MEA2100-Systems

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Overview

MEA Technology

New to microelectrode array (MEA) in vitro technology?

Get an overview of the technical basics and suitable applications on our site about MEA solutions.

The MEA2100-System is the most versatile in vitro recording system from Multi Channel Systems. You can record from neuronal or cardiac cultures, stem cells, or brain or cardiac slices.

It is based on an idea from the 1970’s, when Thomas et al. found that electrical activity can be recorded extracellularly with microelectrode arrays (MEA). Over the decades, many peer-reviewed articles have proven that the MEA technology is indeed a very powerful tool in electrophysiology research and the technology around the MEA has improved significantly.

Today, the MEA2100-System is a very compact solution with integrated amplifier and stimulus generator, temperature control, and the option for real-time signal detection and feedback.

The main advantage of the MEA2100-System is its flexibility. Various headstage types facilitate the usage of different MEAs. You can record from up to 4 MEAs in parallel, all at a sampling rate of 50 kHz per channel, ensuring an excellent data quality.

For more detailed information, please click on the description tab above.

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MCS-IFB

As part of the system, the MCS-IFB 3.0 Multiboot is a new interface board generation which is able to receive data from a MEA2100(-Mini)-Headstage, a Multiwell-MEA-Headstage, a CMOS-MEA5000-Headstage, a MEA2100-Beta-Screen-Headstage, a MCS-SCU or a W2100-Receiver. This makes cost-effective combinations with only one interface board and multiple recording systems possible. You can establish for example your experiments on 60, 120, or 256 electrodes with the MEA2100-System, then add the Multiwell-MEA-Headstage and start high-throughput screening. It's also possible to use the same interface board for in vitro MEA experiments and tethered / wireless in vivo recordings. This leaves you with even more flexibility in switching between possible configurations for your specific research needs.

Key features:

Real-time signal detection and feedback*
Freely programmable DSP*
Multiple inputs/outputs, including digital, analog, and audio
SuperSpeed USB 3.0 ports

* applicable for MEA2100(-Mini), ME2100, and W2100

Read more technical specifications

Description

System Overview

The MEA100-System consists of several components: MEAs, headstage, interface board, PC with software, temperature controller, as well as an optional perfusion cannula and peristaltic perfusion pump. The system is very flexible, regarding electrode count (32, 60, 120 or 256) and number of MEAs that can be recorded from (1-4). By exchanging single hardware components, it is easy to change the set-up anytime. Please click on the arrows on the right to learn more about the single components.

For a fixed set-up with basic components, we also offer the MEA2100-Lite.

MEAs

The recording process starts at the MEA, the microelectrode array with embedded electrodes. You can culture your cells directly on the MEA or place your slices on it. Normally, it is equipped with a ring, which serves as a culture chamber.

The planar electrodes with a dimension of typically 10-30 µm are arranged in a square recording field where the spacing between these electrodes is in a range of 30-700 µm. The electrodes are embedded in glass substrate with a size of 5x5 cm.

Multi Channel Systems offers the widest variety of MEA layouts. Depending on your headstage, you can use MEAs with 32, 60, 120 or 256 electrodes. You find the complete range of MEAs here.

Headstage

The headstage is the core element of the system. It houses and heats the MEA, amplifies and digitizes the signals and has an integrated stimulus generator.

MEA2100-headstages are available in different variants. You can either place one 32-electrode MEA, one 60-electrode MEA, one 120-electrode MEA, one 256-electrode MEA, two 32-electrode MEA or two 60-electrode MEAs in the headstage. The contact unit of the MEA-headstage can be changed according to your experimental needs. The rest of the setup is not affected, so changing the contact unit is simple, quick, and cost-effective.

The lid of the headstage can be opened easily and the MEA is placed in the headstage from the top. By closing the lid, the contact pads surrounding the MEA connect to the contact pins.

The built-in amplifier makes sure that the recorded signals are amplified close to the signal source, thereby minimizing noise. The data is then sampled at 50 kHz/channel on all channels simultaneously, ensuring an excellent data quality.

The headstage also provides an integrated stimulator, which can generate current or voltage stimulation signals on three independent channels (two for MEA2100-256-Systems) per MEA slot. You can select the stimulation electrodes and design the signal shape via the included software.

For long-term recordings, Multi Channel Systems offers a variety of accessories: You can either cover the ring on the MEA with a semipermeable membrane or place a C02-chamber on the MEA slot. Please talk to your product consultant to find the right solution for your application.

Integrated stimulator

The integrated stimulus generator offers up to 3 different stimulation patterns (monophasic, biphasic, bursts) per available MEA. You can choose between current and voltage stimulation and select each electrode for stimulation. All configurations (stimulation patterns, output, and electrodes) are defined via the included Multi Channel Experimenter data acquisition software, so you can control all parameters of your experiment from within a single program.

Higher throughput

Your MEA2100-System can also consist of two headstages. You can then run two or four independent experiments at the same time. The data acquisition software opens one instance per MEA, so you can select all settings individually for each MEA.

Temperature control and perfusion

In the MEA2100-headstage, there is a heating element right beneath the MEA. It is controlled by the included temperature controller, so the temperature of your sample is observed and kept stable at all times. You can select the desired temperature at the device itself or using the included control software TCx-Control.

Multi Channel Systems also offer the MEA2100-System with enhanced perfusion, meaning that the system comes with a heatable perfusion cannula, another temperature controller, and a peristaltic perfusion pump.

The peristaltic pump (PPS2) has two independent channels. The first channel will transport your solution via the perfusion cannula to the sample. The perfusion cannula has a heating element, which is controlled by the temperature controller, so you can define the temperature of your solution. The second channel of the PPS2 can be set independent from the inlet and will take care of the outflow.

The perfusion cannula as well as the outlet tube are hold by magnetic perfusion holders, which can be positioned freely on the headstage.

When ordering a MEA2100-System with enhanced perfusion, you will receive one perfusion cannula and one peristaltic pump per available MEA slot.

Interface board

The interface board receives data from the headstage via a high speed eSATA cable. In the interface board, you find a freely programmable digital signal processor, which can be used for real-time signal detection and feedback. Moreover, you find various analog and digital in- and outputs for synchronization with other instruments. The interface board connects to the computer via USB 3.0 SuperSpeed. The MCS-IFB 3.0 Multiboot is a new interface board generation which is able to receive data from MEA2100-Headstages, a Multiwell-MEA-Headstage, an CMOS-MEA5000-Headstage, MCS-SCU, or a W2100-Receiver. This makes cost-effective combinations with only one interface board and multiple recording systems possible.

Real-time signal detection and feedback

Real-time signal detection/feedback is integrated in all MEA2100-60/120/256-Systems. It is an essential feature if you need fast and predictable reactions related to recorded analog signals without time delay. Normally, the signal must be analyzed by the computer, which leads to an unpredictable time delay of the stimulus of at least 100 ms. By moving the analysis from the PC to the DSP (Digital Signal Processor) integrated in the interface board of the MEA2100-System, the detour is obsolete and the time delay reduced well below 1 ms. Simply define the condition for the feedback and download it to the interface board (1). During recording (2), the DSP filters the data and detects spikes (3), checking whether your condition is fulfilled. When a designated event is detected, the integrated stimulus generator generates the stimulus pulse (4).

Please note that you need a third-party software for programming the DSP. Please contact Multi Channel Systems for more information.

Computer and software

The last component of the system is the computer with the software package Multi Channel Suite. The computer is not included in the scope of delivery; however, you can use any computer with a USB connector. What is included, is the Multi Channel Suite software.

It consists of three programs and updates are available for free here.

Multi Channel Experimenter is the data acquisition and online analysis tool. With an easy-to-use drag’n’drop interface, you simply create your virtual experiment with e.g. data source, filters, spike detection, and recorder. The software indicates the battery level and signal quality and displays the data in real-time.
Multi Channel Analyzer is the offline analysis tool. You just import the data recorded with the Multi Channel Experimenter and then define your in-depth analysis with more instruments. The Multi Channel Analyzer also supports synchronized video input. This is an advantageous feature when doing behavioral research with freely moving animals. The video data and electrophysiological recordings are displayed in parallel and you can easily skip through the data from one event to the next.
Multi Channel DataManager facilitates the data export for analysis with third-party programs. It supports all files generated with the Multi Channel Experimenter and then exports the data into HDF5 (e.g. Matlab, Python), .nex (Neuroexplorer) or .ced (Spike 2). Independent of the file format, the export is done quickly and a data compresssion is included.

Support and Sales team: Always there for you

Multi Channel Systems has a team of highly-qualified scientists, whose only task is to help you with any issue you might have. No matter whether you want to know whether your biological sample is suitable for MEA recordings or if you have a specific software question: Our support team is here to help you.

We have scientists who earned their PhDs in the fields of biology, biophysics, and biochemistry and specialized in:

Neuronal electrophysiology
Cardiac electrophysiology
Xenopus oocyte research
Patch Clamp

Our sales team has years of experience in electrophysiology, too. They can help you in choosing the right system for your specific application, give you advice on the general set-up and useful accessories. They are happy to visit you in your lab anytime to:

Make a demonstration of our systems
Help you with the installation of a new system
Give you training on hard- and software
Discuss any issues you might have with your application

Worldwide, we are supported by our distribution partners. We have long-lasting cooperations with all of our partners and they are regularly trained on our equipment. Be sure that they have the expertise to advise you on all MCS-Systems.

Please do not hesitate to contact us. Normally, we reply to you within 24 hours. You can contact us via:

Phone +49 7121 90925 25
Email support [at] multichannelsystems.com (Support Team); sales [at] multichannelsystems.com (Sales Team)
Contact form
User forum

Benefits

The main benefits of the MEA2100-System are:

Versatile system for a variety of applications
Very flexible because of different headstage types and possibility to connect two headstages to one interface board
Stimulation integrated in MEA-headstage (current and voltage)
Recording and stimulation controlled from within one software
Large variety of microelectrode arrays
Real-time signal detection and feedback possible
Powerful and flexible software Multi Channel Suite with unlimited upgrades included

Media

Videos:

Introduction to MEA2100 System Webinar Recording 11am

Introduction to MEA2100 System Webinar Recording 3pm

Products

Documents

Manual:

MEA2100-System_Manual.pdf

MEA2100-System_InstallationGuide.pdf

MEA-Systems_System Suggestions.pdf

Brochure:

MEA2100-Brochure.pdf

Neuro-Applications-InVitro_Brochure.pdf

MEAs

60MEA100/10iR-ITO

Standard microelectrode array:

TiN electrodes, SiN isolator, contact pads and tracks transparent (ITO), with 1 internal reference electrode, electrode grid 8x8, 59 recording electrodes, electrode spacing 100µm, electrode diameter 10µm, warranty: 6 months.

60MEA100/10iR-Ti

Standard Microelectrode array:

TiN electrodes, SiN isolator, contact pads and tracks opaque (TiN), with 1 internal reference electrode, electrode grid 8x8, 60 electrodes, electrode spacing 100, electrode diameter 10, warranty: 6 months.

60ThinMEA100/10iR-ITO

Microelectrode array with thin recording field:
180 µm thin recording area, TiN electrodes, SiN isolator, ITO conductive strips, with 1 internal reference electrode, electrode grid 8x8, 59 recording electrodes, electrode spacing 100 µm, electrode diameter 10 µm, warranty: 6 months.

60MEA200/10iR-ITO

Standard Microelectrode array:

TiN electrodes, SiN isolator, contact pads and tracks transparent (ITO), with internal reference electrode, electrode grid 8x8, 60 electrodes, electrode spacing 200µm, electrode diameter 10µm, warranty: 6 months.

60MEA200/10iR-Ti

Standard Microelectrode array:

TiN electrodes, SiN isolator, contact pads and tracks opaque (TiN), with internal reference electrode, electrode grid 8x8, 60 electrodes, electrode spacing 200µm, electrode diameter 10µm, warranty: 6 months.

60MEA200/30iR-ITO

Standard Microelectrode array:

60MEA200/30iR-Ti

Standard Microelectrode array:

60ThinMEA200/30iR-ITO

Microelectrode array with thin recording field:

180µm thin recording area, TiN electrodes, SiN isolator, ITO conductive strips, with internal reference electrode, electrode grid 8x8, 60 electrodes, electrode spacing 200µm, electrode diameter 30µm, warranty: 6 months.

60pMEA200/30iR-Ti

Microelectrode array, perforated layout:

TiN electrodes, Polyimid isolator, contact pads and tracks opaque (TiN on glass carrier), with internal reference electrode, electrode grid 8x8, 60 electrodes, electrode spacing 200µm, electrode diameter 30µm, warranty: 6 months.

60EcoMEA

Low priced microelectrode array:

Gold electrodes and tracks, with internal reference electrode, electrode grid 8x8, 60 electrodes, electrode spacing 700µm, electrode diameter 100µm, warranty: 6 months.

60EcoMEA-Glass

Low priced microelectrode array:

Gold electrodes and tracks, base material: glass, with internal reference electrode, electrode grid 8x8, 60 electrodes, electrode spacing 700µm, electrode diameter 100µm, warranty: 6 months.

60SquareMEA200/50iR-Ti

Standard microelectrode array:
TiN electrodes (square), SiN isolator, Contact pads and tracks opaque (TiN), With 1 internal reference electrode, Electrode grid 8x8, 59 recording electrodes, Electrode spacing 200 µm, Electrode size 50 µm x 50 µm, Warranty: 6 months.

60PedotMEA200/30iR-Au

PEDOT-CNT microelectrode array:
PEDOT-CNT electrodes, SiN isolator, Contact pads and tracks opaque (Au), with 1 internal reference electrode, electrode grid 8x8, recording electrodes, electrode spacing 200 µm, electrode diameter 30 µm, warranty: 6 months.

These electrodes feature some superior properties:

Ideally suited for stimulation
Excellent biocompatibility and cell adhesion
Reproducible low impedance

Please find more information on PEDOT-CNT microelectrode arrays in the flyer.

60MEA500/10iR-Ti

Standard Microelectrode array:

TiN electrodes, SiN isolator, contact pads and tracks opaque (TiN), with internal reference electrode, electrode grid 6x10, 60 electrodes, electrode spacing 500µm, electrode diameter 10µm, warranty: 6 months.

60MEA500/30iR-Ti

Standard Microelectrode array:

60pMEA100/30iR-Ti

Microelectrode array, perforated layout:

TiN electrodes, Polyimid isolator, contact pads and tracks opaque (TiN on glass carrier), with internal reference electrode, electrode grid 6x10, 60 electrodes, electrode spacing 100µm, electrode diameter 30µm, warranty: 6 months.

60HDMEA30/10iR-ITO

High dense Microelectrode array:

Double recording field (500µm in-between fields), TiN electrodes, SiN isolator, contact pads and tracks transparent (ITO), with internal reference electrode, electrode grid 2x(5x6), 60 electrodes, electrode spacing 30µm, electrode diameter 10µm, warranty: 6 months.

60ThinMEA30/10iR-ITO

Microelectrode array with thin recording field:

180µm thin recording area, TiN electrodes, SiN isolator, ITO conductive strips, with internal reference electrode, electrode grid 2x(5x6), 60 electrodes, electrode spacing 30, electrode diameter 10, warranty: 6 months.

60HexaMEA40/10iR-ITO

Microelectrode array, hexagonal layout:

TiN electrodes, SiN isolator, contact pads and tracks transparent (ITO), with internal reference electrode, electrode grid hexagonal, 60 electrodes, electrode spacing 40µm, electrode diameter 10µm, warranty: 6 months.

60-6wellMEA200/30iR-Ti

Microelectrode array with 6 recording areas, circular layout:

Tin electrodes, SiN isolator, contact pads and tracks opaque (TiN), with internal reference electrode in each area, electrode grid 3x3 in each area, 54 electrodes, electrode spacing 200µm, electrode diameter 30µm, warranty: 6 months.

60-4QMEA1000iR-Ti

4 quadrants microelectrode array:

TiN electrodes, SiN isolator, contact pads and tracks opaque (TiN), with internal reference electrode, electrode grid 4x (1x4 + 1x5 + 1x4) + center line 1x7, 60 electrodes, electrode spacing 200µm inside the quadrants; 1000µm between the quadrants, electrode diameter 30µm, warranty: 6 months.

120MEA30/10iR-ITO

Microelectrode array for MEA2100-HS120:

TiN electrodes, SiN isolator, contact pads and tracks transparent (ITO), with 4 internal reference electrodes, electrode grid 12x12, 120 recording electrodes, electrode spacing 30µm, electrode diameter 10µm, warranty: 6 months

120MEA100/30iR-ITO

Microelectrode array for MEA2100-HS120:

TiN electrodes, SiN isolator, contact pads and tracks transparent (ITO), with 4 internal reference electrodes, electrode grid 12x12, 120 recording electrodes, electrode spacing 100µm, electrode diameter 30µm, warranty: 6 months

120MEA200/30iR-Ti

Microelectrode array for MEA2100-HS120:

TiN electrodes, SiN isolator, contact pads and tracks opaque (Ti), with internal reference electrodes, electrode grid 12x12, 124 electrodes, electrode spacing 200µm, electrode diameter 30µm, warranty: 6 months.

120MEA1000-1500/30iR-Ti

Microelectrode array for MEA2100-HS120:

TiN electrodes, SiN isolator, contact pads and tracks opaque (Ti), with 4 internal reference electrodes, electrode grid 12x10, 120 electrodes, electrode spacing 1000 µm vertical, 1500 µm horizontal, electrode diameter 30 µm, with plastic ring with thread, warranty: 6 months.

120pMEA100/30iR-Ti

Perforated microelectrode array for MEA2100-HS120:

TiN electrodes, polyimid isolator, contact pads and tracks opaque (Ti on glass carrier), with 4 internal reference electrode, electrode grid 12x12, 120 recording electrodes, electrode spacing 100µm, electrode diameter 30µm, warranty: 6 months.

120pMEA200/30iR-Ti

Perforated microelectrode array for MEA2100-HS120:

TiN electrodes, polyimid isolator, contact pads and tracks opaque (Ti on glass carrier), with 4 internal reference electrode, electrode grid 12x12, 120 recording electrodes, electrode spacing 200µm, electrode diameter 30µm, warranty: 6 months.

pMEA32S12-L1

Microelectrode array, perforated layout for USB-MEA32STIM4-System and MEA2100-HS(2x)32:

Polyimide foil on ceramic carrier, dimension 49x25 mm, total area of perforation 8 mm², TiN electrodes, Polyimide foil isolator, contact pads and tracks opaque Ti, with internal reference electrode, recording electrode grid 1x10+1x12+1x10, stimulation electrode grid 2x6, 32 recording electrodes, electrode spacing 90 and 150 µm, electrode diameter 30 µm, 12 stimulation electrodes, electrode spacing 100 and 125 µm, electrode diameter 50 µm, warranty: 6 months.

pMEA32S12-L2

Microelectrode array, perforated layout for USB-MEA32STIM4-System and MEA2100-HS(2x)32:

Polyimide foil on ceramic carrier, dimension 49x25 mm, total area of perforation 8 mm², TiN electrodes, Polyimide foil isolator, contact pads and tracks opaque Ti, with internal reference electrode, recording electrode grid 1x10+1x12+1x10, stimulation electrode grid 6x2, 32 recording electrodes, electrode spacing 90 and 150 µm, electrode diameter 30 µm, 12 stimulation electrodes, electrode spacing 90 and 150 µm, electrode diameter 50 µm, warranty: 6 months.

pMEA32S12-L3

Microelectrode array, perforated layout for USB-MEA32STIM4-System and MEA2100-HS(2x)32:

Polyimide foil on ceramic carrier, dimension 49x25 mm, total area of perforation 8 mm², TiN electrodes, Polyimide foil isolator, contact pads and tracks opaque Ti, with internal reference electrode, recording electrode grid 1x10+1x12+1x10, stimulation electrode grid 3x4, 32 recording electrodes, electrode spacing 90 and 150 µm, electrode diameter 30 µm, 12 stimulation electrodes, electrode spacing 90 and 100 µm, electrode diameter 50 µm, warranty: 6 months.

pMEA32S12-L4

Microelectrode array, perforated layout for USB-MEA32STIM4-System and MEA2100-HS(2x)32:

Polyimide foil on ceramic carrier, dimension 49x25 mm, total area of perforation 8 mm², TiN electrodes, Polyimide foil isolator, contact pads and tracks opaque Ti, with internal reference electrode, recording electrode grid 4x8, stimulation electrode grid 2x6, 32 recording electrodes, electrode spacing 100 and 100 µm, electrode diameter 30 µm, 12 stimulation electrodes, electrode spacing 100 and 100 µm, electrode diameter 50 µm, warranty: 6 months.

256MEA30/8iR-ITO

Microelectrode array for USB-MEA256-System and MEA2100-HS256:
TiN electrodes, SiN isolator, contact pads and tracks transparent (ITO), with 4 internal reference electrodes, electrode grid 16x16, 252 recording electrodes, electrode spacing 30µm, electrode diameter 8µm, warranty: 6 months

Please note: Channel maps in the Multi Channel Suite software are dependent on the recording system you are using (USB-MEA256-System or MEA2100-256-System).

256MEA60/10iR-ITO

Microelectrode array for MEA2100-HS256 and USB-MEA256-System:

TiN electrodes, SiN isolator, contact pads and tracks transparent (ITO), with internal reference electrode, electrode grid 16x16, 256 electrodes, electrode spacing 60µm, electrode diameter 10µm, warranty: 6 months.

Please note: Channel maps in the Multi Channel Suite software are dependent on the recording system you are using (USB-MEA256-System or MEA2100-256-System).

256MEA100/30iR-ITO

Microelectrode array for USB-MEA256-System and MEA2100-HS256:

TiN electrodes, SiN isolator, contact pads and tracks transparent (ITO), with internal reference electrode, electrode grid 16x16, 256 electrodes, electrode spacing 100µm, electrode diameter 30µm, warranty: 6 months.

Please note: Channel maps in the Multi Channel Suite software are dependent on the recording system you are using (USB-MEA256-System or MEA2100-256-System).

256MEA200/30iR-ITO

Microelectrode array for USB-MEA256-System and MEA2100-HS256:

Please note: Channel maps in the Multi Channel Suite software are dependent on the recording system you are using (USB-MEA256-System or MEA2100-256-System).

256ThinMEA200/30iR-ITO

Microelectrode array with 256 electrodes on thin recording field for USB-MEA256-System and MEA2100-HS256:
180 µm thin recording area, TiN electrodes, SiN isolator, ITO conductive strips, with 4 internal reference electrodes, electrode grid 16x16, 252 recording electrodes, electrode spacing 200 µm, electrode diameter 30 µm, without ring, warranty: 6 months

Please note: Channel maps in the Multi Channel Suite software are dependent on the recording system you are using (USB-MEA256-System or MEA2100-256-System).

256-6wellMEA200/30iR-ITO

6-well microelectrode array for USB-MEA256-System and MEA2100-HS256:

TiN electrodes, SiN isolator, contact pads and tracks transparent (ITO), with 6 internal reference electrodes, electrode grid 7x6 in each well, 252 recording electrodes and 6 internal reference electrodes, 6-well layout, 42 recording electrodes per well, electrode spacing 200µm, electrode diameter 30µm, warranty: 6 months.

Please note: Channel maps in the Multi Channel Suite software are dependent on the recording system you are using (USB-MEA256-System or MEA2100-256-System).

256-9wellMEA300/30iR-ITO

9-well microelectrode array for USB-MEA256-System and MEA2100-HS256:

TiN electrodes, SiN isolator, contact pads and tracks transparent (ITO), with internal reference electrodes, electrode grid 6x5 recording + 2 stimulation electrodes in each well, 252 electrodes plus 9 internal reference electrodes, 9 well layout, 26 recording electrodes per well, electrode spacing 300µm, electrode diameter 30µm, warranty: 6 months.

Please note: Channel maps in the Multi Channel Suite software are dependent on the recording system you are using (USB-MEA256-System or MEA2100-256-System).

Accessories

Tabs

Products

Publications

MEA2100

Aziz Q, Finlay M, Montaigne D, Ojake L, Li Y, Anderson N, Ludwig A, Tinker A (2018) ATP-sensitive potassium channels in the sinoatrial node contribute to heart rate control and adaptation to hypoxia. J Biol Chem.

Brouwer S, Hoffmeister T, Gresch A, Schonhoff L, Dufer M (2018) Resveratrol Influences Pancreatic Islets by Opposing Effects on Electrical Activity and Insulin Release. Mol Nutr Food Res.

Burke JN, Savell KE, Bunner KD (2018) CRISPR/dCas9-Mediated Upregulation of Reelin and Neuronal Excitability. Metamorphosis.

Chong SA, Balosso S, Vandenplas C, Szczesny G, Hanon E, Claes K, Van Damme X, Danis B, Van Eyll J, Wolff C, Vezzani A, Kaminski RM, Niespodziany I (2018) Intrinsic Inflammation Is a Potential Anti-Epileptogenic Target in the Organotypic Hippocampal Slice Model. Neurotherapeutics.

Failor SW, Ng A, Cheng HJ (2018) Monocular enucleation alters retinal waves in the surviving eye. Neural Dev 13:4.

Kodama NX, Feng T, Ullett JJ, Chiel HJ, Sivakumar SS, Galan RF (2018) Anti-correlated cortical networks arise from spontaneous neuronal dynamics at slow timescales. Sci Rep 8:666.

Kshirsagar P, Martina M, D. JP, Buckenmaier S, Kraushaar U, Chassé T, Fleischer M, Burkhardt CJ (2018) Semitransparent Carbon Microelectrodes for Opto- and Electrophysiology. JOURNAL OF MICROMECHANICS AND MICROENGINEERING.

Ma J, Ma S, Yin C, Wu H (2018) Matrine reduces susceptibility to post-infarct atrial fibrillation in rats due to anti-fibrotic properties. J Cardiovasc Electrophysiol.

Ma J, Ma S, Yin C, Wu H (2018) Shengmai San-derived herbal prevents the development of a vulnerable substrate for atrial fibrillation in a rat model of ischemic heart failure. Biomedicine & Pharmacotherapy 100:156-167.

Millard D, Dang Q, Shi H, Zhang X, Strock C, Kraushaar U, Zeng H, Levesque P, Lu HR, Guillon JM, Wu JC, Li Y, Luerman G, Anson B, Guo L, Clements M, Abassi YA, Ross J, Pierson J, Gintant G (2018) Cross-Site Reliability of Human Induced Pluripotent Stem-Cell Derived Cardiomyocyte Based Safety Assays using Microelectrode Arrays: Results from a Blinded CiPA Pilot Study. Toxicol Sci.

Rodgers J, Hughes S, Pothecary CA, Brown LA, Hickey DG, Peirson SN, Hankins MW (2018) Defining the impact of melanopsin missense polymorphisms using in vivo functional rescue. Hum Mol Genet.

Sardi S, Vardi R, Goldental A, Sheinin A, Uzan H, Kanter I (2018) Adaptive nodes enrich nonlinear cooperative learning beyond traditional adaptation by links. Scientific Reports 8:5100.

Takeuchi H, Horie S, Moritoh S, Matsushima H, Hori T, Kimori Y, Kitano K, Tsubo Y, Tachibana M, Koike C (2018) Different Activity Patterns in Retinal Ganglion Cells of TRPM1 and mGluR6 Knockout Mice. BioMed Research International 2018:6.

Aaser P, Knudsen M, Ramstad OH, van de Wijdeven R, Nichele S, Sandvig I, Tufte G, Bauer US, Halaas O, Hendseth S, Sandvig A, Valderhaug V (2017) Towards making a cyborg: A closed-loop reservoir-neuro system. In: ECAL 2017, pp 430-437. Lyon: MIT Press.

Aebersold MJ, Dermutz H, Demko L, Saenz Cogollo JF, Lin SC, Burchert C, Schneider M, Ling D, Forro C, Han H, Zambelli T, Voros J (2017) Local Chemical Stimulation of Neurons with the FluidFM. Chemphyschem.

Artyukhov AS, Dashinimaev EB, Tsvetkov VO, Bolshakov AP, Konovalova EV, Kolbaev SN, Vorotelyak EA, Vasiliev AV (2017) New genes for accurate normalization of qRT-PCR results in study of iPS and iPS-derived cells. Gene 626:234-240.

Bridges DC, Tovar KR, Wu B, Hansma PK, Kosik KS (2017) MEA Viewer: a High-performance Interactive Application for Visualizing Electrophysiological Data. bioRxiv.

Can UI, Nagarajan N, Vural DC, Zorlutuna P (2017) Muscle-Cell-Based “Living Diodes”. Advanced Biosystems 1:n/a-n/a.

Castro-Hernandez J, Adlard PA, Finkelstein DI (2017) Pramipexole restores depressed transmission in the ventral hippocampus following MPTP-lesion. Sci Rep 7:44426.

Dermutz H, Thompson-Steckel G, Forro C, de Lange V, Dorwling-Carter L, Voros J, Demko L (2017) Paper-based patterned 3D neural cultures as a tool to study network activity on multielectrode arrays. RSC Advances 7:39359-39371.

Ellis BW, Acun A, Can UI, Zorlutuna P (2017) Human iPSC-derived myocardium-on-chip with capillary-like flow for personalized medicine. Biomicrofluidics 11:024105.

Goineau S, Castagne V (2017) Proarrhythmic risk assessment using conventional and new in vitro assays. Regul Toxicol Pharmacol 88:1-11.

Jenkinson SP, Grandgirard D, Heidemann M, Tscherter A, Avondet M, Leib SL (2017) Embryonic Stem Cell-Derived Neurons Grown on Multi-Electrode Arrays as a Novel In vitro Bioassay for the Detection of Clostridium botulinum Neurotoxins. Frontiers in Pharmacology 8.

Kraushaar U, Guenther E, Hess D (2017) Addressing Functional Neurotoxicity Using the Microelectrode Array (MEA). In: Stem Cell-Derived Models in Toxicology. Methods in Pharmacology and Toxicology (Clements M, Roquemore L, eds). New York: Humana Press.

Kreutzer J, Yla-Outinen L, Maki AJ, Ristola M, Narkilahti S, Kallio P (2017) Cell culture chamber with gas supply for prolonged recording of human neuronal cells on microelectrode array. J Neurosci Methods 280:27-35.

Lane JD, Montaigne D, Tinker A (2017) Tissue-Level Cardiac Electrophysiology Studied in Murine Myocardium Using a Microelectrode Array: Autonomic and Thermal Modulation. J Membr Biol.

Li B, Yang H, Wang X, Zhan Y, Sheng W, Cai H, Xin H, Liang Q, Zhou P, Lu C, Qian R, Chen S, Yang P, Zhang J, Shou W, Huang G, Liang P, Sun N (2017) Engineering human ventricular heart muscles based on a highly efficient system for purification of human pluripotent stem cell-derived ventricular cardiomyocytes. Stem Cell Res Ther 8:202.

Liu H, Bridges D, Randall C, Solla SA, Wu B, Hansma P, Yan X, Kosik K, Bouchard K (2017) Use of a Neural Circuit Probe to Validate in silico Predictions of Inhibitory Connections. BioRxiv.

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Sardi S, Vardi R, Sheinin A, Goldental A, Kanter I (2017) New Types of Experiments Reveal that a Neuron Functions as Multiple Independent Threshold Units. Sci Rep 7:18036.

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Vardi R, Goldental A, Sheinin A, Sardi S, Kanter I (2017) Fast reversible learning based on neurons functioning as anisotropic multiplex hubs. EPL (Europhysics Letters) 118:46002.

Blanquie O, Liebmann L, Hubner CA, Luhmann HJ, Sinning A (2016) NKCC1-Mediated GABAergic Signaling Promotes Postnatal Cell Death in Neocortical Cajal-Retzius Cells. Cereb Cortex.

Buehler S, Stubbe M, Bonk S, Nissen M, Titipornpun K, Klinkenberg E-D, Baumann W, Gimsa J (2016) Cell Monitoring and Manipulation Systems (CMMSs) based on Glass Cell-Culture Chips (GC3s). Micromachines 7:106.

Chever O, Dossi E, Pannasch U, Derangeon M, Rouach N (2016) Astroglial networks promote neuronal coordination. Sci Signal 9:ra6.

Iftikhar H (2016) Transparent Indium Tin Oxide Microelectrode Arrays for Measuring Beating Cardiomyocytes.

Keren H, Marom S (2016) Long-range synchrony and emergence of neural reentry. Sci Rep 6:36837.

Knudsen AM (2016) NTNU Cyborg: A study into embodying Neuronal Cultures through Robotic Systems. Department of Engineering Cybernetics.

Kuusela J, Kim J, Rasanen E, Aalto-Setala K (2016) The Effects of Pharmacological Compounds on Beat Rate Variations in Human Long QT-Syndrome Cardiomyocytes. Stem Cell Rev.

Nozaki Y, Honda Y, Watanabe H, Saiki S, Koyabu K, Itoh T, Nagasawa C, Nakamori C, Nakayama C, Iwasaki H, Suzuki S, Washio I, Takahashi E, Miyamoto K, Yamanishi A, Endo H, Shinozaki J, Nogawa H, Kunimatsu T (2016) CSAHi study: Validation of multi-electrode array systems (MEA60/2100) for prediction of drug-induced proarrhythmia using human iPS cell-derived cardiomyocytes -assessment of inter-facility and cells lot-to-lot-variability. Regul Toxicol Pharmacol 77:75-86.

Pastore VP, Poli D, Godjoski A, Martinoia S, Massobrio P (2016) ToolConnect: A Functional Connectivity Toolbox for In vitro Networks. Front Neuroinform 10:13.

Sardi S, Goldental A, Amir H, Vardi R, Kanter I (2016) Vitality of Neural Networks under Reoccurring Catastrophic Failures. Sci Rep 6:31674.

Wang Q, Yang H, Bai A, Jiang W, Li X, Wang X, Mao Y, Lu C, Qian R, Guo F, Ding T, Chen H, Chen S, Zhang J, Liu C, Sun N (2016) Functional engineered human cardiac patches prepared from nature's platform improve heart function after acute myocardial infarction. Biomaterials 105:52-65.

Asakura K, Hayashi S, Ojima A, Taniguchi T, Miyamoto N, Nakamori C, Nagasawa C, Kitamura T, Osada T, Honda Y, Kasai C, Ando H, Kanda Y, Sekino Y, Sawada K (2015) Improvement of acquisition and analysis methods in multi-electrode array experiments with iPS cell-derived cardiomyocytes. J Pharmacol Toxicol Methods.

Bartsch H, Himmerlich M, Fischer M, Demkó L, Hyttinen J, Schober A (2015) LTCC-Based Multi-Electrode Arrays for 3D in Vitro Cell Cultures. Journal of Ceramic Science and Technology 6:315-324.

Charkhkar H (2015) Microelectrode Arrays for Neuronal Recordings: Developing Novel Technology and Applications. Doctor of Philosophy.

Finlay MC, Yeoh A, Vyas V, Harmer S, Huang C, Lambiase D, Tinker A (2015) Response to autonomic stimulation is blunted in a murine model of Burgade Syndrome Heart Rhythm 12:S324-S371.

Fleischer W, Theiss S, Slotta J, Holland C, Schnitzler A (2015) High-frequency voltage oscillations in cultured astrocytes. Physiol Rep 3.

Goldental A, Sabo P, Sardi S, Vardi R, Kanter I (2015) Mimicking Collective Firing Patterns of Hundreds of Connected Neurons using a Single-Neuron Experiment. Front Neurosci 9:508.

Goldental A, Vardi R, Sardi S, Sabo P, Kanter I (2015) Broadband macroscopic cortical oscillations emerge from intrinsic neuronal response failures. Front Neural Circuits 9:65.

Hess D, Kraushaar U, Cesare P, Rascher-Eggstein G, Guenther E (2015) A human integrated in vitro Neurotoxicity Safety Platform using hiPS neurons (Peri.4U neurons). In.

Kummer KK, El Rawas R, Kress M, Saria A, Zernig G (2015) Social Interaction and Cocaine Conditioning in Mice Increase Spontaneous Spike Frequency in the Nucleus Accumbens or Septal Nuclei as Revealed by Multielectrode Array Recordings. Pharmacology 95:42-49.

Lu C, Chen Q, Zhou T, Bozic D, Fu Z, Pan JQ, Feng G (2015) Micro-electrode array recordings reveal reductions in both excitation and inhibition in cultured cortical neuron networks lacking Shank3. Mol Psychiatry.

Ng TK, Yung JS, Choy KW, Cao D, Leung CK, Cheung HS, Pang CP (2015) Transdifferentiation of periodontal ligament-derived stem cells into retinal ganglion-like cells and its microRNA signature. Sci Rep 5:16429.

Shimizu H, Schredelseker J, Huang J, Lu K, Naghdi S, Lu F, Franklin S, Fiji HD, Wang K, Zhu H, Tian C, Lin B, Nakano H, Ehrlich A, Nakai J, Stieg AZ, Gimzewski JK, Nakano A, Goldhaber JI, Vondriska TM, Hajnoczky G, Kwon O, Chen JN (2015) Mitochondrial Ca(2+) uptake by the voltage-dependent anion channel 2 regulates cardiac rhythmicity. Elife 4.

Vardi R, Goldental A, Marmari H, Brama H, Stern EA, Sardi S, Sabo P, Kanter I (2015) Neuronal Response Impedance Mechanism Implementing Cooperative Networks with Low Firing Rates and Microsecond Precision. Frontiers in Neural Circuits 9.

Charkhkar H, Frewin C, Nezafati M, Knaack GL, Peixoto N, Saddow SE, Pancrazio JJ (2014) Use of cortical neuronal networks for in vitro material biocompatibility testing. Biosens Bioelectron 53:316-323.

Dossi E, Blauwblomme T, Nabbout R, Huberfeld G, Rouach N (2014) Multi-electrode Array Recordings of Human Epileptic Postoperative Cortical Tissue. J Vis Exp.

George JB, Abraham GM, Singh K, Ankolekar SM, Amrutur B, Sikdar SK (2014) Input coding for neuro-electronic hybrid systems. Biosystems 126C:1-11.

Goldental A, Guberman S, Vardi R, Kanter I (2014) A computational paradigm for dynamic logic-gates in neuronal activity. Front Comput Neurosci 8:52.

Grosser S, Queenan BN, Lalchandani RR, Vicini S (2014) Hilar Somatostatin Interneurons Contribute to Synchronized GABA Activity in an In Vitro Epilepsy Model. PLoS ONE 9:e86250.

Hagar M, Roni V, Ido K (2014) Chaotic and non-chaotic phases in experimental responses of a single neuron. EPL (Europhysics Letters) 106:46002.

Hammad M, Schmidt SL, Zhang X, Bray R, Frohlich F, Ghashghaei HT (2014) Transplantation of GABAergic Interneurons into the Neonatal Primary Visual Cortex Reduces Absence Seizures in Stargazer Mice. Cereb Cortex.

Imbrosci B, Neitz A, Mittmann T (2014) Focal cortical lesions induce bidirectional changes in the excitability of fast spiking and non fast spiking cortical interneurons. PLoS ONE 9:e111105.

Nieto-Posadas A, Flores-Martínez E, Lorea-Hernández J-J, Rivera-Angulo A-J, Pérez-Ortega J-E, Bargas J, Peña-Ortega F (2014) Change in network connectivity during fictive-gasping generation in hypoxia: prevention by a metabolic intermediate. Frontiers in Physiology 5.

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Schmidt SL, Iyengar AK, Foulser AA, Boyle MR, Frohlich F (2014) Endogenous cortical oscillations constrain neuromodulation by weak electric fields. Brain Stimul 7:878-889.

Vardi R, Marmari H, Kanter I (2014) Error correction and fast detectors implemented by ultrafast neuronal plasticity. Phys Rev E 89.

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MEA-256

Yger P, Spampinato GL, Esposito E, Lefebvre B, Deny S, Gardella C, Stimberg M, Jetter F, Zeck G, Picaud S, Duebel J, Marre O (2018) A spike sorting toolbox for up to thousands of electrodes validated with ground truth recordings in vitro and in vivo. Elife 7.

Ameline B, Tshilenge KT, Weber M, Biget M, Libeau L, Caplette R, Mendes-Madeira A, Provost N, Guihal C, Picaud S, Moullier P, Pichard V, Cronin T, Isiegas C (2017) Long-term expression of melanopsin and channelrhodopsin causes no gross alterations in the dystrophic dog retina. Gene Ther.

Eleftheriou CG, Cehajic-Kapetanovic J, Martial FP, Milosavljevic N, Bedford RA, Lucas RJ (2017) Meclofenamic acid improves the signal to noise ratio for visual responses produced by ectopic expression of human rod opsin. Mol Vis 23:334-345.

Ferrari U, Gardella C, Marre O, Mora T (2017) Closed-loop estimation of retinal network sensitivity reveals signature of efficient coding. bioRxiv.

Marcoux D, Xiao H-Y, Murali Dhar TG, Xie J, Lehman-McKeeman LD, Wu D-R, Dabros M, Yang X, Taylor TL, Zhou XD, Heimrich EM, Thomas R, McIntyre KW, Shi H, Levesque PC, Sun H, Yang Z, Marino AM, Cornelius G, D'Arienzo CJ, Gupta A, Pragalathan B, Rampulla R, Mathur A, Shen DR, Cvijic ME, Salter-Cid L, Lombardo LJ, Carter PH, Dyckman AJ (2017) Identification of potent tricyclic prodrug S1P1 receptor modulators. MedChemComm.

Marczenke M, Piccini I, Mengarelli I, Fell J, Ropke A, Seebohm G, Verkerk AO, Greber B (2017) Cardiac Subtype-Specific Modeling of Kv1.5 Ion Channel Deficiency Using Human Pluripotent Stem Cells. Front Physiol 8:469.

Neuille M, Cao Y, Caplette R, Guerrero-Given D, Thomas C, Kamasawa N, Sahel JA, Hamel CP, Audo I, Picaud S, Martemyanov KA, Zeitz C (2017) LRIT3 Differentially Affects Connectivity and Synaptic Transmission of Cones to ON- and OFF-Bipolar Cells. Invest Ophthalmol Vis Sci 58:1768-1778.

Shein-Idelson M, Pammer L, Hemberger M, Laurent G (2017) Large-scale mapping of cortical synaptic projections with extracellular electrode arrays. Nat Methods 14:882-890.

Dhar TGM, Xiao H-Y, Xie J, Lehman-McKeeman LD, Wu D-R, Dabros M, Yang X, Taylor TL, Zhou XD, Heimrich EM, Thomas R, McIntyre KW, Warrack B, Shi H, Levesque PC, Zhu JL, Hennan J, Balimane P, Yang Z, Marino AM, Cornelius G, D’Arienzo CJ, Mathur A, Shen DR, Cvijic ME, Salter-Cid L, Barrish JC, Carter PH, Dyckman AJ (2016) Identification and Preclinical Pharmacology of BMS-986104: A Differentiated S1P1 Receptor Modulator in Clinical Trials. ACS Medicinal Chemistry Letters 7:283-288.

Kofuji P, Mure LS, Massman LJ, Purrier N, Panda S, Engeland WC (2016) Intrinsically Photosensitive Retinal Ganglion Cells (ipRGCs) Are Necessary for Light Entrainment of Peripheral Clocks. PLoS ONE 11:e0168651.

Li S, Yang C, Zhang L, Gao X, Wang X, Liu W, Wang Y, Jiang S, Wong YH, Zhang Y, Liu K (2016) Promoting axon regeneration in the adult CNS by modulation of the melanopsin/GPCR signaling. Proc Natl Acad Sci U S A 113:1937-1942.

Sengupta A, Chaffiol A, Mace E, Caplette R, Desrosiers M, Lampic M, Forster V, Marre O, Lin JY, Sahel JA, Picaud S, Dalkara D, Duebel J (2016) Red-shifted channelrhodopsin stimulation restores light responses in blind mice, macaque retina, and human retina. EMBO Mol Med.

Wanke E, Gullo F, Dossi E, Valenza G, Becchetti A (2016) Neuron-glia crosstalk revealed in reverberating networks by simultaneous extracellular recording of spikes and astrocytes' glutamate transporter and K+ currents. J Neurophysiol:jn 00509 02016.

Yger P, Spampinato GLB, Esposito E, Lefebvre B, Deny S, Gardella C, Stimberg M, Jetter F, Zeck G, Picaud S, Duebel J, Marre O (2016) Fast and accurate spike sorting in vitro and in vivo for up to thousands of electrodes. bioRxiv.

Chen H, Zhao Y, Liu M, Feng L, Puyang Z, Yi J, Liang P, Zhang HF, Cang J, Troy JB, Liu X (2015) Progressive degeneration of retinal and superior collicular functions in mice with sustained ocular hypertension. Invest Ophthalmol Vis Sci 56:1971-1984.

Ju H, Dranias MR, Banumurthy G, VanDongen AM (2015) Spatiotemporal memory is an intrinsic property of networks of dissociated cortical neurons. J Neurosci 35:4040-4051.

Mace E, Caplette R, Marre O, Sengupta A, Chaffiol A, Barbe P, Desrosiers M, Bamberg E, Sahel JA, Picaud S, Duebel J, Dalkara D (2015) Targeting channelrhodopsin-2 to ON-bipolar cells with vitreally administered AAV Restores ON and OFF visual responses in blind mice. Mol Ther 23:7-16.

Nussinovitch U, Gepstein L (2015) Optogenetics for suppression of cardiac electrical activity in human and rat cardiomyocyte cultures. Neurophotonics 2:031204.

Pisano F, Altomare C, Cervio E, Barile L, Rocchetti M, Ciuffreda MC, Malpasso G, Copes F, Mura M, Danieli P, Viarengo G, Zaza A, Gnecchi M (2015) Combination of miRNA499 and miRNA133 exerts a synergic effect on cardiac differentiation. Stem Cells 33:1187-1199.

Rast G, Weber J, Disch C, Schuck E, Ittrich C, Guth BD (2015) An integrated platform for simultaneous multi-well field potential recording and Fura-2-based calcium transient ratiometry in human induced pluripotent stem cell (hiPSC)-derived cardiomyocytes. J Pharmacol Toxicol Methods.

Palacios-Munoz A, Escobar MJ, Vielma A, Araya J, Astudillo A, Valdivia G, Garcia IE, Hurtado J, Schmachtenberg O, Martinez AD, Palacios AG (2014) Role of connexin channels in the retinal light response of a diurnal rodent. Front Cell Neurosci 8:249.

Tkacik G, Marre O, Amodei D, Schneidman E, Bialek W, Berry MJ, 2nd (2014) Searching for collective behavior in a large network of sensory neurons. PLoS Comput Biol 10:e1003408.

Zhang M, D'Aniello C, Verkerk AO, Wrobel E, Frank S, Ward-van Oostwaard D, Piccini I, Freund C, Rao J, Seebohm G, Atsma DE, Schulze-Bahr E, Mummery CL, Greber B, Bellin M (2014) Recessive cardiac phenotypes in induced pluripotent stem cell models of Jervell and Lange-Nielsen syndrome: disease mechanisms and pharmacological rescue. Proc Natl Acad Sci U S A 111:E5383-5392.

Caspi O, Huber I, Gepstein A, Arbel G, Maizels L, Boulos M, Gepstein L (2013) Modeling of arrhythmogenic right ventricular cardiomyopathy with human induced pluripotent stem cells. Circ Cardiovasc Genet 6:557-568.

Feng L, Zhao Y, Yoshida M, Chen H, Yang JF, Kim TS, Cang J, Troy JB, Liu X (2013) Sustained ocular hypertension induces dendritic degeneration of mouse retinal ganglion cells that depends on cell type and location. Invest Ophthalmol Vis Sci 54:1106-1117.

Harris CA, Buckley CL, Nowotny T, Passaro PA, Seth AK, Kemenes G, O'Shea M (2012) Multi-neuronal refractory period adapts centrally generated behaviour to reward. PLoS ONE 7:e42493.

Marre O, Amodei D, Deshmukh N, Sadeghi K, Soo F, Holy TE, Berry MJ, 2nd (2012) Mapping a complete neural population in the retina. J Neurosci 32:14859-14873.

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