Innovations in Electrophysiology

Dissociated cell cultures, hippocampus

Banerjee PS, Goshal S, Giardet C, DeMars KM, Yang C, Niehoff ML, Nguyen AD, Jayanth P, Mersman BA, Xu F, Banks WA, Hansen KM, Zhang J, Candelario-Jalil E, Farr SA, Butler AA (2021) Adropin expression correlates with age-related neuropathologies in the human brain and improves neuroin ammation and cognitive function in aging mice. Research Square.

Brofiga M, Pisano M, Callegari F, Massobrio P (2021) Exploring the contribution of thalamic and hippocampal input on cortical dynamics in a brain-on-a-chip model. IEEE Transactions on Medical Robotics and Bionics:1-1.

Dzyubenko E, Fleischer M, Manrique-Castano D, Borbor M, Kleinschnitz C, Faissner A, Hermann DM (2021) Inhibitory control in neuronal networks relies on the extracellular matrix integrity. Cell Mol Life Sci.

Herzog N, Johnstone AF, Bellamy T, Russell N (2021) Characterization of neuronal viability and network activity under microfluidic flow. Journal of Neuroscience Methods 358:109200.

Lü X-Y, Hou K, Zhao Y-F, An S, Wang Z-G (2021) Conjoint analysis of influence of LC-HCL and Mor-HCL on Vth and neurite length in hippocampal neuronal network. Neuroscience Letters 751:135801.

Molina-Martínez B, Jentsch L-V, Ersoy F, van der Moolen M, Donato S, Ness TV, Heutink P, Jones PD, Cesare P (2021) A multimodal 3D neuro-microphysiological system with neurite-trapping microelectrodes. bioRxiv:2021.2004.2016.436793.

Parrini M, Naskar S, Alberti M, Colombi I, Morelli G, Rocchi A, Nanni M, Piccardi F, Charles S, Ronzitti G, Mingozzi F, Contestabile A, Cancedda L (2021) Restoring neuronal chloride homeostasis with anti-NKCC1 gene therapy rescues cognitive deficits in a mouse model of Down syndrome. Mol Ther.

Pigareva Y, Gladkov A, Kolpakov V, Mukhina I, Bukatin A, Kazantsev VB, Pimashkin A (2021) Experimental Platform to Study Spiking Pattern Propagation in Modular Networks In Vitro. Brain Sci 11.

Rauti R, Ess A, Le Roi B, Kreinin Y, Epshtein M, Korin N, Maoz BM (2021) Transforming a well into a chip: A modular 3D-printed microfluidic chip. APL Bioengineering 5:026103.

Bódi V, Csikós V, Rátkai EA, Szűcs A, Tóth A, Szádeczky-Kardoss K, Dobolyi Á, Schlett K, Világi I, Varró P (2020) Short-term neuronal effects of fumonisin B1 on neuronal activity in rodents. Neurotoxicology 80:41-51.

Costa AR, Sousa SC, Pinto-Costa R, Mateus JC, Lopes CD, Costa AC, Rosa D, Machado D, Pajuelo L, Wang X, Zhou FQ, Pereira AJ, Sampaio P, Rubinstein BY, Mendes Pinto I, Lampe M, Aguiar P, Sousa MM (2020) The membrane periodic skeleton is an actomyosin network that regulates axonal diameter and conduction. Elife 9.

Dzyubenko E, Fleischer M, Manrique-Castano D, Borbor M, Kleinschnitz C, Faissner A, Hermann DM (2020) Extracellular matrix supports excitation-inhibition balance in neuronal networks by stabilizing inhibitory synapses. bioRxiv:2020.2007.2013.200113.

Hong N, Nam Y (2020) Thermoplasmonic neural chip platform for in situ manipulation of neuronal connections in vitro. Nature Communications 11:6313.

Kanders K, Lee HW, Hong N, Nam Y, Stoop R (2020) Fingerprints of a second order critical line in developing neural networks. Communications Physics 3:13.

Lezmy J, Gelman H, Katsenelson M, Styr B, Tikochinsky E, Lipinsky M, Peretz A, Slutsky I, Attali B (2020) M-current inhibition in hippocampal excitatory neurons triggers intrinsic and synaptic homeostatic responses at different temporal scales. J Neurosci.

Manzati M, Sorbo T, Giugliano M, Ballerini L (2020) Foetal neural progenitors contribute to postnatal circuits formation ex vivo: an electrophysiological investigation. Mol Brain 13:78.

Pemberton DK (2020) The Effects of the G Protein-Coupled Estrogen Receptor on Early Neuronal Development in Hippocampal and Cortical Neurons.

Pigareva Y, Grinchuk O, Gladkov A, Kolpakov V, Bukatin A, Kazantsev V, Mukhina I, Pimashkin A (2020) Study of spontaneous bioelectrical activity of two hierarchically connected neural networks in vitro. Journal of Physics: Conference Series 1695:012198.

Rodriguez AR, Anderson ED, O’Neill KM, McEwan PP, Vigilante NF, Kwon M, Akum BF, Stawicki TM, Meaney DF, Firestein BL (2020) Cytosolic PSD-95 Interactor Alters Functional Organization of Neural Circuits and AMPA Receptor Signaling Independent of PSD-95 Binding. Network Neuroscience:1-72.

Shchanikov S, Zuev A, Bordanov I, Danilin S, Lukoyanov V, Korolev D, Belov A, Pigareva Y, Gladkov A, Pimashkin A, Mikhaylov A, Kazantsev V, Serb A (2020) Designing a bidirectional, adaptive neural interface incorporating machine learning capabilities and memristor-enhanced hardware. Chaos, Solitons & Fractals:110504.

Vakili S, Ahooyi TM, Yarandi SS, Donadoni M, Rappaport J, Sariyer IK (2020) Molecular and Cellular Impact of Inflammatory Extracellular Vesicles (EVs) Derived from M1 and M2 Macrophages on Neural Action Potentials. Brain Sci 10.

Vemula SK, Malci A, Junge L, Lehmann A-C, Rama R, Hradsky J, Matute RA, Weber A, Prigge M, Naumann M, Kreutz MR, Seidenbecher CI, Gundelfinger ED, Herrera-Molina R (2020) TRAF6 controls spinogenesis instructing synapse density and neuronal activity through binding neuroplastin. bioRxiv:768341.

Voskobiynyk Y, Roth JR, Cochran JN, Rush T, Carullo NVN, Mesina JS, Waqas M, Vollmer RM, Day JJ, McMahon LL, Roberson ED (2020) Alzheimer’s disease risk gene BIN1 induces Tau-dependent network hyperexcitability. bioRxiv:2020.2003.2029.014720.

Wegrzyn D, Manitz MP, Kostka M, Freund N, Juckel G, Faissner A (2020) Poly I:C-induced maternal immune challenge reduces perineuronal net area and raises spontaneous network activity of hippocampal neurons in vitro. Eur J Neurosci.

Zhao Y, Jiang R, Xu Z, Guzman E, Hansma PK, Petzold L (2020) Scalable Bayesian Functional Connectivity Inference for Multi-Electrode Array Recordings. ArXiv.

Djemil S, Chen X, Zhang Z, Lee J, Rauf M, Pak DTS, Dzakpasu R (2019) Activation of nicotinic acetylcholine receptors induces potentiation and synchronization within in vitro hippocampal networks. J Neurochem:e14938.

Gottschling C, Wegrzyn D, Denecke B, Faissner A (2019) Elimination of the four extracellular matrix molecules tenascin-C, tenascin-R, brevican and neurocan alters the ratio of excitatory and inhibitory synapses. Sci Rep 9:13939.

Kanders K, Stoop N, Stoop R (2019) Universality in the firing of minicolumnar-type neural networks. Chaos: An Interdisciplinary Journal of Nonlinear Science 29:093109.

Kim R, Nam Y (2019) Polydopamine-doped conductive polymer microelectrodes for neural recording and stimulation. J Neurosci Methods 326:108369.

Liu H, Bridges D, Randall C, Solla SA, Wu B, Hansma P, Yan X, Kosik KS, Bouchard K (2019) In vitro validation of in silico identified inhibitory interactions. J Neurosci Methods 321:39-48.

Mateus J, Lopes C, Cerquido M, Leitao L, Leitao DC, Cardoso S, Ventura J, Aguiar P (2019) Improved in vitro electrophysiology using 3D-structured microelectrode arrays with a micro-mushrooms islets architecture capable of promoting topotaxis. J Neural Eng.

Mohseni Ahooyi T, Torkzaban B, Shekarabi M, Tahrir FG, Decoppet EA, Cotto B, Langford D, Amini S, Khalili K (2019) Perturbation of synapsins homeostasis through HIV-1 Tat-mediated suppression of BAG3 in primary neuronal cells. Cell Death Dis 10:473.

Roberts TP, Kern FB, Fernando C, Szathmary E, Husbands P, Philippides AO, Staras K (2019) Encoding Temporal Regularities and Information Copying in Hippocampal Circuits. Sci Rep 9:19036.

Shirokova OM, Sokolov RA, Korotchenko SA, Pershin VI, Ermin KV, Glyavina MM, Zhuchenko M, Andreeva NN, Shchelchkova NA, Mukhina IV (2019) Neurotropic Effect of Carbamylated Darbepoietin on the Model of Primary Hippocampal Culture. Sovremennye tehnologii v medicine 11:87.

Styr B, Gonen N, Zarhin D, Ruggiero A, Atsmon R, Gazit N, Braun G, Frere S, Vertkin I, Shapira I, Harel M, Heim LR, Katsenelson M, Rechnitz O, Fadila S, Derdikman D, Rubinstein M, Geiger T, Ruppin E, Slutsky I (2019) Mitochondrial Regulation of the Hippocampal Firing Rate Set Point and Seizure Susceptibility. Neuron 102:1009-1024 e1008.

van Loo KMJ, Rummel CK, Pitsch J, Alexander Muller J, Bikbaev AF, Martinez Chavez E, Blaess S, Dietrich D, Heine M, Becker AJ, Schoch S (2019) Calcium channel subunit alpha2delta4 is regulated by early growth response 1 and facilitates epileptogenesis. J Neurosci.

Vo HT, Phillips ML, Herskowitz JH, King GD (2019) Klotho deficiency affects the spine morphology and network synchronization of neurons. Mol Cell Neurosci 98:1-11.

An S, Zhao YF, Lu XY, Wang ZG (2018) Quantitative evaluation of extrinsic factors influencing electrical excitability in neuronal networks: Voltage Threshold Measurement Method (VTMM). Neural Regen Res 13:1026-1035.

Bang S, Lee BJ, Lee SR, Na S, Jang JM, Kang M, Kim SY, Min DH, Song JM, Ho WK, Jeon NL (2018) Reliable autapse formation using the single-cell patterning method. Biofabrication 11:015008.

Burke JN, Savell KE, Bunner KD (2018) CRISPR/dCas9-Mediated Upregulation of Reelin and Neuronal Excitability. Metamorphosis.

Chaudhuri AD, Dastgheyb RM, Yoo SW, Trout A, Talbot CC, Jr., Hao H, Witwer KW, Haughey NJ (2018) TNFalpha and IL-1beta modify the miRNA cargo of astrocyte shed extracellular vesicles to regulate neurotrophic signaling in neurons. Cell Death Dis 9:363.

Fan J, Thalody G, Kwagh J, Burnett E, Shi H, Lewen G, Chen SJ, Levesque P (2018) Assessing seizure liability using multi-electrode arrays (MEA). Toxicol In Vitro 55:93-100.

Joo S, Lim J, Nam Y (2018) Design and Fabrication of Miniaturized Neuronal Circuits on Microelectrode Arrays Using Agarose Hydrogel Micro-molding Technique. BioChip Journal.

Joo S, Nam Y (2018) Slow-wave recordings from micro-sized neural clusters using multi-well type microelectrode arrays. IEEE Transactions on Biomedical Engineering:1-1.

Joo S, Song SY, Nam YS, Nam Y (2018) Stimuli-Responsive Neuronal Networking via Removable Alginate Masks. Advanced Biosystems 2:1800030.

Jung H, Kim J, Nam Y (2018) Recovery of early neural spikes from stimulation electrodes using a DC-coupled low gain high resolution data acquisition system. J Neurosci Methods 304:118-125.

Kapkaeva MR, Genrikhs EE, Stelmashook EV, Kondratenko RV, Isaev NK, Khaspekov LG (2018) Neuronal Networks on Multielectrode Arrays as High Sensitive Biosensors of the Functional State of Nerve Cells. Biochemistry (Moscow), Supplement Series A: Membrane and Cell Biology 12.

Kuebler ES (2018) Harnessing the variability of neuronal activity School of Psychology, Faculty of Social Sciences PhD in Experimental Psychology.

Lee JW, Jung H, Cho HH, Lee JH, Nam Y (2018) Gold nanostar-mediated neural activity control using plasmonic photothermal effects. Biomaterials 153:59-69.

Pu J, Li X (2018) NDDN: A Cloud-Based Neuroinformation Database for Developing Neuronal Networks. J Healthc Eng 2018:3839094.

Savell KE, Bach SV, Zipperly ME, Revanna JS, Goska NA, Tuscher JJ, Duke CG, Sultan FA, Burke JN, Williams DM, Ianov L, Day JJ (2018) A neuron-optimized CRISPR/dCas9 activation system for robust and specific gene regulation. bioRxiv.

Spanu A, Tedesco MT, Martines L, Martinoia S, Bonfiglio A (2018) An organic neurophysiological tool for neuronal metabolic activity monitoring. APL Bioengineering 2:046105.

Sun Y, Gao Y, Tidei JJ, Shen M, Hoang JT, Wagner D, Zhao X (2018) Loss of MeCP2 in immature neurons leads to impaired network integration. Hum Mol Genet.

Tovar KR, Bridges DC, Wu B, Randall C, Audouard M, Jang J, Hansma PK, Kosik KS (2018) Action potential propagation recorded from single axonal arbors using multielectrode arrays. J Neurophysiol 120:306-320.

Yoo S, Park JH, Nam Y (2018) Single-Cell Photothermal Neuromodulation for Functional Mapping of Neural Networks. ACS Nano.

Aebersold MJ, Dermutz H, Demko L, Saenz Cogollo JF, Lin SC, Burchert C, Schneider M, Ling D, Forro C, Han H, Zambelli T, Voros J (2017) Local Chemical Stimulation of Neurons with the FluidFM. Chemphyschem.

Dermutz H, Thompson-Steckel G, Forro C, de Lange V, Dorwling-Carter L, Voros J, Demko L (2017) Paper-based patterned 3D neural cultures as a tool to study network activity on multielectrode arrays. RSC Advances 7:39359-39371.

Dzyubenko E, Juckel G, Faissner A (2017) The antipsychotic drugs olanzapine and haloperidol modify network connectivity and spontaneous activity of neural networks in vitro. Sci Rep 7:11609.

Gladkov A, Pigareva Y, Kutyina D, Kolpakov V, Bukatin A, Mukhina I, Kazantsev V, Pimashkin A (2017) Design of Cultured Neuron Networks in vitro with Predefined Connectivity Using Asymmetric Microfluidic Channels. Sci Rep 7:15625.

Gladkov AA, Kolpakov VN, Pigareva YI, Kazantsev V, Mukhina IV, Pimashkin A (2017) Functional Connectivity of Neural Network in Dissociated Hippocampal Culture Grown on Microelectrode Array.

Habibey R, Latifi S, Mousavi H, Pesce M, Arab-Tehrany E, Blau A (2017) A multielectrode array microchannel platform reveals both transient and slow changes in axonal conduction velocity. Sci Rep 7:8558.

Jung H, Kang H, Nam Y (2017) Digital micromirror based near-infrared illumination system for plasmonic photothermal neuromodulation. Biomedical Optics Express 8:2866-2878.

Li Y, Chen X, Dzakpasu R, Conant K (2017) Dopamine-dependent effects on basal and glutamate stimulated network dynamics in cultured hippocampal neurons. J Neurochem 140:550-560.

Liu H, Bridges D, Randall C, Solla SA, Wu B, Hansma P, Yan X, Kosik K, Bouchard K (2017) Use of a Neural Circuit Probe to Validate in silico Predictions of Inhibitory Connections. BioRxiv.

Narula U, Ruiz A, McQuaide M, DeMarse TB, Wheeler BC, Brewer GJ (2017) Narrow microtunnel technology for the isolation and precise identification of axonal communication among distinct hippocampal subregion networks. PLoS ONE 12:e0176868.

Rodriguez A, O'Neill K, Swiatkowski P, Patel MV, Firestein BL (2017) Overexpression of cypin alters dendrite morphology, single neuron activity, and network properties via distinct mechanisms. J Neural Eng.

Rojas Cifuentes CA, Tedesco M, Massobrio P, Marino A, Ciofani G, Martinoia S, Raiteri R (2017) Acoustic stimulation can induce a selective neural network response mediated by piezoelectric nanoparticles. J Neural Eng.

Russo I, Gavello D, Menna E, Vandael D, Veglia C, Morello N, Corradini I, Focchi E, Alfieri A, Angelini C, Bianchi FT, Morellato A, Marcantoni A, Sassoe-Pognetto M, Ottaviani MM, Yekhlef L, Giustetto M, Taverna S, Carabelli V, Matteoli M, Carbone E, Turco E, Defilippi P (2017) p140Cap Regulates GABAergic Synaptogenesis and Development of Hippocampal Inhibitory Circuits. Cereb Cortex:1-15.

Shtrahman E, Maruyama D, Olariu E, Fink CG, Zochowski M (2017) Understanding spatial and temporal patterning of astrocyte calcium transients via interactions between network transport and extracellular diffusion. Phys Biol 14:016001.

Tovar KR, Bridges DC, Wu B, Randall C, Audouard M, Jang J, Hansma PK, Kosik KS (2017) Recording action potential propagation in single axons using multi-electrode arrays. bioRxiv.

Bhattacharya A, Desai H, DeMarse TB, Wheeler BC, Brewer GJ (2016) Repeating Spatial-Temporal Motifs of CA3 Activity Dependent on Engineered Inputs from Dentate Gyrus Neurons in Live Hippocampal Networks. Front Neural Circuits 10:45.

Egor D (2016) Modifying synaptogenesis and functional state of neural networks in vitro: insights from the antipsychotic treatments and extracellular matrix depletion

Gavello D, Carbone E, Carabelli V (2016) Leptin-mediated ion channel regulation: PI3K pathways, physiological role, and therapeutic potential. Channels (Austin) 10:282-296.

Gottschling C, Geissler M, Springer G, Wolf R, Juckel G, Faissner A (2016) First and second generation antipsychotics differentially affect structural and functional properties of rat hippocampal neuron synapses. Neuroscience 337:117-130.

Li Y, Sun R, Wang Y, Li H, Zheng X (2016) A Novel Robot System Integrating Biological and Mechanical Intelligence Based on Dissociated Neural Network-Controlled Closed-Loop Environment. PLoS ONE 11:e0165600.

Shmoel N, Rabieh N, Ojovan SM, Erez H, Maydan E, Spira ME (2016) Multisite electrophysiological recordings by self-assembled loose-patch-like junctions between cultured hippocampal neurons and mushroom-shaped microelectrodes. Sci Rep 6:27110.

Suresh J, Radojicic M, Pesce LL, Bhansali A, Wang J, Tryba AK, Marks JD, van Drongelen W (2016) Network burst activity in hippocampal neuronal cultures: the role of synaptic and intrinsic currents. J Neurophysiol 115:3073-3089.

Timme NM, Marshall NJ, Bennett N, Ripp M, Lautzenhiser E, Beggs JM (2016) Criticality Maximizes Complexity in Neural Tissue. Front Physiol 7:425.

Ungureanu AA, Benilova I, Krylychkina O, Braeken D, De Strooper B, Van Haesendonck C, Dotti CG, Bartic C (2016) Amyloid beta oligomers induce neuronal elasticity changes in age-dependent manner: a force spectroscopy study on living hippocampal neurons. Sci Rep 6:25841.

Charlesworth P, Cotterill E, Morton A, Grant SG, Eglen SJ (2015) Quantitative differences in developmental profiles of spontaneous activity in cortical and hippocampal cultures. Neural Dev 10:1.

Eisenman LN, Emnett CM, Mohan J, Zorumski CF, Mennerick S (2015) Quantification of bursting and synchrony in cultured hippocampal neurons. J Neurophysiol 114:1059-1071.

Emnett CM, Eisenman LN, Mohan J, Taylor AA, Doherty JJ, Paul SM, Zorumski CF, Mennerick S (2015) Interaction between positive allosteric modulators and trapping blockers of the NMDA receptor channel. Br J Pharmacol 172:1333-1347.

Ferrández JM, Lorente V, de la Paz F, Fernández E (2015) Induced functional connectivity in hippocampal cultures using Hebbian electrical stimulation. Neurocomputing 151:4-10.

Kuebler ES, Tauskela JS, Aylsworth A, Zhao X, Thivierge JP (2015) Burst predicting neurons survive an in vitro glutamate injury model of cerebral ischemia. Sci Rep 5:17718.

Li Y, Sun R, Zhang B, Wang Y, Li H (2015) Application of hierarchical dissociated neural network in closed-loop hybrid system integrating biological and mechanical intelligence. PLoS ONE 10:e0127452.

Malishev E, Pimashkin A, Gladkov A, Pigareva Y, Bukatin A, Kazantsev V, Mukhina I, Dubina M (2015) Microfluidic device for unidirectional axon growth. Journal of Physics: Conference Series 643:012025.

Samhaber R, Schottdorf M, Hady AE, Broking K, Daus A, Thielemann C, Stuhmer W, Wolf F (2015) Growing neuronal islands on multi-electrode arrays using an Accurate Positioning-muCP device. J Neurosci Methods.

Schroeter MS, Charlesworth P, Kitzbichler MG, Paulsen O, Bullmore ET (2015) Emergence of rich-club topology and coordinated dynamics in development of hippocampal functional networks in vitro. J Neurosci 35:5459-5470.

Slomowitz E, Styr B, Vertkin I, Milshtein-Parush H, Nelken I, Slutsky M, Slutsky I (2015) Interplay between population firing stability and single neuron dynamics in hippocampal networks. Elife 4.

Tessadori J, Chiappalone M (2015) Closed-loop Neuro-robotic Experiments to Test Computational Properties of Neuronal Networks.e52341.

Bisio M, Bosca A, Pasquale V, Berdondini L, Chiappalone M (2014) Emergence of bursting activity in connected neuronal sub-populations. PLoS ONE 9:e107400.

Frega M, Tedesco M, Massobrio P, Pesce M, Martinoia S (2014) Network dynamics of 3D engineered neuronal cultures: a new experimental model for in-vitro electrophysiology. Sci Rep 4:5489.

George JB, Abraham GM, Singh K, Ankolekar SM, Amrutur B, Sikdar SK (2014) Input coding for neuro-electronic hybrid systems. Biosystems 126C:1-11.

Han H, Hwang SY, Akram F, Hyun JJ, Nam SB, Jun SB, Kim JT, Kim TS (2014) Neural Activity Modulation via Ultrasound Stimulation Measured on Multi-Channel Electrodes. Proceedings of the World Congress on Engineering

Hedrich UB, Liautard C, Kirschenbaum D, Pofahl M, Lavigne J, Liu Y, Theiss S, Slotta J, Escayg A, Dihne M, Beck H, Mantegazza M, Lerche H (2014) Impaired Action Potential Initiation in GABAergic Interneurons Causes Hyperexcitable Networks in an Epileptic Mouse Model Carrying a Human NaV1.1 Mutation. J Neurosci 34:14874-14889.

Illes S, Jakab M, Beyer F, Gelfert R, Couillard-Despres S, Schnitzler A, Ritter M, Aigner L (2014) Intrinsically active and pacemaker neurons in pluripotent stem cell-derived neuronal populations. Stem Cell Reports 2:323-336.

Korotchenko S, Cingolani LA, Kuznetsova T, Bologna LL, Chiappalone M, Dityatev A (2014) Modulation of network activity and induction of homeostatic synaptic plasticity by enzymatic removal of heparan sulfates. Philos Trans R Soc Lond B Biol Sci 369:20140134.

Biffi E, Regalia G, Menegon A, Ferrigno G, Pedrocchi A (2013) The influence of neuronal density and maturation on network activity of hippocampal cell cultures: a methodological study. PLoS ONE 8:e83899.

Brewer GJ, Boehler MD, Leondopulos S, Pan L, Alagapan S, Demarse TB, Wheeler BC (2013) Toward a self-wired active reconstruction of the hippocampal trisynaptic loop: DG-CA3. Front Neural Circuits 7:165.

Colombi I, Mahajani S, Frega M, Gasparini L, Chiappalone M (2013) Effects of antiepileptic drugs on hippocampal neurons coupled to micro-electrode arrays. Front Neuroeng 6:10.

El Hady A, Afshar G, Broking K, Schluter OM, Geisel T, Stuhmer W, Wolf F (2013) Optogenetic stimulation effectively enhances intrinsically generated network synchrony. Front Neural Circuits 7:167.

Gavello D, Rojo-Ruiz J, Marcantoni A, Franchino C, Carbone E, Carabelli V (2012) Leptin counteracts the hypoxia-induced inhibition of spontaneously firing hippocampal neurons: a microelectrode array study. PLoS ONE 7:e41530.

Leondopulos SS, Boehler MD, Wheeler BC, Brewer GJ (2012) Chronic stimulation of cultured neuronal networks boosts low-frequency oscillatory activity at theta and gamma with spikes phase-locked to gamma frequencies. J Neural Eng 9:026015.

Tessadori J, Bisio M, Martinoia S, Chiappalone M (2012) Modular neuronal assemblies embodied in a closed-loop environment: toward future integration of brains and machines. Front Neural Circuits 6:99.

Wuchter J, Beuter S, Treindl F, Herrmann T, Zeck G, Templin MF, Volkmer H (2012) A comprehensive small interfering RNA screen identifies signaling pathways required for gephyrin clustering. J Neurosci 32:14821-14834.

Geissler M, Faissner A (2011) A new indirect co-culture set up of mouse hippocampal neurons and cortical astrocytes on microelectrode arrays. J Neurosci Methods 204:262-272.

Goyal G, Nam Y (2011) Neuronal Micro-culture Engineering by Microchannel Devices of Cellular Scale Dimensions. Biomed Eng Lett 1:89-98.

Mauceri D, Freitag HE, Oliveira AM, Bengtson CP, Bading H (2011) Nuclear Calcium-VEGFD Signaling Controls Maintenance of Dendrite Arborization Necessary for Memory Formation. Neuron 71:117-130.

Verpelli C, Dvoretskova E, Vicidomini C, Rossi F, Chiappalone M, Schoen M, Di Stefano B, Mantegazza R, Broccoli V, Boeckers TM, Dityatev A, Sala C (2011) Importance of shank3 in regulating metabotropic glutamate receptor 5 (mGluR5) expression and signaling at synapses. J Biol Chem.

Dribben WH, Eisenman LN, Mennerick S (2010) Magnesium induces neuronal apoptosis by suppressing excitability. Cell Death Dis 1:e63.

Feldt S, Wang JX, Shtrahman E, Dzakpasu R, Olariu E, Zochowski M (2010) Functional clustering in hippocampal cultures: relating network structure and dynamics. Phys Biol 7:046004.

Herrmann AM, Gobel K, Simon OJ, Melzer N, Schuhmann MK, Stenner MP, Weishaupt A, Kleinschnitz C, Bittner S, Meuth P, Stuve O, Budde T, Kieseier BC, Wiendl H, Meuth SG (2010) Glatiramer acetate attenuates pro-inflammatory T cell responses but does not directly protect neurons from inflammatory cell death. Am J Pathol 177:3051-3060.

Pegoraro S, Broccard FD, Ruaro ME, Bianchini D, Avossa D, Pastore G, Bisson G, Altafini C, Torre V (2010) Sequential steps underlying neuronal plasticity induced by a transient exposure to gabazine. J Cell Physiol 222:713-728.

Varghese K, Molnar P, Das M, Bhargava N, Lambert S, Kindy MS, Hickman JJ (2010) A new target for amyloid beta toxicity validated by standard and high-throughput electrophysiology. PLoS ONE 5:e8643.

Meuth SG, Herrmann AM, Simon OJ, Siffrin V, Melzer N, Bittner S, Meuth P, Langer HF, Hallermann S, Boldakowa N, Herz J, Munsch T, Landgraf P, Aktas O, Heckmann M, Lessmann V, Budde T, Kieseier BC, Zipp F, Wiendl H (2009) Cytotoxic CD8+ T cell-neuron interactions: perforin-dependent electrical silencing precedes but is not causally linked to neuronal cell death. J Neurosci 29:15397-15409.

Wiegert JS, Hofmann F, Bading H, Bengtson CP (2009) A transcription-dependent increase in miniature EPSC frequency accompanies late-phase plasticity in cultured hippocampal neurons. BMC Neurosci 10:124.

Brewer GJ, Boehler MD, Jones TT, Wheeler BC (2008) NbActiv4 medium improvement to Neurobasal/B27 increases neuron synapse densities and network spike rates on multielectrode arrays. J Neurosci Methods 170:181-187.

Ghezzi D, Menegon A, Pedrocchi A, Valtorta F, Ferrigno G (2008) A Micro-Electrode Array device coupled to a laser-based system for the local stimulation of neurons by optical release of glutamate. J Neurosci Methods.

Runne H, Regulier E, Kuhn A, Zala D, Gokce O, Perrin V, Sick B, Aebischer P, Deglon N, Luthi-Carter R (2008) Dysregulation of gene expression in primary neuron models of Huntington's disease shows that polyglutamine-related effects on the striatal transcriptome may not be dependent on brain circuitry. J Neurosci 28:9723-9731.

Wahl AS, Buchthal B, Rode F, Bomholt SF, Freitag HE, Hardingham GE, Ronn LC, Bading H (2008) Hypoxic/ischemic conditions induce expression of the putative pro-death gene Clca1 via activation of extrasynaptic N-methyl-d-aspartate receptors. Neuroscience.

Baruchi I, Ben-Jacob E (2007) Towards neuro-memory-chip: Imprinting multiple memories in cultured neural networks. Phys Rev E 75:050901.

Boehler MD, Wheeler BC, Brewer GJ (2007) Added astroglia promote greater synapse density and higher activity in neuronal networks. Neuron Glia Biol 3:127-140.

Fuchs E, Ayali A, Robinson A, Hulata E, Ben-Jacob E (2007) Coemergence of regularity and complexity during neural network development. Dev Neurobiol 67:1802-1814.

Jacobi S, Moses E (2007) Variability and corresponding amplitude-velocity relation of activity propagating in one-dimensional neural cultures. J Neurophysiol 97:3597-3606.

Li Y, Zhou W, Li X, Zeng S, Luo Q (2007) Dynamics of learning in cultured neuronal networks with antagonists of glutamate receptors. Biophys J 93:4151-4158.

Mazzoni A, Broccard FD, Garcia-Perez E, Bonifazi P, Ruaro ME, Torre V (2007) On the dynamics of the spontaneous activity in neuronal networks. PLoS ONE 2:e439.

Meyer DA, Carter JM, Johnstone AF, Shafer TJ (2007) Pyrethroid modulation of spontaneous neuronal excitability and neurotransmission in hippocampal neurons in culture. Neurotoxicology.

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