Innovations in Electrophysiology

Pancreatic Islet cells

Jaffredo M, Bertin E, Pirog A, Puginier E, Gaitan J, Oucherif S, Lebreton F, Bosco D, Catargi B, Cattaert D, Renaud S, Lang J, Raoux M (2021) Dynamic uni- and Multicellular Patterns Encode Biphasic Activity in Pancreatic Islets. Diabetes:db200214.

Alassaf A, Ishahak M, Bowles A, Agarwal A (2020) Microelectrode Array based Functional Testing of Pancreatic Islet Cells. Micromachines (Basel) 11.

Gresch A, Düfer M (2020) Dextromethorphan and dextrorphan influence insulin secretion by interacting with K(ATP) and L-type Ca(2+) channels in pancreatic β-cells. J Pharmacol Exp Ther.

Schönecker S (2020) Non-invasive extracellular recordings of electrical activity from whole intact islets of Langerhans and the development of the medium throughput BetaScreen device. Mathematisch-Naturwissenschaftlichen Fakultät

Abarkan M, Gaitan J, Lebreton F, Perrier R, Jaffredo M, Mulle C, Magnan C, Raoux M, Lang J (2019) The glutamate receptor GluK2 contributes to the regulation of glucose homeostasis and its deterioration during aging. Mol Metab 30:152-160.

Perrier R, Pirog A, Jaffredo M, Gaitan J, Catargi B, Renaud S, Raoux M, Lang J (2018) Bioelectronic organ-based sensor for microfluidic real-time analysis of the demand in insulin. Biosens Bioelectron 117:253-259.

Schönecker S, Boven KH, Kraushaar U (2018) Beta-Screen: Non-invasive and easy to use MEA-based parallelized screening system for intact islets of Langerhans. Diabetologie und Stoffwechsel 13:LB FV 8.

Koutsouras DA, Perrier R, Villarroel Marquez A, Pirog A, Pedraza E, Cloutet E, Renaud S, Raoux M, Malliaras GG, Lang J (2017) Simultaneous monitoring of single cell and of micro-organ activity by PEDOT:PSS covered multi-electrode arrays. Mater Sci Eng C Mater Biol Appl 81:84-89.

Maczewsky J, Sikimic J, Bauer C, Krippeit-Drews P, Wolke C, Lendeckel U, Barthlen W, Drews G (2017) The LXR Ligand T0901317 Acutely Inhibits Insulin Secretion by Affecting Mitochondrial Metabolism. Endocrinology 158:2145-2154.

Pirog A, Bornat Y, Renaud S, Perrier R, Jaffredo M, Raoux M, Lang J (2017) A versatile electrode sorting module for MEAs: Implementation in a FPGA-based real-time system. 2017 IEEE Biomedical Circuits and Systems Conference (BioCAS):1-4.

Lebreton F, Pirog A, Belouah I, Bosco D, Berney T, Meda P, Bornat Y, Catargi B, Renaud S, Raoux M, Lang J (2015) Slow potentials encode intercellular coupling and insulin demand in pancreatic beta cells. Diabetologia 58:1291-1299.

Pedraza E, Karajic A, Raoux M, Perrier R, Pirog A, Lebreton F, Arbault S, Gaitan J, Renaud S, Kuhn A, Lang J (2015) Guiding pancreatic beta cells to target electrodes in a whole-cell biosensor for diabetes. Lab Chip.

Schonecker S, Kraushaar U, Guenther E, Gerst F, Ullrich S, Haring HU, Konigsrainer A, Barthlen W, Drews G, Krippeit-Drews P (2015) Human Islets Exhibit Electrical Activity on Microelectrode Arrays (MEA). Exp Clin Endocrinol Diabetes.

Leberton F (2014) Electrical signals from pancreatic islets recorded on multielectrode arrays: characterization and application to the phenotyping of transgenic animals. . DOCTEUR DE L’UNIVERSITÉ DE BORDEAUX.

Renaud S, Catargi B, Lang J (2014) Biosensors in diabetes : how to get the most out of evolution and transpose it into a signal. IEEE Pulse 5:30-34.

Schonecker S, Kraushaar U, Dufer M, Sahr A, Hardtner C, Guenther E, Walther R, Lendeckel U, Barthlen W, Krippeit-Drews P, Drews G (2014) Long-term culture and functionality of pancreatic islets monitored using microelectrode arrays. Integr Biol (Camb).

Nguyen QV, Caro A, Raoux M, Quotb A, Floderer JB, Bornat Y, Renaud S, Lang J (2013) A novel bioelectronic glucose sensor to process distinct electrical activities of pancreatic beta-cells. Conf Proc IEEE Eng Med Biol Soc 2013:172-175.

Schönecker S, Kraushaar U, Guenther E, Düfer M, Sahr A, Härdtner C, Walther R, Lendeckel U, Barthlen W, Krippeit-Drews P, Drews G (2013) Microelectrode arrays as a new approach in beta-cell research: from mice to men In: EASD-Meeting. Barcelona.

Quotb A, Bornat Y, Raoux M, Lang J, Renaud S (2012) NeuroBetaMed: A re-configurable wavelet-based event detection circuit for in vitro biological signals. In: Circuits and Systems (ISCAS), 2012 IEEE International Symposium.

Pfeiffer T, Kraushaar U, Dufer M, Schonecker S, Haspel D, Gunther E, Drews G, Krippeit-Drews P (2011) Rapid functional evaluation of beta-cells by extracellular recording of membrane potential oscillations with microelectrode arrays. Pflugers Arch 462:835-840.

Raoux M, Bontorin G, Bornat Y, Lang J, Renaud S (2011) Bioelectronic Sensing of Insulin Demand. In: Biohybrid Systems: Nerves, Interfaces, and Machines (Jung R, ed): Wiley-VCH Verlag GmbH & Co. KGaA.

Raoux M, Bornat Y, Quotb A, Catargi B, Renaud S, Lang J (2011) Non-invasive long-term and real-time analysis of endocrine cells on micro-electrode arrays. J Physiol.

Bornat Y, Raoux M, Boutaib Y, Morin FO, Charpentier G, Lang J, Renaud S (2010) Detection of electrical activity of pancreatic ß-cells using micro-electrode arrays. Proceedings 5th IEEE Int. Symposium on Electronic Design, Test & Applications.