Innovations in Electrophysiology

Dissociated cell cultures, cortex

Brofiga M, Pisano M, Callegari F, Massobrio P (2021) Exploring the contribution of thalamic and hippocampal input on cortical dynamics in a brain-on-a-chip model. IEEE Transactions on Medical Robotics and Bionics:1-1.

Burley R, Harvey JRM (2021) Multielectrode Arrays. In: Patch Clamp Electrophysiology: Methods and Protocols (Dallas M, Bell D, eds), pp 109-132. New York, NY: Springer US.

Dias I, Levers M, Lamberti M, Hassink G, van Wezel R, le Feber J (2021) Consolidation of memory traces in cultured cortical networks requires low cholinergic tone, synchronized activity and high network excitability. J Neural Eng.

Heiney K, Valderhaug V, Ramstad O, Sandvig I, Sandvig A, Nichele S (2021) Hallmarks of Criticality in Neuronal Networks Depend on Cell Type and the Temporal Resolution of Neuronal Avalanches. International Journal of Unconventional Computing 16:303-326.

Milligan CJ, Pachernegg S (2021) Utilising Automated Electrophysiological Platforms in Epilepsy Research. In: Patch Clamp Electrophysiology: Methods and Protocols (Dallas M, Bell D, eds), pp 133-155. New York, NY: Springer US.

Susloparova A, Halliez S, Begard S, Colin M, Buée L, Pecqueur S, Alibart F, Thomy V, Arscott S, Pallecchi E, Coffinier Y (2021) Low impedance and highly transparent microelectrode arrays (MEA) for in vitro neuron electrical activity probing. Sensors and Actuators B: Chemical 327:128895.

Tauskela JS, Kuebler ES, Thivierge J-P, Aylsworth A, Hewitt M, Zhao X, Mielke JG, Martina M (2021) Resilience of network activity in preconditioned neurons exposed to ‘stroke-in-a-dish’ insults. Neurochemistry International 146:105035.

Teneggi J, Chen X, Balu A, Barrett C, Grisolia G, Lucia U, Dzakpasu R (2021) Entropy estimation within in vitro neural-astrocyte networks as a measure of development instability. Physical Review E 103:042412.

Tinarelli F, Ivanova E, Colombi I, Barini E, Balzani E, Garcia CG, Gasparini L, Chiappalone M, Kelsey G, Tucci V (2021) Cell-cell coupling and DNA methylation abnormal phenotypes in the after-hours mice. Epigenetics Chromatin 14:1.

Yalcin YD, Luttge R (2021) Electrical monitoring approaches in 3-dimensional cell culture systems: Toward label-free, high spatiotemporal resolution, and high-content data collection in vitro. Organs-on-a-Chip 3:100006.

Alloisio S, Clericuzio M, Nobile M, Salis A, Damonte G, Canali C, Fortuna-Perez AP, Cornara L, Burlando B (2020) Cannabis-like activity of Zornia latifolia Sm. detected in vitro on rat cortical neurons: major role of the flavone syzalterin. Drug Chem Toxicol:1-13.

Armada-Moreira A, Coelho JE, Lopes LV, Sebastião AM, Städler B, Vaz SH (2020) Multicompartment Microreactors Prevent Excitotoxic Dysfunctions In Rat Primary Cortical Neurons. Adv Biosyst:e2000139.

Badman RP, Moore SL, Killian JL, Feng T, Cleland TA, Hu F, Wang MD (2020) Dextran-coated iron oxide nanoparticle-induced nanotoxicity in neuron cultures. Sci Rep 10:11239.

Ciba M, Bestel R, Nick C, de Arruda GF, Peron T, Henrique CC, Costa LDF, Rodrigues FA, Thielemann C (2020) Comparison of Different Spike Train Synchrony Measures Regarding Their Robustness to Erroneous Data from Bicuculline-Induced Epileptiform Activity. Neural Comput:1-25.

Cornara L, Ambu G, Trombetta D, Denaro M, Alloisio S, Frigerio J, Labra M, Ghimire G, Valussi M, Smeriglio A (2020) Comparative and Functional Screening of Three Species Traditionally used as Antidepressants: Valeriana officinalis L., Valeriana jatamansi Jones ex Roxb. and Nardostachys jatamansi (D.Don) DC. Plants (Basel) 9.

Del Pino I, Tocco C, Magrinelli E, Marcantoni A, Ferraguto C, Tomagra G, Bertacchi M, Alfano C, Leinekugel X, Frick A, Studer M (2020) COUP-TFI/Nr2f1 Orchestrates Intrinsic Neuronal Activity during Development of the Somatosensory Cortex. Cereb Cortex.

Dominguez-Morales JP, Buccelli S, Gutierrez-Galan D, Colombi I, Jimenez-Fernandez A, Chiappalone M (2020) Real-time detection of bursts in neuronal cultures using a Neuromorphic Auditory Sensor and Spiking Neural Networks. bioRxiv:2020.2005.2020.105593.

Frega M, Selten M, Mossink B, Keller JM, Linda K, Moerschen R, Qu J, Koerner P, Jansen S, Oudakker A, Kleefstra T, van Bokhoven H, Zhou H, Schubert D, Nadif Kasri N (2020) Distinct Pathogenic Genes Causing Intellectual Disability and Autism Exhibit a Common Neuronal Network Hyperactivity Phenotype. Cell Rep 30:173-186 e176.

Guaraldi M, Lee S, Shea TB (2020) Synaptic Signals from Glutamate-Treated Neurons Induce Aberrant Post-Synaptic Signals in Untreated Neuronal Networks. TONEUJ 14.

Hakim-Eshed V, Boulos A, Cohen-Rosenzweig C, Yu-Taeger L, Ziv T, Kwon YT, Riess O, Phuc Nguyen HH, Ziv NE, Ciechanover A (2020) Site-specific ubiquitination of pathogenic huntingtin attenuates its deleterious effects. Proc Natl Acad Sci U S A.

Kharouf Q, Phillips AM, Bleakley LE, Morrisroe E, Oyrer J, Jia L, Ludwig A, Jin L, Nicolazzo JA, Cerbai E, Romanelli MN, Petrou S, Reid CA (2020) The hyperpolarization-activated cyclic nucleotide-gated 4 channel as a potential anti-seizure drug target. Br J Pharmacol.

Kumar R, Huang Y-T, Chen CC, Tzeng S-F, Chan CK (2020) Astrocytic regulation of synchronous bursting in cortical cultures: from local to global. bioRxiv:870915.

Mosbacher Y, Khoyratee F, Goldin M, Kanner S, Malakai Y, Silva M, Grassia F, Simon YB, Cortes J, Barzilai A, Levi T, Bonifazi P (2020) Toward neuroprosthetic real-time communication from in silico to biological neuronal network via patterned optogenetic stimulation. Sci Rep 10:7512.

Muzio L, Sirtori R, Gornati D, Eleuteri S, Fossaghi A, Brancaccio D, Manzoni L, Ottoboni L, Feo L, Quattrini A, Mastrangelo E, Sorrentino L, Scalone E, Comi G, Marinelli L, Riva N, Milani M, Seneci P, Martino G (2020) Retromer stabilization results in neuroprotection in a model of Amyotrophic Lateral Sclerosis. Nat Commun 11:3848.

Pemberton DK (2020) The Effects of the G Protein-Coupled Estrogen Receptor on Early Neuronal Development in Hippocampal and Cortical Neurons.

Poston RG, Murphy L, Rejepova A, Ghaninejad-Esfahani M, Segales J, Mulligan K, Saha RN (2020) Certain ortho-hydroxylated brominated ethers are promiscuous kinase inhibitors that impair neuronal signaling and neurodevelopmental processes. J Biol Chem 295:6120-6137.

Rienecker KDA, Poston RG, Segales JS, Saha RN (2020) Mild membrane depolarization in neurons induces immediate early gene transcription and acutely subdues responses to successive stimulus. bioRxiv:2020.2007.2023.217844.

Sambri I, Massa F, Gullo F, Meneghini S, Cassina L, Carraro M, Dina G, Quattrini A, Patanella L, Carissimo A, Iuliano A, Santorelli F, Codazzi F, Grohovaz F, Bernardi P, Becchetti A, Casari G (2020) Impaired flickering of the permeability transition pore causes SPG7 spastic paraplegia. EBioMedicine 61:103050.

Sardi S, Vardi R, Meir Y, Tugendhaft Y, Hodassman S, Goldental A, Kanter I (2020) Brain experiments imply adaptation mechanisms which outperform common AI learning algorithms. Sci Rep 10:6923.

Scanarotti C, Vernazza S, Tirendi S, Calzia D, Alloisio S, Novellino A, Panfoli I, Bassi AM (2020) Evaluation of Potential Risks to Human Health and Ecosystems During Exposure to Discarded Laboratory Chemical Mixtures by In Vitro Multimodel Approach. Applied In Vitro Toxicology 6:131-143.

Smeriglio A, Trombetta D, Alloisio S, Cornara L, Denaro M, Garbati P, Grassi G, Circosta C (2020) Promising in vitro antioxidant, anti-acetylcholinesterase and neuroactive effects of essential oil from two non-psychotropic Cannabis sativa L. biotypes. Phytother Res.

Valderhaug VD, Ramstad OH, van de Wijdeven R, Heiney K, Nichele S, Sandvig A, Sandvig I (2020) Structural and functional alterations associated with the LRRK2 G2019S mutation revealed in structured human neural networks. bioRxiv:2020.2005.2002.073726.

Vernekar VN, LaPlaca MC (2020) 3-D multi-electrode arrays detect early spontaneous electrophysiological activity in 3-D neuronal-astrocytic co-cultures. Biomedical Engineering Letters.

Wanzenboeck HD, Scholze P, Mika JK (2020) Imaging and Electrophysiology of Individual Neurites Functionally Isolated in Microchannels. In: Neurohistology and Imaging Techniques, Neuromethods (Pelc R, Walz W, Doucette J, eds). New York: Humana, New York, NY.

Wegrzyn D, Wegrzyn C, Tedford K, Fischer K-D, Faissner A (2020) Deletion of the Nucleotide Exchange Factor Vav3 Enhances Axonal Complexity and Synapse Formation but Tampers Activity of Hippocampal Neuronal Networks In Vitro. International Journal of Molecular Sciences 21:856.

Zhang X, Yeh FC, Ju H, Jiang Y, Quan GFW, VanDongen AMJ (2020) Familiarity detection and memory consolidation in cortical assemblies. eNeuro.

Buccelli S, Bornat Y, Colombi I, Ambroise M, Martines L, Pasquale V, Bisio M, Tessadori J, Nowak P, Grassia F, Averna A, Tedesco M, Bonifazi P, Difato F, Massobrio P, Levi T, Chiappalone M (2019) A neuroprosthetic system to restore neuronal communication in modular networks. bioRxiv:514836.

Choukairi Z, Hazzaz T, Lkhider M, Ferrandez JM, Fechtali T (2019) Effect of salvia Officinalis L. and Rosmarinus Officinalis L. leaves extracts on anxiety and neural activity. Bioinformation 16.

Datta Chaudhuri A, Dasgheyb RM, DeVine LR, Bi H, Cole RN, Haughey NJ (2019) Stimulus-dependent modifications in astrocyte-derived extracellular vesicle cargo regulate neuronal excitability. Glia 0.

del Pino I, Tocco C, Magrinelli E, Marcantoni A, Ferraguto C, Tomagra G, Alfano C, Leinekugel X, Frick A, Studer M (2019) Intrinsic neuronal excitability and spontaneous activity underlie cortical abnormalities upon Nr2f1/COUP-TFI deficiency. bioRxiv:728402.

Frega M, Linda K, Keller JM, Gümüş-Akay G, Mossink B, van Rhijn J-R, Negwer M, Gunnewiek TK, Foreman K, Kompier N, Schoenmaker C, van den Akker W, Oudakker A, Zhou H, Kleefstra T, Schubert D, van Bokhoven H, Kasri NN (2019) Neuronal network dysfunction in a human model for Kleefstra syndrome mediated by enhanced NMDAR signaling. bioRxiv:585596.

Gao F, Gao K, He C, Liu M, Wan H, Wang P (2019) Multi-site dynamic recording for Aβ oligomers-induced Alzheimer's disease in vitro based on neuronal network chip. Biosensors and Bioelectronics.

Gortz P, Henning U, Theiss S, Lange-Asschenfeldt C (2019) Effect fingerprints of antipsychotic drugs on neural networks in vitro. J Neural Transm (Vienna).

Heiney K, Huse Ramstad O, Sandvig I, Sandvig A, Nichele S (2019) Assessment and manipulation of the computational capacity of in vitro neuronal networks through criticality in neuronal avalanches.

Jackson MR, Loring KE, Homan CC, Thai MH, Maattanen L, Arvio M, Jarvela I, Shaw M, Gardner A, Gecz J, Shoubridge C (2019) Heterozygous loss of function of IQSEC2/Iqsec2 leads to increased activated Arf6 and severe neurocognitive seizure phenotype in females. Life Sci Alliance 2.

Jaudon F, Thalhammer A, Cingolani LA (2019) Correction of β3 integrin haplo-insufficiency by CRISPRa normalizes cortical network activity. bioRxiv:664706.

Köhler T (2019) Auswirkungen elektromagnetischer Strahlung auf die elektrophysiologischen Eigenschaften neuronaler und kardialer Zellnetzwerke Fachbereich Biologie

Maestrelli F, Landucci E, De Luca E, Nerli G, Bergonzi MC, Piazzini V, Pellegrini-Giampietro DE, Gullo F, Becchetti A, Tadini-Buoninsegni F, Francesconi O, Nativi C (2019) Niosomal Formulation of a Lipoyl-Carnosine Derivative Targeting TRPA1 Channels in Brain. Pharmaceutics 11.

Marcuzzo S, Terragni B, Bonanno S, Isaia D, Cavalcante P, Cappelletti C, Ciusani E, Rizzo A, Regalia G, Yoshimura N, Ugolini GS, Rasponi M, Bechi G, Mantegazza M, Mantegazza R, Bernasconi P, Minati L (2019) Hyperexcitability in Cultured Cortical Neuron Networks from the G93A-SOD1 Amyotrophic Lateral Sclerosis Model Mouse and its Molecular Correlates. Neuroscience 416:88-99.

Marta P, Ilaria C, Matteo F, Freschi A, Bandarabadi M, Andrea A, Encarnación BM, Adamantidis AR, Roberto A, Matteo C, Michela C, Valter T (2019) The paternally imprinted gene Snord116 regulates cortical neuronal activity. bioRxiv:809822.

Mateus J, Lopes C, Cerquido M, Leitao L, Leitao DC, Cardoso S, Ventura J, Aguiar P (2019) Improved in vitro electrophysiology using 3D-structured microelectrode arrays with a micro-mushrooms islets architecture capable of promoting topotaxis. J Neural Eng.

Mendis GDC, Berecki G, Morrisroe E, Pachernegg S, Li M, Varney M, Osborne PB, Reid CA, Halgamuge S, Petrou S (2019) Discovering the pharmacodynamics of conolidine and cannabidiol using a cultured neuronal network based workflow. Sci Rep 9:121.

Meng C, Yang X, Liu Y, Zhou Y, Rui J, Li S, Xu C, Zhuang Y, Lao J, Zhao X (2019) Decreased expression of lncRNA Malat1 in rat spinal cord contributes to neuropathic pain by increasing neuron excitability after brachial plexus avulsion. J Pain Res 12:1297-1310.

Miller SJ, Philips T, Kim N, Dastgheyb R, Chen Z, Hsieh YC, Daigle JG, Datta M, Chew J, Vidensky S, Pham JT, Hughes EG, Robinson MB, Sattler R, Tomer R, Suk JS, Bergles DE, Haughey N, Pletnikov M, Hanes J, Rothstein JD (2019) Molecularly defined cortical astroglia subpopulation modulates neurons via secretion of Norrin. Nat Neurosci 22:741-752.

Morrisroe E (2019) Multielectrode Arrays: A tool for modellig genetic epilepsy. FACULTY OF MEDICINE, DENTISTRY & HEALTH SCIENCES

Muzzi L, Hassink G, Levers M, Jansman M, Frega M, Hofmeijer J, van Putten M, le Feber J (2019) Mild stimulation improves neuronal survival in an in vitro model of the ischemic penumbra. J Neural Eng 17:016001.

Nguyen JT, Sahabandu D, Taishi P, Xue M, Jewett K, Dykstra-Aiello C, Roy S, Krueger JM (2019) The neuron-specific interleukin-1 receptor accessory protein alters emergent network state properties in Vitro. Neurobiology of Sleep and Circadian Rhythms 6:35-43.

Okujeni S, Egert U (2019) Self-organization of modular network architecture by activity-dependent neuronal migration and outgrowth. Elife 8.

Savarraj JP, Kelly KC, DeCoster MA (2019) Early glioma is associated with abnormal electrical events in cortical cultures. Med Biol Eng Comput.

Val-Calvo M, Álvarez-Sánchez JR, Alegre-Cortés J, de la Paz-López F, Ferrández-Vicente JM, Fernández-Jover E, Val-Calvo I (2019) Frequency variation analysis in neuronal cultures for stimulus response characterization. Neural Comput & Applic.

Van De Vijver S, Missault S, Van Soom J, Van Der Veken P, Augustyns K, Joossens J, Dedeurwaerdere S, Giugliano M (2019) The effect of pharmacological inhibition of Serine Proteases on neuronal networks in vitro. PeerJ 7:e6796.

Wülfing JM, Kumar SS, Boedecker J, Riedmiller M, Egert U (2019) Adaptive long-term control of biological neural networks with Deep Reinforcement Learning. Neurocomputing.

Xia Q, Nyberg T (2019) Photothermal Inhibition of Cortex Neurons Activity by Infrared Laser. World Congress on Medical Physics and Biomedical Engineering 2018:99-104.

Bar El Y, Kanner S, Barzilai A, Hanein Y (2018) Activity changes in neuron-astrocyte networks in culture under the effect of norepinephrine. PLoS ONE 13:e0203761.

Bar El Y, Kanner S, Barzilai A, Hanein Y (2018) Calcium imaging, MEA recordings and Immunostaining images dataset of Neuron-Astrocyte Networks in Culture under the Effect of Norepinephrine. Gigascience.

Capone C, Gigante G, Del Giudice P (2018) Spontaneous activity emerging from an inferred network model captures complex temporal dynamics of spiking data. arXiv

Caputo L (2018) Chemical and Biological study of natural substances active on the Central Nervous System. Dipartimento di Farmacia.

Casanova A, Bettamin L, Blatche MC, Mathieu F, Martin H, Gonzalez-Dunia D, Nicu L, Larrieu G (2018) Nanowire based bioprobes for electrical monitoring of electrogenic cells. J Phys Condens Matter 30:464001.

Chaudhuri AD, Dastgheyb RM, Yoo SW, Trout A, Talbot CC, Jr., Hao H, Witwer KW, Haughey NJ (2018) TNFalpha and IL-1beta modify the miRNA cargo of astrocyte shed extracellular vesicles to regulate neurotrophic signaling in neurons. Cell Death Dis 9:363.

El Khoueiry C, Moretti D, Renom R, Camera F, Orlacchio R, Garenne A, Poulletier de Gannes F, Poque-Haro E, Lagroye I, Veyret B, Lewis N (2018) DECREASED SPONTANEOUS ELECTRICAL ACTIVITY IN NEURONAL NETWORKS EXPOSED TO RADIOFREQUENCY 1800 MHZ SIGNALS. J Neurophysiol.

Frega M, Selten M, Mossink B, Keller JM, Linda K, Moerschen R, Qu J, Koerner P, Jansen S, Bijvank E, Oudakker A, Kleefstra T, van Bokhoven H, Zhou H, Schubert D, Nadif Kasri N (2018) Distinct pathogenic genes causing intellectual disability and autism exhibit overlapping effects on neuronal network development. bioRxiv.

Gaburro J, Bhatti A, Sundaramoorthy V, Dearnley M, Green D, Nahavandi S, Paradkar PN, Duchemin JB (2018) Zika virus-induced hyper excitation precedes death of mouse primary neuron. Virol J 15:79.

George JB, Abraham GM, Amrutur B, Sikdar SK (2018) Random Neuronal Networks show homeostatic regulation of global activity while showing persistent changes in specific connectivity paths to theta burst stimuli. Sci Rep 8:16568.

Georgopoulos AP, Tsilibary EC, Souto EP, James LM, Engdahl BE, Georgopoulos A (2018) Adverse effects of Gulf War Illness (GWI) serum on neural cultures and their prevention by healthy serum. Journal of Neurology & Neuromedicine 3:19-27.

Hadwen J, Schock S, Mears A, Yang R, Charron P, Zhang L, Xi HS, MacKenzie A (2018) Transcriptomic RNAseq drug screen in cerebrocortical cultures: toward novel neurogenetic disease therapies. Hum Mol Genet 27:3206-3217.

Hagman S, Makinen A, Yla-Outinen L, Huhtala H, Elovaara I, Narkilahti S (2018) Effects of inflammatory cytokines IFN-gamma, TNF-alpha and IL-6 on the viability and functionality of human pluripotent stem cell-derived neural cells. J Neuroimmunol.

Halawa I, Goldental A, Shirota Y, Kanter I, Paulus W (2018) Less Might Be More: Conduction Failure as a Factor Possibly Limiting the Efficacy of Higher Frequencies in rTMS Protocols. Front Neurosci 12:358.

Hassink GC, Raiss CC, Segers-Nolten IMJ, van Wezel RJA, Subramaniam V, le Feber J, Claessens M (2018) Exogenous alpha-synuclein hinders synaptic communication in cultured cortical primary rat neurons. PLoS ONE 13:e0193763.

Kuebler ES (2018) Harnessing the variability of neuronal activity School of Psychology, Faculty of Social Sciences PhD in Experimental Psychology.

le Feber J, Dummer A, Hassink GC, van Putten M, Hofmeijer J (2018) Evolution of Excitation-Inhibition Ratio in Cortical Cultures Exposed to Hypoxia. Front Cell Neurosci 12:183.

Lopes CDF, Mateus JC, Aguiar P (2018) Interfacing Microfluidics with Microelectrode Arrays for Studying Neuronal Communication and Axonal Signal Propagation. J Vis Exp.

Moskalyuk A, Kooy FR, Giugliano M (2018) Single-cell and neuronal network alterations in an in vitro model of Fragile X syndrome. bioRxiv.

Pastore VP, Massobrio P, Godjoski A, Martinoia S (2018) Identification of excitatory-inhibitory links and network topology in large-scale neuronal assemblies from multi-electrode recordings. PLoS Comput Biol 14:e1006381.

Perez-Gomez A, Cabrera-Garcia D, Warm D, Marini AM, Salas Puig J, Fernandez-Sanchez MT, Novelli A (2018) Selective Enhancement of Domoic Acid Toxicity in Primary Cultures of Cerebellar Granule Cells by Lowering Extracellular Na+ Concentration. Toxicol Sci 161:103-114.

Perez-Gomez A, Cabrera-Garcia D, Warm D, Marini AM, Salas Puig J, Fernandez-Sanchez MT, Novelli A (2018) From the Cover: Selective Enhancement of Domoic Acid Toxicity in Primary Cultures of Cerebellar Granule Cells by Lowering Extracellular Na+ Concentration. Toxicol Sci 161:103-114.

Piasetzky Y, Bisio M, Kanner S, Goldin M, Olivenboim M, Ben-Jacob E, Hanein Y, Chiappalone M, Barzilai A, Bonifazi P (2018) The emergence of dynamical instantaneous memory in the spontaneous activity of spatially confined neuronal assemblies in vitro. bioRxiv.

Poli D, Massobrio P (2018) High-frequency electrical stimulation promotes reshaping of the functional connections and synaptic plasticity in in vitro cortical networks. Phys Biol 15:06LT01.

Prakash M, Medendorp WE, Hochgeschwender U (2018) Defining parameters of specificity for bioluminescent optogenetic activation of neurons using in vitro multi electrode arrays (MEA). J Neurosci Res.

Saberi-Moghadam S, Simi A, Setareh H, Mikhail C, Tafti M (2018) In vitro Cortical Network Firing is Homeostatically Regulated: A Model for Sleep Regulation. Sci Rep 8:6297.

Sardi S, Vardi R, Goldental A, Sheinin A, Uzan H, Kanter I (2018) Adaptive nodes enrich nonlinear cooperative learning beyond traditional adaptation by links. Scientific Reports 8:5100.

Teppola H, Okujeni S, Linne M-L, Egert U (2018) AMPA, NMDA and GABAA receptor mediated network burst dynamics in cortical cultures in vitro. arXiv.

Van De Vijver S, Missault S, Van Soom J, Van der Veken P, Augustyns K, Joossens J, Dedeurwaerdere S, Giugliano M (2018) The Effect of Acute Pharmacological Inhibition of Urokinase Plasminogen Activator and Neuropsin Extracellular Proteases on Neuronal Networks in vitro. bioRxiv:263616.

Bourke JL, Quigley AF, Duchi S, O'Connell CD, Crook JM, Wallace GG, Cook MJ, Kapsa RMI (2017) Three-dimensional neural cultures produce networks that mimic native brain activity. Journal of Tissue Engineering and Regenerative Medicine:n/a-n/a.

Chan SC, Mok SY, Ng DW, Goh SY (2017) The role of neuron-glia interactions in the emergence of ultra-slow oscillations. Biol Cybern 111:459-472.

Dermutz H, Thompson-Steckel G, Forro C, de Lange V, Dorwling-Carter L, Voros J, Demko L (2017) Paper-based patterned 3D neural cultures as a tool to study network activity on multielectrode arrays. RSC Advances 7:39359-39371.

Fedorovich S, Hofmeijer J, van Putten MJ, le Feber J (2017) Reduced Synaptic Vesicle Recycling during Hypoxia in Cultured Cortical Neurons. Front Cell Neurosci 11:32.

Gertz ML, Baker Z, Jose S, Peixoto N (2017) Time-dependent Increase in the Network Response to the Stimulation of Neuronal Cell Cultures on Micro-electrode Arrays.e55726.

Kirischuk S, Sinning A, Blanquie O, Yang JW, Luhmann HJ, Kilb W (2017) Modulation of Neocortical Development by Early Neuronal Activity: Physiology and Pathophysiology. Front Cell Neurosci 11:379.

Kohler T, Wolfel M, Ciba M, Bochtler U, Thielemann C (2017) Terrestrial Trunked Radio (TETRA) exposure of neuronal in vitro networks. Environ Res 162:1-7.

Kuykendal M, Guvanasen G, Potter S, Grover M, DeWeerth S (2017) Closed-Loop Characterization of Neuronal Activation Using Electrical Stimulation and Optical Imaging. Processes 5:30.

Kuykendal M, Potter S, Grover M, DeWeerth S (2017) Targeted Stimulation Using Differences in Activation Probability across the Strength–Duration Space. Processes 5:14.

le Feber J, Erkamp N, van Putten M, Hofmeijer J (2017) Loss and recovery of functional connectivity in cultured cortical networks exposed to hypoxia. J Neurophysiol 118:394-403.

Mack CM, Hall DR, Herr DW, Shafer TJ (2017) Low and High-Frequency Field Potentials in Cortical Networks Exhibit Distinct Responses to Chemicals. The FASEB Journal 31:861.814.

Mendis GDC (2017) Detection of Phenotypic Network Signatures in Cultured Neuronal Networks. Department of Mechanical Engineering.

Okujeni S, Kandler S, Egert U (2017) Mesoscale architecture shapes initiation and richness of spontaneous network activity. J Neurosci.

Orenstein O, Keren H (2017) Development of Cortical Networks under Continuous Stimulation. Front Mol Neurosci 10:18.

Pasquale V, Martinoia S, Chiappalone M (2017) Stimulation triggers endogenous activity patterns in cultured cortical networks. Sci Rep 7:9080.

Pérez-Gómez A, Cabrera-García D, Warm D, Marini AM, Salas Puig J, Fernández-Sánchez MT, Novelli A (2017) Selective Enhancement of Domoic Acid Toxicity in Primary Cultures of Cerebellar Granule Cells by Lowering Extracellular Na+ Concentration. Toxicological Sciences:kfx201-kfx201.

Rojas Cifuentes CA, Tedesco M, Massobrio P, Marino A, Ciofani G, Martinoia S, Raiteri R (2017) Acoustic stimulation can induce a selective neural network response mediated by piezoelectric nanoparticles. J Neural Eng.

Sardi S, Vardi R, Sheinin A, Goldental A, Kanter I (2017) New Types of Experiments Reveal that a Neuron Functions as Multiple Independent Threshold Units. Sci Rep 7:18036.

Satuvuori E, Mulansky M, Bozanic N, Malvestio I, Zeldenrust F, Lenk K, Kreuz T (2017) Measures of spike train synchrony for data with multiple time scales. J Neurosci Methods 287:25-38.

Scarsi F, Tessadori J, Chiappalone M, Pasquale V (2017) Investigating the impact of electrical stimulation temporal distribution on cortical network responses. BMC Neurosci 18:49.

Simon DM, Charkhkar H, St John C, Rajendran S, Kang T, Reit R, Arreaga-Salas D, McHail DG, Knaack GL, Sloan A, Grasse D, Dumas TC, Rennaker RL, Pancrazio JJ, Voit WE (2017) Design and demonstration of an intracortical probe technology with tunable modulus. J Biomed Mater Res A 105:159-168.

Smeriglio A, Alloisio S, Raimondo FM, Denaro M, Xiao J, Cornara L, Trombetta D (2017) Essential oil of Citrus lumia Risso: Phytochemical profile, antioxidant properties and activity on the central nervous system. Food Chem Toxicol.

Ugbode CI, Smith I, Whalley BJ, Hirst WD, Rattray M (2017) Sonic hedgehog signalling mediates astrocyte crosstalk with neurons to confer neuroprotection. J Neurochem 142:429-443.

Valkki IA, Lenk K, Mikkonen JE, Kapucu FE, Hyttinen JAK (2017) Network-Wide Adaptive Burst Detection Depicts Neuronal Activity with Improved Accuracy. Front Comput Neurosci 11:40.

Vardi R, Goldental A, Sheinin A, Sardi S, Kanter I (2017) Fast reversible learning based on neurons functioning as anisotropic multiplex hubs. EPL (Europhysics Letters) 118:46002.

Vassallo A, Chiappalone M, De Camargos Lopes R, Scelfo B, Novellino A, Defranchi E, Palosaari T, Weisschu T, Ramirez T, Martinoia S, Johnstone AFM, Mack CM, Landsiedel R, Whelan M, Bal-Price A, Shafer TJ (2017) A multi-laboratory evaluation of microelectrode array-based measurements of neural network activity for acute neurotoxicity testing. Neurotoxicology 60:280-292.

Alagapan S, Franca E, Pan L, Leondopulos S, Wheeler BC, DeMarse TB (2016) Structure, Function, and Propagation of Information across Living Two, Four, and Eight Node Degree Topologies. Front Bioeng Biotechnol 4:15.

Bart Martens M, Frega M, Classen J, Epping L, Bijvank E, Benevento M, van Bokhoven H, Tiesinga P, Schubert D, Nadif Kasri N (2016) Euchromatin histone methyltransferase 1 regulates cortical neuronal network development. Sci Rep 6:35756.

Barykina NV, Subach OM, Doronin DA, Sotskov VP, Roshchina MA, Kunitsyna TA, Malyshev AY, Smirnov IV, Azieva AM, Sokolov IS, Piatkevich KD, Burtsev MS, Varizhuk AM, Pozmogova GE, Anokhin KV, Subach FV, Enikolopov GN (2016) A new design for a green calcium indicator with a smaller size and a reduced number of calcium-binding sites. Sci Rep 6:34447.

Berglund K, Tung JK, Higashikubo B, Gross RE, Moore CI, Hochgeschwender U (2016) Combined Optogenetic and Chemogenetic Control of Neurons. Methods Mol Biol 1408:207-225.

Blanquie O, Liebmann L, Hubner CA, Luhmann HJ, Sinning A (2016) NKCC1-Mediated GABAergic Signaling Promotes Postnatal Cell Death in Neocortical Cajal-Retzius Cells. Cereb Cortex.

Caputo L, Souza LF, Alloisio S, Cornara L, De Feo V (2016) Coriandrum sativum and Lavandula angustifolia Essential Oils: Chemical Composition and Activity on Central Nervous System. Int J Mol Sci 17.

Colombi I, Tinarelli F, Pasquale V, Tucci V, Chiappalone M (2016) A Simplified In vitro Experimental Model Encompasses the Essential Features of Sleep. Front Neurosci 10:315.

Dvorkin R, Ziv NE (2016) Relative Contributions of Specific Activity Histories and Spontaneous Processes to Size Remodeling of Glutamatergic Synapses. PLoS Biol 14:e1002572.

Hasan F, Berdichevsky Y (2016) Neural Circuits on a Chip. Micromachines 7.

Huang Y, Chang Y, Chen C, Lai P, Chan CK (2016) Positive Feedback and Synchronized Bursts in Neuronal

Cultures. In: arXiv.

Kapucu FE, Valkki I, Mikkonen JE, Leone C, Lenk K, Tanskanen JM, Hyttinen JA (2016) Spectral Entropy Based Neuronal Network Synchronization Analysis Based on Microelectrode Array Measurements. Front Comput Neurosci 10:112.

Keren H, Marom S (2016) Long-range synchrony and emergence of neural reentry. Sci Rep 6:36837.

Knudsen AM (2016) NTNU Cyborg: A study into embodying Neuronal Cultures through Robotic Systems. Department of Engineering Cybernetics.

Kumar SS, Wulfing J, Okujeni S, Boedecker J, Riedmiller M, Egert U (2016) Autonomous Optimization of Targeted Stimulation of Neuronal Networks. PLoS Comput Biol 12:e1005054.

Latifi S, Tamayol A, Habibey R, Sabzevari R, Kahn C, Geny D, Eftekharpour E, Annabi N, Blau A, Linder M, Arab-Tehrany E (2016) Natural lecithin promotes neural network complexity and activity. Sci Rep 6:25777.

Liljemalm R, Nyberg T (2016) Damage criteria for cerebral cortex cells subjected to hyperthermia. Int J Hyperthermia 32:704-712.

Martens MB, Frega M, Classen J, Epping L, Bijvank E, Benevento M, van Bokhoven H, Tiesinga P, Schubert D, Nadif Kasri N (2016) Euchromatin histone methyltransferase 1 regulates cortical neuronal network development. Sci Rep 6:35756.

Mohana Krishnan B, Prakhya BM (2016) In vitro evaluation of pyrethroid-mediated changes on neuronal burst parameters using microelectrode arrays. Neurotoxicology 57:270-281.

Perez-Alcazar M, Culley G, Lyckenvik T, Mobarrez K, Bjorefeldt A, Wasling P, Seth H, Asztely F, Harrer A, Iglseder B, Aigner L, Hanse E, Illes S (2016) Human Cerebrospinal Fluid Promotes Neuronal Viability and Activity of Hippocampal Neuronal Circuits In Vitro. Front Cell Neurosci 10:54.

Pigareva Y, Malishev E, Gladkov A, Kolpakov V, Bukatin A, Mukhina I, Kazantsev V, Pimashkin A (2016) Neural signal registration and analysis of axons grown in microchannels. Journal of Physics: Conference Series 741.

Poon VY, Gu M, Ji F, VanDongen AM, Fivaz M (2016) miR-27b shapes the presynaptic transcriptome and influences neurotransmission by silencing the polycomb group protein Bmi1. BMC Genomics 17:777.

Pulizzi R, Musumeci G, Van den Haute C, Van De Vijver S, Baekelandt V, Giugliano M (2016) Brief wide-field photostimuli evoke and modulate oscillatory reverberating activity in cortical networks. Sci Rep 6:24701.

Ryu JR, Jang MJ, Jo Y, Joo S, Lee do H, Lee BY, Nam Y, Sun W (2016) Synaptic compartmentalization by micropatterned masking of a surface adhesive cue in cultured neurons. Biomaterials 92:46-56.

Sardi S, Goldental A, Amir H, Vardi R, Kanter I (2016) Vitality of Neural Networks under Reoccurring Catastrophic Failures. Sci Rep 6:31674.

Shaukat A, Thivierge JP (2016) Statistical Evaluation of Waveform Collapse Reveals Scale-Free Properties of Neuronal Avalanches. Front Comput Neurosci 10:29.

Shein-Idelson M, Cohen G, Ben-Jacob E, Hanein Y (2016) Modularity Induced Gating and Delays in Neuronal Networks. PLoS Comput Biol 12:e1004883.

Vardi R, Goldental A, Sardi S, Sheinin A, Kanter I (2016) Simultaneous multi-patch-clamp and extracellular-array recordings: Single neuron reflects network activity. Sci Rep 6:36228.

Wanke E, Gullo F, Dossi E, Valenza G, Becchetti A (2016) Neuron-glia crosstalk revealed in reverberating networks by simultaneous extracellular recording of spikes and astrocytes' glutamate transporter and K+ currents. J Neurophysiol:jn 00509 02016.

Wijdenes P, Ali H, Armstrong R, Zaidi W, Dalton C, Syed NI (2016) A novel bio-mimicking, planar nano-edge microelectrode enables enhanced long-term neural recording. Sci Rep 6:34553.

Wilk N, Habibey R, Golabchi A, Latifi S, Ingebrandt S, Blau A (2016) Selective comparison of gelling agents as neural cell culture matrices for long-term microelectrode array electrophysiology. OCL 23.

Afshar G, El Hady A, Geisel T, Stuehmer W, Wolf F (2015) Enhancing burst activation and propagation in cultured neuronal networks by photo-stimulation. bioRxiv.

Bartsch H, Himmerlich M, Fischer M, Demkó L, Hyttinen J, Schober A (2015) LTCC-Based Multi-Electrode Arrays for 3D in Vitro Cell Cultures. Journal of Ceramic Science and Technology 6:315-324.

Carrillo-Reid L, Lopez-Huerta VG, Garcia-Munoz M, Theiss S, Arbuthnott GW (2015) Cell Assembly Signatures Defined by Short-Term Synaptic Plasticity in Cortical Networks. Int J Neural Syst 25:1550026.

Charlesworth P, Cotterill E, Morton A, Grant SG, Eglen SJ (2015) Quantitative differences in developmental profiles of spontaneous activity in cortical and hippocampal cultures. Neural Dev 10:1.

Charlesworth P, Morton A, Eglen SJ, Komiyama NH, Grant SG (2015) Canalization of genetic and pharmacological perturbations in developing primary neuronal activity patterns. Neuropharmacology 100:47-55.

Croom EL, Shafer TJ, Evans MV, Mundy WR, Eklund CR, Johnstone AF, Mack CM, Pegram RA (2015) Improving in vitro to in vivo extrapolation by incorporating toxicokinetic measurements: a case study of lindane-induced neurotoxicity. Toxicol Appl Pharmacol 283:9-19.

de Ceglia R, Chaabane L, Biffi E, Bergamaschi A, Ferrigno G, Amadio S, Del Carro U, Mazzocchi N, Comi G, Bianchi V, Taverna S, Forti L, D'Adamo P, Martino G, Menegon A, Muzio L (2015) Down-sizing of neuronal network activity and density of presynaptic terminals by pathological acidosis are efficiently prevented by Diminazene Aceturate. Brain Behav Immun 45:263-276.

Dranias MR, Westover MB, Cash S, VanDongen AM (2015) Stimulus information stored in lasting active and hidden network states is destroyed by network bursts. Front Integr Neurosci 9:14.

Farah N, Levinsky A, Brosh I, kahn I, Shoam S (2015) Holographic fiber bundle system for patterned optogenetic activation of large-scale neuronal networks. Neurophotonics 2.

Fong MF, Newman JP, Potter SM, Wenner P (2015) Upward synaptic scaling is dependent on neurotransmission rather than spiking. Nat Commun 6:6339.

Garcia-Munoz M, Lopez-Huerta VG, Carrillo-Reid L, Arbuthnott GW (2015) Extrasynaptic glutamate NMDA receptors: key players in striatal function. Neuropharmacology 89:54-63.

Garcia-Munoz M, Taillefer E, Pnini R, Vickers C, Miller J, Arbuthnott GW (2015) Rebuilding a realistic corticostriatal "social network" from dissociated cells. Front Syst Neurosci 9:63.

Goldental A, Sabo P, Sardi S, Vardi R, Kanter I (2015) Mimicking Collective Firing Patterns of Hundreds of Connected Neurons using a Single-Neuron Experiment. Front Neurosci 9:508.

Goldental A, Vardi R, Sardi S, Sabo P, Kanter I (2015) Broadband macroscopic cortical oscillations emerge from intrinsic neuronal response failures. Front Neural Circuits 9:65.

Hamilton F, Graham R, Luu L, Peixoto N (2015) Time-Dependent Increase in Network Response to Stimulation. PLoS ONE 10:e0142399.

Haroush N, Marom S (2015) Slow dynamics in features of synchronized neural network responses. Front Comput Neurosci 9:40.

Ju H, Dranias MR, Banumurthy G, VanDongen AM (2015) Spatiotemporal memory is an intrinsic property of networks of dissociated cortical neurons. J Neurosci 35:4040-4051.

Kanner S, Bisio M, Cohen G, Goldin M, Tedesco M, Hanein Y, Ben-Jacob E, Barzilai A, Chiappalone M, Bonifazi P (2015) Design, Surface Treatment, Cellular Plating, and Culturing of Modular Neuronal Networks Composed of Functionally Inter-connected Circuits.e52572.

Kuebler ES, Tauskela JS, Aylsworth A, Zhao X, Thivierge JP (2015) Burst predicting neurons survive an in vitro glutamate injury model of cerebral ischemia. Sci Rep 5:17718.

Lee S, Sohal IS, Therrien MA, Pal AK, Bello D, Shea TB (2015) Additive Impairment of Synaptic Signaling in Cultured Cortical Neurons by Exogenously-Applied Oligomerized Amyloid-beta and Airborne Nanoparticles Generated during Photocopying. J Alzheimers Dis 47:49-54.

Li Y, Li H, Wang Y (2015) A Multichannel Waveform Generator for Spatiotemporal Stimulation of Dissociated Neuronal Network on MEA Journal of Medical and Bioengineering 4.

Lu C, Chen Q, Zhou T, Bozic D, Fu Z, Pan JQ, Feng G (2015) Micro-electrode array recordings reveal reductions in both excitation and inhibition in cultured cortical neuron networks lacking Shank3. Mol Psychiatry.

Newman JP, Fong MF, Millard DC, Whitmire CJ, Stanley GB, Potter SM (2015) Optogenetic feedback control of neural activity. Elife 4:e07192.

Peelaerts W, Bousset L, Van der Perren A, Moskalyuk A, Pulizzi R, Giugliano M, Van den Haute C, Melki R, Baekelandt V (2015) alpha-Synuclein strains cause distinct synucleinopathies after local and systemic administration. Nature 522:340-344.

Pirino V, Riccomagno E, Martinoia S, Massobrio P (2015) A topological study of repetitive co-activation networks in in vitro cortical assemblies. Phys Biol 12:016007.

Ryan TM, Roberts BR, McColl G, Hare DJ, Doble PA, Li QX, Lind M, Roberts AM, Mertens HD, Kirby N, Pham CL, Hinds MG, Adlard PA, Barnham KJ, Curtain CC, Masters CL (2015) Stabilization of nontoxic Abeta-oligomers: insights into the mechanism of action of hydroxyquinolines in Alzheimer's disease. J Neurosci 35:2871-2884.

Smith I, Haag M, Ugbode C, Tams D, Rattray M, Przyborski S, Bithell A, Whalley BJ (2015) Neuronal-glial populations form functional networks in a biocompatible 3D scaffold. Neurosci Lett 609:198-202.

Vardi R, Goldental A, Marmari H, Brama H, Stern EA, Sardi S, Sabo P, Kanter I (2015) Neuronal Response Impedance Mechanism Implementing Cooperative Networks with Low Firing Rates and Microsecond Precision. Frontiers in Neural Circuits 9.

Charkhkar H, Frewin C, Nezafati M, Knaack GL, Peixoto N, Saddow SE, Pancrazio JJ (2014) Use of cortical neuronal networks for in vitro material biocompatibility testing. Biosens Bioelectron 53:316-323.

Goldental A, Guberman S, Vardi R, Kanter I (2014) A computational paradigm for dynamic logic-gates in neuronal activity. Front Comput Neurosci 8:52.

Gullo F, Amadeo A, Donvito G, Lecchi M, Costa B, Constanti A, Wanke E (2014) Atypical "seizure-like" activity in cortical reverberating networks in vitro can be caused by LPS-induced inflammation: a multi-electrode array study from a hundred neurons. Front Cell Neurosci 8:361.

Gullo F, Manfredi I, Lecchi M, Casari G, Wanke E, Becchetti A (2014) Multi-electrode array study of neuronal cultures expressing nicotinic beta2-V287L subunits, linked to autosomal dominant nocturnal frontal lobe epilepsy. An in vitro model of spontaneous epilepsy. Front Neural Circuits 8:87.

Hagar M, Roni V, Ido K (2014) Chaotic and non-chaotic phases in experimental responses of a single neuron. EPL (Europhysics Letters) 106:46002.

Hedrich UB, Liautard C, Kirschenbaum D, Pofahl M, Lavigne J, Liu Y, Theiss S, Slotta J, Escayg A, Dihne M, Beck H, Mantegazza M, Lerche H (2014) Impaired Action Potential Initiation in GABAergic Interneurons Causes Hyperexcitable Networks in an Epileptic Mouse Model Carrying a Human NaV1.1 Mutation. J Neurosci 34:14874-14889.

Illes S, Jakab M, Beyer F, Gelfert R, Couillard-Despres S, Schnitzler A, Ritter M, Aigner L (2014) Intrinsically active and pacemaker neurons in pluripotent stem cell-derived neuronal populations. Stem Cell Reports 2:323-336.

Keren H, Marom S (2014) Controlling neural network responsiveness: tradeoffs and constraints. Front Neuroeng 7:11.

le Feber J, Stoyanova, II, Chiappalone M (2014) Connectivity, excitability and activity patterns in neuronal networks. Phys Biol 11:036005.

Martens MB, Chiappalone M, Schubert D, Tiesinga PH (2014) Separating burst from background spikes in multichannel neuronal recordings using return map analysis. Int J Neural Syst 24:1450012.

Napoli A, Xie J, Obeid I (2014) Understanding the temporal evolution of neuronal connectivity in cultured networks using statistical analysis. BMC Neurosci 15:17.

Stoyanova, II, le Feber J (2014) Ghrelin accelerates synapse formation and activity development in cultured cortical networks. BMC Neurosci 15:49.

Vardi R, Marmari H, Kanter I (2014) Error correction and fast detectors implemented by ultrafast neuronal plasticity. Phys Rev E 89.

Weir K, Blanquie O, Kilb W, Luhmann HJ, Sinning A (2014) Comparison of spike parameters from optically identified GABAergic and glutamatergic neurons in sparse cortical cultures. Front Cell Neurosci 8:460.

Dranias MR, Ju H, Rajaram E, Vandongen AM (2013) Short-term memory in networks of dissociated cortical neurons. J Neurosci 33:1940-1953.

Hammond MW, Xydas D, Downes JH, Bucci G, Becerra V, Warwick K, Constanti A, Nasuto SJ, Whalley BJ (2013) Endogenous cholinergic tone modulates spontaneous network level neuronal activity in primary cortical cultures grown on multi-electrode arrays. BMC Neurosci 14:38.

Jantzen SU, Ferrea S, Wach C, Quasthoff K, Illes S, Scherfeld D, Hartung HP, Seitz RJ, Dihne M (2013) In vitro neuronal network activity in NMDA receptor encephalitis. BMC Neurosci 14:17.

Kiiski H, Aanismaa R, Tenhunen J, Hagman S, Yla-Outinen L, Aho A, Yli-Hankala A, Bendel S, Skottman H, Narkilahti S (2013) Healthy human CSF promotes glial differentiation of hESC-derived neural cells while retaining spontaneous activity in existing neuronal networks. Biol Open 2:605-612.

Lavi A, Sheinin A, Shapira R, Zelmanoff D, Ashery U (2013) DOC2B and Munc13-1 Differentially Regulate Neuronal Network Activity. Cereb Cortex.

Mack CM, Lin B, Turner JD, Johnstone AF, Burgoon LD, Shafer TJ (2013) Burst and principal components analyses of mea data for 16 chemicals describe at least three effects classes. Neurotoxicology.

Moretti D, Garenne A, Haro E, Poulletierde Gannes F, Lagroye I, Leveque P, Veyret B, Lewis N (2013) InVitro Exposure of Neuronal Networks to a GSM-1800 Signal. Bioelectromagnetics.

Nimmervoll B, White R, Yang JW, An S, Henn C, Sun JJ, Luhmann HJ (2013) LPS-induced microglial secretion of TNFalpha increases activity-dependent neuronal apoptosis in the neonatal cerebral cortex. Cereb Cortex 23:1742-1755.

Pu J, Gong H, Li X, Luo Q (2013) Developing neuronal networks: self-organized criticality predicts the future. Sci Rep 3:1081.

Vardi R, Goldental A, Guberman S, Kalmanovich A, Marmari H, Kanter I (2013) Sudden synchrony leaps accompanied by frequency multiplications in neuronal activity. Front Neural Circuits 7:176.

Vardi R, Guberman S, Goldental A, Kanter I (2013) An experimental evidence-based computational paradigm for new logic-gates in neuronal activity. EPL (Europhysics Letters) 103.

Vardi R, Timor R, Marom S, Abeles M, Kanter I (2013) Synchronization by elastic neuronal latencies. Phys Rev E Stat Nonlin Soft Matter Phys 87:012724.

Vincent K, Tauskela JS, Mealing GA, Thivierge JP (2013) Altered network communication following a neuroprotective drug treatment. PLoS ONE 8:e54478.

Weihberger O, Okujeni S, Mikkonen JE, Egert U (2013) Quantitative examination of stimulus-response relations in cortical networks in vitro. J Neurophysiol 109:1764-1774.

Albrecht P, Bouchachia I, Goebels N, Henke N, Hofstetter HH, Issberner A, Kovacs Z, Lewerenz J, Lisak D, Maher P, Mausberg AK, Quasthoff K, Zimmermann C, Hartung HP, Methner A (2012) Effects of dimethyl fumarate on neuroprotection and immunomodulation. J Neuroinflammation 9:163.

Becchetti A, Gullo F, Bruno G, Dossi E, Lecchi M, Wanke E (2012) Exact distinction of excitatory and inhibitory neurons in neural networks: a study with GFP-GAD67 neurons optically and electrophysiologically recognized on multielectrode arrays. Front Neural Circuits 6:63.

Biffi E, Piraino F, Pedrocchi A, Fiore GB, Ferrigno G, Redaelli A, Menegon A, Rasponi M (2012) A microfluidic platform for controlled biochemical stimulation of twin neuronal networks. Biomicrofluidics 6:24106-2410610.

Gullo F, Maffezzoli A, Dossi E, Lecchi M, Wanke E (2012) Classifying heterogeneity of spontaneous up-states: a method for revealing variations in firing probability, engaged neurons and Fano factor. J Neurosci Methods 203:407-417.

Hales CM, Zeller-Townson R, Newman JP, Shoemaker JT, Killian NJ, Potter SM (2012) Stimulus-evoked high frequency oscillations are present in neuronal networks on microelectrode arrays. Front Neural Circuits 6:29.

Hinard V, Mikhail C, Pradervand S, Curie T, Houtkooper RH, Auwerx J, Franken P, Tafti M (2012) Key electrophysiological, molecular, and metabolic signatures of sleep and wakefulness revealed in primary cortical cultures. J Neurosci 32:12506-12517.

Kanagasabapathi TT, Massobrio P, Barone RA, Tedesco M, Martinoia S, Wadman WJ, Decre MM (2012) Functional connectivity and dynamics of cortical-thalamic networks co-cultured in a dual compartment device. J Neural Eng 9:036010.

Kapucu FE, Tanskanen JM, Mikkonen JE, Yla-Outinen L, Narkilahti S, Hyttinen JA (2012) Burst analysis tool for developing neuronal networks exhibiting highly varying action potential dynamics. Front Comput Neurosci 6:38.

Kaufman M, Corner MA, Ziv NE (2012) Long-term Relationships between Cholinergic Tone, Synchronous Bursting and Synaptic Remodeling. PLoS ONE 7:e40980.

Levy O, Ziv NE, Marom S (2012) Enhancement of neural representation capacity by modular architecture in networks of cortical neurons. Eur J Neurosci 35:1753-1760.

Marconi E, Nieus T, Maccione A, Valente P, Simi A, Messa M, Dante S, Baldelli P, Berdondini L, Benfenati F (2012) Emergent functional properties of neuronal networks with controlled topology. PLoS ONE 7:e34648.

Newman JP, Zeller-Townson R, Fong MF, Arcot Desai S, Gross RE, Potter SM (2012) Closed-Loop, Multichannel Experimentation Using the Open-Source NeuroRighter Electrophysiology Platform. Front Neural Circuits 6:98.

Schock SC, Jolin-Dahel KS, Schock PC, Theiss S, Arbuthnott GW, Garcia-Munoz M, Staines WA (2012) Development of dissociated cryopreserved rat cortical neurons in vitro. J Neurosci Methods 205:324-333.

Stephens CL, Toda H, Palmer TD, DeMarse TB, Ormerod BK (2012) Adult neural progenitor cells reactivate superbursting in mature neural networks. Exp Neurol 234:20-30.

van Drongelen W, Wildeman A, Radojicic M, Suresh J, Wang J, Marks J (2012) A Novel Technique to Evaluate Network Properties. In: Gordon Research Conference 2012, Mechanisms of Epilepsy & Neuronal Synchronization.

Vardi R, Wallach A, Kopelowitz E, Abeles M, Marom S, Kanter I (2012) Synthetic reverberating activity patterns embedded in networks of cortical neurons. EPL (Europhysics Letters) 97:66002.

Wallach A, Marom S (2012) Interactions between network synchrony and the dynamics of neuronal threshold. J Neurophysiol 107:2926-2936.

Zemianek JM, Serra M, Guaraldi M, Shea TB (2012) Stimulation with a low-amplitude, digitized synaptic signal to invoke robust activity within neuronal networks on multielectrode arrays. Biotechniques 52:177-182.

Zullo L, Chiappalone M, Martinoia S, Benfenati F (2012) A "spike-based" grammar underlies directional modification in network connectivity: effect on bursting activity and implications for bio-hybrids systems. PLoS ONE 7:e49299.

Baltz T, Herzog A, Voigt T (2011) Slow oscillating population activity in developing cortical networks: models and experimental results. J Neurophysiol 106:1500-1514.

Chevalier G, Suberbielle E, Monnet C, Duplan V, Martin-Blondel G, Farrugia F, Le Masson G, Liblau R, Gonzalez-Dunia D (2011) Neurons are MHC class I-dependent targets for CD8 T cells upon neurotropic viral infection. PLoS Pathog 7:e1002393.

Clifford MA, Kanwal JK, Dzakpasu R, Donoghue MJ (2011) EphA4 expression promotes network activity and spine maturation in cortical neuronal cultures. Neural Dev 6:21.

Defranchi E, Novellino A, Whelan M, Vogel SA, Ramirez-Hernandez T, Van Ravenzwaay B, Landsiedel R (2011) Feasibility assessment of Micro electrode chip assay (MEA) as a method of detecting neurotoxicity in vitro. Frontiers in Neuroengineering 4.

Difato F, Dal Maschio M, Marconi E, Ronzitti G, Maccione A, Fellin T, Berdondini L, Chieregatti E, Benfenati F, Blau A (2011) Combined optical tweezers and laser dissector for controlled ablation of functional connections in neural networks. J Biomed Opt 16:051306.

Ferrández JM, Lorente V, Garrigós J, Fernandez E (2011) Image Coding for Robotic Guidance Using Neuroblastoma Cultures. Majlesi Journal of Electrical Engineering 5.

Frega M, Pasquale V, Tedesco M, Marcoli M, Contestabile A, Nanni M, Bonzano L, Maura G, Chiappalone M (2011) Cortical cultures coupled to Micro-Electrode Arrays: A novel approach to perform in vitro excitotoxicity testing. Neurotoxicol Teratol.

Hogberg HT, Sobanski T, Novellino A, Whelan M, Weiss DG, Bal-Price AK (2011) Application of micro-electrode arrays (MEAs) as an emerging technology for developmental neurotoxicity: evaluation of domoic acid-induced effects in primary cultures of rat cortical neurons. Neurotoxicology 32:158-168.

Kanagasabapathi TT, Ciliberti D, Martinoia S, Wadman WJ, Decre MM (2011) Dual-compartment neurofluidic system for electrophysiological measurements in physically segregated and functionally connected neuronal cell culture. Front Neuroeng 4:13.

Levine-Small N, Yekutieli Z, Aljadeff Y, Boccaletti S, Ben Jacob E, Barzilai A (2011) Reduced Synchronization Persistence in Neural Networks derived from Atm-Deficient Mice. Frontiers in Neuroscience 5.

Novellino A, Scelfo B, Palosaari T, Price A, Sobanski T, Shafer TJ, Johnstone AFM, Gross GW, Gramowski A, Schroeder O, J?gelt K, Chiappalone M, Benfenati F, Martinoia S, Tedesco MT, Defranchi E, D'Angelo P, Whelan M (2011) Development of micro-electrode array based tests for neurotoxicity: assessment of interlaboratory reproducibility with neuroactive chemicals. Frontiers in Neuroengineering 4.

Ortman RL, Venayagamoorthy K, Potter SM (2011) Input Separability in Living Liquid State Machines. In: ICANNGA 2011, Part I, LNCS 6593 (Dobnikar A, Lotrič U, Šter B, eds), pp 220–229.

Pan L, Alagapan S, Franca E, Brewer GJ, Wheeler BC (2011) Propagation of action potential activity in a predefined microtunnel neural network. J Neural Eng 8:046031.

Piet R, Garenne A, Farrugia F, Le Masson G, Marsicano G, Chavis P, Manzoni OJ (2011) State-dependent, bidirectional modulation of neural network activity by endocannabinoids. J Neurosci 31:16591-16596.

Robinette BL, Harrill JA, Mundy WR, Shafer TJ (2011) In vitro assessment of developmental neurotoxicity: use of microelectrode arrays to measure functional changes in neuronal network ontogeny. Front Neuroengineering 4:1.

Scelfo B, Politi M, Reniero F, Zaldivar JM (2011) Application of multielectrode array (MEA) chips for studying the neurotoxicity of mixtures. In: JRC Scientific and Technical Reports: European Comission.

Shein-Idelson M, Ben-Jacob E, Hanein Y (2011) Engineered neuronal circuits: a new platform for studying the role of modular topology. Front Neuroeng 4:10.

Shew WL, Yang H, Yu S, Roy R, Plenz D (2011) Information capacity and transmission are maximized in balanced cortical networks with neuronal avalanches. J Neurosci 31:55-63.

Verpelli C, Dvoretskova E, Vicidomini C, Rossi F, Chiappalone M, Schoen M, Di Stefano B, Mantegazza R, Broccoli V, Boeckers TM, Dityatev A, Sala C (2011) Importance of shank3 in regulating metabotropic glutamate receptor 5 (mGluR5) expression and signaling at synapses. J Biol Chem.

Wallach A, Eytan D, Gal A, Zrenner C, Marom S (2011) Neuronal Response Clamp. Frontiers in Neuroengineering 4.

Xydas D, Downes JH, Spencer MC, Hammond MW, Nasuto SJ, Whalley BJ, Becerra VM, Warwick K (2011) Revealing ensemble state transition patterns in multi-electrode neuronal recordings using hidden Markov models. IEEE Trans Neural Syst Rehabil Eng 19:345-355.

Baltz T, de Lima AD, Voigt T (2010) Contribution of GABAergic interneurons to the development of spontaneous activity patterns in cultured neocortical networks. Front Cell Neurosci 4:15.

Biffi E, Ghezzi D, Pedrocchi A, Ferrigno G (2010) Development and validation of a spike detection and classification algorithm aimed at implementation on hardware devices. Comput Intell Neurosci:659050.

Bologna LL, Nieus T, Tedesco M, Chiappalone M, Benfenati F, Martinoia S (2010) Low-frequency stimulation enhances burst activity in cortical cultures during development. Neuroscience 165:692-704.

Destro-Filho JB, Estombelo-Montesco CA, Murta-Junior LO, Martinoia S, Chiappalone M, Moreira-Marques S, Neves AF (2010) Quantitative estimation of the nonstationary behavior of neural spontaneous activity. Comput Intell Neurosci:785919.

Finberg JP, Gluzman Z, Reshef M, Loboda Y, Mohsen U, Bressler-Stramer T, Miari R, Gepstein L, Marom S, Feld Y (2010) Modulation of excessive neuronal activity by fibroblasts: potential use in treatment of Parkinson's disease. Restor Neurol Neurosci 28:803-815.

Gal A, Eytan D, Wallach A, Sandler M, Schiller J, Marom S (2010) Dynamics of Excitability over Extended Timescales in Cultured Cortical Neurons. J Neurosci 30:16332-16342.

Gambazzi L, Gokce O, Seredenina T, Katsyuba E, Runne H, Markram H, Giugliano M, Luthi-Carter R (2010) Diminished activity-dependent BDNF expression underlies cortical neuron microcircuit hypoconnectivity resulting from exposure to mutant huntingtin fragments. J Pharmacol Exp Ther.

Garcia-Munoz M, Carrillo-Reid L, Arbuthnott GW (2010) Functional anatomy: dynamic States in Basal Ganglia circuits. Front Neuroanat 4:144.

Golbs A, Nimmervoll B, Sun JJ, Sava IE, Luhmann HJ (2010) Control of Programmed Cell Death by Distinct Electrical Activity Patterns. Cereb Cortex.

Gritsun TA, Le Feber J, Stegenga J, Rutten WL (2010) Network bursts in cortical cultures are best simulated using pacemaker neurons and adaptive synapses. Biol Cybern 102:293-310.

Gullo F, Mazzetti S, Maffezzoli A, Dossi E, Lecchi M, Amadeo A, Krajewski J, Wanke E (2010) Orchestration of "presto" and "largo" synchrony in up-down activity of cortical networks. Frontiers in Neural Circuits 4.

Hales CM, Rolston JD, Potter SM (2010) How to culture, record and stimulate neuronal networks on micro-electrode arrays (MEAs). J Vis Exp.

Kermany E, Gal A, Lyakhov V, Meir R, Marom S, Eytan D (2010) Tradeoffs and constraints on neural representation in networks of cortical neurons. J Neurosci 30:9588-9596.

Kim JH, Kang G, Nam Y, Choi YK (2010) Surface-modified microelectrode array with flake nanostructure for neural recording and stimulation. Nanotechnology 21:85303.

le Feber J, Stegenga J, Rutten WL (2010) The effect of slow electrical stimuli to achieve learning in cultured networks of rat cortical neurons. PLoS ONE 5:e8871.

Mennerick S, Chisari M, Shu HJ, Taylor A, Vasek M, Eisenman LN, Zorumski CF (2010) Diverse voltage-sensitive dyes modulate GABAA receptor function. J Neurosci 30:2871-2879.

Rolston JD, Gross RE, Potter SM (2010) Closed-loop, open-source electrophysiology. Front Neurosci 4.

Rubinsky L, Raichman N, Lavee J, Frenk H, Ben-Jacob E, Bickler PE (2010) Antifreeze protein suppresses spontaneous neural activity and protects neurons from hypothermia/re-warming injury. Neurosci Res.

Shein Idelson M, Ben-Jacob E, Hanein Y (2010) Innate synchronous oscillations in freely-organized small neuronal circuits. PLoS ONE 5:e14443.

Shteingart H, Raichman N, Baruchi I, Ben-Jacob E (2010) Wrestling model of the repertoire of activity propagation modes in quadruple neural networks. Front Comput Neurosci 4:12.

Sun JJ, Kilb W, Luhmann HJ (2010) Self-organization of repetitive spike patterns in developing neuronal networks in vitro. Eur J Neurosci 32:1289-1299.

Tetzlaff C, Okujeni S, Egert U, Worgotter F, Butz M (2010) Self-organized criticality in developing neuronal networks. PLoS Comput Biol 6:e1001013.

Warwick K, Xydas D, Nasuto SJ, Becerra VM, Hammond MW, Downes JH, Marshall S, Whalley BJ (2010) Controlling a mobile robot with a biological brain. Defence Science Journal 60

Zebinden CF (2010) Leader neurons in living neural networks and in leaky integrate and fire neuron models. Département de physique théorique.

Zrenner C, Eytan D, Wallach A, Thier P, Marom S (2010) A generic framework for real-time multi-channel neuronal signal analysis, telemetry control, and sub-millisecond latency feedback generation. Front Neurosci 4:173.

Baljon PL, Chiappalone M, Martinoia S (2009) Interaction of electrically evoked responses in networks of dissociated cortical neurons. Phys Rev E Stat Nonlin Soft Matter Phys 80:031906.

Berdondini L, Massobrio P, Chiappalone M, Tedesco M, Imfeld K, Maccione A, Gandolfo M, Koudelka-Hep M, Martinoia S (2009) Extracellular recordings from locally dense microelectrode arrays coupled to dissociated cortical cultures. J Neurosci Methods 177:386-396.

Blau A, Neumann T, Ziegler C, Benfenati F (2009) Replica-moulded polydimethylsiloxane culture vessel lids attenuate osmotic drift in long-term cell cultures. Journal of Biosciences 34.

Brewer GJ, Boehler MD, Ide AN, Wheeler BC (2009) Chronic electrical stimulation of cultured hippocampal networks increases spontaneous spike rates. J Neurosci Methods 184:104-109.

Brewer GJ, Boehler MD, Pearson RA, Demaris AA, Ide AN, Wheeler BC (2009) Neuron network activity scales exponentially with synapse density. J Neural Eng 6:14001.

Broccard FD, Pegoraro S, Ruaro ME, Altafini C, Torre V (2009) Characterization of the time course of changes of the evoked electrical activity in a model of a chemically-induced neuronal plasticity. BMC Res Notes 2:13.

Chen L, Pan H (2009) Precisely Repeating Spike Temporal Sequences in Spontaneous

Activity of Cultured Hippocampal Neuronal Networks on

Multi-electrode Arrays. Seventh International Conference on Photonics and Imaging in Biology and Medicine.

Dong CY, Lim J, Nam Y, Cho KH (2009) Systematic analysis of synchronized oscillatory neuronal networks reveals an enrichment for coupled direct and indirect feedback motifs. Bioinformatics 25:1680-1685.

Dworak BJ, Wheeler BC (2009) Novel MEA platform with PDMS microtunnels enables the detection of action potential propagation from isolated axons in culture. Lab Chip 9:404-410.

Eick S, Wallys J, Hofmann B, van Ooyen A, Schnakenberg U, Ingebrandt S, Offenhausser A (2009) Iridium oxide microelectrode arrays for in vitro stimulation of individual rat neurons from dissociated cultures. Front Neuroengineering 2:16.

Garofalo M, Nieus T, Massobrio P, Martinoia S (2009) Evaluation of the performance of information theory-based methods and cross-correlation to estimate the functional connectivity in cortical networks. PLoS One 4:e6482.

Gullo F, Maffezzoli A, Dossi E, Wanke E (2009) Short-latency cross- and autocorrelation identify clusters of interacting cortical neurons recorded from multi-electrode array. J Neurosci Methods 181:186-198.

Jungblut M, Knoll W, Thielemann C, Pottek M (2009) Triangular neuronal networks on microelectrode arrays: an approach to improve the properties of low-density networks for extracellular recording. Biomed Microdevices.

Maccione A, Gandolfo M, Massobrio P, Novellino A, Martinoia S, Chiappalone M (2009) A novel algorithm for precise identification of spikes in extracellularly recorded neuronal signals. J Neurosci Methods 177:241-249.

Massobrio P, Tedesco M, Giachello C, Ghirardi M, Fiumara F, Martinoia S (2009) Helix neuronal ensembles with controlled cell type composition and placement develop functional polysynaptic circuits on Micro-Electrode Arrays. Neurosci Lett.

Minerbi A, Kahana R, Goldfeld L, Kaufman M, Marom S, Ziv NE (2009) Long-Term Relationships between Synaptic Tenacity, Synaptic Remodeling, and Network Activity. PLoS Biol 7:e1000136.

Mok SY, Lim YM, Goh SY (2009) A device to facilitate preparation of high-density neural cell cultures in MEAs. J Neurosci Methods 179:284-291.

Musick K, Khatami D, Wheeler BC (2009) Three-dimensional micro-electrode array for recording dissociated neuronal cultures. Lab Chip 9:2036-2042.

Pajevic S, Plenz D (2009) Efficient network reconstruction from dynamical cascades identifies small-world topology of neuronal avalanches. PLoS Comput Biol 5:e1000271.

Pasquale V, Martinoia S, Chiappalone M (2009) A self-adapting approach for the detection of bursts and network bursts in neuronal cultures. J Comput Neurosci.

Zhou W, Li X, Liu M, Zhao Y, Zhu G, Luo Q (2009) Homeostatically regulated synchronized oscillations induced by short-term tetrodotoxin treatment in cultured neuronal network. Biosystems 95:61-66.

Bakkum DJ, Chao ZC, Potter SM (2008) Long-Term Activity-Dependent Plasticity of Action Potential Propagation Delay and Amplitude in Cortical Networks. PLoS ONE 3:e2088.

Bakkum DJ, Chao ZC, Potter SM (2008) Spatio-temporal electrical stimuli shape behavior of an embodied cortical network in a goal-directed learning task. J Neural Eng 5:310-323.

Baruchi I, Volman V, Raichman N, Shein M, Ben-Jacob E (2008) The emergence and properties of mutual synchronization in in vitro coupled cortical networks. Eur J Neurosci 28:1825-1835.

Chao ZC, Bakkum DJ, Potter SM (2008) Shaping embodied neural networks for adaptive goal-directed behavior. PLoS Comput Biol 4:e1000042.

Chiappalone M, Casagrande S, Tedesco M, Valtorta F, Baldelli P, Martinoia S, Benfenati F (2008) Opposite Changes in Glutamatergic and GABAergic Transmission Underlie the Diffuse Hyperexcitability of Synapsin I-Deficient Cortical Networks. Cereb Cortex.

Chiappalone M, Massobrio P, Martinoia S (2008) Network plasticity in cortical assemblies. Eur J Neurosci 28:221-237.

Dockendorf KP, Park I, He P, Principe JC, Demarse TB (2008) Liquid state machines and cultured cortical networks: The separation property. Biosystems.

Eckmann JP, Shimshon Jacobi S, Marom S, Moses E, Zbinden C (2008) Leader neurons in population bursts of 2D living neural networks. New Journal of Physics 10:19pp.

Gireesh ED, Plenz D (2008) Neuronal avalanches organize as nested theta- and beta/gamma-oscillations during development of cortical layer 2/3. Proc Natl Acad Sci U S A.

Massobrio P, Martinoia S (2008) Modelling small-patterned neuronal networks coupled to microelectrode arrays. J Neural Eng 5:350-359.

Pasquale V, Massobrio P, Bologna LL, Chiappalone M, Martinoia S (2008) Self-organization and neuronal avalanches in networks of dissociated cortical neurons. Neuroscience.

Raichman N, Ben-Jacob E (2008) Identifying repeating motifs in the activation of synchronized bursts in cultured neuronal networks. J Neurosci Methods 170:96-110.

Rubinsky L, Raichman N, Lavee J, Frenk H, Ben-Jacob E (2008) Spatio-temporal motifs 'remembered' in neuronal networks following profound hypothermia. Neural Netw.

Scarlatos A, Cadotte AJ, DeMarse TB, Welt BA (2008) Cortical networks grown on microelectrode arrays as a biosensor for botulinum toxin. J Food Sci 73:E129-136.

Serra M, Chan A, Dubey M, Gilman V, Shea TB (2008) Folate and S-adenosylmethionine modulate synaptic activity in cultured cortical neurons: acute differential impact on normal and apolipoprotein-deficient mice. Phys Biol 5:44002.

Shahaf G, Eytan D, Gal A, Kermany E, Lyakhov V, Zrenner C, Marom S (2008) Order-based representation in random networks of cortical neurons. PLoS Comput Biol 4:e1000228.

Shein M, Volman V, Raichman N, Hanein Y, Ben-Jacob E (2008) Management of synchronized network activity by highly active neurons. Phys Biol 5:36008.

Smith JL, Hobbs J, Tang A, Jackson D, Chen W, Patel H, Prieto A, Sher A, Litke A, Beggs JM (2008) Network comparison of epileptogenic human cortex and excited rat cortex. In: J Neurosurg Pediatrics, pp A351-352.

Tang A, Jackson D, Hobbs J, Chen W, Smith JL, Patel H, Prieto A, Petrusca D, Grivich MI, Sher A, Hottowy P, Dabrowski W, Litke AM, Beggs JM (2008) A Maximum Entropy Model Applied to Spatial and Temporal Correlations from Cortical Networks In Vitro. J Neurosci 28:505-518.

Vajda I, van Pelt J, Wolters P, Chiappalone M, Martinoia S, van Someren EJ, van Ooyen A (2008) Low-Frequency Stimulation Induces Stable Transitions in Stereotypical Activity in Cortical Networks. Biophys J.

Wallach A, Eytan D, Marom S, Meir R (2008) Selective adaptation in networks of heterogeneous populations: model, simulation, and experiment. PLoS Comput Biol 4:e29.

Baruchi I, Ben-Jacob E (2007) Towards neuro-memory-chip: Imprinting multiple memories in cultured neural networks. Phys Rev E 75:050901.

Bontorin G, Renaud S, Garenne A, Alvado L, Le Masson G, Tomas J (2007) A real-time closed-loop setup for hybrid neural networks. Conf Proc IEEE Eng Med Biol Soc 1:3004-3007.

Chao ZC, Bakkum DJ, Potter SM (2007) Region-specific network plasticity in simulated and living cortical networks: comparison of the center of activity trajectory (CAT) with other statistics. J Neural Eng 4:294-308.

Chiappalone M, Vato A, Berdondini L, Koudelka-Hep M, Martinoia S (2007) Network dynamics and synchronous activity in cultured cortical neurons. Int J Neural Syst 17:87-103.

Esposti F, Signorini MG, Lamanna J, Gullo F, Wanke E (2007) How do TTX and AP5 affect the post-recovery neuronal network activity synchronization? Conf Proc IEEE Eng Med Biol Soc 2007:3012-3015.

Feber Jl, Rutten WLC, Stegenga J, Wolters PS, Ramakers GJA, Pelt Jv (2007) Conditional firing probabilities in cultured neuronal networks: a stable underlying structure in widely varying spontaneous activity patterns. Journal of Neural Engineering:54.

Fuchs E, Ayali A, Robinson A, Hulata E, Ben-Jacob E (2007) Coemergence of regularity and complexity during neural network development. Dev Neurobiol 67:1802-1814.

Gabay T, Ben-David M, Kalifa I, Sorkin R, Abrams ZR, Ben-Jacob E, Hanein Y (2007) Electro-chemical and biological properties of carbon nanotube based multi-electrode arrays. Nanotechnology 18:035201.

Jimbo Y (2007) MEA-based recording of neuronal activity in vitro. Arch Ital Biol 145:289-297.

le Feber J, Rutten WLC, Stegenga J, Wolters PS, Ramakers GJA, van Pelt J (2007) Conditional firing probabilities in cultured neuronal networks: a stable underlying structure in widely varying spontaneous activity patterns. J Neural Eng 4:54-67.

le Feber J, van Pelt J, Rutten W (2007) Latency dependent development of related firing patterns of cultured cortical neurons. Conf Proc IEEE Eng Med Biol Soc 1:3000-3003.

Li X, Zhou W, Zeng S, Liu M, Luo Q (2007) Long-term recording on multi-electrode array reveals degraded inhibitory connection in neuronal network development. Biosens Bioelectron 22:1538-1543.

Madhavan R, Chao ZC, Potter SM (2007) Plasticity of recurring spatiotemporal activity patterns in cortical networks. Phys Biol 4:181-193.

Massobrio P, Massobrio G, Martinoia S (2007) Multi-program approach for simulating recorded extracellular signals generated by neurons coupled to microelectrode arrays. Neurocomputing 70:2467-2476.

Plenz D, Thiagarajan TC (2007) The organizing principles of neuronal avalanches: cell assemblies in the cortex? Trends Neurosci 30:101-110.

Rolston JD, Wagenaar DA, Potter SM (2007) Precisely timed spatiotemporal patterns of neural activity in dissociated cortical cultures. Neuroscience.

Rubinsky L, Raichman N, Baruchi I, Shein M, Lavee J, Frenk H, Ben-Jacob E (2007) Study of hypothermia on cultured neuronal networks using multi-electrode arrays. J Neurosci Methods 160:288-293.

Rutten WL, Ruardij TG, Marani E, Roelofsen BH (2007) Neural networks on chemically patterned electrode arrays: towards a cultured probe. Acta Neurochir Suppl 97:547-554.

Stewart CV, Plenz D (2007) Homeostasis of neuronal avalanches during postnatal cortex development in vitro. J Neurosci Methods.

Volman V, Ben-Jacob E, Levine H (2007) The astrocyte as a gatekeeper of synaptic information transfer. Neural Comput 19:303-326.

Volmer R, Prat CM, Le Masson G, Garenne A, Gonzalez-Dunia D (2007) Borna disease virus infection impairs synaptic plasticity. J Virol 81:8833-8837.

Alessio R, Cozzi L, D'Angelo P, Sanguineti V (2006) Cultures of dissociated neurons display a variety of avalanche behaviours. European Symposium on Artificial Neural Networks.

Berdondini L, Chiappalone M, vanderWala PD, Imfelda K, deRooija NF, Koudelka-Hepa M, Tedescob M, Martinoiab S, vanPeltd J, LeMassonc G, Garennec A (2006) A microelectrodearray (MEA) integrated with clustering structures for investigating in vitro neurodynamics in confined interconnected sub-populations of neurons. Sensors and Actuators B 114:530–541.

Chiappalone M, Bove M, Vato A, Tedesco M, Martinoia S (2006) Dissociated cortical networks show spontaneously correlated activity patterns during in vitro development. Brain Res 1093:41-53.

Cozzi L, D'Angelo P, Sanguineti V (2006) Encoding of time-varying stimuli in populations of cultured neurons. Biol Cybern 94:335-349.

Eytan D, Marom S (2006) Dynamics and effective topology underlying synchronization in networks of cortical neurons. J Neurosci 26:8465-8476.

Giugliano M, Martinoia S (2006) Substrate arrays of microelectrodes for in vitro electrophysiology. In: Wiley Encyclopedia on Biomedical Engineering, pp 1-11.

Schneidman E, Berry MJ, 2nd, Segev R, Bialek W (2006) Weak pairwise correlations imply strongly correlated network states in a neural population. Nature 440:1007-1012.

Wagenaar DA, Pine J, Potter SM (2006) An extremely rich repertoire of bursting patterns during the development of cortical cultures. BMC Neurosci 7:11.

Wagenaar DA, Pine J, Potter SM (2006) Searching for plasticity in dissociated cortical cultures on multi-electrode arrays. J Negat Results Biomed 5:16.

Cadotte AJ, Schwarz C, T. B. (2005) Poly-HEMA as a drug delivery device for in vitro neural networks on micro-electrode arrays. J Neural Eng 2:114-122.

Chao ZC, Bakkum DJ, Wagenaar DA, Potter SM (2005) Effects of random external background stimulation on network synaptic stability after tetanization: a modeling study. Neuroinformatics 3:263-280.

Geis M (2005) Mustererkennung mit künstlichen neuralen Netzen am Beispiel von neuronenbasierten Biosensoren. Diplomarbeit an der Uni Mainz:69.

Hentschke H, Schwarz C, Antkowiak B (2005) Neocortex is the major target of sedative concentrations of volatile anaesthetics: strong depression of firing rates and increase of GABAA receptor-mediated inhibition. Eur J Neurosci 21:93-102.

Li X, Zhou W, Liu M, Luo Q (2005) Synchronized spontaneous spikes on multi-electrode array show development of cultured neuronal network. Conf Proc IEEE Eng Med Biol Soc 2:2134-2137.

Martinoia S, Bonzano L, Chiappalone M, Tedesco M (2005) Electrophysiological activity modulation by chemical stimulation in networks of cortical neurons coupled to microelectrode arrays: A biosensor for neuropharmacological applications. Sensors and Actuators B: Chemical 108:589-596.

Martinoia S, Bonzano L, Chiappalone M, Tedesco M, Marcoli M, Maura G (2005) In vitro cortical neuronal networks as a new high-sensitive system for biosensing applications. Biosens Bioelectron 20:2071-2078.

Otto F, Kieseier BC, Gortz P, Hartung HP, Siebler M (2005) The pentapeptide QYNAD does not inhibit neuronal network activity. Can J Neurol Sci 32:344-348.

Potter SM, Wagenaar DA, DeMarse TB (2005) Closing the loop: Stimulation feedback systems for embodies MEA cultures. Springer:32.

Prado GR, Ross JD, DeWeerth SP, LaPlaca MC (2005) Mechanical trauma induces immediate changes in neuronal network activity. J Neural Eng 2:148-158.

van Pelt J, Vajda I, Wolters PS, Corner MA, Ramakers GJ (2005) Dynamics and plasticity in developing neuronal networks in vitro. Prog Brain Res 147:173-188.

Wagenaar DA, Madhavan R, Pine J, Potter SM (2005) Controlling bursting in cortical cultures with closed-loop multi-electrode stimulation. J Neurosci 25:680-688.

Baruchi I, Ben-Jacob E (2004) Functional holography of recorded neuronal networks activity. Neuroinformatics 2:333-352.

Chiappalone M, Novellino A, Vajda I, Vato A, Martinoia S, van Pelt J (2004) Burst detection algorithms for the analysis of spatio-temporal patterns in cortical networks of neurons. Neurocomputing 65-66:653-662.

Cozzi L, D'Angelo P, Ide AN, Novellino A, Sanguineti V (2004) Coding and decoding performance in a bi-directional neural interface between in vitro cultured neurons and a mobile robot.

Darbon P, Yvon C, Legrand JC, Streit J (2004) INaP underlies intrinsic spiking and rhythm generation in networks of cultured rat spinal cord neurons. Eur J Neurosci 20:976-988.

Eytan D, Minerbi A, Ziv N, Marom S (2004) Dopamine-induced dispersion of correlations between action potentials in networks of cortical neurons. J Neurophysiol 92:1817-1824.

Giugliano M, Darbon P, Arsiero M, Luscher HR, Streit J (2004) Single-neuron discharge properties and network activity in dissociated cultures of neocortex. J Neurophysiol 92:977-996.

Gortz P, Hoinkes A, Fleischer W, Otto F, Schwahn B, Wendel U, Siebler M (2004) Implications for hyperhomocysteinemia: not homocysteine but its oxidized forms strongly inhibit neuronal network activity. J Neurol Sci 218:109-114.

Hulata E, Baruchi I, Segev R, Shapira Y, Ben-Jacob E (2004) Self-regulated complexity in cultured neuronal networks. Phys Rev Lett 92:198105.

Martinoia S, Massobrio P, Bove M, Massobrio G (2004) Cultured neurons coupled to microelectrode arrays: circuit models, simulations and experimental data. IEEE Trans Biomed Eng 51:859-864.

Nam Y, Wheeler BC (2004) Multichannel recording and stimulation of neuronal cultures grown on microstamped poly-D-lysin.

Potter SM, Bakkum DJ, Shkolnik A, Bu-Ary G, Gamblen P, DeMarse TB (2004) Removing some "A" from AI: Embodied Cultured Networks. Springer:17.

Segev R, Baruchi I, Hulata E, Ben-Jacob E (2004) Hidden neuronal correlations in cultured networks. Phys Rev Lett 92:118102.

Stillo G, Bonzano L, Chiappalone M, Vato A, Davide FA, Martinoia S (2004) Burst on Hurst algorithm for detecting activity patterns in networks of cortical neurons. International Journal of Information Technology 1.

Van Pelt J, Corner MA, Wolters PS, Rutten WL, Ramakers GJ (2004) Longterm stability and developmental changes in spontaneous network burst firing patterns in dissociated rat cerebral cortex cell cultures on multielectrode arrays. Neurosci Lett 361:86-89.

van Pelt J, Wolters PS, Corner MA, Rutten WL, Ramakers GJ (2004) Long-term characterization of firing dynamics of spontaneous bursts in cultured neural networks. IEEE Trans Biomed Eng 51:2051-2062.

Wagenaar DA, Pine J, Potter SM (2004) Effective parameters for stimulation of dissociated cultures using multi-electrode arrays. J Neurosci Methods 138:27-37.

Wagenaar DA, Potter SM (2004) A versatile all-channel stimulator for electrode arrays, with real-time control. J Neural Eng 1:39-45.

Darbon P, Tscherter A, Yvon C, Streit J (2003) Role of the electrogenic Na/K pump in disinhibition-induced bursting in cultured spinal networks. J Neurophysiol 90:3119-3129.

de Weerth S, Ross JD, Prado GR, Choi Y, Allen M, La Placa M (2003) A novel system for Measurememt of electrophysiological Signals associeted with traumatic neuronal injury. 7th International Conference on M Chemical an Biochemical Analysis Systems.

Eytan D, Brenner N, Marom S (2003) Selective adaptation in networks of cortical neurons. J Neurosci 23:9349-9356.

Otto F, Gortz P, Fleischer W, Siebler M (2003) Cryopreserved rat cortical cells develop functional neuronal networks on microelectrode arrays. J Neurosci Methods 128:173-181.

Potter SM, DeMarse TB, Wagenaar A, Madhavan R (2003) Long-Term Bidirectional Neuron Interfaces for Robotic Control, and In Vitro Learning Studies. Proceedings of the IEEE-EMBS:4.

Segev R, Benveniste M, Shapira Y, Ben-Jacob E (2003) Formation of electrically active clusterized neural networks. Phys Rev Lett 90:168101.

Corner MA, van Pelt J, Wolters PS, Baker RE, Nuytinck RH (2002) Physiological effects of sustained blockade of excitatory synaptic transmission on spontaneously active developing neuronal networks--an inquiry into the reciprocal linkage between intrinsic biorhythms and neuroplasticity in early ontogeny. Neurosci Biobehav Rev 26:127-185.

Marom S, Shahaf G (2002) Development, learning and memory in large random networks of cortical neurons: lessons beyond anatomy. Q Rev Biophys 35:63-87.

Segev R, Benveniste M, Hulata E, Cohen N, Palevski A, Kapon E, Shapira Y, Ben-Jacob E (2002) Long term behavior of lithographically prepared in vitro neuronal networks. Phys Rev Lett 88:118102.

Potter SM (2001) Distributed processing in cultured neuronal networks. Prog Brain Res 130:49-62.

Potter SM, DeMarse TB (2001) A new approach to neural cell culture for long-term studies. J Neurosci Methods 110:17-24.

Potter SM, Lukina N, Wu Y, Longmuir K (2001) Multi-side two-photon imaging of neurons on multi-electrode arrays. Proceeding of SPIE:7.

Segev R, Shapira Y, Benveniste M, Ben-Jacob E (2001) Observations and modeling of synchronized bursting in two-dimensional neural networks. Phys Rev E Stat Nonlin Soft Matter Phys 64:011920.

Shahaf G, Marom S (2001) Learning in networks of cortical neurons. J Neurosci 21:8782-8788.