CMOS-MEA5000-System

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Overview

The CMOS-MEA5000-System is the in vitro recording system from Multi Channel Systems for extracellular recordings and stimulation at the highest resolution.

Based on the complementary metal-oxide semiconductor technology, it opens up new possibilities in electrophysiological research.

With more than 4000 recording sites, each of them sampled at 25 kHz, the chip allows extracellular recordings at a very high spatio-temporal resolution. By including amplification on the chip itself, noise is minimized and a high signal quality is guaranteed.

For more detailed information, please click on the description tab above.

CMOS-MEA5000-System

High resolution: The video shows the propagation of an average action potential along a single unmyelinated axon of a rat ganglion cell. Details can be found in the paper of H.Stutzki et al. in Frontiers Cell. Neurosci. 8:38 (2014) (link is external).
Data courtesy to F.Jetter, H.Stutzki and G.Zeck, NMI Reutlingen (link is external)

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MCS-InterfaceBoard-3.0-Multiboot IFB-C

As part of the system, the IFB-C multiboot is a new interface board generation which is able to receive data from a MEA2100(-Mini)-Headstage, a Multiwell-MEA-Headstage, a CMOS-MEA5000-Headstage, a MEA2100-Beta-Screen-Headstage, a ME2100-Headstage, or a W2100-Receiver. This makes cost-effective combinations with only one interface board and multiple recording systems possible. You can establish for example your experiments on 60, 120, or 256 electrodes with the MEA2100-System, then add the Multiwell-MEA-Headstage and start high-throughput screening. It's also possible to use the same interface board for in vitro MEA experiments and tethered / wireless in vivo recordings. This leaves you with even more flexibility in switching between possible configurations for your specific research needs.

Key features:

  • Real-time signal detection and feedback*
  • Freely programmable DSP*
  • Multiple inputs/outputs, including digital, analog, and audio
  • SuperSpeed USB 3.0 ports

* applicable for MEA2100(-Mini), ME2100, and W2100

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Description

The CMOS-MEA5000-System consists of four components, which are all designed to be efficient and powerful, while fitting ideally on the lab bench and microscopes.

After opening the lid of the headstage, you just place the chip inside an. When the lid is closed, the contact pins are pressed on the pads on the chip and signals are transmitted. The headstage connects with only one cable (eSATA) to the interface board. Connection to the computer is done via USB 3.0. Summarizing, there is no need for many cables and the system is easy-to-use.

Please click on the arrows on the right to learn more about the single components.

Benefits

The advantages of the CMOS-MEA5000-System are:

  • 4225 recording electrodes on an active chip
  • 1024 dedicated stimulation sites
  • 25 kHz sampling rate on all channels
  • Outstanding signal quality
  • Recordings at sub-cellular level
  • Powerful software package CMOS-MEA-Control included (free updates available)
Media
Videos: 
Video tutorials: 
Products
CMOS-MEA5000-Components

CMOS-MEA5000-System

CMOS-MEA workstation for recording and analyzing data from active CMOS-MEAs. With integrated data acquisition for recording from 4225 MEA electrodes and 8 additional analog channels. Integrated filter amplifier and 3-channel voltage stimulus generator for stimulating 1024 stimulation sites on the CMOS chip.
Complete with CMOS-MEA-headstage, interface board, and accessories. USB High Speed data transfer with a sampling rate of up to 25 kHz/channel.

 

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CMOS-MEA5000_MEA2100-256

CMOS-MEA5000+MEA2100-256-System

Bundle of CMOS-MEA5000 and MEA2100-256-System.
CMOS-MEA workstation for recording and analyzing data from active CMOS-MEAs. With integrated data acquisition for recording from 4225 MEA electrodes and 8 additional analog channels. Integrated filter amplifier and 3-channel voltage stimulus generator for stimulating 1024 stimulation sites on the CMOS chip.

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CMOS-MEA5000_Multiwell-MEA

Multiwell+CMOS-MEA5000-System

Bundle of Multiwell and CMOS-MEA5000-System.
Multiwell-MEA workstation for recording and analyzing data from multiwell MEA plates. With integrated data acquisition for recording from 288 MEA electrodes and 8 additional analog channels. Integrated filter amplifier and voltage stimulus generator (simultaneous stimulation in all wells possible. Any electrode can be selected for stimulation).

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Documents
Manual: 
PDF icon MCS_CMOS-MEA5000-System_Quickstart_Manual.pdf
PDF icon MCS_CMOS-MEA5000-System_Manual.pdf
Data sheet: 
PDF icon MCS_CMOS-MEA5000-System_Datasheet.pdf
Brochure: 
PDF icon CMOS-MEA5000-System_Brochure.pdf
PDF icon Neuro-Applications-InVitro_Brochure.pdf
Customer voices: 
PDF icon MCS_Customer-Voices_CMOS-MEA5000_Guenther-Zeck.pdf
MEAs
HBIO_Culture Chamber CCM+MEA-MEA

CMOS-MEAs

CMOS-MEA chips for the CMOS-MEA5000-System:

Active CMOS chips with 4225 recording electrodes and 1024 stimulation sites. Electrode grid of 65x65 and spacing between recording electrodes with 16 or 32 µm. Optional with culture chamber or basic/advanced slice chamber.

Accessories

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Products
CMOS-MEA5000-HS

CMOS-MEA5000-HS

CMOS-MEA headstage for recording and analyzing data from active CMOS-MEAs. With integrated data acquisition for recording from 4225 MEA electrodes and 8 additional analog channels. Integrated filter amplifier and 3-channel voltage stimulus generator for stimulating 1024 stimulation sites on the CMOS chip.
USB High Speed data transfer with a sampling rate of up to 25 kHz/channel. Needs to be connected to IFB with an USB 3.0 interface (needs to be ordered separately).

CMOS-MEA headstage for recording and analyzing data from active CMOS-MEAs.

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MEA2100-Mini-E.jpg

Perfusion-Kit

Perfusion kit for MEA-Systems including TC02, PH01, PPS2, and 2 MPH.

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IFB-C

IFB-C

Interface board with signal processor for real-time signal detection and feedback.

Interface board with signal processor for real-time signal detection and feedback. Receives data from MEA2100-Headstages, Multiwell-MEA-Headstage, CMOS-MEA5000-Headstage, ME2100-Systems or W2100-Systems.

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Test-CMOS-MEA

Test-CMOS-MEA

Test model probe with CB-GND cable (for ground connection). For all CMOS-MEA5000-Systems.

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mcs-product-no-image

CMOS-TH - CMOS tissue holder

CMOS tissue holder for CMOS-MEA5000-System

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CMOS-DC

CMOS dark chamber (CMOS-DC)

CMOS dark chamber for CMOS-MEA5000-System

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C-BNC-Lemo2m

C-BNC-Lemo1m

Cable with one Lemo and one BNC connector, 1m.

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Publications

Please note: Currently, our publications library includes articles up to 2021 only. Contact us for publications from 2022 – present. Contact Us

Höfling L, Berens P, Zeck G (2019) Probing and predicting ganglion cell responses to smooth electrical stimulation in healthy and blind mouse retina. bioRxiv:609826.

Wickham J, Corna A, Schwarz N, Uysal B, Layer N, Wuttke TV, Koch H, Zeck G (2019) Human cerebrospinal fluid induces neuronal excitability changes in resected human neocortical and hippocampal brain slices. bioRxiv:730036.

Yger P, Spampinato GL, Esposito E, Lefebvre B, Deny S, Gardella C, Stimberg M, Jetter F, Zeck G, Picaud S, Duebel J, Marre O (2018) A spike sorting toolbox for up to thousands of electrodes validated with ground truth recordings in vitro and in vivo. Elife 7.

Bertotti G, Jetter F, Keil S, Dodel N, Schreiter M, Wolansky D, Boucsein C, Boven KH, Zeck G (2017) Optical Stimulation Effects on TiO2 Sensor Dielectric Used in Capacitively-Coupled High-Density CMOS Microelectrode Array. IEEE Electron Device Letters 38.

Zeck G, Jetter F, Channappa L, Bertotti G, Thewes R (2017) Electrical Imaging: Investigating Cellular Function at High Resolution. Advanced Biosystems:1700107-n/a.

Channappa L (2016) Electrical Imaging of Aberrant Activity in Neural Tissues Using High Density Microelectrode Arrays Medizinischen Fakultät.

Leibig C, Wachtler T, Zeck G (2016) Unsupervised neural spike sorting for high-density microelectrode arrays with convolutive independent component analysis. Journal of Neuroscience Methods 271:1-13.

Yger P, Spampinato GLB, Esposito E, Lefebvre B, Deny S, Gardella C, Stimberg M, Jetter F, Zeck G, Picaud S, Duebel J, Marre O (2016) Fast and accurate spike sorting in vitro and in vivo for up to thousands of electrodes. bioRxiv.

Bertotti G, Velychko D, Dodel N, Keil S, Wolansky D, Tillak B, Schreiter M, Grall A, Jesinger P, Möller A, Boven KH, Röhler S, Eickenscheidt M, Stett A, Zeck G, Thewes R (2014) A CMOS-Based Sensor Array for In-Vitro Neural Tissue Interfacing with 4225 Recording Sites and 1024 Stimulation Sites. In: BioCAS. Lausanne.

Eickenscheidt M, Zeck G (2014) Action potentials in retinal ganglion cells are initiated at the site of maximal curvature of the extracellular potential. J Neural Eng 11:036006.

Stutzki H, Leibig C, Andreadaki A, Fischer D, Zeck G (2014) Inflammatory stimulation preserves physiological properties of retinal ganglion cells after optic nerve injury. Front Cell Neurosci 8:38.

Eickenscheidt M, Jenkner M, Thewes R, Fromherz P, Zeck G (2012) Electrical stimulation of retinal neurons in epiretinal and subretinal configuration using a multicapacitor array. J Neurophysiol 107:2742-2755.

Zeck G, Lambacher A, Fromherz P (2011) Axonal transmission in the retina introduces a small dispersion of relative timing in the ganglion cell population response. PLoS ONE 6:e20810.

 

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