelialized Biological Scaffold (BioVaSc). Advanced Biosystems 1:1600005-n/a.

Shaban H, O'Connor R, Ovsepian SV, Dinan TG, Cryan JF, Schellekens H (2017) Electrophysiological approaches to unravel the neurobiological basis of appetite and satiety: use of the multielectrode array as a screening strategy. In: Drug Discov Today, 2016/09/17 Edition, pp 31-42.

Shein-Idelson M, Pammer L, Hemberger M, Laurent G (2017) Large-scale mapping of cortical synaptic projections with extracellular electrode arrays. Nat Methods 14:882-890.

Svoboda O, Skopalik J, Baiazitova L, Gabrielova E, Cmiel V, Provaznik I, Fohlerova Z, Hubalik J (2017) An Evaluation of Different Coatings for TiN Microelectrode Chambers used for Neonatal Cardiomyocytes Computing in Cardiology 43.

Tixier E, Raphel F, Lombardi D, Gerbeau J-F (2017) Optimal Biomarkers Design for Drug Safety Evaluation Using Microelectrode Array Measurements. In.

Toivanen M, Pelkonen A, Makinen M, Yla-Outinen L, Sukki L, Kallio P, Ristola M, Narkilahti S (2017) Optimised PDMS Tunnel Devices on MEAs Increase the Probability of Detecting Electrical Activity from Human Stem Cell-Derived Neuronal Networks. Front Neurosci 11:606.

Tovar KR, Bridges DC, Wu B, Randall C, Audouard M, Jang J, Hansma PK, Kosik KS (2017) Recording action potential propagation in single axons using multi-electrode arrays. bioRxiv.

Vardi R, Goldental A, Sheinin A, Sardi S, Kanter I (2017) Fast reversible learning based on neurons functioning as anisotropic multiplex hubs. EPL (Europhysics Letters) 118:46002.

Wu J, Wang X, Chung YY, Koh CH, Liu Z, Guo H, Yuan Q, Wang C, Su S, Wei H (2017) L-Type Calcium Channel Inhibition Contributes to the Proarrhythmic Effects of Aconitine in Human Cardiomyocytes. PLoS ONE 12:e0168435.

Barykina NV, Subach OM, Doronin DA, Sotskov VP, Roshchina MA, Kunitsyna TA, Malyshev AY, Smirnov IV, Azieva AM, Sokolov IS, Piatkevich KD, Burtsev MS, Varizhuk AM, Pozmogova GE, Anokhin KV, Subach FV, Enikolopov GN (2016) A new design for a green calcium indicator with a smaller size and a reduced number of calcium-binding sites. Sci Rep 6:34447.

Blanquie O, Liebmann L, Hubner CA, Luhmann HJ, Sinning A (2016) NKCC1-Mediated GABAergic Signaling Promotes Postnatal Cell Death in Neocortical Cajal-Retzius Cells. Cereb Cortex.

Buehler S, Stubbe M, Bonk S, Nissen M, Titipornpun K, Klinkenberg E-D, Baumann W, Gimsa J (2016) Cell Monitoring and Manipulation Systems (CMMSs) based on Glass Cell-Culture Chips (GC3s). Micromachines 7:106.

Chever O, Dossi E, Pannasch U, Derangeon M, Rouach N (2016) Astroglial networks promote neuronal coordination. Sci Signal 9:ra6.

Corbett MA, Bellows ST, Li M, Carroll R, Micallef S, Carvill GL, Myers CT, Howell KB, Maljevic S, Lerche H, Gazina EV, Mefford HC, Bahlo M, Berkovic SF, Petrou S, Scheffer IE, Gecz J (2016) Dominant KCNA2 mutation causes episodic ataxia and pharmacoresponsive epilepsy. Neurology 87:1975-1984.

Dhar TGM, Xiao H-Y, Xie J, Lehman-McKeeman LD, Wu D-R, Dabros M, Yang X, Taylor TL, Zhou XD, Heimrich EM, Thomas R, McIntyre KW, Warrack B, Shi H, Levesque PC, Zhu JL, Hennan J, Balimane P, Yang Z, Marino AM, Cornelius G, D’Arienzo CJ, Mathur A, Shen DR, Cvijic ME, Salter-Cid L, Barrish JC, Carter PH, Dyckman AJ (2016) Identification and Preclinical Pharmacology of BMS-986104: A Differentiated S1P1 Receptor Modulator in Clinical Trials. ACS Medicinal Chemistry Letters 7:283-288.

Helbig KL, Hedrich UB, Shinde DN, Krey I, Teichmann AC, Hentschel J, Schubert J, Chamberlin AC, Huether R, Lu HM, Alcaraz WA, Tang S, Jungbluth C, Dugan SL, Vainionpaa L, Karle KN, Synofzik M, Schols L, Schule R, Lehesjoki AE, Helbig I, Lerche H, Lemke JR (2016) A recurrent mutation in KCNA2 as a novel cause of hereditary spastic paraplegia and ataxia. Ann Neurol 80.

Iftikhar H (2016) Transparent Indium Tin Oxide Microelectrode Arrays for Measuring Beating Cardiomyocytes.

Jaffer S, Valasek P, Luke G, Batarfi M, Whalley BJ, Patel K (2016) Characterisation of Development and Electrophysiological Mechanisms Underlying Rhythmicity of the Avian Lymph Heart. PLoS ONE 11:e0166428.

Keren H, Marom S (2016) Long-range synchrony and emergence of neural reentry. Sci Rep 6:36837.

Knudsen AM (2016) NTNU Cyborg: A study into embodying Neuronal Cultures through Robotic Systems. Department of Engineering Cybernetics.

Kofuji P, Mure LS, Massman LJ, Purrier N, Panda S, Engeland WC (2016) Intrinsically Photosensitive Retinal Ganglion Cells (ipRGCs) Are Necessary for Light Entrainment of Peripheral Clocks. PLoS ONE 11:e0168651.

Kuusela J, Kim J, Rasanen E, Aalto-Setala K (2016) The Effects of Pharmacological Compounds on Beat Rate Variations in Human Long QT-Syndrome Cardiomyocytes. Stem Cell Rev.

Li S, Yang C, Zhang L, Gao X, Wang X, Liu W, Wang Y, Jiang S, Wong YH, Zhang Y, Liu K (2016) Promoting axon regeneration in the adult CNS by modulation of the melanopsin/GPCR signaling. Proc Natl Acad Sci U S A 113:1937-1942.

Nozaki Y, Honda Y, Watanabe H, Saiki S, Koyabu K, Itoh T, Nagasawa C, Nakamori C, Nakayama C, Iwasaki H, Suzuki S, Washio I, Takahashi E, Miyamoto K, Yamanishi A, Endo H, Shinozaki J, Nogawa H, Kunimatsu T (2016) CSAHi study: Validation of multi-electrode array systems (MEA60/2100) for prediction of drug-induced proarrhythmia using human iPS cell-derived cardiomyocytes -assessment of inter-facility and cells lot-to-lot-variability. Regul Toxicol Pharmacol 77:75-86.

Pastore VP, Poli D, Godjoski A, Martinoia S, Massobrio P (2016) ToolConnect: A Functional Connectivity Toolbox for In vitro Networks. Front Neuroinform 10:13.

Perez-Alcazar M, Culley G, Lyckenvik T, Mobarrez K, Bjorefeldt A, Wasling P, Seth H, Asztely F, Harrer A, Iglseder B, Aigner L, Hanse E, Illes S (2016) Human Cerebrospinal Fluid Promotes Neuronal Viability and Activity of Hippocampal Neuronal Circuits In Vitro. Front Cell Neurosci 10:54.

Sardi S, Goldental A, Amir H, Vardi R, Kanter I (2016) Vitality of Neural Networks under Reoccurring Catastrophic Failures. Sci Rep 6:31674.

Sengupta A, Chaffiol A, Mace E, Caplette R, Desrosiers M, Lampic M, Forster V, Marre O, Lin JY, Sahel JA, Picaud S, Dalkara D, Duebel J (2016) Red-shifted channelrhodopsin stimulation restores light responses in blind mice, macaque retina, and human retina. EMBO Mol Med.

Vardi R, Goldental A, Sardi S, Sheinin A, Kanter I (2016) Simultaneous multi-patch-clamp and extracellular-array recordings: Single neuron reflects network activity. Sci Rep 6:36228.

Wang Q, Yang H, Bai A, Jiang W, Li X, Wang X, Mao Y, Lu C, Qian R, Guo F, Ding T, Chen H, Chen S, Zhang J, Liu C, Sun N (2016) Functional engineered human cardiac patches prepared from nature's platform improve heart function after acute myocardial infarction. Biomaterials 105:52-65.

Wanke E, Gullo F, Dossi E, Valenza G, Becchetti A (2016) Neuron-glia crosstalk revealed in reverberating networks by simultaneous extracellular recording of spikes and astrocytes' glutamate transporter and K+ currents. J Neurophysiol:jn 00509 02016.

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