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Innovations in Electrophysiology

Cardiac Electrophysiology

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We offer a wide range of systems and components for extracellular recordings in vitro on various types of preparations. Find here a few of the most important examples of cardiac application studies with the MEA-System.

Lonza white paper: Cryopreserved Neonatal Rat Ventricular Cardiomyocytes in Long-term Culture Display Normal Morphology and Functional Activity

Application notes for using Cardiomyocytes with the Multi Channel MEA-Systems:

  1. Cor.4U® in microelectrode array (MEA) assays: Protocol_Cor.4U_MEA.pdf
  2. Pluricyte® Cardiomyocytes in combination with the Multiwell-MEA-System: User Guide _Pluricyte Cardiomyocyte_MCS96.pdf
  3. Cellular Dynamics iCell cardiomyocytes2 on 96-well multiwell plates (kindly provided by Dr. Udo Kraushaar, NMI)
  4. PDF icon Application of Cellartis Cardiomyocytes in Multi Channel Systems 96-well Multiwell-MEA-System for EFP Recordings.pdf
  5. Multi-Well Electrode Array Restoration to Reconstruct Cardiomyocyte Networks for Repetitive Electrophysiological Studies:
    PDF icon Smart-Ephys MCS_Customer App Note_Multiwell MEA repeated use.pdf
  6. MEA Based Cardiac-Electronic Interface: A Novel Resource for AP Measurements
    PDF icon Smart-Ephys MCS_Customer App Note_MEA AP Measurements.pdf
  7. Application Card Epicardial Mapping
    PDF icon AC_EpicardialMapping.pdf

JoVE Video

Human iPSC-Derived Cardiomyocyte Networks on Multiwell Micro-electrode Arrays for Recurrent Action Potential Recordings

General Cardiac Applications

General Cardiac Applications
Category: 
Applications
Cardiac Electrophysiology

Chip on a heart - Heart on a chip

An overview of some generic examples of in vivo and in vitro applications.

Cardiac Signals

Cardiac Signals
Category: 
Applications
Cardiac Electrophysiology

The MEA system can be used for in vitro studies of the electrical properties of cardiac myocytes and, for example, effects of drug candidates on field potential waveforms and kinetics.

Cardiac Slices from Adult Mouse Ventricle

Cardiac Slices from Adult Mouse Ventricle
Category: 
Applications
Cardiac Electrophysiology

This application note includes a complete protocol for the dissection of mouse heart and the preparation of ventricular slices for acute experiments.

Event based analysis of cardiac activity

Event based analysis of cardiac activity
Category: 
Applications
Cardiac Electrophysiology

The Spike Sorter is a general event detector for neuronal or cardiac applications that can either operate in two modes: One method uses a threshold, the other recognizes the amplitude and slope of a waveform.

HL-1 Cardiac Cell Line by Dr. W. Claycomb

HL-1 Cardiac Cell Line by Dr. W. Claycomb
Category: 
Applications
Cardiac Electrophysiology

This application note includes a complete protocol for the cultivation of HL-1 cells from Dr. W. Claycomb.

Primary Culture Cardiac Myocytes from Chicken Embryo

Primary Culture Cardiac Myocytes from Chicken Embryo
Category: 
Applications
Cardiac Electrophysiology

This application note describes solutions for studying conduction velocity, rhythmic/arrhythmic behavior, and QT-prolongation in acute heart preparations.