Innovations in Electrophysiology

Pharmacology (other)

Chong SA, Balosso S, Vandenplas C, Szczesny G, Hanon E, Claes K, Van Damme X, Danis B, Van Eyll J, Wolff C, Vezzani A, Kaminski RM, Niespodziany I (2018) Intrinsic Inflammation Is a Potential Anti-Epileptogenic Target in the Organotypic Hippocampal Slice Model. Neurotherapeutics.

Distasi C, Ruffinatti FA, Dionisi M, Antoniotti S, Gilardino A, Croci G, Riva B, Bassino E, Alberto G, Castroflorio E, Incarnato D, Morandi E, Martra G, Oliviero S, Munaron L, Lovisolo D (2018) SiO2 nanoparticles modulate the electrical activity of neuroendocrine cells without exerting genomic effects. Sci Rep 8:2760.

Gaburro J, Bhatti A, Sundaramoorthy V, Dearnley M, Green D, Nahavandi S, Paradkar PN, Duchemin JB (2018) Zika virus-induced hyper excitation precedes death of mouse primary neuron. Virol J 15:79.

Hassink GC, Raiss CC, Segers-Nolten IMJ, van Wezel RJA, Subramaniam V, le Feber J, Claessens M (2018) Exogenous alpha-synuclein hinders synaptic communication in cultured cortical primary rat neurons. PLoS ONE 13:e0193763.

Perez-Gomez A, Cabrera-Garcia D, Warm D, Marini AM, Salas Puig J, Fernandez-Sanchez MT, Novelli A (2018) Selective Enhancement of Domoic Acid Toxicity in Primary Cultures of Cerebellar Granule Cells by Lowering Extracellular Na+ Concentration. Toxicol Sci 161:103-114.

Perez-Gomez A, Cabrera-Garcia D, Warm D, Marini AM, Salas Puig J, Fernandez-Sanchez MT, Novelli A (2018) From the Cover: Selective Enhancement of Domoic Acid Toxicity in Primary Cultures of Cerebellar Granule Cells by Lowering Extracellular Na+ Concentration. Toxicol Sci 161:103-114.

Serafini M, Griglio A, Aprile S, Seiti F, Travelli C, Pattarino F, Grosa G, Sorba G, Genazzani AA, Gonzalez-Rodriguez S, Butron L, Devesa I, Fernandez-Carvajal A, Pirali T, Ferrer-Montiel A (2018) Targeting Transient Receptor Potential Vanilloid 1 (TRPV1) Channel Softly: The Discovery of Passerini Adducts as a Topical Treatment for Inflammatory Skin Disorders. J Med Chem 61:4436-4455.

Teppola H, Okujeni S, Linne M-L, Egert U (2018) AMPA, NMDA and GABAA receptor mediated network burst dynamics in cortical cultures in vitro. arXiv.

Aebersold MJ, Dermutz H, Demko L, Saenz Cogollo JF, Lin SC, Burchert C, Schneider M, Ling D, Forro C, Han H, Zambelli T, Voros J (2017) Local Chemical Stimulation of Neurons with the FluidFM. Chemphyschem.

Castro-Hernandez J, Adlard PA, Finkelstein DI (2017) Pramipexole restores depressed transmission in the ventral hippocampus following MPTP-lesion. Sci Rep 7:44426.

Choi GY, Kim HB, Hwang ES, Lee S, Kim MJ, Choi JY, Lee SO, Kim SS, Park JH (2017) Curcumin Alters Neural Plasticity and Viability of Intact Hippocampal Circuits and Attenuates Behavioral Despair and COX-2 Expression in Chronically Stressed Rats. Mediators Inflamm 2017:6280925.

Dzyubenko E, Juckel G, Faissner A (2017) The antipsychotic drugs olanzapine and haloperidol modify network connectivity and spontaneous activity of neural networks in vitro. Sci Rep 7:11609.

Hwang ES, Kim HB, Lee S, Kim MJ, Lee SO, Han SM, Maeng S, Park JH (2017) Loganin enhances long-term potentiation and recovers scopolamine-induced learning and memory impairments. Physiol Behav 171:243-248.

Jenkinson SP, Grandgirard D, Heidemann M, Tscherter A, Avondet M, Leib SL (2017) Embryonic Stem Cell-Derived Neurons Grown on Multi-Electrode Arrays as a Novel In vitro Bioassay for the Detection of Clostridium botulinum Neurotoxins. Frontiers in Pharmacology 8.

Kraushaar U, Guenther E, Hess D (2017) Addressing Functional Neurotoxicity Using the Microelectrode Array (MEA). In: Stem Cell-Derived Models in Toxicology. Methods in Pharmacology and Toxicology (Clements M, Roquemore L, eds). New York: Humana Press.

Li Y, Chen X, Dzakpasu R, Conant K (2017) Dopamine-dependent effects on basal and glutamate stimulated network dynamics in cultured hippocampal neurons. J Neurochem 140:550-560.

Liu Q, Shi J, Lin R, Wen T (2017) Dopamine and dopamine receptor D1 associated with decreased social interaction. Behav Brain Res 324:51-57.

Mack CM, Hall DR, Herr DW, Shafer TJ (2017) Low and High-Frequency Field Potentials in Cortical Networks Exhibit Distinct Responses to Chemicals. The FASEB Journal 31:861.814.

Pérez-Gómez A, Cabrera-García D, Warm D, Marini AM, Salas Puig J, Fernández-Sánchez MT, Novelli A (2017) Selective Enhancement of Domoic Acid Toxicity in Primary Cultures of Cerebellar Granule Cells by Lowering Extracellular Na+ Concentration. Toxicological Sciences:kfx201-kfx201.

Pistollato F, Canovas-Jorda D, Zagoura D, Price A (2017) Protocol for the Differentiation of Human Induced Pluripotent Stem Cells into Mixed Cultures of Neurons and Glia for Neurotoxicity Testing. JoVE:e55702.

Seidel D, Jahnke H-G, Englich B, Girard M, Robitzki AA (2017) In vitro field potential monitoring on a multi-microelectrode array for the electrophysiological long-term screening of neural stem cell maturation. Analyst 142:1929-1937.

Shaban H, O'Connor R, Ovsepian SV, Dinan TG, Cryan JF, Schellekens H (2017) Electrophysiological approaches to unravel the neurobiological basis of appetite and satiety: use of the multielectrode array as a screening strategy. In: Drug Discov Today, 2016/09/17 Edition, pp 31-42.

Smeriglio A, Alloisio S, Raimondo FM, Denaro M, Xiao J, Cornara L, Trombetta D (2017) Essential oil of Citrus lumia Risso: Phytochemical profile, antioxidant properties and activity on the central nervous system. Food Chem Toxicol.

Smith BJ, Cote PD, Tremblay F (2017) Contribution of Nav1.8 sodium channels to retinal function. Neuroscience 340:279-290.

Sors A, Panayi F, Bert L, Favale D, Nosjean O, Audinot V, Arrang JM, Buisson B, Steidl E, Delbos JM, Huhtala T, Kontkanen O, Chollet AM, Casara P, Lestage P (2017) Mechanistic characterization of S 38093, a novel inverse agonist at histamine H3 receptors. Eur J Pharmacol 803:11-23.

Vassallo A, Chiappalone M, De Camargos Lopes R, Scelfo B, Novellino A, Defranchi E, Palosaari T, Weisschu T, Ramirez T, Martinoia S, Johnstone AFM, Mack CM, Landsiedel R, Whelan M, Bal-Price A, Shafer TJ (2017) A multi-laboratory evaluation of microelectrode array-based measurements of neural network activity for acute neurotoxicity testing. Neurotoxicology 60:280-292.

Zagoura D, Canovas-Jorda D, Pistollato F, Bremer-Hoffmann S, Bal-Price A (2017) Evaluation of the rotenone-induced activation of the Nrf2 pathway in a neuronal model derived from human induced pluripotent stem cells. Neurochem Int 106:62-73.

Accardi MV, Pugsley MK, Forster R, Troncy E, Huang H, Authier S (2016) The emerging role of in vitro electrophysiological methods in CNS safety pharmacology. J Pharmacol Toxicol Methods.

Akhtar MW, Sanz-Blasco S, Dolatabadi N, Parker J, Chon K, Lee MS, Soussou W, McKercher SR, Ambasudhan R, Nakamura T, Lipton SA (2016) Elevated glucose and oligomeric beta-amyloid disrupt synapses via a common pathway of aberrant protein S-nitrosylation. Nat Commun 7:10242.

Cain SM, Ahn S, Garcia E, Zhang Y, Waheed Z, Tyson JR, Yang Y, Van Sung T, Phillips AG, Snutch TP (2016) Heantos-4, a natural plant extract used in the treatment of drug addiction, modulates T-type calcium channels and thalamocortical burst-firing. Mol Brain 9:94.

Caputo L, Souza LF, Alloisio S, Cornara L, De Feo V (2016) Coriandrum sativum and Lavandula angustifolia Essential Oils: Chemical Composition and Activity on Central Nervous System. Int J Mol Sci 17.

Flachs D, Ciba M (2016) Cell-based sensor chip for neurotoxicity measurements in drinking water. LékaĜ a technika 46:46-50.

Frega M (2016) Neuronal Network Dynamics in 2D and 3D in vitro Neuroengineered Systems. PhD.

Koulchitsky S, Delairesse C, Beeken T, Monteforte A, Dethier J, Quertemont E, Findeisen R, Bullinger E, Seutin V (2016) Activation of D2 autoreceptors alters cocaine-induced locomotion and slows down local field oscillations in the rat ventral tegmental area. Neuropharmacology.

Latifi S, Tamayol A, Habibey R, Sabzevari R, Kahn C, Geny D, Eftekharpour E, Annabi N, Blau A, Linder M, Arab-Tehrany E (2016) Natural lecithin promotes neural network complexity and activity. Sci Rep 6:25777.

Lu H-C, Chang W-J, Chang W-P, Shyu B-C (2016) Direct-current Stimulation and Multi-electrode Array Recording of Seizure-like Activity in Mice Brain Slice Preparation. JoVE:e53709.

Volkmann RA, Fanger CM, Anderson DR, Sirivolu VR, Paschetto K, Gordon E, Virginio C, Gleyzes M, Buisson B, Steidl E, Mierau SB, Fagiolini M, Menniti FS (2016) MPX-004 and MPX-007: New Pharmacological Tools to Study the Physiology of NMDA Receptors Containing the GluN2A Subunit. PLoS ONE 11:e0148129.

de Vin F, Choi SM, Bolognesi ML, Lefebvre RA (2015) Presynaptic M3 muscarinic cholinoceptors mediate inhibition of excitatory synaptic transmission in area CA1 of rat hippocampus. Brain Res 1629:260-269.

Hess D, Kraushaar U, Cesare P, Rascher-Eggstein G, Guenther E (2015) A human integrated in vitro Neurotoxicity Safety Platform using hiPS neurons (Peri.4U neurons). In.

Kuebler ES, Tauskela JS, Aylsworth A, Zhao X, Thivierge JP (2015) Burst predicting neurons survive an in vitro glutamate injury model of cerebral ischemia. Sci Rep 5:17718.

Kummer KK, El Rawas R, Kress M, Saria A, Zernig G (2015) Social Interaction and Cocaine Conditioning in Mice Increase Spontaneous Spike Frequency in the Nucleus Accumbens or Septal Nuclei as Revealed by Multielectrode Array Recordings. Pharmacology 95:42-49.

Peelaerts W, Bousset L, Van der Perren A, Moskalyuk A, Pulizzi R, Giugliano M, Van den Haute C, Melki R, Baekelandt V (2015) alpha-Synuclein strains cause distinct synucleinopathies after local and systemic administration. Nature 522:340-344.

Smith I, Haag M, Ugbode C, Tams D, Rattray M, Przyborski S, Bithell A, Whalley BJ (2015) Neuronal-glial populations form functional networks in a biocompatible 3D scaffold. Neurosci Lett 609:198-202.

Charkhkar H, Frewin C, Nezafati M, Knaack GL, Peixoto N, Saddow SE, Pancrazio JJ (2014) Use of cortical neuronal networks for in vitro material biocompatibility testing. Biosens Bioelectron 53:316-323.

Korotchenko S, Cingolani LA, Kuznetsova T, Bologna LL, Chiappalone M, Dityatev A (2014) Modulation of network activity and induction of homeostatic synaptic plasticity by enzymatic removal of heparan sulfates. Philos Trans R Soc Lond B Biol Sci 369:20140134.

Stoyanova, II, le Feber J (2014) Ghrelin accelerates synapse formation and activity development in cultured cortical networks. BMC Neurosci 15:49.

Colombi I, Mahajani S, Frega M, Gasparini L, Chiappalone M (2013) Effects of antiepileptic drugs on hippocampal neurons coupled to micro-electrode arrays. Front Neuroeng 6:10.

Jantzen SU, Ferrea S, Wach C, Quasthoff K, Illes S, Scherfeld D, Hartung HP, Seitz RJ, Dihne M (2013) In vitro neuronal network activity in NMDA receptor encephalitis. BMC Neurosci 14:17.

Laurenza I, Pallocca G, Mennecozzi M, Scelfo B, Pamies D, Bal-Price A (2013) A human pluripotent carcinoma stem cell-based model for in vitro developmental neurotoxicity testing: effects of methylmercury, lead and aluminum evaluated by gene expression studies. Int J Dev Neurosci 31:679-691.

Liu JS, Li JB, Gong XW, Gong HQ, Zhang PM, Liang PJ, Lu QC (2013) Spatiotemporal dynamics of high-K(+)-induced epileptiform discharges in hippocampal slice and the effects of valproate. Neurosci Bull 29:28-36.

Mack CM, Lin B, Turner JD, Johnstone AF, Burgoon LD, Shafer TJ (2013) Burst and principal components analyses of mea data for 16 chemicals describe at least three effects classes. Neurotoxicology.

Mladinic M, Nistri A (2013) Microelectrode arrays in combination with in vitro models of spinal cord injury as tools to investigate pathological changes in network activity: facts and promises. Front Neuroeng 6:2.

Schmidt SL, Chew EY, Bennett DV, Hammad MA, Frohlich F (2013) Differential effects of cholinergic and noradrenergic neuromodulation on spontaneous cortical network dynamics. Neuropharmacology 72:259-273.

Vincent K, Tauskela JS, Mealing GA, Thivierge JP (2013) Altered network communication following a neuroprotective drug treatment. PLoS ONE 8:e54478.

Zhang D, Zhang F, Zhang Q, Lu Y, Liu Q, Wang P (2013) Umami evaluation in taste epithelium on microelectrode array by extracellular electrophysiological recording. Biochem Biophys Res Commun 438:334-339.

Albrecht P, Bouchachia I, Goebels N, Henke N, Hofstetter HH, Issberner A, Kovacs Z, Lewerenz J, Lisak D, Maher P, Mausberg AK, Quasthoff K, Zimmermann C, Hartung HP, Methner A (2012) Effects of dimethyl fumarate on neuroprotection and immunomodulation. J Neuroinflammation 9:163.

Chabrol FP, Eglen SJ, Sernagor E (2012) GABAergic control of retinal ganglion cell dendritic development. Neuroscience 227:30-43.

Gavello D, Rojo-Ruiz J, Marcantoni A, Franchino C, Carbone E, Carabelli V (2012) Leptin counteracts the hypoxia-induced inhibition of spontaneously firing hippocampal neurons: a microelectrode array study. PLoS ONE 7:e41530.


Gonzalez-Sulser A, Wang J, Queenan BN, Avoli M, Vicini S, Dzakpasu R (2012) Hippocampal neuron firing and local field potentials in the in vitro 4-aminopyridine epilepsy model. J Neurophysiol 108:2568-2580.

Kaufman M, Corner MA, Ziv NE (2012) Long-term Relationships between Cholinergic Tone, Synchronous Bursting and Synaptic Remodeling. PLoS ONE 7:e40980.

Motamedi GK, Gonzalez-Sulser A, Dzakpasu R, Vicini S (2012) Cellular mechanisms of desynchronizing effects of hypothermia in an in vitro epilepsy model. Neurotherapeutics 9:199-209.

Sequiera GL, Mehta A, Ooi TH, Shim W (2012) Ontogenic Development of Cardiomyocytes Derived from Transgene-Free Human Induced Pluripotent Stem Cells and Its Homology with Human Heart. Life Sci.

Yanovsky Y, Schubring SR, Yao Q, Zhao Y, Li S, May A, Haas HL, Lin JS, Sergeeva OA (2012) Waking action of ursodeoxycholic acid (UDCA) involves histamine and GABAA receptor block. PLoS ONE 7:e42512.

Defranchi E, Novellino A, Whelan M, Vogel SA, Ramirez-Hernandez T, Van Ravenzwaay B, Landsiedel R (2011) Feasibility assessment of Micro electrode chip assay (MEA) as a method of detecting neurotoxicity in vitro. Frontiers in Neuroengineering 4.

Frega M, Pasquale V, Tedesco M, Marcoli M, Contestabile A, Nanni M, Bonzano L, Maura G, Chiappalone M (2011) Cortical cultures coupled to Micro-Electrode Arrays: A novel approach to perform in vitro excitotoxicity testing. Neurotoxicol Teratol.

Hogberg HT, Sobanski T, Novellino A, Whelan M, Weiss DG, Bal-Price AK (2011) Application of micro-electrode arrays (MEAs) as an emerging technology for developmental neurotoxicity: evaluation of domoic acid-induced effects in primary cultures of rat cortical neurons. Neurotoxicology 32:158-168.

Novellino A, Scelfo B, Palosaari T, Price A, Sobanski T, Shafer TJ, Johnstone AFM, Gross GW, Gramowski A, Schroeder O, J?gelt K, Chiappalone M, Benfenati F, Martinoia S, Tedesco MT, Defranchi E, D'Angelo P, Whelan M (2011) Development of micro-electrode array based tests for neurotoxicity: assessment of interlaboratory reproducibility with neuroactive chemicals. Frontiers in Neuroengineering 4.

Piet R, Garenne A, Farrugia F, Le Masson G, Marsicano G, Chavis P, Manzoni OJ (2011) State-dependent, bidirectional modulation of neural network activity by endocannabinoids. J Neurosci 31:16591-16596.

Robinette BL, Harrill JA, Mundy WR, Shafer TJ (2011) In vitro assessment of developmental neurotoxicity: use of microelectrode arrays to measure functional changes in neuronal network ontogeny. Front Neuroengineering 4:1.

Scelfo B, Politi M, Reniero F, Zaldivar JM (2011) Application of multielectrode array (MEA) chips for studying the neurotoxicity of mixtures. In: JRC Scientific and Technical Reports: European Comission.

Aitchison E, Weston SE, Constanti A, Whalley BJ (2010) Anticholinesterase-induced epileptiform activity in immature rat piriform cortex slices, in vitro. Neurosci Lett 473:252-256.

Dinklo T, Shaban H, Thuring JW, Lavreysen H, Stevens KE, Zheng L, Mackie C, Grantham C, Vandenberk I, Meulders G, Peeters L, Verachtert H, De Prins E, Lesage AS (2010) Characterization of 2-[[ 4-fluoro-3-(trifluoromethyl)phenyl]amino]-4-(4-pyridinyl)-5- thiazolemethanol (JNJ-1930942), a novel positive allosteric modulator of the {alpha}7 nicotinic acetylcholine receptor. J Pharmacol Exp Ther.

Dribben WH, Eisenman LN, Mennerick S (2010) Magnesium induces neuronal apoptosis by suppressing excitability. Cell Death Dis 1:e63.

Gambazzi L, Gokce O, Seredenina T, Katsyuba E, Runne H, Markram H, Giugliano M, Luthi-Carter R (2010) Diminished activity-dependent BDNF expression underlies cortical neuron microcircuit hypoconnectivity resulting from exposure to mutant huntingtin fragments. J Pharmacol Exp Ther.

Gonzalez-Sulser A, Wang J, Motamedi GK, Avoli M, Vicini S, Dzakpasu R (2010) The 4-aminopyridine in vitro epilepsy model analyzed with a perforated multi-electrode array. Neuropharmacology.

Herrmann AM, Gobel K, Simon OJ, Melzer N, Schuhmann MK, Stenner MP, Weishaupt A, Kleinschnitz C, Bittner S, Meuth P, Stuve O, Budde T, Kieseier BC, Wiendl H, Meuth SG (2010) Glatiramer acetate attenuates pro-inflammatory T cell responses but does not directly protect neurons from inflammatory cell death. Am J Pathol 177:3051-3060.

Johnstone AF, Gross GW, Weiss DG, Schroeder OH, Gramowski A, Shafer TJ (2010) Microelectrode arrays: A physiologically based neurotoxicity testing platform for the 21st century. Neurotoxicology.

Jones NA, Hill AJ, Smith I, Bevan SA, Williams CM, Whalley BJ, Stephens GJ (2010) Cannabidiol displays antiepileptiform and antiseizure properties in vitro and in vivo. J Pharmacol Exp Ther 332:569-577.

Rubinsky L, Raichman N, Lavee J, Frenk H, Ben-Jacob E, Bickler PE (2010) Antifreeze protein suppresses spontaneous neural activity and protects neurons from hypothermia/re-warming injury. Neurosci Res.

Seki M, Soussou W, Manabe S, Lipton SA (2010) Protection of retinal ganglion cells by caspase substrate-binding peptide IQACRG from N-methyl-D-aspartate receptor-mediated excitotoxicity. Invest Ophthalmol Vis Sci 51:1198-1207.

Varghese K, Molnar P, Das M, Bhargava N, Lambert S, Kindy MS, Hickman JJ (2010) A new target for amyloid beta toxicity validated by standard and high-throughput electrophysiology. PLoS ONE 5:e8643.

Yla-Outinen L, Heikkila J, Skottman H, Suuronen R, Aanismaa R, Narkilahti S (2010) Human cell-based micro electrode array platform for studying neurotoxicity. Front Neuroengineering 3.

Braam SR, Tertoolen L, van de Stolpe A, Meyer T, Passier R, Mummery CL (2009) Prediction of drug-induced cardiotoxicity using human embryonic stem cell-derived cardiomyocytes. Stem Cell Res.

Dworak BJ, Wheeler BC (2009) Novel MEA platform with PDMS microtunnels enables the detection of action potential propagation from isolated axons in culture. Lab Chip 9:404-410.

Hill AJ, Jones NA, Williams CM, Stephens GJ, Whalley BJ (2009) Development of multi-electrode array screening for anticonvulsants in acute rat brain slices. J Neurosci Methods.

Liu X, Zhang YY, Gong HQ, Liang PJ (2009) The GABA(A) receptor-mediated inhibitory pathway increases the correlated activities in retinal ganglion cells. Sheng Li Xue Bao 61:99-107.

Magloire V, Streit J (2009) Intrinsic activity and positive feedback in motor circuits in organotypic spinal cord slice cultures. Eur J Neurosci 30:1487-1497.

Marshall SP, Lang EJ (2009) Local changes in the excitability of the cerebellar cortex produce spatially restricted changes in complex spike synchrony. J Neurosci 29:14352-14362.

Meuth SG, Herrmann AM, Simon OJ, Siffrin V, Melzer N, Bittner S, Meuth P, Langer HF, Hallermann S, Boldakowa N, Herz J, Munsch T, Landgraf P, Aktas O, Heckmann M, Lessmann V, Budde T, Kieseier BC, Zipp F, Wiendl H (2009) Cytotoxic CD8+ T cell-neuron interactions: perforin-dependent electrical silencing precedes but is not causally linked to neuronal cell death. J Neurosci 29:15397-15409.

Otto F, Illes S, Opatz J, Laryea M, Theiss S, Hartung HP, Schnitzler A, Siebler M, Dihne M (2009) Cerebrospinal fluid of brain trauma patients inhibits in vitro neuronal network function via NMDA receptors. Ann Neurol 66:546-555.

Zhou W, Li X, Liu M, Zhao Y, Zhu G, Luo Q (2009) Homeostatically regulated synchronized oscillations induced by short-term tetrodotoxin treatment in cultured neuronal network. Biosystems 95:61-66.

Dunlop J, Bowlby M, Peri R, Vasilyev D, Arias R (2008) High-throughput electrophysiology: an emerging paradigm for ion-channel screening and physiology. Nat Rev Drug Discov.

Ma YL, Weston SE, Whalley BJ, Stephens GJ (2008) The phytocannabinoid Delta(9)-tetrahydrocannabivarin modulates inhibitory neurotransmission in the cerebellum. Br J Pharmacol.

Scarlatos A, Cadotte AJ, DeMarse TB, Welt BA (2008) Cortical networks grown on microelectrode arrays as a biosensor for botulinum toxin. J Food Sci 73:E129-136.

Boehler MD, Wheeler BC, Brewer GJ (2007) Added astroglia promote greater synapse density and higher activity in neuronal networks. Neuron Glia Biol 3:127-140.

Cater HL, Gitterman D, Davis SM, Benham CD, Morrison B, 3rd, Sundstrom LE (2007) Stretch-induced injury in organotypic hippocampal slice cultures reproduces in vivo post-traumatic neurodegeneration: role of glutamate receptors and voltage-dependent calcium channels. J Neurochem 101:434-447.

Esposti F, Signorini MG, Lamanna J, Gullo F, Wanke E (2007) How do TTX and AP5 affect the post-recovery neuronal network activity synchronization? Conf Proc IEEE Eng Med Biol Soc 2007:3012-3015.

Heck N, Golbs A, Riedemann T, Sun JJ, Lessmann V, Luhmann HJ (2007) Activity-Dependent Regulation of Neuronal Apoptosis in Neonatal Mouse Cerebral Cortex. Cereb Cortex.

Illes S, Fleischer W, Siebler M, Hartung HP, Dihne M (2007) Development and pharmacological modulation of embryonic stem cell-derived neuronal network activity. Exp Neurol.

Li Y, Zhou W, Li X, Zeng S, Luo Q (2007) Dynamics of learning in cultured neuronal networks with antagonists of glutamate receptors. Biophys J 93:4151-4158.

Marcantoni A, Baldelli P, Hernandez-Guijo JM, Comunanza V, Carabelli V, Carbone E (2007) L-type calcium channels in adrenal chromaffin cells: Role in pace-making and secretion. Cell Calcium.

Meyer DA, Carter JM, Johnstone AF, Shafer TJ (2007) Pyrethroid modulation of spontaneous neuronal excitability and neurotransmission in hippocampal neurons in culture. Neurotoxicology.

Su J, Yang L, Zhang X, Rojas A, Shi Y, Jiang C (2007) High CO2 chemosensitivity versus wide sensing spectrum: a paradoxical problem and its solutions in cultured brainstem neurons. J Physiol 578:831-841.

Tu Y, Kroener S, Abernathy K, Lapish C, Seamans J, Chandler LJ, Woodward JJ (2007) Ethanol inhibits persistent activity in prefrontal cortical neurons. J Neurosci 27:4765-4775.

Xiang G, Pan L, Huang L, Yu Z, Song X, Cheng J, Xing W, Zhou Y (2007) Microelectrode array-based system for neuropharmacological applications with cortical neurons cultured in vitro. Biosens Bioelectron 22:2478-2484.

Yvon C, Czarnecki A, Streit J (2007) Riluzole-induced oscillations in spinal networks. J Neurophysiol 97:3607-3620.

Aton SJ, Huettner JE, Straume M, Herzog ED (2006) GABA and Gi/o differentially control circadian rhythms and synchrony in clock neurons. Proc Natl Acad Sci U S A 103:19188-19193.

Blenkinsop TA, Lang EJ (2006) Block of inferior olive gap junctional coupling decreases Purkinje cell complex spike synchrony and rhythmicity. J Neurosci 26:1739-1748.

Butovas S, Hormuzdi SG, Monyer H, Schwarz C (2006) Effects of electrically coupled inhibitory networks on local neuronal responses to intracortical microstimulation. J Neurophysiol 96:1227-1236.

Giugliano M, Martinoia S (2006) Substrate arrays of microelectrodes for in vitro electrophysiology. In: Wiley Encyclopedia on Biomedical Engineering, pp 1-11.

Hofmann F, Bading H (2006) Long term recordings with microelectrode arrays: studies of transcription-dependent neuronal plasticity and axonal regeneration. J Physiol Paris 99:125-132.

Kim MT, Soussou W, Gholmieh G, Ahuja A, Tanguay A, Berger TW, Brinton RD (2006) 17beta-Estradiol potentiates field excitatory postsynaptic potentials within each subfield of the hippocampus with greatest potentiation of the associational/commissural afferents of CA3. Neuroscience 141:391-406.

Lang EJ, Sugihara I, Llinas R (2006) Olivocerebellar modulation of motor cortex ability to generate vibrissal movements in rat. J Physiol 571:101-120.

Lante F, de Jesus Ferreira MC, Guiramand J, Recasens M, Vignes M (2006) Low-frequency stimulation induces a new form of LTP, metabotropic glutamate (mGlu5) receptor- and PKA-dependent, in the CA1 area of the rat hippocampus. Hippocampus 16:345-360.

Soriano FX, Papadia S, Hofmann F, Hardingham NR, Bading H, Hardingham GE (2006) Preconditioning doses of NMDA promote neuroprotection by enhancing neuronal excitability. J Neurosci 26:4509-4518.

Stewart CV, Plenz D (2006) Inverted-U profile of dopamine-NMDA-mediated spontaneous avalanche recurrence in superficial layers of rat prefrontal cortex. J Neurosci 26:8148-8159.

Aton SJ, Colwell CS, Harmar AJ, Waschek J, Herzog ED (2005) Vasoactive intestinal polypeptide mediates circadian rhythmicity and synchrony in mammalian clock neurons. Nat Neurosci 8:476-483.

Burrell BD, Sahley CL (2005) Serotonin mediates learning-induced potentiation of excitability. J Neurophysiol 94:4002-4010.

Hentschke H, Schwarz C, Antkowiak B (2005) Neocortex is the major target of sedative concentrations of volatile anaesthetics: strong depression of firing rates and increase of GABAA receptor-mediated inhibition. Eur J Neurosci 21:93-102.

Klusmann A, Fleischer W, Waldhaus A, Siebler M, Mayatepek E (2005) Influence of D-arabitol and ribitol on neuronal network activity. J Inherit Metab Dis 28:1181-1183.

Legrand JC, Darbon P, Streit J (2005) Effects of brain-derived neurotrophic factor (BDNF) on activity mediated by NMDA receptors in rat spinal cord cultures. Neurosci Lett 390:145-149.

Martinoia S, Bonzano L, Chiappalone M, Tedesco M (2005) Electrophysiological activity modulation by chemical stimulation in networks of cortical neurons coupled to microelectrode arrays: A biosensor for neuropharmacological applications. Sensors and Actuators B: Chemical 108:589-596.

Martinoia S, Bonzano L, Chiappalone M, Tedesco M, Marcoli M, Maura G (2005) In vitro cortical neuronal networks as a new high-sensitive system for biosensing applications. Biosens Bioelectron 20:2071-2078.

Otto F, Kieseier BC, Gortz P, Hartung HP, Siebler M (2005) The pentapeptide QYNAD does not inhibit neuronal network activity. Can J Neurol Sci 32:344-348.

Giugliano M, Darbon P, Arsiero M, Luscher HR, Streit J (2004) Single-neuron discharge properties and network activity in dissociated cultures of neocortex. J Neurophysiol 92:977-996.

Gortz P, Fleischer W, Rosenbaum C, Otto F, Siebler M (2004) Neuronal network properties of human teratocarcinoma cell line-derived neurons. Brain Res 1018:18-25.

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